R Deumens

Summary

Affiliation: Maastricht University
Country: The Netherlands

Publications

  1. ncbi Functional investigations into the role of dopamine and serotonin in partial bilateral striatal 6-hydroxydopamine lesioned rats
    Bart Scholtissen
    Department of Psychiatry and Neuropsychology, Maastricht University, EURON, P O Box 616, 6200 MD Maastricht, The Netherlands
    Pharmacol Biochem Behav 83:175-85. 2006
  2. doi Inverse relation between intensity of GFAP expression in the substantia gelatinosa and degree of chronic mechanical allodynia
    Ronald Deumens
    Pain Management and Research Center, Department of Anesthesiology, Academic Hospital Maastricht, Maastricht, The Netherlands
    Neurosci Lett 452:101-5. 2009
  3. ncbi Mice lacking L1 have reduced CGRP fibre in-growth into spinal transection lesions
    Ronald Deumens
    Pain Management and Research Center, Department of Anesthesiology, Academic Hospital Maastricht, and European Graduate School of Neuroscience EURON, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands
    Neurosci Lett 420:277-81. 2007
  4. ncbi The CatWalk gait analysis in assessment of both dynamic and static gait changes after adult rat sciatic nerve resection
    Ronald Deumens
    Department of Anesthesiology, Maastricht University, Maastricht, The Netherlands
    J Neurosci Methods 164:120-30. 2007
  5. ncbi Stimulation of neurite outgrowth on neonatal cerebral astrocytes is enhanced in the presence of BDNF
    Ronald Deumens
    Department of Psychiatry and Neuropsychology, Division Cellular Neuroscience, University of Maastricht, Maastricht, The Netherlands
    Neurosci Lett 407:268-73. 2006
  6. ncbi Limitations in transplantation of astroglia-biomatrix bridges to stimulate corticospinal axon regrowth across large spinal lesion gaps
    Ronald Deumens
    Department of Psychiatry and Neuropsychology, Division Cellular Neuroscience, University of Maastricht, P O Box 616, 6200 MD, Maastricht, The Netherlands
    Neurosci Lett 400:208-12. 2006
  7. ncbi Olfactory ensheathing cells, olfactory nerve fibroblasts and biomatrices to promote long-distance axon regrowth and functional recovery in the dorsally hemisected adult rat spinal cord
    R Deumens
    Department of Psychiatry and Neuropsychology, Division Neuroscience, European Graduate School of Neuroscience EURON, University of Maastricht, 6200 MD, Maastricht, The Netherlands
    Exp Neurol 200:89-103. 2006
  8. ncbi Alignment of glial cells stimulates directional neurite growth of CNS neurons in vitro
    R Deumens
    Department of Psychiatry and Neuropsychology, European Graduate School for Neuroscience EURON, Universiteit Maastricht, PO Box 616, 6200 MD, Maastricht, The Netherlands
    Neuroscience 125:591-604. 2004
  9. ncbi Chronically injured corticospinal axons do not cross large spinal lesion gaps after a multifactorial transplantation strategy using olfactory ensheathing cell/olfactory nerve fibroblast-biomatrix bridges
    R Deumens
    Department of Psychiatry and Neuropsychology, Division Neuroscience, European Graduate School of Neuroscience EURON, University of Maastricht, Maastricht, The Netherlands
    J Neurosci Res 83:811-20. 2006
  10. ncbi Neurite outgrowth promoting effects of enriched and mixed OEC/ONF cultures
    Ronald Deumens
    Department of Psychiatry and Neuropsychology, Division Neuroscience, European Graduate School of Neuroscience EURON, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands
    Neurosci Lett 397:20-4. 2006

Detail Information

Publications21

  1. ncbi Functional investigations into the role of dopamine and serotonin in partial bilateral striatal 6-hydroxydopamine lesioned rats
    Bart Scholtissen
    Department of Psychiatry and Neuropsychology, Maastricht University, EURON, P O Box 616, 6200 MD Maastricht, The Netherlands
    Pharmacol Biochem Behav 83:175-85. 2006
    ..Taken together, since serotonergic ligands have the same effect as dopaminergic ligands on reaction time responding indicated that 5-HT and DA release are agonistically linked in control and 6-OHDA lesioned rats...
  2. doi Inverse relation between intensity of GFAP expression in the substantia gelatinosa and degree of chronic mechanical allodynia
    Ronald Deumens
    Pain Management and Research Center, Department of Anesthesiology, Academic Hospital Maastricht, Maastricht, The Netherlands
    Neurosci Lett 452:101-5. 2009
    ..Although astroglia are known to play a pro-nociceptive role in early neuropathic pain states, this role may shift to anti-nociception in more chronic pain states...
  3. ncbi Mice lacking L1 have reduced CGRP fibre in-growth into spinal transection lesions
    Ronald Deumens
    Pain Management and Research Center, Department of Anesthesiology, Academic Hospital Maastricht, and European Graduate School of Neuroscience EURON, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands
    Neurosci Lett 420:277-81. 2007
    ..Our results may have important implications on the development and assessment of repair strategies that should not only stimulate functional recovery, but also prevent the development of pain or autonomic dysreflexia...
  4. ncbi The CatWalk gait analysis in assessment of both dynamic and static gait changes after adult rat sciatic nerve resection
    Ronald Deumens
    Department of Anesthesiology, Maastricht University, Maastricht, The Netherlands
    J Neurosci Methods 164:120-30. 2007
    ....
  5. ncbi Stimulation of neurite outgrowth on neonatal cerebral astrocytes is enhanced in the presence of BDNF
    Ronald Deumens
    Department of Psychiatry and Neuropsychology, Division Cellular Neuroscience, University of Maastricht, Maastricht, The Netherlands
    Neurosci Lett 407:268-73. 2006
    ..A multi-factorial strategy based on transplantation of neonatal astrocytes in the presence of additional BDNF is recommended and may stimulate axon regrowth after experimental injury to the central nervous system...
  6. ncbi Limitations in transplantation of astroglia-biomatrix bridges to stimulate corticospinal axon regrowth across large spinal lesion gaps
    Ronald Deumens
    Department of Psychiatry and Neuropsychology, Division Cellular Neuroscience, University of Maastricht, P O Box 616, 6200 MD, Maastricht, The Netherlands
    Neurosci Lett 400:208-12. 2006
    ..We conclude that although multifactorial strategies may be needed to stimulate long-distance CS axon regrowth, future studies should focus on enhancing the viability of cell/biomatrix complexes within large spinal lesion gaps...
  7. ncbi Olfactory ensheathing cells, olfactory nerve fibroblasts and biomatrices to promote long-distance axon regrowth and functional recovery in the dorsally hemisected adult rat spinal cord
    R Deumens
    Department of Psychiatry and Neuropsychology, Division Neuroscience, European Graduate School of Neuroscience EURON, University of Maastricht, 6200 MD, Maastricht, The Netherlands
    Exp Neurol 200:89-103. 2006
    ..Although multifactorial strategies may be needed to stimulate repair of large spinal lesion gaps, we conclude that the combined use of OEC/ONF and poly(D,L)-lactide biomatrices is rather limited...
  8. ncbi Alignment of glial cells stimulates directional neurite growth of CNS neurons in vitro
    R Deumens
    Department of Psychiatry and Neuropsychology, European Graduate School for Neuroscience EURON, Universiteit Maastricht, PO Box 616, 6200 MD, Maastricht, The Netherlands
    Neuroscience 125:591-604. 2004
    ..These data have significant implications for in vivo experiments focusing on glial transplantation. Transplanting glial/biomatrix complexes may stimulate the directional regrowth of severed axons across a lesion site...
  9. ncbi Chronically injured corticospinal axons do not cross large spinal lesion gaps after a multifactorial transplantation strategy using olfactory ensheathing cell/olfactory nerve fibroblast-biomatrix bridges
    R Deumens
    Department of Psychiatry and Neuropsychology, Division Neuroscience, European Graduate School of Neuroscience EURON, University of Maastricht, Maastricht, The Netherlands
    J Neurosci Res 83:811-20. 2006
    ..We conclude that our multifactorial transplantation strategy should be optimized to create an OEC/ONF continuum in the injured spinal cord and thereby stimulate regrowth of injured CS axons across large spinal lesion gaps...
  10. ncbi Neurite outgrowth promoting effects of enriched and mixed OEC/ONF cultures
    Ronald Deumens
    Department of Psychiatry and Neuropsychology, Division Neuroscience, European Graduate School of Neuroscience EURON, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands
    Neurosci Lett 397:20-4. 2006
    ..Hence, our data indicate that there is no preference for the use of enriched OEC or mixed OEC/ONF cultures with respect to stimulation of neurite growth in vitro...
  11. ncbi Regeneration of descending axon tracts after spinal cord injury
    Ronald Deumens
    Department of Psychiatry and Neuropsychology, Division Neuroscience, European Graduate School of Neuroscience EURON, University of Maastricht, Maastricht, The Netherlands
    Prog Neurobiol 77:57-89. 2005
    ..The present review discusses the axon-tract-specific requirements for regeneration in the rat. This knowledge is very important for the development and optimalization of therapies to repair the injured spinal cord...
  12. doi Locomotor dysfunction and pain: the scylla and charybdis of fiber sprouting after spinal cord injury
    Ronald Deumens
    Pain Management and Research Center, Department of Anesthesiology, Maastricht University Hospital, P Debyelaan 25, P O Box 5800, 6200 AZ, Maastricht, The Netherlands
    Mol Neurobiol 37:52-63. 2008
    ..We highlight the importance of careful attentiveness to off-target molecular- and circuit-level modulation of nociceptive processing while moving forward with the development of therapies that will restore motor function after SCI...
  13. ncbi Acute rolipram/thalidomide treatment improves tissue sparing and locomotion after experimental spinal cord injury
    Guido C Koopmans
    Department of Anesthesiology, Academic Hospital Maastricht, Maastricht, 6200 AZ, The Netherlands
    Exp Neurol 216:490-8. 2009
    ..The present data suggest that clinical trials for the acute combined application of rolipram and thalidomide may be warranted. The use of such "established drugs" could facilitate the early initiation of trials...
  14. ncbi Effect of spinal cord stimulation in an animal model of neuropathic pain relates to degree of tactile "allodynia"
    H Smits
    Pain Management and Research Center, Department of Anaesthesiology, Maastricht University Hospital, P Debyelaan 25, PO Box 5800, 6202 AZ Maastricht, The Netherlands
    Neuroscience 143:541-6. 2006
    ....
  15. ncbi Strain and locomotor speed affect over-ground locomotion in intact rats
    Guido C Koopmans
    Department of Anesthesiology, Academic Hospital Maastricht, Maastricht, The Netherlands
    Physiol Behav 92:993-1001. 2007
    ..We conclude that differences in gait traits exist between the three laboratory rat strains investigated and several of the examined gait parameters showed strain dependent interdependency with locomotor speed...
  16. doi The effect of Spinal Cord Stimulation in mice with chronic neuropathic pain after partial ligation of the sciatic nerve
    Michiel Truin
    Pain Management and Research Center, Department of Anaesthesiology, Maastricht University Hospital, P Debyelaan 25, PO Box 5800, 6202 AZ Maastricht, The Netherlands
    Pain 145:312-8. 2009
    ..This model allows future molecular-genetic studies on the mechanisms of SCS in chronic neuropathic pain...
  17. ncbi The assessment of locomotor function in spinal cord injured rats: the importance of objective analysis of coordination
    Guido C Koopmans
    Department of Psychiatry and Neuropsychology, Division Neuroscience, European Graduate School of Neuroscience EURON, University of Maastricht, Maastricht, The Netherlands
    J Neurotrauma 22:214-25. 2005
    ..This new method has been tested successfully in determination of positive effects of enriched housing on functional recovery after spinal cord injury (SCI)...
  18. doi Synaptic plasticity in the substantia gelatinosa in a model of chronic neuropathic pain
    Robby J P Jaken
    Pain Management and Research Center, Department of Anesthesiology, Institute of Brain and Behavior, Maastricht University Academic Hospital Maastricht, Maastricht, The Netherlands
    Neurosci Lett 469:30-3. 2010
    ..From these data we conclude that structural synaptic changes within the substantia gelatinosa are present months after complete nerve injury and that this plasticity may be involved in maintaining neuropathic pain states...
  19. doi Systemic but not local administration of retinoic acid reduces early transcript levels of pro-inflammatory cytokines after experimental spinal cord injury
    S van Neerven
    Department of Anesthesiology, School for Mental Health and Neuroscience, Maastricht University Medical Center, P Debyelaan 25, 6202 AZ, Maastricht, The Netherlands
    Neurosci Lett 485:21-5. 2010
    ..Future studies are required to investigate the effects of single intraperitoneal RA treatment on long-term SCI outcome...
  20. ncbi Modeling Parkinson's disease in rats: an evaluation of 6-OHDA lesions of the nigrostriatal pathway
    Ronald Deumens
    Department of Psychiatry and Neuropsychology, Brain and Behavior Institute, 6200 MD Maastricht, The Netherlands
    Exp Neurol 175:303-17. 2002
    ..The choice of the behavioral parameters determines the use of unilateral or bilateral lesions, although it is obvious that the bilateral model mimics the human situation more closely...
  21. doi Evaluation of functional nerve recovery with Visual-SSI--a novel computerized approach for the assessment of the static sciatic index (SSI)
    Ahmet Bozkurt
    Department of Plastic, Reconstructive, and Hand Surgery, Burn Center, University Hospital RWTH Aachen, Pauwelsstrasse 30, Aachen, Germany
    J Neurosci Methods 170:117-22. 2008
    ..05). The present method combines efficiency (simplicity of use, rapid and economical setup) with accurate and precise quantification of the functional regeneration in the sciatic nerve lesion model of the rat...