Arnaud Zaldumbide

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. pmc Genetically engineered human islets protected from CD8-mediated autoimmune destruction in vivo
    Arnaud Zaldumbide
    Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
    Mol Ther 21:1592-601. 2013
  2. pmc Adenoviral vectors stimulate glucagon transcription in human mesenchymal stem cells expressing pancreatic transcription factors
    Arnaud Zaldumbide
    Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 7:e48093. 2012
  3. doi request reprint A potentially immunologically inert derivative of the reverse tetracycline-controlled transactivator
    Arnaud Zaldumbide
    Department of Molecular Cell Biology, Leiden University Medical Center, Postal Zone S1 P, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Biotechnol Lett 32:749-54. 2010
  4. pmc Conversion of mature human β-cells into glucagon-producing α-cells
    H Siebe Spijker
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Diabetes 62:2471-80. 2013
  5. ncbi request reprint The nested open reading frame in the Epstein-Barr virus nuclear antigen-1 mRNA encodes a protein capable of inhibiting antigen presentation in cis
    Martine Ossevoort
    Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
    Mol Immunol 44:3588-96. 2007
  6. doi request reprint Isolated human islets contain a distinct population of mesenchymal stem cells
    Francoise Carlotti
    Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
    Islets 2:164-73. 2010
  7. doi request reprint Posttranslational modification of HLA-DQ binding islet autoantigens in type 1 diabetes
    Menno van Lummel
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Diabetes 63:237-47. 2014
  8. doi request reprint The 45-kDa form of Pdx-1 does not result from post-translational modifications
    Francoise Carlotti
    Department of Molecular Cell Biology Virus and Stem Cell Biology Laboratory, Leiden University Medical Center, Postal Zone S1 P, P O Box 9600, 2300 RC Leiden, The Netherlands
    Biochem Biophys Res Commun 370:225-9. 2008
  9. ncbi request reprint Critical role for TNF in the induction of human antigen-specific regulatory T cells by tolerogenic dendritic cells
    Fleur S Kleijwegt
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    J Immunol 185:1412-8. 2010
  10. pmc Type 1 diabetes-associated HLA-DQ8 transdimer accommodates a unique peptide repertoire
    Menno van Lummel
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    J Biol Chem 287:9514-24. 2012

Collaborators

Detail Information

Publications13

  1. pmc Genetically engineered human islets protected from CD8-mediated autoimmune destruction in vivo
    Arnaud Zaldumbide
    Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
    Mol Ther 21:1592-601. 2013
    ..Collectively, our data provide proof of concept that human β cells can be efficiently genetically modified to provide protection from killing mediated by autoreactive T cells and retain their function in vitro and in vivo. ..
  2. pmc Adenoviral vectors stimulate glucagon transcription in human mesenchymal stem cells expressing pancreatic transcription factors
    Arnaud Zaldumbide
    Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 7:e48093. 2012
    ..From these data we conclude that E1-deleted adenoviral vectors are not inert gene-transfer vectors and contribute to the modulation of the cellular differentiation pathways...
  3. doi request reprint A potentially immunologically inert derivative of the reverse tetracycline-controlled transactivator
    Arnaud Zaldumbide
    Department of Molecular Cell Biology, Leiden University Medical Center, Postal Zone S1 P, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Biotechnol Lett 32:749-54. 2010
    ..Antigenic peptides of the fusion protein were not presented in MHC class I...
  4. pmc Conversion of mature human β-cells into glucagon-producing α-cells
    H Siebe Spijker
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Diabetes 62:2471-80. 2013
    ..Our findings reveal an unknown plasticity of human adult endocrine cells that can be modulated. This endocrine cell plasticity could have implications for islet development, (patho)physiology, and regeneration. ..
  5. ncbi request reprint The nested open reading frame in the Epstein-Barr virus nuclear antigen-1 mRNA encodes a protein capable of inhibiting antigen presentation in cis
    Martine Ossevoort
    Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
    Mol Immunol 44:3588-96. 2007
    ..Even though the physiological function of pGZr remains to be elucidated, the GZ-repeat protein may be valuable as inhibitor of presentation of antigenic peptides derived from transgenes in gene therapy...
  6. doi request reprint Isolated human islets contain a distinct population of mesenchymal stem cells
    Francoise Carlotti
    Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
    Islets 2:164-73. 2010
    ..0 ± 0.8% of CD105/CD90 double-positive cells. Confocal microscopy showed that these cells reside within the human islets. Altogether our data revealed the presence of a distinct MSC-like stem cell population in isolated human islets...
  7. doi request reprint Posttranslational modification of HLA-DQ binding islet autoantigens in type 1 diabetes
    Menno van Lummel
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Diabetes 63:237-47. 2014
    ..Most patients responded by interferon-γ, whereas most healthy donors produced interleukin-10 only. Thus, T-cell autoreactivity exists to modified islet epitopes that differs in quality and quantity between patients and healthy donors. ..
  8. doi request reprint The 45-kDa form of Pdx-1 does not result from post-translational modifications
    Francoise Carlotti
    Department of Molecular Cell Biology Virus and Stem Cell Biology Laboratory, Leiden University Medical Center, Postal Zone S1 P, P O Box 9600, 2300 RC Leiden, The Netherlands
    Biochem Biophys Res Commun 370:225-9. 2008
    ..Taken together, these data, validated by mass spectrometry techniques, establish that anomalous migration of Pdx-1 on SDS-PAGE does not result from post-translational modifications...
  9. ncbi request reprint Critical role for TNF in the induction of human antigen-specific regulatory T cells by tolerogenic dendritic cells
    Fleur S Kleijwegt
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    J Immunol 185:1412-8. 2010
    ..Interaction between mTNF and TNFRII instructs the induction of suppressive Tregs by VD3-DCs. Anti-TNF therapy may therefore act adversely in different patients or disease pathways...
  10. pmc Type 1 diabetes-associated HLA-DQ8 transdimer accommodates a unique peptide repertoire
    Menno van Lummel
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    J Biol Chem 287:9514-24. 2012
    ..Our findings provide a molecular basis for the association between HLA-DQ transdimers and T1D and set the stage for rational testing of potential diabetogenic peptide epitopes...
  11. pmc β-Cell Generation: Can Rodent Studies Be Translated to Humans?
    Francoise Carlotti
    Department of Nephrology, Leiden University Medical Center, Postal Zone C3 P, P O Box 9600, 2300 RC Leiden, The Netherlands
    J Transplant 2011:892453. 2011
    ....
  12. doi request reprint Changing faces, unmasking the beta-cell: post-translational modification of antigens in type 1 diabetes
    Menno van Lummel
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Curr Opin Endocrinol Diabetes Obes 20:299-306. 2013
    ..Description on post-translational modification of islet-autoantigens in type 1 diabetes (T1D)...
  13. ncbi request reprint In cis inhibition of antigen processing by the latency-associated nuclear antigen I of Kaposi sarcoma herpes virus
    Arnaud Zaldumbide
    Department of Molecular Cell Biology, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Mol Immunol 44:1352-60. 2007
    ..These data demonstrate for the first time that the acidic-repeat region of LANA-1 could function as an in cis acting inhibitor of antigen presentation. This may contribute to the immune evasion of cells latently infected by KSHV...