Mieke A Dentener

Summary

Affiliation: Maastricht University
Country: The Netherlands

Publications

  1. pmc Differences in local versus systemic TNFalpha production in COPD: inhibitory effect of hyaluronan on LPS induced blood cell TNFalpha release
    M A Dentener
    Nutrition and Toxicology Research Institute Maastricht, Department of Respiratory Medicine, University Hospital Maastricht, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    Thorax 61:478-84. 2006
  2. pmc Enhanced levels of hyaluronan in lungs of patients with COPD: relationship with lung function and local inflammation
    M A Dentener
    Toxicology Research Institute Maastricht, Department of Respiratory Medicine, University Hospital Maastricht, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    Thorax 60:114-9. 2005
  3. pmc Systemic anti-inflammatory mediators in COPD: increase in soluble interleukin 1 receptor II during treatment of exacerbations
    M A Dentener
    Department of Pulmonology and Surgery, Maastricht University, Nutrition and Toxicology Research Institute Maastricht NUTRIM, 6202 AZ Maastricht, The Netherlands
    Thorax 56:721-6. 2001
  4. doi request reprint Effect of infliximab on local and systemic inflammation in chronic obstructive pulmonary disease: a pilot study
    Mieke A Dentener
    Nutrition and Toxicology Research Institute Maastricht, Department of Respiratory Medicine, University Hospital Maastricht, Maastricht, The Netherlands
    Respiration 76:275-82. 2008
  5. doi request reprint Association of glutathione-S-transferase omega haplotypes with susceptibility to chronic obstructive pulmonary disease
    Dilyara G Yanbaeva
    Department of Respiratory Medicine, Nutrition and Toxicology Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, The Netherlands
    Free Radic Res 43:738-43. 2009
  6. pmc Patterns of inflammation and the use of reversibility testing in smokers with airway complaints
    Niels H Chavannes
    Department of General Practice, Caphri Research Institute, Maastricht University, The Netherlands
    BMC Pulm Med 6:11. 2006
  7. pmc IL6 and CRP haplotypes are associated with COPD risk and systemic inflammation: a case-control study
    Dilyara G Yanbaeva
    Department of Respiratory Medicine, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University Medical Centre, Maastricht, The Netherlands
    BMC Med Genet 10:23. 2009
  8. ncbi request reprint Rapid pulmonary expression of acute-phase reactants after local lipopolysaccharide exposure in mice is followed by an interleukin-6 mediated systemic acute-phase response
    Juanita H J Vernooy
    Nutrition and Toxicology Research Institute Maastricht NUTRIM, Department of Respiratory Medicine, University Hospital Maastricht, Maastricht, The Netherlands
    Exp Lung Res 31:855-71. 2005
  9. ncbi request reprint Systemic inflammation in COPD: is genetic susceptibility a key factor?
    Dilyara G Yanbaeva
    Department of Respiratory Medicine, University Hospital Maastricht, 6202 AZ Maastricht, The Netherlands
    COPD 3:51-61. 2006
  10. ncbi request reprint Longitudinal follow-up of systemic inflammation after acute exacerbations of COPD
    Karin H Groenewegen
    Department of Respiratory Medicine, University Hospital Maastricht, The Netherlands
    Respir Med 101:2409-15. 2007

Collaborators

Detail Information

Publications33

  1. pmc Differences in local versus systemic TNFalpha production in COPD: inhibitory effect of hyaluronan on LPS induced blood cell TNFalpha release
    M A Dentener
    Nutrition and Toxicology Research Institute Maastricht, Department of Respiratory Medicine, University Hospital Maastricht, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    Thorax 61:478-84. 2006
    ....
  2. pmc Enhanced levels of hyaluronan in lungs of patients with COPD: relationship with lung function and local inflammation
    M A Dentener
    Toxicology Research Institute Maastricht, Department of Respiratory Medicine, University Hospital Maastricht, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    Thorax 60:114-9. 2005
    ..HA levels in induced sputum from patients with COPD were measured and related to local inflammation. The expression of hyaluronan synthase 2 (HAS2) and hyaluronidase 2 (HYAL2) was analysed in lung tissue...
  3. pmc Systemic anti-inflammatory mediators in COPD: increase in soluble interleukin 1 receptor II during treatment of exacerbations
    M A Dentener
    Department of Pulmonology and Surgery, Maastricht University, Nutrition and Toxicology Research Institute Maastricht NUTRIM, 6202 AZ Maastricht, The Netherlands
    Thorax 56:721-6. 2001
    ..The aim of this study was to test the hypothesis that the chronic inflammatory process present in chronic obstructive pulmonary disease (COPD) is due to a defective endogenous anti-inflammatory mechanism...
  4. doi request reprint Effect of infliximab on local and systemic inflammation in chronic obstructive pulmonary disease: a pilot study
    Mieke A Dentener
    Nutrition and Toxicology Research Institute Maastricht, Department of Respiratory Medicine, University Hospital Maastricht, Maastricht, The Netherlands
    Respiration 76:275-82. 2008
    ..Also, baseline levels of new inflammatory markers were compared to control subjects...
  5. doi request reprint Association of glutathione-S-transferase omega haplotypes with susceptibility to chronic obstructive pulmonary disease
    Dilyara G Yanbaeva
    Department of Respiratory Medicine, Nutrition and Toxicology Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, The Netherlands
    Free Radic Res 43:738-43. 2009
    ..In conclusion, GSTO2 is a candidate gene for COPD, but is not associated with FEV(1)...
  6. pmc Patterns of inflammation and the use of reversibility testing in smokers with airway complaints
    Niels H Chavannes
    Department of General Practice, Caphri Research Institute, Maastricht University, The Netherlands
    BMC Pulm Med 6:11. 2006
    ..This study aimed to reveal what inflammatory patterns prevail in clinically established diagnosis groups, and what factors are associated with eosinophilia...
  7. pmc IL6 and CRP haplotypes are associated with COPD risk and systemic inflammation: a case-control study
    Dilyara G Yanbaeva
    Department of Respiratory Medicine, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University Medical Centre, Maastricht, The Netherlands
    BMC Med Genet 10:23. 2009
    ..The aim of this study was to examine the association between haplotypes of CRP, IL6 and FGB genes, systemic inflammation, COPD risk and COPD-related phenotypes (respiratory impairment, exercise capacity and body composition)...
  8. ncbi request reprint Rapid pulmonary expression of acute-phase reactants after local lipopolysaccharide exposure in mice is followed by an interleukin-6 mediated systemic acute-phase response
    Juanita H J Vernooy
    Nutrition and Toxicology Research Institute Maastricht NUTRIM, Department of Respiratory Medicine, University Hospital Maastricht, Maastricht, The Netherlands
    Exp Lung Res 31:855-71. 2005
    ..In conclusion, pulmonary LPS exposure induced rapid APR expression in lung, which precedes IL-6-mediated systemic elevation of APRs associated with hepatic APRs expression...
  9. ncbi request reprint Systemic inflammation in COPD: is genetic susceptibility a key factor?
    Dilyara G Yanbaeva
    Department of Respiratory Medicine, University Hospital Maastricht, 6202 AZ Maastricht, The Netherlands
    COPD 3:51-61. 2006
    ..However, large carefully designed studies in well-characterized COPD cohorts are required to unravel the exact role of genetic background in the systemic component of this disease...
  10. ncbi request reprint Longitudinal follow-up of systemic inflammation after acute exacerbations of COPD
    Karin H Groenewegen
    Department of Respiratory Medicine, University Hospital Maastricht, The Netherlands
    Respir Med 101:2409-15. 2007
    ..Systemic inflammation is now considered as an important component in the disease process. In this study we evaluated longitudinally the systemic inflammation during hospital treatment for acute exacerbation and after clinical recovery...
  11. ncbi request reprint Systemic inflammation in chronic obstructive pulmonary disease: the role of exacerbations
    Emiel F M Wouters
    Department of Respiratory Medicine, University Hospital Maastricht, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    Proc Am Thorac Soc 4:626-34. 2007
    ..Many overlapping connections and promising avenues of future research come to light with such a viewpoint...
  12. ncbi request reprint Systemic effects of smoking
    Dilyara G Yanbaeva
    Department of Respiratory Medicine, University Hospital Maastricht Maastricht University, 6202 AZ Maastricht, The Netherlands
    Chest 131:1557-66. 2007
    ..New longitudinal epidemiologic and genetic studies are required to evaluate the role of smoking itself and possible gene/environment interplay in initiation and development of smoking-induced common diseases affecting humans...
  13. ncbi request reprint Childhood asthma: exhaled markers of airway inflammation, asthma control score, and lung function tests
    Philippe P R Rosias
    Department of Pediatric Pulmonology, University Hospital Maastricht, The Netherlands
    Pediatr Pulmonol 38:107-14. 2004
    ..To further evaluate the clinical utility of exhaled markers in monitoring childhood asthma, more studies are required on a wider range of asthma severity, and preferably with repeated measurements of markers and of asthma control...
  14. pmc Efficacy of IFN-λ1 to protect human airway epithelial cells against human rhinovirus 1B infection
    Fahad Gulraiz
    Department of Medical Microbiology, Maastricht University Medical Centre, Maastricht, The Netherlands
    PLoS ONE 9:e95134. 2014
    ..Yet, the long-lasting induction of ISGs by IFN-λ1 and most likely less incitement of side effects due to more localized expression of its receptors could make it an even more promising candidate for prophylactic treatment than IFN-β. ..
  15. doi request reprint Decreased plasma sRAGE levels in COPD: influence of oxygen therapy
    Poornima Gopal
    Department of Respiratory Medicine, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center, Maastricht, The Netherlands
    Eur J Clin Invest 42:807-14. 2012
    ..Here the levels of plasma sRAGE and CML were determined and their variation in relation to lung function, external long-term oxygen therapy (LTOT) and plasma levels of inflammatory molecules in COPD evaluated...
  16. pmc Tumor necrosis factor-alpha +489G/A gene polymorphism is associated with chronic obstructive pulmonary disease
    Mehmet Küçükaycan
    Nutrition and Toxicology Research Institute Maastricht, Department of Pulmonology, Maastricht University, Maastricht, The Netherlands
    Respir Res 3:29. 2002
    ..In the present study the putative involvement of TNF-alpha gene polymorphisms in pathogenesis of COPD was studied by analysis of four TNF-alpha gene polymorphisms in a Caucasian COPD population...
  17. doi request reprint Systemic and local inflammation in asthma and chronic obstructive pulmonary disease: is there a connection?
    Emiel F M Wouters
    NUTRIM School for Nutrition, Toxicology and Metabolism, Department of Respiratory Medicine, Maastricht University Medical Center, Maastricht, The Netherlands
    Proc Am Thorac Soc 6:638-47. 2009
    ..Adipose tissue-mediated inflammation is discussed as a connecting link of systemic inflammation in asthma and COPD...
  18. doi request reprint Gender differences in the adipose secretome system in chronic obstructive pulmonary disease (COPD): a pivotal role of leptin
    Marie Kathrin Breyer
    Department of Respiratory Medicine, Maastricht University Medical Centre, PO Box 5800, 6202 AZ Maastricht, The Netherlands
    Respir Med 105:1046-53. 2011
    ..The role of circulating leptin and other adipokines in the involvement of the systemic inflammation in COPD is only studied scarcely...
  19. ncbi request reprint Local and systemic inflammation in patients with chronic obstructive pulmonary disease: soluble tumor necrosis factor receptors are increased in sputum
    Juanita H Vernooy
    Nutrition and Toxicology Research Institute Maastricht, Department of Pulmonology, Maastricht University, The Netherlands
    Am J Respir Crit Care Med 166:1218-24. 2002
    ....
  20. ncbi request reprint Antagonistic effects of lipopolysaccharide binding protein and bactericidal/permeability-increasing protein on lipopolysaccharide-induced cytokine release by mononuclear phagocytes. Competition for binding to lipopolysaccharide
    M A Dentener
    Department of Surgery, University of Limburg, Maastricht, The Netherlands
    J Immunol 151:4258-65. 1993
    ..We conclude from this study that LBP and BPI have counteractive effects on LPS-induced mononuclear phagocytic cell cytokine release by competing for binding to LPS...
  21. ncbi request reprint Intratracheal instillation of lipopolysaccharide in mice induces apoptosis in bronchial epithelial cells: no role for tumor necrosis factor-alpha and infiltrating neutrophils
    J H Vernooy
    Department of Pulmonology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Am J Respir Cell Mol Biol 24:569-76. 2001
    ....
  22. ncbi request reprint Long-term intratracheal lipopolysaccharide exposure in mice results in chronic lung inflammation and persistent pathology
    Juanita H J Vernooy
    Department of Pulmonology, Maastricht University, Maastricht, The Netherlands
    Am J Respir Cell Mol Biol 26:152-9. 2002
    ....
  23. ncbi request reprint Lipopolysaccharide binding protein and serum amyloid A secretion by human intestinal epithelial cells during the acute phase response
    A C Vreugdenhil
    Department of General Surgery, Maastricht University, The Netherlands
    J Immunol 163:2792-8. 1999
    ..Furthermore, the results demonstrate that tissues other than the liver are involved in the acute phase response...
  24. doi request reprint Enhanced pulmonary leptin expression in patients with severe COPD and asymptomatic smokers
    J H J Vernooy
    Department of Respiratory Medicine, University Hospital Maastricht, Maastricht, The Netherlands
    Thorax 64:26-32. 2009
    ..This study was undertaken to test the hypothesis that severe COPD is associated with increased leptin expression in epithelial cells...
  25. ncbi request reprint Production of the acute-phase protein lipopolysaccharide-binding protein by respiratory type II epithelial cells: implications for local defense to bacterial endotoxins
    M A Dentener
    Departments of Pulmonology and Surgery, Maastricht University, Maastricht, The Netherlands
    Am J Respir Cell Mol Biol 23:146-53. 2000
    ..The local production of this endotoxin binding protein by lung epithelial cells might contribute to a highly specific response at the site of exposure to bacteria and bacterial endotoxins...
  26. ncbi request reprint Disturbances in leptin metabolism are related to energy imbalance during acute exacerbations of chronic obstructive pulmonary disease
    E C Creutzberg
    Department of Pulmonology, Heart and Lung Function Laboratory, University Hospital Maastricht, Maastricht, The Netherlands
    Am J Respir Crit Care Med 162:1239-45. 2000
    ..Evidence was found that the elevated leptin concentrations were in turn under control of the systemic inflammatory response, and, presumably, the high-dose systemic glucocorticosteroid treatment...
  27. ncbi request reprint Leptin as local inflammatory marker in COPD
    R Broekhuizen
    Department of Respiratory Medicine, Nutrition and Toxicology Research Institute Maastricht, University Hospital Maastricht, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    Respir Med 99:70-4. 2005
    ....
  28. doi request reprint Interferon-β induces a long-lasting antiviral state in human respiratory epithelial cells
    Giel R Gaajetaan
    Department of Medical Microbiology, Maastricht University Medical Centre, PO Box 5800, 6202 AZ Maastricht, The Netherlands
    J Infect 66:163-9. 2013
    ..We therefore investigated the effects of prophylactic IFNβ on respiratory epithelial cells infected with rhinovirus (RV)...
  29. pmc The effects of treatment with chemotherapy on energy metabolism and inflammatory mediators in small-cell lung carcinoma
    A J Staal van den Brekel
    Department of Pulmonology, University Hospital, Maastricht, The Netherlands
    Br J Cancer 76:1630-5. 1997
    ..No correlation, however, existed between the decrease in REE and the decrease in the acute-phase proteins. In conclusion, chemotherapeutic treatment attenuates the tumour-related metabolic derangements and acute-phase response...
  30. pmc Similar matrix alterations in alveolar and small airway walls of COPD patients
    Irene Mj Eurlings
    Nutrition and Toxicology Research Institute Maastricht NUTRIM, Department of Respiratory Medicine, University Hospital Maastricht, P, O, Box 5800, 6202 AZ Maastricht, The Netherlands
    BMC Pulm Med 14:90. 2014
    ..The aim of this study was to characterise and assess similarities in alveolar and small airway wall matrix remodelling, and TGF-β signalling in COPD patients of different GOLD stages...
  31. ncbi request reprint Role of tumour necrosis factor in the enhanced sensitivity of mice to endotoxin after exposure to lead
    M A Dentener
    Department of Surgery, University of Limburg, Maastricht, The Netherlands
    Immunopharmacol Immunotoxicol 11:321-34. 1989
    ..The enhanced susceptibility to endotoxin is caused by an enhanced susceptibility to TNF and possibly by a prolonged exposure to a higher level of TNF...
  32. ncbi request reprint Chronic obstructive pulmonary disease is associated with the -1055 IL-13 promoter polymorphism
    T C T M van der Pouw Kraan
    Department of Molecular Cell Biology, Free University, Amsterdam, The Netherlands
    Genes Immun 3:436-9. 2002
    ..2 and 0.9, respectively). These results could implicate a functional role for the IL-13 promoter polymorphism in the enhanced risk to develop COPD...
  33. ncbi request reprint The bactericidal/permeability-increasing protein (BPI) is present in specific granules of human eosinophils
    J Calafat
    Division of Cell Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Blood 91:4770-5. 1998
    ..The presence of BPI in eosinophils suggests a role for these cells in host defense against Gram-negative bacterial invasion or may suggest a role for BPI against parasitic infestation...