Pauline Aalten

Summary

Affiliation: Maastricht University
Country: The Netherlands

Publications

  1. ncbi request reprint A prospective study of the effects of behavioral symptoms on the institutionalization of patients with dementia
    Marjolein E de Vugt
    Department of Psychiatry and Neuropsychology, University of Maastricht, The Netherlands
    Int Psychogeriatr 17:577-89. 2005
  2. ncbi request reprint Awareness and behavioral problems in dementia patients: a prospective study
    Pauline Aalten
    Department of Psychiatry and Neuropsychology, Brain and Behavior Institute, University of Maastricht, Maastricht, The Netherlands
    Int Psychogeriatr 18:3-17. 2006
  3. doi request reprint Prevalence of neuropsychiatric symptoms in young-onset compared to late-onset Alzheimer's disease - part 1: findings of the two-year longitudinal NeedYD-study
    Deliane van Vliet
    School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University Medical Center, Maastricht, The Netherlands
    Dement Geriatr Cogn Disord 34:319-27. 2012
  4. ncbi request reprint Consistency of neuropsychiatric syndromes across dementias: results from the European Alzheimer Disease Consortium. Part II
    Pauline Aalten
    Department of Psychiatry and Neuropsychology, Alzheimer Centre Limburg, Maastricht University Hospital, Maastricht, The Netherlands
    Dement Geriatr Cogn Disord 25:1-8. 2008
  5. ncbi request reprint Cognitive functioning in spousal caregivers of dementia patients: findings from the prospective MAASBED study
    Marjolein E de Vugt
    Department of Psychiatry and Neuropsychology, University of Maastricht, PO Box 616, 6200 MD Maastricht, The Netherlands
    Age Ageing 35:160-6. 2006
  6. ncbi request reprint Do caregiver management strategies influence patient behaviour in dementia?
    Marjolein E de Vugt
    Department of Psychiatry and Neuropsychology, University of Maastricht, The Netherlands
    Int J Geriatr Psychiatry 19:85-92. 2004
  7. ncbi request reprint The influence of neuropsychological functioning on neuropsychiatric problems in dementia
    Pauline Aalten
    Department of Psychiatry and Neuropsychology, University Hospital of Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands
    J Neuropsychiatry Clin Neurosci 19:50-6. 2007
  8. doi request reprint The predictive value of memory strategies for Alzheimer's disease in subjects with mild cognitive impairment
    Inez H G B Ramakers
    Department of Psychiatry and Neuropsychology Alzheimer Center Limburg, School for Mental Health and Neurosciences, Maastricht University Medical Center, Maastricht, The Netherlands
    Arch Clin Neuropsychol 25:71-7. 2010
  9. ncbi request reprint The course of neuropsychiatric symptoms in dementia. Part II: relationships among behavioural sub-syndromes and the influence of clinical variables
    Pauline Aalten
    Department of Psychiatry and Neuropsychology, University of Maastricht, The Netherlands
    Int J Geriatr Psychiatry 20:531-6. 2005
  10. ncbi request reprint The course of neuropsychiatric symptoms in dementia. Part I: findings from the two-year longitudinal Maasbed study
    Pauline Aalten
    Department of Psychiatry and Neuropsychology, University of Maastricht, The Netherlands
    Int J Geriatr Psychiatry 20:523-30. 2005

Collaborators

Detail Information

Publications26

  1. ncbi request reprint A prospective study of the effects of behavioral symptoms on the institutionalization of patients with dementia
    Marjolein E de Vugt
    Department of Psychiatry and Neuropsychology, University of Maastricht, The Netherlands
    Int Psychogeriatr 17:577-89. 2005
    ..The aim of the present study was to examine the impact of specific behavioral subsyndromes and caregivers' emotional reaction on NHP...
  2. ncbi request reprint Awareness and behavioral problems in dementia patients: a prospective study
    Pauline Aalten
    Department of Psychiatry and Neuropsychology, Brain and Behavior Institute, University of Maastricht, Maastricht, The Netherlands
    Int Psychogeriatr 18:3-17. 2006
    ..Specifically, it was hypothesized that relatively intact awareness was related to affective disorders...
  3. doi request reprint Prevalence of neuropsychiatric symptoms in young-onset compared to late-onset Alzheimer's disease - part 1: findings of the two-year longitudinal NeedYD-study
    Deliane van Vliet
    School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University Medical Center, Maastricht, The Netherlands
    Dement Geriatr Cogn Disord 34:319-27. 2012
    ..The aim of this study is to assess frequency parameters of neuropsychiatric symptoms in YO-AD over 2 years and investigate whether there are differences compared with late-onset Alzheimer's disease (LO-AD)...
  4. ncbi request reprint Consistency of neuropsychiatric syndromes across dementias: results from the European Alzheimer Disease Consortium. Part II
    Pauline Aalten
    Department of Psychiatry and Neuropsychology, Alzheimer Centre Limburg, Maastricht University Hospital, Maastricht, The Netherlands
    Dement Geriatr Cogn Disord 25:1-8. 2008
    ..g. dementia subtypes, dementia severity, medication use, age and gender) in a large sample of outpatients with dementia...
  5. ncbi request reprint Cognitive functioning in spousal caregivers of dementia patients: findings from the prospective MAASBED study
    Marjolein E de Vugt
    Department of Psychiatry and Neuropsychology, University of Maastricht, PO Box 616, 6200 MD Maastricht, The Netherlands
    Age Ageing 35:160-6. 2006
    ..Spousal caregivers are usually of the same age as the dementia patient and therefore at risk of age-related cognitive decline. Suboptimal cognitive functioning in caregivers may have profound implications...
  6. ncbi request reprint Do caregiver management strategies influence patient behaviour in dementia?
    Marjolein E de Vugt
    Department of Psychiatry and Neuropsychology, University of Maastricht, The Netherlands
    Int J Geriatr Psychiatry 19:85-92. 2004
    ..However, identification of specific caregiver strategies may provide useful information on the management and manifestation of behavioural problems in dementia...
  7. ncbi request reprint The influence of neuropsychological functioning on neuropsychiatric problems in dementia
    Pauline Aalten
    Department of Psychiatry and Neuropsychology, University Hospital of Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands
    J Neuropsychiatry Clin Neurosci 19:50-6. 2007
    ..In particular, a low level of language expression was related to higher levels of overall neuropsychiatric problems and to psychosis. Impairment of abstract reasoning was related to psychosis and aberrant motor behavior...
  8. doi request reprint The predictive value of memory strategies for Alzheimer's disease in subjects with mild cognitive impairment
    Inez H G B Ramakers
    Department of Psychiatry and Neuropsychology Alzheimer Center Limburg, School for Mental Health and Neurosciences, Maastricht University Medical Center, Maastricht, The Netherlands
    Arch Clin Neuropsychol 25:71-7. 2010
    ..Prodromal AD is characterized by a decreased use of effortful learning strategies. This finding may have implications for the early detection of AD in MCI subjects and for the development of cognitive training programs...
  9. ncbi request reprint The course of neuropsychiatric symptoms in dementia. Part II: relationships among behavioural sub-syndromes and the influence of clinical variables
    Pauline Aalten
    Department of Psychiatry and Neuropsychology, University of Maastricht, The Netherlands
    Int J Geriatr Psychiatry 20:531-6. 2005
    ..Although several studies have mentioned associations between neuropsychiatric symptoms, there have been no prospective studies determining interrelations among behavioural sub-syndromes...
  10. ncbi request reprint The course of neuropsychiatric symptoms in dementia. Part I: findings from the two-year longitudinal Maasbed study
    Pauline Aalten
    Department of Psychiatry and Neuropsychology, University of Maastricht, The Netherlands
    Int J Geriatr Psychiatry 20:523-30. 2005
    ..Although neuropsychiatric symptoms in dementia are common, there have been few large long-term prospective studies assessing the course of a broad range of neuropsychiatric symptoms in dementia...
  11. ncbi request reprint Impact of behavioural problems on spousal caregivers: a comparison between Alzheimer's disease and frontotemporal dementia
    Marjolein E de Vugt
    Department of Psychiatry and Neuropsychology, University of Maastricht, Maastricht, The Netherlands
    Dement Geriatr Cogn Disord 22:35-41. 2006
    ..The aim of this study was to compare caregivers' distress related to behavioural symptoms of AD and FTD...
  12. ncbi request reprint Behavioral problems in dementia patients and salivary cortisol patterns in caregivers
    Marjolein E de Vugt
    Department of Psychiatry and Neuropsychology, University Hospital of Maastricht, The Netherlands
    J Neuropsychiatry Clin Neurosci 17:201-7. 2005
    ..Elevated morning cortisol levels could predispose caregivers to negative health consequences, with caregivers of patients with BPSD at greater risk...
  13. doi request reprint Neuropsychological correlates of apathy in mild cognitive impairment and Alzheimer's disease: the role of executive functioning
    Rosa L Drijgers
    Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience Alzheimer Center Limburg, Maastricht University Medical Center, Maastricht, The Netherlands
    Int Psychogeriatr 23:1327-33. 2011
    ..The aim of the current study was to examine the association between apathy and neuropsychological functioning in patients with MCI and AD...
  14. ncbi request reprint Neuropsychiatric syndromes in dementia. Results from the European Alzheimer Disease Consortium: part I
    Pauline Aalten
    Department of Psychiatry and Neuropsychology, Alzheimer Centre Limburg, Maastricht University Hospital, Maastricht, The Netherlands
    Dement Geriatr Cogn Disord 24:457-63. 2007
    ..The aim of this study was to identify neuropsychiatric subsyndromes of the Neuropsychiatric Inventory in a large sample of outpatients with Alzheimer's disease (AD)...
  15. ncbi request reprint Behavioural disturbances in dementia patients and quality of the marital relationship
    Marjolein E de Vugt
    Department of Psychiatry and Neuropsychology, University of Maastricht, 6200 MD Maastricht, The Netherlands
    Int J Geriatr Psychiatry 18:149-54. 2003
    ..To investigate the relationship between behavioural problems in patients with dementia and changes in the marital relationship...
  16. doi request reprint Dynamic cerebral autoregulation in subjects with Alzheimer's disease, mild cognitive impairment, and controls: evidence for increased peripheral vascular resistance with possible predictive value
    Erik D Gommer
    Department of Clinical Neurophysiology, Maastricht University Medical Centre, Maastricht, The Netherlands
    J Alzheimers Dis 30:805-13. 2012
    ..AD, p = 0.004). In conclusion, AD patients compared to MCI patients and controls have increased CVRi, whereas dCA parameters do not seem to differentiate AD patients. For MCI patients, CVRi might have predictive value in developing AD...
  17. ncbi request reprint Relationship between measures of dementia severity and observation of daily life functioning as measured with the Assessment of Motor and Process Skills (AMPS)
    Sharon F M Bouwens
    School for Mental Health and Neuroscience Alzheimer Centrum Limburg, Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, The Netherlands
    Dement Geriatr Cogn Disord 25:81-7. 2008
    ..The relationship between these domains is unclear. The Assessment of Motor and Process Skills (AMPS) is a relatively unexplored instrument in people with dementia, measuring severity by direct observation...
  18. ncbi request reprint Symptoms of preclinical dementia in general practice up to five years before dementia diagnosis
    Inez H G B Ramakers
    Department of Psychiatry and Neuropsychology, Institute of Brain and Behavior, Maastricht University, Maastricht, The Netherlands
    Dement Geriatr Cogn Disord 24:300-6. 2007
    ..To investigate which symptoms are indicative of preclinical dementia in general practice and whether subjects with preclinical dementia have an increased contact frequency with their general practitioner (GP)...
  19. doi request reprint Measurements of medial temporal lobe atrophy for prediction of Alzheimer's disease in subjects with mild cognitive impairment
    Lies Clerx
    Department of Psychiatry and Neuropsychology, Maastricht University, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht, The Netherlands
    Neurobiol Aging 34:2003-13. 2013
    ..MTA-score and lateral ventricle volume correlated with CSF beta-amyloid 1-42. We can conclude that volumetric hippocampal measurements are the best predictors of AD conversion in subjects with MCI...
  20. ncbi request reprint Behavioral problems in dementia: a factor analysis of the neuropsychiatric inventory
    Pauline Aalten
    Brain and Behavior Institute, University of Maastricht, The Netherlands
    Dement Geriatr Cogn Disord 15:99-105. 2003
    ..Anxiety was regarded as a separate symptom. The subsyndrome mood/apathy was the most common, occurring in almost 80% of the patients, versus psychosis and hyperactivity, which occurred in 37 and 60% of the patients, respectively...
  21. doi request reprint New MRI markers for Alzheimer's disease: a meta-analysis of diffusion tensor imaging and a comparison with medial temporal lobe measurements
    Lies Clerx
    Alzheimer Centre Limburg, School for Mental Health and NeuroScience MHeNS, University Medical Centre, Maastricht, The Netherlands
    J Alzheimers Dis 29:405-29. 2012
    ..Furthermore, it seems that MD values have somewhat more discriminative power than FA values with higher ES in the frontal, parietal, occipital and temporal lobe...
  22. doi request reprint The role of the dopaminergic system in mood, motivation and cognition in Parkinson's disease: a double blind randomized placebo-controlled experimental challenge with pramipexole and methylphenidate
    Rosa L Drijgers
    Department of Psychiatry, Maastricht University Medical Centre, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    J Neurol Sci 320:121-6. 2012
    ..The acute effects of a methylphenidate challenge on anhedonia and vigor in PD patients make this drug an interesting choice for further studies of the treatment of mood and motivational disorders in this population...
  23. doi request reprint Neuroanatomical correlates of apathy in Parkinson's disease: A magnetic resonance imaging study using voxel-based morphometry
    Jennifer S A M Reijnders
    Department of Psychiatry, Maastricht University Medical Centre, Maastricht, The Netherlands
    Mov Disord 25:2318-25. 2010
    ..Further studies addressing the pathogenesis of apathy are needed...
  24. doi request reprint Pharmacological treatment of apathy in neurodegenerative diseases: a systematic review
    Rosa L Drijgers
    Department of Psychiatry, Maastricht University Medical Centre, Maastricht, The Netherlands
    Dement Geriatr Cogn Disord 28:13-22. 2009
    ..To evaluate the efficacy of pharmacological treatment of apathy in patients with neurodegenerative diseases...
  25. doi request reprint Test sequence of CSF and MRI biomarkers for prediction of AD in subjects with MCI
    Stephanie Vos
    Department of Psychiatry and Neuropsychology, Maastricht University, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht, The Netherlands
    Neurobiol Aging 33:2272-81. 2012
    ..These results provide further support for the use of CSF and magnetic resonance imaging biomarkers to identify prodromal AD...
  26. ncbi request reprint Awareness in dementia: a review of clinical correlates
    Pauline Aalten
    University of Maastricht, Netherlands
    Aging Ment Health 9:414-22. 2005
    ..Factors that may be of influence on the inconclusive data are discussed, as are future directions of research...