H R Gosker

Summary

Affiliation: Maastricht University
Country: The Netherlands

Publications

  1. ncbi request reprint Skeletal muscle fibre-type shifting and metabolic profile in patients with chronic obstructive pulmonary disease
    H R Gosker
    Dept of Pulmonology, University of Maastricht, The Netherlands
    Eur Respir J 19:617-25. 2002
  2. ncbi request reprint Skeletal muscle dysfunction in chronic obstructive pulmonary disease and chronic heart failure: underlying mechanisms and therapy perspectives
    H R Gosker
    Departments of Pulmonology and Physiology, Maastricht University, Maastricht, Netherlands
    Am J Clin Nutr 71:1033-47. 2000
  3. ncbi request reprint Reduced mitochondrial density in the vastus lateralis muscle of patients with COPD
    H R Gosker
    Dept of Respiratory Medicine, Maastricht University, Nutrition and Toxicology Research Institute Maastricht, PO Box 616, 6200 MD Maastricht, The Netherlands
    Eur Respir J 30:73-9. 2007
  4. ncbi request reprint Muscle metabolic modulation by chronic hypoxia
    Harry R Gosker
    Department of Respiratory Medicine, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    J Proteome Res 6:3400-1. 2007
  5. doi request reprint TNF-alpha impairs regulation of muscle oxidative phenotype: implications for cachexia?
    A H V Remels
    Department of Respiratory Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands
    FASEB J 24:5052-62. 2010
  6. ncbi request reprint Exercise training restores uncoupling protein-3 content in limb muscles of patients with chronic obstructive pulmonary disease
    Harry R Gosker
    Dept of Respiratory Medicine, Maastricht Univ, Nutrition and Toxicology Research Institute Maastricht, P O Box 616, 6200 MD Maastricht, The Netherlands
    Am J Physiol Endocrinol Metab 290:E976-81. 2006
  7. ncbi request reprint Altered antioxidant status in peripheral skeletal muscle of patients with COPD
    Harry R Gosker
    Department of Respiratory Medicine, Nutrition Toxicology and Environment Research Institute, Maastricht University, Maastricht, The Netherlands
    Respir Med 99:118-25. 2005
  8. ncbi request reprint Myopathological features in skeletal muscle of patients with chronic obstructive pulmonary disease
    H R Gosker
    Dept of Pulmonology, Nutrition Toxicology and Environment Research Institute Maastricht, Maastricht, The Netherlands
    Eur Respir J 22:280-5. 2003
  9. ncbi request reprint Uncoupling protein-3 content is decreased in peripheral skeletal muscle of patients with COPD
    H R Gosker
    Dept of Pulmonology, Maastricht University, Maastricht, The Netherlands
    Eur Respir J 22:88-93. 2003
  10. ncbi request reprint Striking similarities in systemic factors contributing to decreased exercise capacity in patients with severe chronic heart failure or COPD
    Harry R Gosker
    Department of Pulmonology, University of Maastricht, The Netherlands
    Chest 123:1416-24. 2003

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Skeletal muscle fibre-type shifting and metabolic profile in patients with chronic obstructive pulmonary disease
    H R Gosker
    Dept of Pulmonology, University of Maastricht, The Netherlands
    Eur Respir J 19:617-25. 2002
    ..Low oxidative capacity is closely related to the proportion of type-I fibres, but an additional reduction of oxidative enzyme activity is present within IIA fibres. Fibre-type abnormalities may be aggravated in emphysema...
  2. ncbi request reprint Skeletal muscle dysfunction in chronic obstructive pulmonary disease and chronic heart failure: underlying mechanisms and therapy perspectives
    H R Gosker
    Departments of Pulmonology and Physiology, Maastricht University, Maastricht, Netherlands
    Am J Clin Nutr 71:1033-47. 2000
    ....
  3. ncbi request reprint Reduced mitochondrial density in the vastus lateralis muscle of patients with COPD
    H R Gosker
    Dept of Respiratory Medicine, Maastricht University, Nutrition and Toxicology Research Institute Maastricht, PO Box 616, 6200 MD Maastricht, The Netherlands
    Eur Respir J 30:73-9. 2007
    ....
  4. ncbi request reprint Muscle metabolic modulation by chronic hypoxia
    Harry R Gosker
    Department of Respiratory Medicine, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    J Proteome Res 6:3400-1. 2007
    ..Proteome Res. 2007, 6(5), 1974-1984). For this, relatively young animals were used. In our communication, we note that, based on other literature, it is likely that the adaptive response of skeletal muscle to hypoxia attenuates with age...
  5. doi request reprint TNF-alpha impairs regulation of muscle oxidative phenotype: implications for cachexia?
    A H V Remels
    Department of Respiratory Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands
    FASEB J 24:5052-62. 2010
    ..In conclusion, these results demonstrate that TNF-α impairs muscle oxphen in a NF-κB-dependent manner...
  6. ncbi request reprint Exercise training restores uncoupling protein-3 content in limb muscles of patients with chronic obstructive pulmonary disease
    Harry R Gosker
    Dept of Respiratory Medicine, Maastricht Univ, Nutrition and Toxicology Research Institute Maastricht, P O Box 616, 6200 MD Maastricht, The Netherlands
    Am J Physiol Endocrinol Metab 290:E976-81. 2006
    ..We conclude that exercise-training can restore muscle UCP3 protein level in COPD, and the nature of this response complies with the hypothesis that UCP3 may protect against lipotoxicity...
  7. ncbi request reprint Altered antioxidant status in peripheral skeletal muscle of patients with COPD
    Harry R Gosker
    Department of Respiratory Medicine, Nutrition Toxicology and Environment Research Institute, Maastricht University, Maastricht, The Netherlands
    Respir Med 99:118-25. 2005
    ....
  8. ncbi request reprint Myopathological features in skeletal muscle of patients with chronic obstructive pulmonary disease
    H R Gosker
    Dept of Pulmonology, Nutrition Toxicology and Environment Research Institute Maastricht, Maastricht, The Netherlands
    Eur Respir J 22:280-5. 2003
    ..Also, in this group of clinically and weight stable chronic obstructive pulmonary disease patients, apoptosis appeared not to be involved in muscle pathology...
  9. ncbi request reprint Uncoupling protein-3 content is decreased in peripheral skeletal muscle of patients with COPD
    H R Gosker
    Dept of Pulmonology, Maastricht University, Maastricht, The Netherlands
    Eur Respir J 22:88-93. 2003
    ..The low uncoupling protein-3 content is independent of the loss of oxidative capacity observed in these patients...
  10. ncbi request reprint Striking similarities in systemic factors contributing to decreased exercise capacity in patients with severe chronic heart failure or COPD
    Harry R Gosker
    Department of Pulmonology, University of Maastricht, The Netherlands
    Chest 123:1416-24. 2003
    ....
  11. ncbi request reprint Muscle fiber type IIX atrophy is involved in the loss of fat-free mass in chronic obstructive pulmonary disease
    Harry R Gosker
    Department of Pulmonology, University of Maastricht, Maastricht, Netherlands
    Am J Clin Nutr 76:113-9. 2002
    ..Although the loss of peripheral muscle mass has been shown convincingly in chronic obstructive pulmonary disease (COPD), the underlying pathogenesis remains unclear...
  12. doi request reprint Extrapulmonary manifestations of chronic obstructive pulmonary disease in a mouse model of chronic cigarette smoke exposure
    Harry R Gosker
    Department of Respiratory Medicine, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Am J Respir Cell Mol Biol 40:710-6. 2009
    ..In this mouse model, chronic cigarette smoke exposure resulted in systemic features that closely resemble the early signs of the extrapulmonary manifestations observed in patients with COPD...
  13. pmc Muscle fibre type shifting in the vastus lateralis of patients with COPD is associated with disease severity: a systematic review and meta-analysis
    Harry R Gosker
    Department of Respiratory Medicine, NUTRIM, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Thorax 62:944-9. 2007
    ..A study was conducted to determine whether vastus lateralis muscle fibre type proportions are associated with COPD disease severity and to provide reference values for the proportions of fibre types in the vastus lateralis in COPD...
  14. ncbi request reprint Activation of alternative NF-κB signaling during recovery of disuse-induced loss of muscle oxidative phenotype
    A H V Remels
    NUTRIM School for Nutrition, Toxicology, and Metabolism, Department of Respiratory Medicine, Maastricht University Medical Center, Maastricht, The Netherlands
    Am J Physiol Endocrinol Metab 306:E615-26. 2014
    ..We conclude that RL-induced recovery of muscle OXPHEN is associated with activation of alternative NF-κB signaling. ..
  15. ncbi request reprint Peroxisome proliferator-activated receptor expression is reduced in skeletal muscle in COPD
    A H Remels
    Department of Respiratory Medicine, University of Maastricht, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    Eur Respir J 30:245-52. 2007
    ..Therefore, a disturbed expression of these regulatory factors may well underlie the disturbed skeletal muscle functioning in chronic obstructive pulmonary disease...
  16. doi request reprint Regulation of mitochondrial biogenesis during myogenesis
    A H V Remels
    Department of Respiratory Medicine, Maastricht University Medical Centre, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    Mol Cell Endocrinol 315:113-20. 2010
    ..In particular, PGC-1alpha and PPAR-alpha may be involved in the regulation of mitochondrial biogenesis during myogenesis...
  17. doi request reprint Peroxisome proliferator-activated receptors: a therapeutic target in COPD?
    A H Remels
    Dept of Respiratory Medicine, University of Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands
    Eur Respir J 31:502-8. 2008
    ..Proposed mechanisms will be outlined in the present article, as well as the therapeutic potential of peroxisome proliferator-activated receptor modulation in the treatment of skeletal muscle dysfunction...
  18. doi request reprint Classical NF-κB activation impairs skeletal muscle oxidative phenotype by reducing IKK-α expression
    A H V Remels
    NUTRIM School for Nutrition, Toxicology and Metabolism, Department of Respiratory Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands Electronic address
    Biochim Biophys Acta 1842:175-85. 2014
    ..We hypothesised that inflammation-induced classical NF-κB activation contributes to loss of muscle OXPHEN in COPD by reducing IKK-α expression...
  19. doi request reprint Regulation of skeletal muscle oxidative phenotype by classical NF-κB signalling
    A H V Remels
    NUTRIM School for Nutrition, Toxicology and Metabolism, Department of Respiratory Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands
    Biochim Biophys Acta 1832:1313-25. 2013
    ..Therefore, we hypothesised that muscle activation of classical NF-κB signalling is sufficient and required for inflammation-induced impairment of muscle OXPHEN...
  20. doi request reprint The mechanisms of cachexia underlying muscle dysfunction in COPD
    A H V Remels
    NUTRIM School for Nutrition, Toxicology and Metabolism, Department of Respiratory Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands
    J Appl Physiol (1985) 114:1253-62. 2013
    ..Furthermore, loss of peripheral muscle oxidative phenotype may increase the muscle's susceptibility to inflammation- and oxidative stress-induced muscle damage and wasting...
  21. ncbi request reprint Exercise-induced lactate increase in relation to muscle substrates in patients with chronic obstructive pulmonary disease
    M P Engelen
    Departments of Pulmonology and Surgery, University Hospital Maastricht, Maastricht, The Netherlands
    Am J Respir Crit Care Med 162:1697-704. 2000
    ..However, factors other than physical inactivity, such as Pa(O(2)) or DL(CO), play a role in the different La responses during exercise in subjects with different subtypes of COPD...
  22. ncbi request reprint Triggers and mechanisms of skeletal muscle wasting in chronic obstructive pulmonary disease
    R C J Langen
    NUTRIM School for Nutrition, Toxicology and Metabolism, Department of Respiratory Medicine, Maastricht University Medical Center, Maastricht, The Netherlands
    Int J Biochem Cell Biol 45:2245-56. 2013
    ..This article is part of a Directed Issue entitled: Molecular basis of muscle wasting. ..
  23. ncbi request reprint PPARgamma inhibits NF-kappaB-dependent transcriptional activation in skeletal muscle
    A H V Remels
    Department of Respiratory Medicine, Maastricht University, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    Am J Physiol Endocrinol Metab 297:E174-83. 2009
    ..These findings demonstrate that muscle-specific inhibition of NF-kappaB activation may be an interesting therapeutic avenue for treatment of several inflammation-associated skeletal muscle abnormalities...
  24. doi request reprint Pulmonary function in diabetes: a metaanalysis
    Bram van den Borst
    Department of Respiratory Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands
    Chest 138:393-406. 2010
    ..Research into the association between diabetes and pulmonary function has resulted in inconsistent outcomes among studies. We performed a metaanalysis to clarify this association...
  25. doi request reprint The pathophysiology of cachexia in chronic obstructive pulmonary disease
    Annemie M W J Schols
    Department of Respiratory Medicine, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, P O Box 5800, 6202 AZ, Maastricht, The Netherlands
    Curr Opin Support Palliat Care 3:282-7. 2009
    ..The focus of this review is on translation of putative mechanisms of altered energy metabolism and muscle maintenance in cachexia to clinical comparative and intervention studies on chronic obstructive pulmonary disease (COPD)...
  26. doi request reprint Systemic and pulmonary oxidative stress after single-leg exercise in COPD
    Evi M Mercken
    Departments of Respiratory Medicine, Maastricht University, Maastricht, The Netherlands
    Chest 136:1291-300. 2009
    ..Our aim for this study was to disentangle the contribution of muscular vs pulmonary oxidative stress during endurance exercise in patients with COPD...
  27. ncbi request reprint Systemic inflammation and skeletal muscle dysfunction in chronic obstructive pulmonary disease: state of the art and novel insights in regulation of muscle plasticity
    Alexander H Remels
    Department of Respiratory Medicine, Nutrition and Toxicology Research Institute, University of Maastricht, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    Clin Chest Med 28:537-52, vi. 2007
    ..This article describes state-of-the-art knowledge and novel insights in the role of inflammatory processes on several aspects of inflammation-related skeletal muscle pathology and offers new insights in therapeutic perspectives...
  28. ncbi request reprint The major limitation to exercise performance in COPD is inadequate energy supply to the respiratory and locomotor muscles vs. lower limb muscle dysfunction vs. dynamic hyperinflation. Missing pieces
    Harry R Gosker
    Department of Respiratory Medicine, Maastricht University, The Netherlands
    J Appl Physiol 105:761. 2008
  29. ncbi request reprint The functional, metabolic, and anabolic responses to exercise training in renal transplant and hemodialysis patients
    Eugénie C H van den Ham
    Department of Internal Medicine, University Hospital Maastricht, Maastricht, The Netherlands
    Transplantation 83:1059-68. 2007
    ..The aim of the study was to compare intrinsic muscular parameters between HD and RTx patients and controls, and to assess the response to exercise training on exercise capacity and muscular structure and function in these groups...
  30. ncbi request reprint ACE Gene Polymorphism in COPD
    Harry R Gosker
    Am J Respir Crit Care Med 170:572; author reply 572-3. 2004