J F Glatz

Summary

Affiliation: Maastricht University
Country: The Netherlands

Publications

  1. ncbi request reprint Molecular mechanism of cellular uptake and intracellular translocation of fatty acids
    J F Glatz
    Department of Physiology, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, The Netherlands
    Prostaglandins Leukot Essent Fatty Acids 57:3-9. 1997
  2. ncbi request reprint Unravelling the significance of cellular fatty acid-binding proteins
    J F Glatz
    Department of Physiology, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, The Netherlands
    Curr Opin Lipidol 12:267-74. 2001
  3. ncbi request reprint Involvement of membrane-associated proteins in the acute regulation of cellular fatty acid uptake
    J F Glatz
    Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, The Netherlands
    J Mol Neurosci 16:123-32; discussion 151-7. 2001
  4. ncbi request reprint Fatty acid-binding protein and the early detection of acute myocardial infarction
    J F Glatz
    Dept of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, The Netherlands
    Clin Chim Acta 272:87-92. 1998
  5. ncbi request reprint Role of membrane-associated and cytoplasmic fatty acid-binding proteins in cellular fatty acid metabolism
    J F Glatz
    Department of Physiology, Cardiovascular Research Institute Maastricht, The Netherlands
    Prostaglandins Leukot Essent Fatty Acids 57:373-8. 1997
  6. ncbi request reprint Cellular lipid binding proteins as facilitators and regulators of lipid metabolism
    Jan F C Glatz
    Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Mol Cell Biochem 239:3-7. 2002
  7. ncbi request reprint Exercise and insulin increase muscle fatty acid uptake by recruiting putative fatty acid transporters to the sarcolemma
    Jan F C Glatz
    Department of Physiology, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, Maastricht, The Netherlands
    Curr Opin Clin Nutr Metab Care 5:365-70. 2002
  8. ncbi request reprint Co-expression in rat heart and skeletal muscle of four genes coding for proteins implicated in long-chain fatty acid uptake
    F A van Nieuwenhoven
    Department of Physiology, Maastricht University, Netherlands
    Int J Biochem Cell Biol 31:489-98. 1999
  9. ncbi request reprint Estimation of myocardial infarct size from plasma myoglobin or fatty acid-binding protein. Influence of renal function
    K W Wodzig
    Department of Clinical Chemistry, Academic Hospital, Maastricht, The Netherlands
    Eur J Clin Chem Clin Biochem 35:191-8. 1997
  10. ncbi request reprint One-step purification of rat heart-type fatty acid-binding protein expressed in Escherichia coli
    F G Schaap
    Department of Physiology, University of Limburg, Maastricht, Netherlands
    J Chromatogr B Biomed Appl 679:61-7. 1996

Detail Information

Publications91

  1. ncbi request reprint Molecular mechanism of cellular uptake and intracellular translocation of fatty acids
    J F Glatz
    Department of Physiology, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, The Netherlands
    Prostaglandins Leukot Essent Fatty Acids 57:3-9. 1997
    ..The mechanism of cellular uptake of fatty acids probably involves both a passive and carrier-mediated transmembrane translocation...
  2. ncbi request reprint Unravelling the significance of cellular fatty acid-binding proteins
    J F Glatz
    Department of Physiology, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, The Netherlands
    Curr Opin Lipidol 12:267-74. 2001
    ..Evidence is also emerging for concerted actions between the membrane and cytoplasmic fatty acid-binding proteins that allow for efficient regulation of FA transport and metabolism...
  3. ncbi request reprint Involvement of membrane-associated proteins in the acute regulation of cellular fatty acid uptake
    J F Glatz
    Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, The Netherlands
    J Mol Neurosci 16:123-32; discussion 151-7. 2001
    ..These new findings establish a significant role of membrane-associated proteins in the cellular fatty acid-uptake process. Possible implications for the uptake and transport of long-chain fatty acids by the brain are discussed...
  4. ncbi request reprint Fatty acid-binding protein and the early detection of acute myocardial infarction
    J F Glatz
    Dept of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, The Netherlands
    Clin Chim Acta 272:87-92. 1998
    ..Rapid and sensitive immunochemical assay systems for FABP in plasma are now being developed and soon will enable the introduction of this marker in clinical practice...
  5. ncbi request reprint Role of membrane-associated and cytoplasmic fatty acid-binding proteins in cellular fatty acid metabolism
    J F Glatz
    Department of Physiology, Cardiovascular Research Institute Maastricht, The Netherlands
    Prostaglandins Leukot Essent Fatty Acids 57:373-8. 1997
    ..In conclusion, long-chain fatty acids are subject to continuous interaction with multiple proteins, which interplay influences their cellular metabolism...
  6. ncbi request reprint Cellular lipid binding proteins as facilitators and regulators of lipid metabolism
    Jan F C Glatz
    Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Mol Cell Biochem 239:3-7. 2002
    ....
  7. ncbi request reprint Exercise and insulin increase muscle fatty acid uptake by recruiting putative fatty acid transporters to the sarcolemma
    Jan F C Glatz
    Department of Physiology, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, Maastricht, The Netherlands
    Curr Opin Clin Nutr Metab Care 5:365-70. 2002
    ..The focus of this review is to describe newly obtained insights on the recruitment of fatty acid transporters and their malfunctioning in diabetes...
  8. ncbi request reprint Co-expression in rat heart and skeletal muscle of four genes coding for proteins implicated in long-chain fatty acid uptake
    F A van Nieuwenhoven
    Department of Physiology, Maastricht University, Netherlands
    Int J Biochem Cell Biol 31:489-98. 1999
    ..In conclusion, this study shows the co-expression of FATP, FAT, FABPpm and H-FABPc in rat muscles. This finding supports the possible cooperation of these proteins in the uptake of long-chain fatty acids by muscle cells...
  9. ncbi request reprint Estimation of myocardial infarct size from plasma myoglobin or fatty acid-binding protein. Influence of renal function
    K W Wodzig
    Department of Clinical Chemistry, Academic Hospital, Maastricht, The Netherlands
    Eur J Clin Chem Clin Biochem 35:191-8. 1997
    ....
  10. ncbi request reprint One-step purification of rat heart-type fatty acid-binding protein expressed in Escherichia coli
    F G Schaap
    Department of Physiology, University of Limburg, Maastricht, Netherlands
    J Chromatogr B Biomed Appl 679:61-7. 1996
    ..Some heterogeneity upon isoelectric focusing was observed, presumably due to differences in N-terminal processing of the proteins. In conclusion, a method is presented for efficient high-yield production of recombinant rat H-FABP...
  11. ncbi request reprint Discrimination between myocardial and skeletal muscle injury by assessment of the plasma ratio of myoglobin over fatty acid-binding protein
    F A van Nieuwenhoven
    Department of Physiology, University of Limburg, Maastricht, The Netherlands
    Circulation 92:2848-54. 1995
    ..Myoglobin and fatty acid-binding protein (FABP) each are useful as early biochemical markers of muscle injury. We studied whether the ratio of myoglobin over FABP in plasma can be used to distinguish myocardial from skeletal muscle injury...
  12. ncbi request reprint Electrostimulation enhances FAT/CD36-mediated long-chain fatty acid uptake by isolated rat cardiac myocytes
    J J Luiken
    Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, NL-6200 MD Maastricht, The Netherlands
    Am J Physiol Endocrinol Metab 281:E704-12. 2001
    ..These data indicate that, in contracting cardiac myocytes, palmitate uptake is increased due to increased flux through FAT/CD36...
  13. ncbi request reprint Measurement of myocardial infarct size from plasma fatty acid-binding protein or myoglobin, using individually estimated clearance rates
    M J de Groot
    Cardiovascular Research Institute Maastricht, Maastricht University, The Netherlands
    Cardiovasc Res 44:315-24. 1999
    ..We investigated whether or not more accurate values of infarct size could be obtained with individually estimated clearance rates...
  14. ncbi request reprint Release of proteins from isolated neonatal rat cardiomyocytes subjected to simulated ischemia or metabolic inhibition is independent of molecular mass
    F A van Nieuwenhoven
    Department of Physiology, Cardiovascular Research Institute Maastricht CARIM, University of Limburg, The Netherlands
    J Mol Cell Cardiol 28:1429-34. 1996
    ..In contrast, our data suggest that sarcolemmal disruption is a relatively fast process resulting in the simultaneous release of all soluble cytoplasmic proteins, irrespective of their molecular mass...
  15. ncbi request reprint Fasting-induced changes in the expression of genes controlling substrate metabolism in the rat heart
    K A Van der Lee
    Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, Universiteitssingel 50, 6229 ER Maastricht, The Netherlands
    J Lipid Res 42:1752-8. 2001
    ..In conclusion, the adult rat heart responds to changes in nutritional status, as provoked by 46 h fasting, through adjustment of glucose as well as FA metabolism at the level of gene expression...
  16. ncbi request reprint Skeletal muscle fatty acid transport and transporters
    J J Luiken
    Department of Physiology, Maastricht University, The Netherlands
    Int J Sport Nutr Exerc Metab 11:S92-6. 2001
    ....
  17. ncbi request reprint Heart fatty acid binding protein and cardiac troponin T plasma concentrations as markers for myocardial infarction after coronary artery ligation in mice
    W M Aartsen
    Department of Pharmacology and Toxicology, Cardiovascular Research Institute Maastricht, Universiteit Maastricht, The Netherlands
    Pflugers Arch 439:416-22. 2000
    ..In conclusion, plasma cTnT concentration at 48 h after infarction can be used to distinguish MI from sham mice, whereas H-FABP concentration at 4 h can be used for stratification of animals according to infarct size...
  18. ncbi request reprint One-step enzyme-linked immunosorbent assay (ELISA) for plasma fatty acid-binding protein
    K W Wodzig
    Department of Physiology, Cardiovascular Research Institute Maastricht, University of Limburg, Maastricht
    Ann Clin Biochem 34:263-8. 1997
    ..6 (0.8) [mean (SD), range 0.3-5.0] micrograms/L. The assay can be used for rapid plasma or serum FABP measurement in the early diagnosis of acute myocardial infarction...
  19. ncbi request reprint Cytochrome P450, peroxisome proliferation, and cytoplasmic fatty acid-binding protein content in liver, heart and kidney of the diabetic rat
    W Engels
    Department of Internal Medicine, Maastricht University, The Netherlands
    Mol Cell Biochem 192:53-61. 1999
    ..Consequently, it is not likely that dicarboxylic acids are involved in the induction of peroxisome proliferation in the heart...
  20. pmc A new principle for rapid immunoassay of proteins based on in situ precipitate-enhanced ellipsometry
    M Robers
    Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Biophys J 76:2769-76. 1999
    ..A possible future application of the method in the development of a one-step ELISA is discussed...
  21. ncbi request reprint Skeletal muscle metabolic characteristics before and after energy restriction in human obesity: fibre type, enzymatic beta-oxidative capacity and fatty acid-binding protein content
    K P Kempen
    University of Maastricht, Maastricht, The Netherlands
    Eur J Clin Invest 28:1030-7. 1998
    ..The aim of the present study was to investigate the effects of energy restriction on skeletal muscle metabolic characteristics in obese women...
  22. ncbi request reprint Fatty acid binding protein in heart and skeletal muscles of the migratory barnacle goose throughout development
    M M Pelsers
    Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, 6200 MD Maastricht, The Netherlands
    Am J Physiol 276:R637-43. 1999
    ..6 micro/g wet wt). These results suggest that the experience of flight activity may be of critical importance in achieving maximal expression of FABP in the pectoralis muscles of postfledging and mature geese immediately before migration...
  23. ncbi request reprint Cardiac fatty acid uptake and transport in health and disease
    G J Van der Vusse
    Department of Physiology, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, The Netherlands
    Cardiovasc Res 45:279-93. 2000
    ..Alterations in tissue content of fatty acid-transport proteins may contribute to myocardial diseases such as the diabetic heart, and cardiac hypertrophy and failure...
  24. ncbi request reprint Increase in skeletal muscle fatty acid binding protein (FABPC) content is directly related to weight loss and to changes in fat oxidation following a very low calorie diet
    E E Blaak
    Department of Human Biology, Nutrition Research Centre, Maastricht University, Maastricht, The Netherlands
    Diabetologia 44:2013-7. 2001
    ....
  25. ncbi request reprint Fatty acid-binding proteins in the heart
    F G Schaap
    Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, The Netherlands
    Mol Cell Biochem 180:43-51. 1998
    ..In this review, the roles of membrane-associated and cytoplasmic FABPs in cardiac fatty acid metabolism under (patho)physiological circumstances are discussed...
  26. ncbi request reprint Membrane-associated and cytoplasmic fatty acid-binding proteins
    F A van Nieuwenhoven
    Department of Physiology, Cardiovascular Research Institute Maastricht CARIM, University of Limburg, The Netherlands
    Lipids 31:S223-7. 1996
    ..In this review, a short summary is provided of the latest developments in this research area...
  27. ncbi request reprint Modelling intracellular fatty acid transport: possible mechanistic role of cytoplasmic fatty acid-binding protein
    M M Vork
    Department of Physiology, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, The Netherlands
    Prostaglandins Leukot Essent Fatty Acids 57:11-6. 1997
    ....
  28. ncbi request reprint Impaired long-chain fatty acid utilization by cardiac myocytes isolated from mice lacking the heart-type fatty acid binding protein gene
    F G Schaap
    Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, the Netherlands Germany
    Circ Res 85:329-37. 1999
    ....
  29. ncbi request reprint Intracellular transport of fatty acids in muscle. Role of cytoplasmic fatty acid-binding protein
    J F Glatz
    Department of Physiology, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, The Netherlands
    Adv Exp Med Biol 441:207-18. 1998
    ....
  30. ncbi request reprint Molecular cloning of fatty acid-transport protein cDNA from rat
    F G Schaap
    Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, The Netherlands
    Biochim Biophys Acta 1354:29-34. 1997
    ..Given the large evolutionary distance between these species, these regions might be important for protein function. The predicted membrane topology of rat FATP is discussed...
  31. ncbi request reprint Fatty acids in cell signalling: modulation by lipid binding proteins
    J F Glatz
    Department of Physiology, University of Limburg, Maastricht, The Netherlands
    Prostaglandins Leukot Essent Fatty Acids 52:121-7. 1995
    ..In this paper a survey is given on the biological significance and possible modulatory action of intracellular lipid binding proteins for fatty acid-mediated signal transduction pathways...
  32. ncbi request reprint Selection-dominant and nonaccessible epitopes on cell-surface receptors revealed by cell-panning with a large phage antibody library
    H R Hoogenboom
    CESAME at the Department of Pathology, Maastricht University, The Netherlands
    Eur J Biochem 260:774-84. 1999
    ..Our results show that, although cells can be used as antigen carriers to select and screen phage antibodies, the nature of the antigen target has a profound effect on the outcome of the selection...
  33. pmc Mitochondrial long chain fatty acid oxidation, fatty acid translocase/CD36 content and carnitine palmitoyltransferase I activity in human skeletal muscle during aerobic exercise
    Graham P Holloway
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Canada
    J Physiol 571:201-10. 2006
    ..We further suggest that decreased CPTI M-CoA sensitivity and increased mitochondrial FAT/CD36 protein are both important for increasing whole body fatty acid oxidation during prolonged exercise...
  34. pmc Differential effects of contraction and PPAR agonists on the expression of fatty acid transporters in rat skeletal muscle
    Carley R Benton
    Department of Kinesiology, University of Waterloo, Waterloo, Ontario, Canada N2L 2W1
    J Physiol 573:199-210. 2006
    ....
  35. ncbi request reprint Purification, immunochemical quantification and localization in rat heart of putative fatty acid translocase (FAT/CD36)
    Joep F F Brinkmann
    Department of Physiology, Cardiovascular Research Institute Maastricht, CARIM, Maastricht University, Maastricht, The Netherlands
    Mol Cell Biochem 284:127-34. 2006
    ..This study established that FAT/CD36 is a relatively abundant protein in the cardiomyocyte. In addition, the further developed purification procedure is the first method for isolating FAT/CD36 from rat heart and cardiomyocyte FAT/CD36...
  36. ncbi request reprint Fatty acid transport and FAT/CD36 are increased in red but not in white skeletal muscle of ZDF rats
    Adrian Chabowski
    Dept of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, N1G 2W1, Canada
    Am J Physiol Endocrinol Metab 291:E675-82. 2006
    ....
  37. ncbi request reprint Prolonged AMPK activation increases the expression of fatty acid transporters in cardiac myocytes and perfused hearts
    Adrian Chabowski
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, N1G 2W1, Canada
    Mol Cell Biochem 288:201-12. 2006
    ..Thus, activation of AMPK is a key mechanism regulating the expression as well as the plasmalemmal localization of fatty acid transporters...
  38. ncbi request reprint Up-regulation of CD36/FAT in preadipocytes in familial combined hyperlipidemia
    Steven J R Meex
    Laboratory of Molecular Metabolism and Endocrinology, Department of Internal Medicine, Maastricht, The Netherlands
    FASEB J 19:2063-5. 2005
    ..The present data suggest that CD36/FAT overexpression in FCHL occurs very early in adipocyte differentiation and may be of genetic origin...
  39. ncbi request reprint Identification of fatty acid translocase on human skeletal muscle mitochondrial membranes: essential role in fatty acid oxidation
    Veronic Bezaire
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, ON, Canada
    Am J Physiol Endocrinol Metab 290:E509-15. 2006
    ....
  40. ncbi request reprint Detection of brain injury by fatty acid-binding proteins
    Maurice M A L Pelsers
    Department of Molecular Genetics, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Clin Chem Lab Med 43:802-9. 2005
    ....
  41. ncbi request reprint Long-chain fatty acid uptake and FAT/CD36 translocation in heart and skeletal muscle
    Debby P Y Koonen
    Department of Molecular Genetics, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, NL 6200 MD Maastricht, The Netherlands
    Biochim Biophys Acta 1736:163-80. 2005
    ..Hence, FAT/CD36 might provide a useful therapeutic target for the prevention or treatment of insulin resistance...
  42. ncbi request reprint The subcellular compartmentation of fatty acid transporters is regulated differently by insulin and by AICAR
    Adrian Chabowski
    Department of Human Biology and Nutritional Sciences, University of Guelph, Ont, Canada
    FEBS Lett 579:2428-32. 2005
    ....
  43. ncbi request reprint Brain arachidonic acid incorporation is decreased in heart fatty acid binding protein gene-ablated mice
    Eric J Murphy
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota, Grand Forks, North Dakota 58202 9037, USA
    Biochemistry 44:6350-60. 2005
    ..Thus, these results demonstrate for the first time that H-FABP expression influences brain 20:4n-6 uptake and trafficking as well as steady-state brain lipid levels...
  44. ncbi request reprint Fatty acid-binding proteins as plasma markers of tissue injury
    Maurice M A L Pelsers
    Department of Molecular Genetics, Cardiovascular Research Institute Maastricht, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Clin Chim Acta 352:15-35. 2005
    ..One of the novel and promising plasma markers for detection of tissue injury is the family of 15 kDa cytoplasmic fatty acid-binding proteins of which various tissue-specific types occur...
  45. ncbi request reprint Signalling components involved in contraction-inducible substrate uptake into cardiac myocytes
    Joost J F P Luiken
    Department of Molecular Genetics, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, NL 6200 MD Maastricht, The Netherlands
    Proc Nutr Soc 63:251-8. 2004
    ..The unravelling of further components along this contraction pathway can provide valuable information on the coordinated regulation of the uptake of glucose and of LCFA by an increase in mechanical activity of heart and skeletal muscle...
  46. ncbi request reprint Tissue-specific and fatty acid transporter-specific changes in heart and soleus muscle over a 1-yr period
    Arend Bonen
    Department of Human Health and Nutritional Sciences University of Guelph, Guelph, Ontario, N1G 2W1, Canada
    Mol Cell Biochem 291:145-54. 2006
    ..We speculate that the rapid upregulation of fatty acid transport rates in heart and muscle are needed to support the increased rates of fatty oxidation that have been previously observed in these tissues...
  47. pmc Cardiac substrate uptake and metabolism in obesity and type-2 diabetes: role of sarcolemmal substrate transporters
    Susan L M Coort
    Department of Molecular Genetics, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, Maastricht, The Netherlands
    Mol Cell Biochem 299:5-18. 2007
    ..These novel insights may result in new strategies for the prevention of development of cardiac dysfunction and insulin resistance in obesity and T2DM...
  48. doi request reprint Regulation of sarcolemmal glucose and fatty acid transporters in cardiac disease
    Robert W Schwenk
    Department of Molecular Genetics, Cardiovascular Research Institute Maastricht, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Cardiovasc Res 79:249-58. 2008
    ....
  49. doi request reprint Insulin-induced translocation of CD36 to the plasma membrane is reversible and shows similarity to that of GLUT4
    Masja M van Oort
    Division of Endocrinology and Metabolism, Department of Biology and Institute of Biomembranes, Utrecht University, NL 3584 CH Utrecht, The Netherlands
    Biochim Biophys Acta 1781:61-71. 2008
    ..Taken together, this study is the first to present morphological evidence for CD36 translocation, and shows this process to resemble GLUT4 translocation...
  50. doi request reprint Identification of protein kinase D as a novel contraction-activated kinase linked to GLUT4-mediated glucose uptake, independent of AMPK
    Joost J F P Luiken
    Department of Molecular Genetics, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, Maastricht, The Netherlands
    Cell Signal 20:543-56. 2008
    ....
  51. ncbi request reprint Modest PGC-1alpha overexpression in muscle in vivo is sufficient to increase insulin sensitivity and palmitate oxidation in subsarcolemmal, not intermyofibrillar, mitochondria
    Carley R Benton
    Departments of Kinesiology and Biology, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada
    J Biol Chem 283:4228-40. 2008
    ....
  52. ncbi request reprint Gender-related differences in the metabolic response to fasting
    Maarten R Soeters
    Department of Endocrinology and Metabolism, Laboratory of Endocrinology, Academic Medical Center, PO Box 22660, 1100 DD Amsterdam, The Netherlands
    J Clin Endocrinol Metab 92:3646-52. 2007
    ..During fasting, women have lower plasma glucose levels than men despite higher plasma FFA, suggesting protection from FFA-induced insulin resistance...
  53. ncbi request reprint Sarcolemmal fatty acid transport in normal and diseased hearts
    Jan F C Glatz
    Department of Molecular Genetics, Cardiovascular Research Institute Maastricht, Maastricht University, PO Box 616, NL 6200 MD Maastricht, The Netherlands
    Curr Hypertens Rep 9:450-4. 2007
    ..As a result, membrane fatty acid transporters are now regarded as a promising therapeutic target to rectify abnormalities in cardiac fatty acid use in chronic cardiac disease...
  54. ncbi request reprint Metabolic challenges reveal impaired fatty acid metabolism and translocation of FAT/CD36 but not FABPpm in obese Zucker rat muscle
    Xiao Xia Han
    Dept of Human Health and Nutritional Sciences, Univ of Guelph, Guelph, Ontario, Canada N1G 2W1
    Am J Physiol Endocrinol Metab 293:E566-75. 2007
    ..Finally, 4) there is no evidence that plasmalemmal fatty acid transporters contribute to the channeling of fatty acids to specific metabolic destinations within the muscle...
  55. pmc Fatty acid binding protein facilitates sarcolemmal fatty acid transport but not mitochondrial oxidation in rat and human skeletal muscle
    Graham P Holloway
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Canada, N1G 2W1
    J Physiol 582:393-405. 2007
    ....
  56. ncbi request reprint Is membrane transport of FFA mediated by lipid, protein, or both? Mechanisms and regulation of protein-mediated cellular fatty acid uptake: molecular, biochemical, and physiological evidence
    Arend Bonen
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
    Physiology (Bethesda) 22:15-29. 2007
  57. ncbi request reprint AMPK-mediated increase in myocardial long-chain fatty acid uptake critically depends on sarcolemmal CD36
    Daphna D J Habets
    Department of Molecular Genetics, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Biochem Biophys Res Commun 355:204-10. 2007
    ..CD36 is almost entirely responsible for AMPK-mediated stimulation of LCFA uptake in cardiomyocytes, indicating a pivotal role for CD36 in mediating changes in cardiac LCFA fluxes...
  58. ncbi request reprint A null mutation in skeletal muscle FAT/CD36 reveals its essential role in insulin- and AICAR-stimulated fatty acid metabolism
    Arend Bonen
    Department of Human Health and Nutritional Science, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Am J Physiol Endocrinol Metab 292:E1740-9. 2007
    ..7-fold greater in WT compared with KO mice. In conclusion, the present studies demonstrate that FAT/CD36 has a critical role in regulating fatty acid esterification and oxidation, particularly during stimulation with insulin or AICAR...
  59. ncbi request reprint Regulation of sarcolemmal transport of substrates in the healthy and diseased heart
    Jan F C Glatz
    Dept of Molecular Genetics, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands
    Cardiovasc Drugs Ther 20:471-6. 2006
    ....
  60. ncbi request reprint Arsenite modulates cardiac substrate preference by translocation of GLUT4, but not CD36, independent of mitogen-activated protein kinase signaling
    Joost J F P Luiken
    Department of Molecular Genetics, Cardiovascular Research Institute Maastricht, Maastricht University, P O Box 616, NL 6200 MD Maastricht, The Netherlands
    Endocrinology 147:5205-16. 2006
    ....
  61. ncbi request reprint Regulation of fatty acid transport by fatty acid translocase/CD36
    Arend Bonen
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    Proc Nutr Soc 63:245-9. 2004
    ..Clearly, FAT/CD36 has an important role in FA homeostasis in skeletal muscle and the heart...
  62. ncbi request reprint Enhanced sarcolemmal FAT/CD36 content and triacylglycerol storage in cardiac myocytes from obese zucker rats
    Susan L M Coort
    Department of Molecular Genetics, Cardiovascular Research Institute Maastricht, Maastricht University, P O Box 616, NL 6200 Maastricht, Netherlands
    Diabetes 53:1655-63. 2004
    ....
  63. ncbi request reprint Brain- and heart-type fatty acid-binding proteins in the brain: tissue distribution and clinical utility
    Maurice M A L Pelsers
    Department of Molecular Genetics, Cardiovascular Research Institute Maastricht, Maastricht University, The Netherlands
    Clin Chem 50:1568-75. 2004
    ..We investigated the tissue distribution of brain- and heart-type fatty acid-binding proteins (B-FABP and H-FABP) in segments of the human brain and the potential of either protein to serve as plasma marker for diagnosis of brain injury...
  64. ncbi request reprint Contraction-induced fatty acid translocase/CD36 translocation in rat cardiac myocytes is mediated through AMP-activated protein kinase signaling
    Joost J F P Luiken
    Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Diabetes 52:1627-34. 2003
    ..We conclude that AMP kinase regulates cardiac FA use through mobilization of FAT/CD36 from a contraction-inducible intracellular storage compartment...
  65. pmc Myocardial recovery from ischemia is impaired in CD36-null mice and restored by myocyte CD36 expression or medium-chain fatty acids
    Hiroshi Irie
    Department of Physiology and Biophysics, Stony Brook University, NY 11794, USA
    Proc Natl Acad Sci U S A 100:6819-24. 2003
    ..It would be important to determine whether the findings apply to the human situation where polymorphisms of the CD36 gene are relatively common...
  66. ncbi request reprint Use of two biomarkers of renal ischemia to assess machine-perfused non-heart-beating donor kidneys
    Muhammed A Gok
    Department of Surgery, The Medical School, University of Newcastle, Newcastle upon Tyne NE7 7DN, England
    Clin Chem 49:172-5. 2003
  67. pmc Ketone bodies disturb fatty acid handling in isolated cardiomyocytes derived from control and diabetic rats
    Danny M Hasselbaink
    Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Biochem J 371:753-60. 2003
    ..The concomitantly increased FA uptake in diabetic cells, mainly due to the elevated extracellular FA levels, may be responsible for the accumulation of FA and triacylglycerol, as observed in the diabetic heart in situ...
  68. ncbi request reprint Sulfo-N-succinimidyl esters of long chain fatty acids specifically inhibit fatty acid translocase (FAT/CD36)-mediated cellular fatty acid uptake
    Susan L M Coort
    Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Mol Cell Biochem 239:213-9. 2002
    ....
  69. ncbi request reprint Regulation of fatty acid transport and membrane transporters in health and disease
    Arend Bonen
    Department of Kinesiology, University of Waterloo, Waterloo, ON, Canada
    Mol Cell Biochem 239:181-92. 2002
    ....
  70. ncbi request reprint Critical steps in cellular fatty acid uptake and utilization
    Ger J Van der Vusse
    Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Mol Cell Biochem 239:9-15. 2002
    ..Circumstantial evidence indicates that FA themselves are able to modulate the expression of FA-handling genes via nuclear transcription factors such as peroxisome proliferator-activated receptors (PPARs)...
  71. ncbi request reprint Liver fatty acid-binding protein as a sensitive serum marker of acute hepatocellular damage in liver transplant recipients
    Maurice M A L Pelsers
    Department of Physiology, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Clin Chem 48:2055-7. 2002
  72. ncbi request reprint Insulin stimulates long-chain fatty acid utilization by rat cardiac myocytes through cellular redistribution of FAT/CD36
    Joost J F P Luiken
    Department of Physiology, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, The Netherlands
    Diabetes 51:3113-9. 2002
    ..In conclusion, we have demonstrated a novel role of insulin in cardiac FA utilization. Malfunctioning of insulin-induced FAT/CD36 translocation may be involved in the development of type 2 diabetic cardiomyopathies...
  73. ncbi request reprint Changes in fatty acid transport and transporters are related to the severity of insulin deficiency
    Joost J F P Luiken
    Department of Kinesiology, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada
    Am J Physiol Endocrinol Metab 283:E612-21. 2002
    ....
  74. pmc New insights into long-chain fatty acid uptake by heart muscle: a crucial role for fatty acid translocase/CD36
    Joep F F Brinkmann
    Cardiovascular Research Institute Maastricht CARIM, Department of Physiology, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Biochem J 367:561-70. 2002
    ....
  75. ncbi request reprint Insulin induces the translocation of the fatty acid transporter FAT/CD36 to the plasma membrane
    Joost J F P Luiken
    Department of Physiology, Maastricht University, 6200 MD Maastricht, The Netherlands
    Am J Physiol Endocrinol Metab 282:E491-5. 2002
    ..This reveals a previously unknown level of regulation of fatty acid transport by insulin and may well have important consequences in furthering our understanding of the relation between fatty acid metabolism and insulin resistance...
  76. ncbi request reprint A null mutation in H-FABP only partially inhibits skeletal muscle fatty acid metabolism
    Bert Binas
    Deptartment of Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station 77843, USA
    Am J Physiol Endocrinol Metab 285:E481-9. 2003
    ..The substantial increase in FA metabolism in contracting H-FABP-null muscle may indicate that other FABPs are also present, a possibility that we were not able to completely eliminate...
  77. ncbi request reprint The responses of fatty acid-binding protein and creatine kinase to acute and chronic exercise in junior rowers
    Yvonne Yuan
    Sports Science Department of the Hong Kong Sports Development Board, Sports Institute, Shatin, NT
    Res Q Exerc Sport 74:277-83. 2003
    ..362, p < .01) and on the combined training on the previous 2 days (F = 4.606, p < .005). The present results suggest that FABP and CK could be used to monitor acute exercise and chronic exercise, respectively...
  78. ncbi request reprint Uncoupling protein 3 as a mitochondrial fatty acid anion exporter
    Patrick Schrauwen
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, The Netherlands
    FASEB J 17:2272-4. 2003
    ..These data are compatible with a physiological function of UCP3 in facilitating outward transport of long-chain fatty acid anions, which cannot be oxidized, from the mitochondrial matrix...
  79. ncbi request reprint Heart fatty acid uptake is decreased in heart fatty acid-binding protein gene-ablated mice
    Eric J Murphy
    Department of Pharmacology, Physiology, and Therapeutics, School of Medicine and Health Sciences, University of North Dakota, 501 N Columbia Road, Grand Forks, ND 58202 9037, USA
    J Biol Chem 279:34481-8. 2004
    ..In summary, H-FABP was important for heart fatty acid uptake and targeting of fatty acids to specific heart lipid pools as well as for maintenance of phospholipid pool mass and acyl chain composition...
  80. ncbi request reprint Insulin stimulates fatty acid transport by regulating expression of FAT/CD36 but not FABPpm
    Adrian Chabowski
    Department of Human Biology and Nutritional Sciences, University of Guelph, ON N1G 2W1, Canada
    Am J Physiol Endocrinol Metab 287:E781-9. 2004
    ..The present studies have shown that insulin regulates protein expression of FAT/CD36, but not FABPpm, via the PI 3-kinase/Akt insulin-signaling pathway...
  81. ncbi request reprint A novel function for fatty acid translocase (FAT)/CD36: involvement in long chain fatty acid transfer into the mitochondria
    Shannon E Campbell
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    J Biol Chem 279:36235-41. 2004
    ....
  82. ncbi request reprint Lipid-binding proteins and lipoprotein lipase activity in human skeletal muscle: influence of physical activity and gender
    Bente Kiens
    Department of Human Physiology, The Copenhagen Muscle Research Centre, Institute of Exercise and Sport Sciences, University of Copenhagen, DK 2100 Copenhagen, Denmark
    J Appl Physiol 97:1209-18. 2004
    ....
  83. ncbi request reprint Different mechanisms can alter fatty acid transport when muscle contractile activity is chronically altered
    Debby P Y Koonen
    Department of Molecular Genetics, Cardiovascular Reseasrch Institute Maastricht, Maastricht University, The Netherlands
    Am J Physiol Endocrinol Metab 286:E1042-9. 2004
    ....
  84. ncbi request reprint Triacylglycerol accumulation in human obesity and type 2 diabetes is associated with increased rates of skeletal muscle fatty acid transport and increased sarcolemmal FAT/CD36
    Arend Bonen
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, N1G 2W1, Canada
    FASEB J 18:1144-6. 2004
    ....
  85. ncbi request reprint One-step immunoassay for measuring protein concentrations in plasma, based on precipitate-enhanced ellipsometry
    Han Speijer
    Cardiovascular Research Institute Maastricht, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Anal Biochem 326:257-61. 2004
    ..More importantly, the presence of substrate-converting enzyme-antibody complexes in the buffer caused a large enhancement of precipitation...
  86. ncbi request reprint Dipyridamole alters cardiac substrate preference by inducing translocation of FAT/CD36, but not that of GLUT4
    Joost J F P Luiken
    Department of Molecular Genetics, CARIM, Maastricht University, Maastricht, The Netherlands
    Mol Pharmacol 65:639-45. 2004
    ....
  87. ncbi request reprint Regulation of cardiac long-chain fatty acid and glucose uptake by translocation of substrate transporters
    Joost J F P Luiken
    Department of Molecular Genetics, Cardiovascular Research Institute Maastricht, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Pflugers Arch 448:1-15. 2004
    ..In the latter case, a unique set of proteins would be dedicated to FAT/CD36 recycling, which would then provide an attractive target for manipulating cardiac substrate preference...
  88. ncbi request reprint Subcellular immunolocalisation of fatty acid translocase (FAT)/CD36 in human type-1 and type-2 skeletal muscle fibres
    Hans A Keizer
    Department of Movement Sciences, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands
    Histochem Cell Biol 121:101-7. 2004
    ..One of the antibodies raised against mouse CD36 also detected myosin heavy chain 1, which makes it unsuitable in skeletal muscle research. The fixation (acetone or methanol/acetone) was found to be highly important for the result...
  89. ncbi request reprint Overexpression of membrane-associated fatty acid binding protein (FABPpm) in vivo increases fatty acid sarcolemmal transport and metabolism
    David C Clarke
    Department of Kinesiology, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada
    Physiol Genomics 17:31-7. 2004
    ..This suggests that other mechanisms are required to realize the full potential offered by FABPpm overexpression...
  90. ncbi request reprint Intestinal-type and liver-type fatty acid-binding protein in the intestine. Tissue distribution and clinical utility
    Maurice M A L Pelsers
    Department of Molecular Genetics, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Clin Biochem 36:529-35. 2003
    ..We have investigated the tissue distribution of I-FABP and L-FABP in segments of the human intestine along the duodenal to colonal axis and the potential of both proteins to serve as plasma marker for the diagnosis of intestinal injury...
  91. ncbi request reprint Chronic leptin administration decreases fatty acid uptake and fatty acid transporters in rat skeletal muscle
    Gregory R Steinberg
    Department of Human Biology and Nutritional Sciences, University of Guelph, Ontario N1G 2W1, Canada
    J Biol Chem 277:8854-60. 2002
    ..88, p < 0.01) and plasma membrane FABPpm protein (r = 0.94, p < 0.01). These studies provide the first evidence that protein-mediated long chain fatty acid transport is subject to long term regulation by leptin...