M C G J Brouwers

Summary

Affiliation: Maastricht University
Country: The Netherlands

Publications

  1. doi Plasma PAI-1 levels are independently related to fatty liver and hypertriglyceridemia in familial combined hyperlipidemia, involvement of apolipoprotein E
    Martijn C G J Brouwers
    Department of Internal Medicine, University Hospital Maastricht, The Netherlands
    Thromb Res 122:466-72. 2008
  2. ncbi Increased arterial stiffness in familial combined hyperlipidemia
    Martijn C G J Brouwers
    Department of Internal Medicine and Endocrinology, Maastricht University Medical Centre, Maastricht, The Netherlands
    J Hypertens 27:1009-16. 2009
  3. doi Does glucose infusion exacerbate metformin-associated lactate acidosis? A case report
    M C G J Brouwers
    Department of Medicine and Endocrinology, Maastricht University Medical Centre, Maastricht, The Netherlands
    Diabetes Res Clin Pract 85:e1-3. 2009
  4. ncbi Parabolic relationship between plasma triacylglycerols and LDL-cholesterol in familial combined hyperlipidaemia: the multiple-type hyperlipidaemia explained?
    Martijn C G J Brouwers
    Department of Medicine, University Hospital Maastricht, Maastricht, The Netherlands
    Clin Sci (Lond) 114:393-401. 2008
  5. ncbi Fatty liver--based identification of two distinct hypertriglyceridemic subgroups in familial combined hyperlipidemia
    Martijn C G J Brouwers
    Laboratory of Molecular Metabolism and Endocrinology, Department of Medicine, University Hospital Maastricht, PO Box 616, 6200 MD Maastricht, The Netherlands
    Metabolism 56:1311-7. 2007
  6. ncbi Five-year follow-up of waist circumference, insulin and ALT levels in familial combined hyperlipidaemia
    Martijn C G J Brouwers
    Department of Medicine, University Hospital Maastricht, University of Maastricht, Maastricht, The Netherlands
    Clin Sci (Lond) 113:375-81. 2007
  7. ncbi Five-year incidence of type 2 diabetes mellitus in patients with familial combined hyperlipidaemia
    M C G J Brouwers
    Departments of Medicine and Endocrinology, Laboratory of Vascular Medicine and Metabolism, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, The Netherlands
    Neth J Med 68:163-7. 2010
  8. ncbi Heritability and genetic loci of fatty liver in familial combined hyperlipidemia
    Martijn C G J Brouwers
    Department of Medicine and Cardiovascular Research Institute Maastricht, Academic Hospital Maastricht, Maastricht, The Netherlands
    J Lipid Res 47:2799-807. 2006
  9. ncbi Fatty liver is an integral feature of familial combined hyperlipidaemia: relationship with fat distribution and plasma lipids
    Martijn C G J Brouwers
    Department of Medicine, University Hospital Maastricht, Maastricht, The Netherlands
    Clin Sci (Lond) 112:123-30. 2007
  10. doi Plasma triglycerides and LDL cholesterol are related in a parabolic fashion in the general population and patients with Type 2 diabetes mellitus: long-term follow-up results from the Hoorn study
    M C G J Brouwers
    Department of Medicine, University Hospital Maastricht, Laboratory of Metabolism and Vascular Biology, and Cardiovascular Research Institute Maastricht, University of Maastricht, The Netherlands
    Diabet Med 25:1121-4. 2008

Detail Information

Publications19

  1. doi Plasma PAI-1 levels are independently related to fatty liver and hypertriglyceridemia in familial combined hyperlipidemia, involvement of apolipoprotein E
    Martijn C G J Brouwers
    Department of Internal Medicine, University Hospital Maastricht, The Netherlands
    Thromb Res 122:466-72. 2008
    ....
  2. ncbi Increased arterial stiffness in familial combined hyperlipidemia
    Martijn C G J Brouwers
    Department of Internal Medicine and Endocrinology, Maastricht University Medical Centre, Maastricht, The Netherlands
    J Hypertens 27:1009-16. 2009
    ....
  3. doi Does glucose infusion exacerbate metformin-associated lactate acidosis? A case report
    M C G J Brouwers
    Department of Medicine and Endocrinology, Maastricht University Medical Centre, Maastricht, The Netherlands
    Diabetes Res Clin Pract 85:e1-3. 2009
    ..We describe here a case of metformin-associated lactate acidosis that rapidly deteriorated probably as a consequence of concomitant glucose infusion that was initiated to correct sulphonylurea-induced hypoglycemia...
  4. ncbi Parabolic relationship between plasma triacylglycerols and LDL-cholesterol in familial combined hyperlipidaemia: the multiple-type hyperlipidaemia explained?
    Martijn C G J Brouwers
    Department of Medicine, University Hospital Maastricht, Maastricht, The Netherlands
    Clin Sci (Lond) 114:393-401. 2008
    ....
  5. ncbi Fatty liver--based identification of two distinct hypertriglyceridemic subgroups in familial combined hyperlipidemia
    Martijn C G J Brouwers
    Laboratory of Molecular Metabolism and Endocrinology, Department of Medicine, University Hospital Maastricht, PO Box 616, 6200 MD Maastricht, The Netherlands
    Metabolism 56:1311-7. 2007
    ....
  6. ncbi Five-year follow-up of waist circumference, insulin and ALT levels in familial combined hyperlipidaemia
    Martijn C G J Brouwers
    Department of Medicine, University Hospital Maastricht, University of Maastricht, Maastricht, The Netherlands
    Clin Sci (Lond) 113:375-81. 2007
    ....
  7. ncbi Five-year incidence of type 2 diabetes mellitus in patients with familial combined hyperlipidaemia
    M C G J Brouwers
    Departments of Medicine and Endocrinology, Laboratory of Vascular Medicine and Metabolism, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, The Netherlands
    Neth J Med 68:163-7. 2010
    ..The current study was conducted to investigate whether patients with familial combined hyperlipidaemia (FCHL ) are predisposed to the development of type 2 diabetes mellitus (T2DM)...
  8. ncbi Heritability and genetic loci of fatty liver in familial combined hyperlipidemia
    Martijn C G J Brouwers
    Department of Medicine and Cardiovascular Research Institute Maastricht, Academic Hospital Maastricht, Maastricht, The Netherlands
    J Lipid Res 47:2799-807. 2006
    ..This study shows that fatty liver is a heritable aspect of FCHL. Replication of particularly the 7p region is awaited...
  9. ncbi Fatty liver is an integral feature of familial combined hyperlipidaemia: relationship with fat distribution and plasma lipids
    Martijn C G J Brouwers
    Department of Medicine, University Hospital Maastricht, Maastricht, The Netherlands
    Clin Sci (Lond) 112:123-30. 2007
    ..18, P=0.001 respectively). These results show that fatty liver is a central aspect of FCHL, i.e. patients and normolipidaemic relatives. Both visceral and subcutaneous adiposity contribute to its 3-4-fold higher risk in FCHL...
  10. doi Plasma triglycerides and LDL cholesterol are related in a parabolic fashion in the general population and patients with Type 2 diabetes mellitus: long-term follow-up results from the Hoorn study
    M C G J Brouwers
    Department of Medicine, University Hospital Maastricht, Laboratory of Metabolism and Vascular Biology, and Cardiovascular Research Institute Maastricht, University of Maastricht, The Netherlands
    Diabet Med 25:1121-4. 2008
    ..We anticipated that a parabolic relation between plasma triglycerides and LDL-C, as previously demonstrated in familial combined hyperlipidaemia (FCHL), might account for this phenomenon...
  11. doi Plasma proprotein convertase subtilisin kexin type 9 is not altered in subjects with impaired glucose metabolism and type 2 diabetes mellitus, but its relationship with non-HDL cholesterol and apolipoprotein B may be modified by type 2 diabetes mellitus:
    M C G J Brouwers
    Department of Internal Medicine, Division of General Internal Medicine, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands
    Atherosclerosis 217:263-7. 2011
    ..The present study was conducted to investigate the role of plasma proprotein convertase subtilisin kexin type 9 (PCSK9) levels, a regulator of LDL-receptor expression, in the occurrence of diabetic dyslipidemia...
  12. pmc Up-regulation of the complement system in subcutaneous adipocytes from nonobese, hypertriglyceridemic subjects is associated with adipocyte insulin resistance
    M M J van Greevenbroek
    Department of Internal Medicine, Division of General Internal Medicine, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, 6200 MD Maastricht, The Netherlands
    J Clin Endocrinol Metab 97:4742-52. 2012
    ..Dysfunctional adipose tissue plays an important role in the etiology of the metabolic syndrome, type 2 diabetes, and dyslipidemia. However, the molecular mechanisms underlying adipocyte dysfunction are incompletely understood...
  13. ncbi Subclasses of low-density lipoprotein and very low-density lipoprotein in familial combined hyperlipidemia: relationship to multiple lipoprotein phenotype
    A M Georgieva
    Cardiovascular Research Institute Maastricht, Laboratory of Molecular Metabolism and Endocrinology, Department of Medicine, University of Maastricht, The Netherlands
    Arterioscler Thromb Vasc Biol 24:744-9. 2004
    ..The present study addresses the presence of distinct metabolic phenotypes in familial combined hyperlipidemia (FCHL) in relation to small dense low-density lipoprotein (sd LDL) and very low-density lipoprotein (VLDL) subclasses...
  14. doi Plasma proprotein convertase subtilisin kexin type 9 levels are related to markers of cholesterol synthesis in familial combined hyperlipidemia
    M C G J Brouwers
    Department of Internal Medicine, Divisions of General Internal Medicine and Endocrinology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, PO Box 5800, 6202 AZ Maastricht, The Netherlands Electronic address
    Nutr Metab Cardiovasc Dis 23:1115-21. 2013
    ..The present study was conducted to study the relationship between plasma PCSK9 and markers of cholesterol synthesis in FCHL...
  15. doi Metformin-associated lactic acidosis in a patient with normal kidney function
    T T van Sloten
    Department of Internal Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands
    Diabetes Res Clin Pract 96:e57-8. 2012
    ..This report describes the presence of lactic acidosis in a patient with normal kidney function and normal doses of metformin. Subsequent positive rechallenge with metformin confirms causality...
  16. ncbi The circulating PBEF/NAMPT/visfatin level is associated with a beneficial blood lipid profile
    Ping Wang
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands
    Pflugers Arch 454:971-6. 2007
    ..The relation to lipid metabolism does not depend on visceral obesity and insulin resistance, but may be linked to its enzymatic function in NAD metabolism...
  17. ncbi Radiological evidence of nonalcoholic fatty liver disease in familial combined hyperlipidemia
    Tjerk W A de Bruin
    Cardiovascular Research Institute Maastricht, Laboratory of Molecular Metabolism and Endocrinology, Department of Medicine, University of Maastricht, Maastricht, The Netherlands
    Am J Med 116:847-9. 2004
  18. doi Plasma pigment epithelium-derived factor is positively associated with obesity in Caucasian subjects, in particular with the visceral fat depot
    Ping Wang
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Eur J Endocrinol 159:713-8. 2008
    ....
  19. ncbi Longitudinal differences in familial combined hyperlipidemia quantitative trait loci
    Martijn C G J Brouwers
    Arterioscler Thromb Vasc Biol 26:e118-9. 2006