Ellen Blaak

Summary

Affiliation: Maastricht University
Country: The Netherlands

Publications

  1. ncbi request reprint Fatty acid metabolism in obesity and type 2 diabetes mellitus
    E E Blaak
    Dept of Human Biology, Nutrition Research Centre, Maastricht University, PO Box 6166200, MD Maastricht, The Netherlands
    Proc Nutr Soc 62:753-60. 2003
  2. ncbi request reprint Microdialysis assessment of local adipose tissue lipolysis during beta-adrenergic stimulation in upper-body-obese subjects with type II diabetes
    E E Blaak
    Department of Human Biology, Maastricht University and University Hospital, P O Box 616, 6200 MD Maastricht, The Netherlands
    Clin Sci (Lond) 97:421-8. 1999
  3. ncbi request reprint The fate of [U-(13)C]palmitate extracted by skeletal muscle in subjects with type 2 diabetes and control subjects
    Ellen E Blaak
    Department of Human Biology, Nutrition Research Center, Maastricht University, Maastricht, The Netherlands
    Diabetes 51:784-9. 2002
  4. ncbi request reprint Fat oxidation before and after a high fat load in the obese insulin-resistant state
    Ellen E Blaak
    Department of Human Biology, Nutrition Research Centre, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    J Clin Endocrinol Metab 91:1462-9. 2006
  5. doi request reprint Sex differences in the control of glucose homeostasis
    Ellen Blaak
    Department of Human Biology, Nutrition and Toxicology Research Institute, Maastricht University, Maastricht, The Netherlands
    Curr Opin Clin Nutr Metab Care 11:500-4. 2008
  6. ncbi request reprint Basic disturbances in skeletal muscle fatty acid metabolism in obesity and type 2 diabetes mellitus
    E E Blaak
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Proc Nutr Soc 63:323-30. 2004
  7. ncbi request reprint Impaired beta-adrenergically mediated lipolysis in skeletal muscle of obese subjects
    E E Blaak
    Department of Human Biology, Nutrition Research Centre, Maastricht University, Maastricht, The Netherlands
    Diabetologia 47:1462-8. 2004
  8. ncbi request reprint Impaired fat-induced thermogenesis in obese subjects: the NUGENOB study
    Ellen E Blaak
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht, The Netherlands
    Obesity (Silver Spring) 15:653-63. 2007
  9. ncbi request reprint Metabolic fluxes in skeletal muscle in relation to obesity and insulin resistance
    Ellen E Blaak
    Department of Human Biology, Nutrition Research Centre, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Best Pract Res Clin Endocrinol Metab 19:391-403. 2005
  10. ncbi request reprint Increase in skeletal muscle fatty acid binding protein (FABPC) content is directly related to weight loss and to changes in fat oxidation following a very low calorie diet
    E E Blaak
    Department of Human Biology, Nutrition Research Centre, Maastricht University, Maastricht, The Netherlands
    Diabetologia 44:2013-7. 2001

Detail Information

Publications68

  1. ncbi request reprint Fatty acid metabolism in obesity and type 2 diabetes mellitus
    E E Blaak
    Dept of Human Biology, Nutrition Research Centre, Maastricht University, PO Box 6166200, MD Maastricht, The Netherlands
    Proc Nutr Soc 62:753-60. 2003
    ..The present review describes the reported disturbances in pathways of lipolysis and skeletal muscle fatty acid handling, and discusses underlying mechanisms and metabolic consequences of these disturbances...
  2. ncbi request reprint Microdialysis assessment of local adipose tissue lipolysis during beta-adrenergic stimulation in upper-body-obese subjects with type II diabetes
    E E Blaak
    Department of Human Biology, Maastricht University and University Hospital, P O Box 616, 6200 MD Maastricht, The Netherlands
    Clin Sci (Lond) 97:421-8. 1999
    ..The last two findings contrast with previous data from obese subjects, indicating that the regulation of lipolysis may differ in obesity and obesity-associated type II diabetes...
  3. ncbi request reprint The fate of [U-(13)C]palmitate extracted by skeletal muscle in subjects with type 2 diabetes and control subjects
    Ellen E Blaak
    Department of Human Biology, Nutrition Research Center, Maastricht University, Maastricht, The Netherlands
    Diabetes 51:784-9. 2002
    ....
  4. ncbi request reprint Fat oxidation before and after a high fat load in the obese insulin-resistant state
    Ellen E Blaak
    Department of Human Biology, Nutrition Research Centre, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    J Clin Endocrinol Metab 91:1462-9. 2006
    ..Obesity may be associated with a lowered use of fat as a fuel, which may contribute to the enlarged adipose tissue stores...
  5. doi request reprint Sex differences in the control of glucose homeostasis
    Ellen Blaak
    Department of Human Biology, Nutrition and Toxicology Research Institute, Maastricht University, Maastricht, The Netherlands
    Curr Opin Clin Nutr Metab Care 11:500-4. 2008
    ..A markedly higher prevalence of impaired glucose tolerance has been reported in women than in men, whereas the opposite was seen for impaired fasting glucose. The present review focuses on the underlying mechanisms...
  6. ncbi request reprint Basic disturbances in skeletal muscle fatty acid metabolism in obesity and type 2 diabetes mellitus
    E E Blaak
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Proc Nutr Soc 63:323-30. 2004
    ..Clearly, the precise sequence of events leading to an increased adiposity and insulin resistance in obesity and type 2 diabetes mellitus is not yet fully understood...
  7. ncbi request reprint Impaired beta-adrenergically mediated lipolysis in skeletal muscle of obese subjects
    E E Blaak
    Department of Human Biology, Nutrition Research Centre, Maastricht University, Maastricht, The Netherlands
    Diabetologia 47:1462-8. 2004
    ....
  8. ncbi request reprint Impaired fat-induced thermogenesis in obese subjects: the NUGENOB study
    Ellen E Blaak
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht, The Netherlands
    Obesity (Silver Spring) 15:653-63. 2007
    ..To study energy expenditure before and 3 hours after a high-fat load in a large cohort of obese subjects (n = 701) and a lean reference group (n = 113)...
  9. ncbi request reprint Metabolic fluxes in skeletal muscle in relation to obesity and insulin resistance
    Ellen E Blaak
    Department of Human Biology, Nutrition Research Centre, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Best Pract Res Clin Endocrinol Metab 19:391-403. 2005
    ..Many of these abnormalities have been reported both in the obese and the type 2 diabetic state. The role of obesity per se in these disturbances is an important question that needs to be addressed...
  10. ncbi request reprint Increase in skeletal muscle fatty acid binding protein (FABPC) content is directly related to weight loss and to changes in fat oxidation following a very low calorie diet
    E E Blaak
    Department of Human Biology, Nutrition Research Centre, Maastricht University, Maastricht, The Netherlands
    Diabetologia 44:2013-7. 2001
    ....
  11. ncbi request reprint Gender differences in fat metabolism
    E Blaak
    Department of Human Biology, Nutrition Research Centre, Maastricht University, The Netherlands
    Curr Opin Clin Nutr Metab Care 4:499-502. 2001
    ..Further studies are necessary to investigate the significance of differences in exercise-induced fat oxidation on 24-h fat balance...
  12. ncbi request reprint Impaired oxidation of plasma-derived fatty acids in type 2 diabetic subjects during moderate-intensity exercise
    E E Blaak
    Department of Human Biology, Nutrition Research Centre, Maastricht University, The Netherlands
    Diabetes 49:2102-7. 2000
    ..05). It is hypothesized that these impairments in fatty acid utilization may play a role in the etiology of skeletal muscle and hepatic insulin resistance...
  13. ncbi request reprint Weight reduction and the impaired plasma-derived free fatty acid oxidation in type 2 diabetic subjects
    E E Blaak
    Department of Human Biology, Nutrition Research Center, Maastricht University, 6200 MD Maastricht, The Netherlands
    J Clin Endocrinol Metab 86:1638-44. 2001
    ....
  14. ncbi request reprint Beta-adrenergically stimulated fat oxidation is diminished in middle-aged compared to young subjects
    E E Blaak
    Department of Human Biology, Nutrition Research Center, University of Maastricht, The Netherlands
    J Clin Endocrinol Metab 84:3764-9. 1999
    ..This diminished fat oxidation may be an important etiological factor in the age-related increase in body fatness and obesity by favoring fat storage above oxidation...
  15. ncbi request reprint Plasma FFA utilization and fatty acid-binding protein content are diminished in type 2 diabetic muscle
    E E Blaak
    Department of Human Biology, Maastricht University and Academic Hospital, 6200 MD Maastricht, The Netherlands
    Am J Physiol Endocrinol Metab 279:E146-54. 2000
    ..We conclude that the uptake and oxidation of plasma FFA are impaired in the forearm muscles of type 2 diabetic subjects in the overnight fasted state with and without Iso stimulation...
  16. ncbi request reprint Lipolytic and nutritive blood flow response to beta-adrenoceptor stimulation in situ in subcutaneous abdominal adipose tissue in obese men
    S L H Schiffelers
    Department of Human Biology, Maastricht University, The Netherlands
    Int J Obes Relat Metab Disord 27:227-31. 2003
    ..This study investigated whether local adipocyte beta-adrenergic sensitivity and changes in nutritive blood flow in subcutaneous abdominal adipose tissue contribute to this impaired response...
  17. doi request reprint Metabolic flexibility in the development of insulin resistance and type 2 diabetes: effects of lifestyle
    E Corpeleijn
    Department of Human Biology, The Nutrition and Toxicology Research Institute NUTRIM, Maastricht University, Maastricht, The Netherlands
    Obes Rev 10:178-93. 2009
    ..Lifestyle changes in dietary fat intake, physical activity and weight loss may improve metabolic flexibility in skeletal muscle, and thereby contribute to the prevention of type 2 diabetes...
  18. doi request reprint Effects of dietary fat modification on skeletal muscle fatty acid handling in the metabolic syndrome
    A M J van Hees
    Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
    Int J Obes (Lond) 34:859-70. 2010
    ..The objective of this study was to examine the effects of dietary fat modification on the capacity of skeletal muscle to handle dietary and endogenous fatty acids (FAs)...
  19. ncbi request reprint Direct association of a promoter polymorphism in the CD36/FAT fatty acid transporter gene with Type 2 diabetes mellitus and insulin resistance
    E Corpeleijn
    Department of Medicine and Endocrinology, Cardiovascular Research Institute CARIM, University Hospital Maastricht, Maastricht, The Netherlands
    Diabet Med 23:907-11. 2006
    ..Genetic variation in the CD36 gene may contribute to the aetiology of diabetes...
  20. ncbi request reprint Effect of short-term ACE inhibitor treatment on peripheral insulin sensitivity in obese insulin-resistant subjects
    G H Goossens
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Universiteitssingel 50, 6229 ER Maastricht, MD, Maastricht, The Netherlands
    Diabetologia 49:3009-16. 2006
    ..This study was designed to investigate the effect of short-term ACE inhibitor treatment on insulin sensitivity and to examine possible underlying metabolic and haemodynamic effects in obese insulin-resistant subjects...
  21. doi request reprint Several obesity- and nutrient-related gene polymorphisms but not FTO and UCP variants modulate postabsorptive resting energy expenditure and fat-induced thermogenesis in obese individuals: the NUGENOB study
    G H Goossens
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Int J Obes (Lond) 33:669-79. 2009
    ..Part of the heterogeneity of the obesity phenotype may originate from genetic differences between obese individuals that may influence energy expenditure (EE)...
  22. ncbi request reprint Improvements in glucose tolerance and insulin sensitivity after lifestyle intervention are related to changes in serum fatty acid profile and desaturase activities: the SLIM study
    E Corpeleijn
    Department of Human Biology, The Nutrition and Toxicology Research Institute NUTRIM, Maastricht University, Maastricht, The Netherlands
    Diabetologia 49:2392-401. 2006
    ....
  23. ncbi request reprint Association of a beta-2 adrenoceptor (ADRB2) gene variant with a blunted in vivo lipolysis and fat oxidation
    J W E Jocken
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Int J Obes (Lond) 31:813-9. 2007
    ..We investigated whether polymorphisms in codon 16, 27 and 164 of the beta (2)-adrenoceptor gene (ADRB2) and exon 10 of the G protein beta (3)-subunit gene (GNB3) are associated with alterations in in vivo lipolysis and fat oxidation...
  24. ncbi request reprint Substrate source utilisation in long-term diagnosed type 2 diabetes patients at rest, and during exercise and subsequent recovery
    H Boon
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, Maastricht, The Netherlands
    Diabetologia 50:103-12. 2007
    ..However, data on substrate source utilisation in type 2 diabetes are inconclusive...
  25. ncbi request reprint Skeletal muscle uncoupling protein-3 restores upon intervention in the prediabetic and diabetic state: implications for diabetes pathogenesis?
    M Mensink
    Department of Human Biology, Nutrition and Toxicology Research Institute NUTRIM, Maastricht University, Maastricht, The Netherlands
    Diabetes Obes Metab 9:594-6. 2007
    ..Here we examined whether intervention programs known to improve insulin sensitivity are paralleled by an increase in skeletal muscle UCP3 protein levels...
  26. pmc Effect of beta-adrenergic stimulation on whole-body and abdominal subcutaneous adipose tissue lipolysis in lean and obese men
    J W E Jocken
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, and Department of Nuclear Medicine, University Hospital Maastricht, Maastricht, The Netherlands
    Diabetologia 51:320-7. 2008
    ..We hypothesised that the beta-adrenergically mediated effect on lipolysis in abdominal SAT is also impaired in vivo in obese humans...
  27. doi request reprint Low-grade inflammation can partly explain the association between the metabolic syndrome and either coronary artery disease or severity of peripheral arterial disease: the CODAM study
    M Jacobs
    Laboratory for Metabolism and Vascular Medicine, Maastricht University, Maastricht, The Netherlands
    Eur J Clin Invest 39:437-44. 2009
    ..The aim was to study whether the association between the metabolic syndrome and CAD or the severity of PAD can be explained by low-grade inflammation...
  28. doi request reprint Short-term beta-adrenergic regulation of leptin, adiponectin and interleukin-6 secretion in vivo in lean and obese subjects
    G H Goossens
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, Maastricht, The Netherlands
    Diabetes Obes Metab 10:1029-38. 2008
    ....
  29. doi request reprint Impact of 3-year lifestyle intervention on postprandial glucose metabolism: the SLIM study
    C Roumen
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, NUTRIM, Maastricht University, Maastricht, The Netherlands
    Diabet Med 25:597-605. 2008
    ....
  30. doi request reprint Expression of genes involved in lipid metabolism in men with impaired glucose tolerance: impact of insulin stimulation and weight loss
    E Konings
    Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
    J Nutrigenet Nutrigenomics 3:9-17. 2010
    ..Conclusions:SREBP-2 shows altered insulin responsiveness in IGT men compared with NGT men, while there were no differences in basal gene expression...
  31. doi request reprint Intravenous AICAR administration reduces hepatic glucose output and inhibits whole body lipolysis in type 2 diabetic patients
    H Boon
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Diabetologia 51:1893-900. 2008
    ..In this study, we aimed to assess the impact of the AMPK activator 5-aminoimidazole-4-carboxamide riboside (AICAR) on both glucose and fatty acid metabolism in vivo in type 2 diabetic patients...
  32. ncbi request reprint Insulin acutely upregulates protein expression of the fatty acid transporter CD36 in human skeletal muscle in vivo
    E Corpeleijn
    From the Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    J Physiol Pharmacol 59:77-83. 2008
    ..We conclude that also in obese humans the FAT/CD36 protein content in skeletal muscle is dynamically regulated by insulin in vivo on the short term...
  33. ncbi request reprint Angiotensin II: a hormone that affects lipid metabolism in adipose tissue
    G H Goossens
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, Maastricht, The Netherlands
    Int J Obes (Lond) 31:382-4. 2007
    ..Alterations in adipose tissue lipolysis may contribute to the pathophysiology of obesity and insulin resistance. We examined the effects of angiotensin II (Ang II) on abdominal subcutaneous adipose tissue lipolysis in humans...
  34. pmc Angiotensin II: a major regulator of subcutaneous adipose tissue blood flow in humans
    G H Goossens
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, Maastricht, The Netherlands
    J Physiol 571:451-60. 2006
    ..Locally produced Ang II does not appear to regulate ATBF. Ang II appears to have no major effect on the postprandial enhancement of ATBF...
  35. ncbi request reprint Subscapular skinfold thickness distinguishes between transient and persistent impaired glucose tolerance: Study on Lifestyle-Intervention and Impaired Glucose Tolerance Maastricht (SLIM)
    M Mensink
    Department of Human Biology, Nutrition and Toxicology Research Institute NUTRIM, Maastricht University, Maastricht, The Netherlands
    Diabet Med 20:552-7. 2003
    ..To assess whether adding anthropometric measurements to an oral glucose tolerance test (OGTT) can help to distinguish between transient and persistent impaired glucose tolerance (IGT)...
  36. ncbi request reprint Study on Lifestyle Intervention and Impaired Glucose Tolerance Maastricht (SLIM): preliminary results after one year
    M Mensink
    Department of Human Biology, Maastricht University, Maastricht, The Netherlands
    Int J Obes Relat Metab Disord 27:377-84. 2003
    ..The aim of this study is to evaluate the effect of a lifestyle-intervention programme on glucose tolerance in Dutch subjects with impaired glucose tolerance (IGT)...
  37. ncbi request reprint Possible involvement of the adipose tissue renin-angiotensin system in the pathophysiology of obesity and obesity-related disorders
    G H Goossens
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Obes Rev 4:43-55. 2003
    ..Finally, we will focus on the different pharmaceutical agents that interfere with the RAS and highlight the possible implications of these drugs in the treatment of obesity-related disorders...
  38. ncbi request reprint Uncoupling protein 3 content is decreased in skeletal muscle of patients with type 2 diabetes
    P Schrauwen
    Department of Human Biology, Maastricht University, Maastricht, The Netherlands
    Diabetes 50:2870-3. 2001
    ..In conclusion, UCP3 content is lower in type 2 diabetic patients compared with healthy control subjects. These results are consistent with a role for UCP3 in glucose homeostasis and suggest a role for UCP3 in type 2 diabetes...
  39. ncbi request reprint Lifestyle changes and lipid metabolism gene expression and protein content in skeletal muscle of subjects with impaired glucose tolerance
    M Mensink
    Nutrition and Toxicology Research Institute Maastricht, Maastricht University, 6200 MD Maastricht, The Netherlands
    Diabetologia 46:1082-9. 2003
    ....
  40. ncbi request reprint Plasma free Fatty Acid uptake and oxidation are already diminished in subjects at high risk for developing type 2 diabetes
    M Mensink
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, Maastricht, The Netherlands
    Diabetes 50:2548-54. 2001
    ....
  41. ncbi request reprint Angiotensin II-induced effects on adipose and skeletal muscle tissue blood flow and lipolysis in normal-weight and obese subjects
    G H Goossens
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, 6200 MD Maastricht, The Netherlands
    J Clin Endocrinol Metab 89:2690-6. 2004
    ..These effects were not significantly different in obese and normal-weight subjects in both tissues...
  42. ncbi request reprint beta-Adrenoceptor-mediated thermogenesis and lipolysis in patients with chronic obstructive pulmonary disease
    S L Schiffelers
    Department of Human Biology, Maastricht University, PO Box 616, NL 6200 MD Maastricht, The Netherlands
    Am J Physiol Endocrinol Metab 280:E357-64. 2001
    ..05). In conclusion, beta-adrenoceptor-mediated lipolysis and thermogenesis are impaired in COPD patients. This may play a role in the development or maintenance of their relatively increased fat mass...
  43. ncbi request reprint In vivo beta3-adrenergic stimulation of human thermogenesis and lipid use
    S L Schiffelers
    Nutrition Toxicology and Environment Research Institute Maastricht, Department of Human Biology, Maastricht University, The Netherlands
    Clin Pharmacol Ther 67:558-66. 2000
    ..To investigate the role of the human beta3-adrenergic receptor in in vivo isoproterenol (INN, isoprenaline)-induced thermogenesis and lipid use...
  44. ncbi request reprint Determinants of the acetate recovery factor: implications for estimation of [13C]substrate oxidation
    P Schrauwen
    Department of Human Biology, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Clin Sci (Lond) 98:587-92. 2000
    ..Failure to do this might result in large under- or over-estimation of plasma substrate oxidation, and hence to artificial differences between groups...
  45. doi request reprint Changes in transferrin are related to changes in insulin resistance: the SLIM study
    C Roumen
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht NUTRIM, University of Maastricht, Maastricht, The Netherlands
    Diabet Med 25:1478-82. 2008
    ..To determine the effect of a lifestyle intervention on serum transferrin and ferritin levels and the relationship between changes in transferrin and ferritin and changes in glucose tolerance and insulin resistance...
  46. doi request reprint Obesity and the lung: 5. Obesity and COPD
    F M E Franssen
    Department of Respiratory Medicine, University Hospital Maastricht, Maastricht, The Netherlands
    Thorax 63:1110-7. 2008
    ..The potential interaction between abnormal adipose tissue function, systemic inflammation and COPD may provide more insight into the pathogenesis and reversibility of systemic pathology in this disease...
  47. pmc Hormone-sensitive lipase serine phosphorylation and glycerol exchange across skeletal muscle in lean and obese subjects: effect of beta-adrenergic stimulation
    Johan W E Jocken
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Diabetes 57:1834-41. 2008
    ..We aimed to investigate whether a blunted fasting or beta-adrenergically mediated lipolysis contributes to this increased IMTG storage in obesity...
  48. ncbi request reprint Reduced oxidation of dietary fat after a short term high-carbohydrate diet
    Rachel Roberts
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom
    Am J Clin Nutr 87:824-31. 2008
    ..The underlying tissue-specific alterations in fatty acid metabolism are not well understood...
  49. doi request reprint Upstream transcription factor 1 (USF1) in risk of type 2 diabetes: association study in 2000 Dutch Caucasians
    Steven J R Meex
    University of Maastricht, Cardiovascular Research Institute Maastricht CARIM, Department of Internal Medicine, Maastricht, The Netherlands
    Mol Genet Metab 94:352-5. 2008
    ..5%. In conclusion, the major allele of rs2073658 in the USF1 gene is associated with a modestly increased risk to develop type 2 diabetes in Dutch Caucasians, with considerable impact at the population level...
  50. ncbi request reprint Substrate oxidation, obesity and exercise training
    Ellen E Blaak
    Department of Human Biology, Nutrition Research Centre, Maastricht University, The Netherlands
    Best Pract Res Clin Endocrinol Metab 16:667-78. 2002
    ..Because disturbed muscle fat oxidation may be a primary event in the aetiology of obesity it is of the utmost importance to obtain more information on how and whether exercise training may be able to compensate for these impairments...
  51. ncbi request reprint Glycemic index and glycemic load in relation to food and nutrient intake and metabolic risk factors in a Dutch population
    Huaidong Du
    National Institute for Public Health and the Environment RIVM, Bilthoven, Netherlands
    Am J Clin Nutr 87:655-61. 2008
    ..Previous studies on the glycemic index (GI) and glycemic load (GL) reported inconsistent findings on their association with metabolic risk factors. This may partly have been due to differences in underlying dietary patterns...
  52. ncbi request reprint Study on lifestyle-intervention and impaired glucose tolerance Maastricht (SLIM): design and screening results
    Marco Mensink
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, P O Box 616, 6200 MD Maastricht, Netherlands
    Diabetes Res Clin Pract 61:49-58. 2003
    ..SLIM will address this topic in the Dutch population...
  53. doi request reprint Catecholamine-induced lipolysis in adipose tissue and skeletal muscle in obesity
    Johan W E Jocken
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, Maastricht, The Netherlands
    Physiol Behav 94:219-30. 2008
    ....
  54. ncbi request reprint Reduced skeletal muscle uncoupling protein-3 content in prediabetic subjects and type 2 diabetic patients: restoration by rosiglitazone treatment
    Patrick Schrauwen
    Nutrition and Toxicology Research Institute Maastricht, Department of Human Biology, Maastricht University, P O Box 616, NL 6200 MD Maastricht, The Netherlands
    J Clin Endocrinol Metab 91:1520-5. 2006
    ..Recent evidence points toward mitochondrial aberrations as a major contributor to the development of insulin resistance and diabetes, and UCP3 is reduced in diabetes...
  55. ncbi request reprint Lifestyle intervention and fatty acid metabolism in glucose-intolerant subjects
    Marco Mensink
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, The Netherlands
    Obes Res 13:1354-62. 2005
    ..Because exercise training is known to increase fatty acid (FA) oxidation, we investigated whether a combined diet and physical activity intervention program can improve FA oxidation in subjects with IGT...
  56. ncbi request reprint Genotype-by-nutrient interactions assessed in European obese women. A case-only study
    Jose L Santos
    Dept of Physiology and Nutrition, University of Navarra, 31008, Pamplona, Spain
    Eur J Nutr 45:454-62. 2006
    ..Whereas changes in the environment appear to be responsible for the increasing prevalence of obesity, genetic factors interacting with environmental factors would contribute to explain obesity onset and severity...
  57. ncbi request reprint Validation of capillary glucose measurements to detect glucose intolerance or type 2 diabetes mellitus in the general population
    Margriet Kruijshoop
    Laboratory for Molecular Metabolism and Endocrinology, Department of Internal Medicine, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, Mailbox 14, P O Box 616, 6200 MD Maastricht, The Netherlands
    Clin Chim Acta 341:33-40. 2004
    ....
  58. ncbi request reprint Preferential uptake of dietary Fatty acids in adipose tissue and muscle in the postprandial period
    Alex S T Bickerton
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, UK
    Diabetes 56:168-76. 2007
    ..With this integrative physiological approach, we have revealed hidden complexities in pathways of fatty acid uptake in adipose tissue and skeletal muscle...
  59. ncbi request reprint Endocrine role of the renin-angiotensin system in human adipose tissue and muscle: effect of beta-adrenergic stimulation
    Gijs H Goossens
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Hypertension 49:542-7. 2007
    ..In contrast, AGT is released from adipose tissue and muscle in obese subjects during beta-adrenergic stimulation, which may contribute to the increased plasma Ang II concentrations during beta-adrenergic stimulation in obese subjects...
  60. ncbi request reprint Adipose triglyceride lipase and hormone-sensitive lipase protein expression is decreased in the obese insulin-resistant state
    Johan W E Jocken
    Department of Human Biology, Maastricht University, Maastricht, The Netherlands
    J Clin Endocrinol Metab 92:2292-9. 2007
    ..In addition, we investigated whether a possible impaired expression could be reversed by a period of weight reduction...
  61. ncbi request reprint Postprandial interleukin-6 release from skeletal muscle in men with impaired glucose tolerance can be reduced by weight loss
    Eva Corpeleijn
    Department of Human Biology, Nutrition and Toxicology Research Institute, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    J Clin Endocrinol Metab 90:5819-24. 2005
    ..Obesity and type 2 diabetes mellitus are associated with increased levels of IL-6, a marker of inflammation...
  62. ncbi request reprint Lifestyle intervention according to general recommendations improves glucose tolerance
    Marco Mensink
    Department of Human Biology, Nutrition and Toxicology Research Institute, Maastricht University, The Netherlands
    Obes Res 11:1588-96. 2003
    ..We evaluated the impact of a 2-year combined diet and physical activity intervention program on glucose tolerance in Dutch subjects at increased risk for developing diabetes...
  63. ncbi request reprint Lifestyle intervention and adipokine levels in subjects at high risk for type 2 diabetes: the Study on Lifestyle intervention and Impaired glucose tolerance Maastricht (SLIM)
    Eva Corpeleijn
    Human Biology, Nutrition and Toxicology Research Institute, Maastricht, The Netherlands
    Diabetes Care 30:3125-7. 2007
    ....
  64. ncbi request reprint The effects of hydralazine on lipolysis in subcutaneous adipose tissue in humans
    Niels Boon
    Nutrition and Toxicology Research Institute Maastricht, University of Maastricht, Maastricht, The Netherlands
    Metabolism 56:1742-8. 2007
    ..05). The present results indicate that hydralazine increases lipolysis in abdominal subcutaneous adipose tissue in healthy lean subjects, but hydralazine had no significant effects on local blood flow in adipose tissue...
  65. ncbi request reprint Substrate source use in older, trained males after decades of endurance training
    Hanneke Boon
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Med Sci Sports Exerc 39:2160-70. 2007
    ..The purpose of this study was to compare substrate source use in older, long-term exercising, endurance-trained males with sedentary controls...
  66. pmc Adipose triglyceride lipase (ATGL) expression in human skeletal muscle is type I (oxidative) fiber specific
    Johan W E Jocken
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Histochem Cell Biol 129:535-8. 2008
    ..Moreover, ATGL is exclusively expressed in type I (oxidative) muscle fibers, suggesting a pivotal role for ATGL in intramuscular fatty acid handling, lipid storage and breakdown...
  67. doi request reprint Blunted beta-adrenoceptor-mediated fat oxidation in overweight subjects: a role for the hormone-sensitive lipase gene
    Johan W E Jocken
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, Maastricht, The Netherlands
    Metabolism 57:326-32. 2008
    ..In conclusion, our results suggest that variation in i7 and i6 of the HSL gene might be associated with a physiological effect on in vivo beta-adrenoceptor-mediated fat oxidation, at least in overweight-obese female subjects...
  68. doi request reprint Impaired skeletal muscle substrate oxidation in glucose-intolerant men improves after weight loss
    Eva Corpeleijn
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Obesity (Silver Spring) 16:1025-32. 2008
    ....