M Yazdanbakhsh

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint Selective probiotic bacteria induce IL-10-producing regulatory T cells in vitro by modulating dendritic cell function through dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin
    Hermelijn H Smits
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    J Allergy Clin Immunol 115:1260-7. 2005
  2. ncbi request reprint The role of helminth infections in protection from atopic disorders
    Maria Yazdanbakhsh
    Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
    Curr Opin Allergy Clin Immunol 5:386-91. 2005
  3. pmc Influenza in Africa
    Maria Yazdanbakhsh
    Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
    PLoS Med 6:e1000182. 2009
  4. pmc The effect of three-monthly albendazole treatment on malarial parasitemia and allergy: a household-based cluster-randomized, double-blind, placebo-controlled trial
    Aprilianto E Wiria
    Department of Parasitology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia
    PLoS ONE 8:e57899. 2013
  5. pmc Schistosome-derived omega-1 drives Th2 polarization by suppressing protein synthesis following internalization by the mannose receptor
    Bart Everts
    Department of Parasitology, Leiden University Medical Center, 2333 ZA Leiden, Netherlands
    J Exp Med 209:1753-67, S1. 2012
  6. pmc Peanut-specific IgE antibodies in asymptomatic Ghanaian children possibly caused by carbohydrate determinant cross-reactivity
    Abena S Amoah
    Department of Parasitology, Noguchi Memorial Institute for Medical Research, Accra, Ghana
    J Allergy Clin Immunol 132:639-47. 2013
  7. pmc ABO blood group and the risk of placental malaria in sub-Saharan Africa
    Ayola A Adegnika
    Medical Research Unit, Albert Schweitzer Hospital, Lambarene, Gabon
    Malar J 10:101. 2011
  8. pmc High body mass index is not associated with atopy in schoolchildren living in rural and urban areas of Ghana
    Irene A Larbi
    Division of Epidemiology and Biostatistics, School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
    BMC Public Health 11:469. 2011
  9. pmc A longitudinal study of allergy and intestinal helminth infections in semi urban and rural areas of Flores, Indonesia (ImmunoSPIN Study)
    Firdaus Hamid
    Department of Microbiology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
    BMC Infect Dis 11:83. 2011
  10. pmc Does treatment of intestinal helminth infections influence malaria? Background and methodology of a longitudinal study of clinical, parasitological and immunological parameters in Nangapanda, Flores, Indonesia (ImmunoSPIN Study)
    Aprilianto E Wiria
    Department of Parasitology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia
    BMC Infect Dis 10:77. 2010

Detail Information

Publications80

  1. ncbi request reprint Selective probiotic bacteria induce IL-10-producing regulatory T cells in vitro by modulating dendritic cell function through dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin
    Hermelijn H Smits
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    J Allergy Clin Immunol 115:1260-7. 2005
    ..On the basis of pathogenic or tissue-specific priming, dendritic cells (DC) acquire different T cell-instructive signals and drive the differentiation of naive T H cells into either T H 1, T H 2, or regulatory effector T cells...
  2. ncbi request reprint The role of helminth infections in protection from atopic disorders
    Maria Yazdanbakhsh
    Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
    Curr Opin Allergy Clin Immunol 5:386-91. 2005
    ..Here, we review recent studies conducted in developing countries...
  3. pmc Influenza in Africa
    Maria Yazdanbakhsh
    Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
    PLoS Med 6:e1000182. 2009
    ..Maria Yazdanbakhsh and Peter Kremsner argue that there needs to be better awareness, surveillance, and clinical management of common febrile diseases in Africa, especially influenza...
  4. pmc The effect of three-monthly albendazole treatment on malarial parasitemia and allergy: a household-based cluster-randomized, double-blind, placebo-controlled trial
    Aprilianto E Wiria
    Department of Parasitology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia
    PLoS ONE 8:e57899. 2013
    ..We evaluated the effects of albendazole treatment, every three months for 21 months, on STH, malarial parasitemia and allergy...
  5. pmc Schistosome-derived omega-1 drives Th2 polarization by suppressing protein synthesis following internalization by the mannose receptor
    Bart Everts
    Department of Parasitology, Leiden University Medical Center, 2333 ZA Leiden, Netherlands
    J Exp Med 209:1753-67, S1. 2012
    ..These experiments reveal an unrecognized pathway involving MR and interference with protein synthesis that conditions DCs for Th2 priming...
  6. pmc Peanut-specific IgE antibodies in asymptomatic Ghanaian children possibly caused by carbohydrate determinant cross-reactivity
    Abena S Amoah
    Department of Parasitology, Noguchi Memorial Institute for Medical Research, Accra, Ghana
    J Allergy Clin Immunol 132:639-47. 2013
    ..The prevalence of peanut allergy has increased in developed countries, but little is known about developing countries with high peanut consumption and widespread parasitic infections...
  7. pmc ABO blood group and the risk of placental malaria in sub-Saharan Africa
    Ayola A Adegnika
    Medical Research Unit, Albert Schweitzer Hospital, Lambarene, Gabon
    Malar J 10:101. 2011
    ..Here, the association between ABO blood group and incidence of placental malaria was assessed in order to determine the possible influence of the former on the latter...
  8. pmc High body mass index is not associated with atopy in schoolchildren living in rural and urban areas of Ghana
    Irene A Larbi
    Division of Epidemiology and Biostatistics, School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
    BMC Public Health 11:469. 2011
    ..We therefore investigated the association between high BMI and atopy among schoolchildren living in rural and urban areas of Ghana...
  9. pmc A longitudinal study of allergy and intestinal helminth infections in semi urban and rural areas of Flores, Indonesia (ImmunoSPIN Study)
    Firdaus Hamid
    Department of Microbiology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
    BMC Infect Dis 11:83. 2011
    ..The question of whether helminth infections play a role in allergic diseases can best be addressed by intervention studies. None of the studies so far have been based on a large scale placebo-controlled trial...
  10. pmc Does treatment of intestinal helminth infections influence malaria? Background and methodology of a longitudinal study of clinical, parasitological and immunological parameters in Nangapanda, Flores, Indonesia (ImmunoSPIN Study)
    Aprilianto E Wiria
    Department of Parasitology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia
    BMC Infect Dis 10:77. 2010
    ..Different cross-sectional studies using diverse methodologies have reported that helminth infections might either exacerbate or reduce the severity of malaria attacks. The same discrepancies have been reported for parasitemia...
  11. pmc Evaluation of regression methods when immunological measurements are constrained by detection limits
    Hae Won Uh
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands
    BMC Immunol 9:59. 2008
    ..The second aim is to compare these methods by simulation studies based on real data...
  12. pmc A guide to modern statistical analysis of immunological data
    Bernd Genser
    BMC Immunol 8:27. 2007
    ..Such approaches are used in many other scientific disciplines, but immunological studies on the whole still use simple statistical techniques for data analysis...
  13. pmc Combined TLR2 and TLR4 ligation in the context of bacterial or helminth extracts in human monocyte derived dendritic cells: molecular correlates for Th1/Th2 polarization
    Elly van Riet
    Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
    BMC Immunol 10:9. 2009
    ....
  14. ncbi request reprint Allergy, parasites, and the hygiene hypothesis
    Maria Yazdanbakhsh
    Department of Parasitology, Leiden University Medical Center, Leiden, Netherlands
    Science 296:490-4. 2002
    ..The induction of a robust anti-inflammatory regulatory network by persistent immune challenge offers a unifying explanation for the observed inverse association of many infections with allergic disorders...
  15. ncbi request reprint Parasites and the hygiene hypothesis: regulating the immune system?
    Maria Yazdanbakhsh
    Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
    Clin Rev Allergy Immunol 26:15-24. 2004
    ..In this review, recent findings and new concepts relating to the associations between parasites and allergies at the epidemiological, cellular and molecular level are discussed...
  16. ncbi request reprint Th2 responses without atopy: immunoregulation in chronic helminth infections and reduced allergic disease
    M Yazdanbakhsh
    Dept of Parasitology, Leiden University Medical Centre, Leiden, 2300 RC, The Netherlands
    Trends Immunol 22:372-7. 2001
    ..This is of relevance in explaining how the "hygiene hypothesis" might operate immunologically and in the design of therapeutics...
  17. ncbi request reprint Clustering of Brugia malayi infection in a community in South-Sulawesi, Indonesia
    A J Terhell
    Department of Parasitology, Leiden University Medical Centre, The Netherlands
    Parasitology 120:23-9. 2000
    ..For anti-filarial IgG4, all 3 clustering models gave significant results, suggesting that genetic, household and/or environmental factors influence specific IgG4 antibodies...
  18. ncbi request reprint Adults acquire filarial infection more rapidly than children: a study in Indonesian transmigrants
    A J Terhell
    Department of Parasitology, Leiden University Medical Centre, The Netherlands
    Parasitology 122:633-40. 2001
    ..Examining microfilaraemia, it was confirmed that infection establishes more rapidly in adults than in children...
  19. doi request reprint Point and period prevalences of eczema in rural and urban schoolchildren in Ghana, Gabon and Rwanda
    A A Hogewoning
    Dermatology, Korle Bu Teaching Hospital, University of Ghana Medical School, Accra, Ghana
    J Eur Acad Dermatol Venereol 26:488-94. 2012
    ..Eczema is a growing problem in Africa, particularly amongst children...
  20. pmc Differential antibody isotype reactivity to specific antigens in human lymphatic filariasis: gp15/400 preferentially induces immunoglobulin E (IgE), IgG4, and IgG2
    M Yazdanbakhsh
    Department of Parasitology, University of Leiden, The Netherlands
    Infect Immun 63:3772-9. 1995
    ..This indicates that an imbalance of isotypes of antibodies to particular filarial antigens might play a role in the pathogenesis of chronic disease...
  21. ncbi request reprint Cellular and humoral responses to tetanus vaccination in Gabonese children
    E van Riet
    Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
    Vaccine 26:3690-5. 2008
    ..In conclusion, a tetanus booster vaccination induced a stronger Th2 over Th1 cytokine profile to tetanus toxoid (TT) in rural children who showed the highest levels of IgG1 and IgG3 anti-TT antibody responses...
  22. ncbi request reprint Immunologic activity of schistosomal and bacterial TLR2 ligands in Gabonese children
    K Retra
    Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
    Parasite Immunol 30:39-46. 2008
    ..This information may be important for exploitation of immune modulatory molecules...
  23. ncbi request reprint Long-term follow-up of treatment with diethylcarbamazine on anti-filarial IgG4: dosage, compliance, and differential patterns in adults and children
    A J Terhell
    Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Trop Med Hyg 68:33-9. 2003
    ....
  24. doi request reprint Prevalence and causative fungal species of tinea capitis among schoolchildren in Gabon
    A A Hogewoning
    Department of Dermatology, University of Ghana Medical School, Korle Bu Teaching Hospital, Accra, Ghana
    Mycoses 54:e354-9. 2011
    ..0%). Clinically manifest tinea capitis is endemic among schoolchildren in the Lambaréné region in Gabon. The prevalence of tinea capitis and the causative species depended on the type of school that was investigated...
  25. ncbi request reprint Cellular and humoral responses to influenza in gabonese children living in rural and semi-urban areas
    E van Riet
    Department of Parasitology, Leiden University Medical Center, Leiden, Leiden, 2300 RC, The Netherlands
    J Infect Dis 196:1671-8. 2007
    ..In addition, the effects of influenza vaccination in African countries could be very different from the effects in regions with less exposure to microorganisms and parasites...
  26. ncbi request reprint Clustering of filarial infection in an age-graded study: genetic, household and environmental influences
    S Wahyuni
    Department of Parasitology, Hasanuddin University, Jalan Perintis Kemerdekaan KM 10 Tamalanrea 90245, Makassar, Indonesia
    Parasitology 128:315-21. 2004
    ....
  27. ncbi request reprint Chronic schistosomiasis: dendritic cells generated from patients can overcome antigen-specific T cell hyporesponsiveness
    A H van den Biggelaar
    Department of Parasitology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    J Infect Dis 182:260-5. 2000
    ..Cytokine responses representing the Th1 and (more importantly) Th2 types can be restored in vitro when DC are used as APC...
  28. doi request reprint Allergic characteristics of urban schoolchildren with atopic eczema in Ghana
    A A Hogewoning
    Dermatology, University of Ghana Medical School, Korle Bu Teaching Hospital, Accra, Ghana
    J Eur Acad Dermatol Venereol 24:1406-12. 2010
    ..Atopic eczema is an increasing clinical problem in Africa...
  29. doi request reprint Application of a circulating-cathodic-antigen (CCA) strip test and real-time PCR, in comparison with microscopy, for the detection of Schistosoma haematobium in urine samples from Ghana
    B B Obeng
    Department of Parasitology, Leiden University Medical Centre LUMC, P4 37a, Albinusdreef 2333 ZA Leiden, The Netherlands
    Ann Trop Med Parasitol 102:625-33. 2008
    ..A more thorough re-evaluation of the sensitivity and specificity of microscopy and these newer diagnostic methods, with an estimation of the cost-effectiveness of each technique, is recommended...
  30. ncbi request reprint Common features of T cell reactivity in persistent helminth infections: lymphatic filariasis and schistosomiasis
    M Yazdanbakhsh
    Department of Parasitology, Leiden University Medical Center, The Netherlands
    Immunol Lett 65:109-15. 1999
    ..These heightened responses are gradually down-regulated with increased length of exposure to infection...
  31. ncbi request reprint Adverse reactions following diethylcarbamazine (DEC) intake in 'endemic normals', microfilaraemics and elephantiasis patients
    M Haarbrink
    Department of Parasitology, Leiden University Medical Centre, The Netherlands
    Trans R Soc Trop Med Hyg 93:91-6. 1999
    ..Concentrations of DEC were measured in plasma, but could not explain the differences in the severity of adverse reactions...
  32. ncbi request reprint Schistosome infection is negatively associated with mite atopy, but not wheeze and asthma in Ghanaian Schoolchildren
    B B Obeng
    Department of Parasitology, Leiden University Medical Centre, Leiden, The Netherlands Department of Parasitology, Noguchi Memorial Institute for Medical Research, Accra, Ghana
    Clin Exp Allergy 44:965-75. 2014
    ..Epidemiological evidence suggests that helminth infection and rural living are inversely associated with allergic disorders...
  33. ncbi request reprint The prevalence of parasite infestation and house dust mite sensitization in Gabonese schoolchildren
    A H van den Biggelaar
    Department of Parasitology, Leiden University Medical Center, NL 2300 RC Leiden, The Netherlands
    Int Arch Allergy Immunol 126:231-8. 2001
    ..Altogether not much is known about the association between chronic infections with tissue and blood-dwelling parasites and atopy...
  34. doi request reprint Doxycycline treatment of Brugia malayi-infected persons reduces microfilaremia and adverse reactions after diethylcarbamazine and albendazole treatment
    Taniawati Supali
    Department of Parasitology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia
    Clin Infect Dis 46:1385-93. 2008
    ..We assessed whether doxycycline alone or in combination with diethylcarbamazine-albendazole would lead to sustained amicrofilaremia and reduced incidence of adverse reactions...
  35. ncbi request reprint Antibody responses to Ascaris-derived proteins and glycolipids: the role of phosphorylcholine
    E van Riet
    Department of Parasitology, Leiden University Medical Centre, Leiden, The Netherlands
    Parasite Immunol 28:363-71. 2006
    ..Differences found in antibody profiles to glycolipids and (glyco)proteins, indicate that these different classes of compounds may have distinct roles in shaping of and interacting with humoral immune responses...
  36. ncbi request reprint Anti-filarial and total IgG4 and IgE antibody levels are correlated in mothers and their offspring
    A J Terhell
    Department of Parasitology, Leiden University Medical Centre, P O Box 9605, 2300 RC, Leiden, The Netherlands
    Trans R Soc Trop Med Hyg 96:334-9. 2002
    ....
  37. ncbi request reprint HLA and elephantiasis revisited
    M Yazdanbakhsh
    Department of Parasitology, University Hospital Leiden, The Netherlands
    Eur J Immunogenet 24:439-42. 1997
    ..The complete data are presented also for anthropological reference purposes...
  38. pmc Omega-1, a glycoprotein secreted by Schistosoma mansoni eggs, drives Th2 responses
    Bart Everts
    Department of Parasitology, Leiden University Medical Centre, Leiden 2333 ZA, The Netherlands
    J Exp Med 206:1673-80. 2009
    ..Collectively, we identify omega-1, a single component of SEA, as a potent inducer of Th2 responses...
  39. ncbi request reprint Schistosome glycans and innate immunity
    C H Hokke
    Department of Parasitology, Centre of Infectious Diseases, Leiden University Medical Centre, Leiden, The Netherlands
    Parasite Immunol 27:257-64. 2005
    ..The relevant schistosome glycan elements and the possible mechanisms through which they act on the innate immune system are discussed in this review...
  40. ncbi request reprint Immune responses induced by repeated treatment do not result in protective immunity to Schistosoma haematobium: interleukin (IL)-5 and IL-10 responses
    Anita H J van den Biggelaar
    Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
    J Infect Dis 186:1474-82. 2002
    ..After adjusting for variables, such as sex, age, and infection status at study onset, high levels of parasite-specific IL-10 were a risk factor for reinfection, and high levels of IL-5 were associated with hematuria development...
  41. pmc Functional impairment of human myeloid dendritic cells during Schistosoma haematobium infection
    Bart Everts
    Department of Parasitology, Leiden University Medical Centre, Leiden, The Netherlands
    PLoS Negl Trop Dis 4:e667. 2010
    ..haematobium infection is associated with functional impairment of human DC function in vivo and provide new insights into the underlying mechanisms of T cell hyporesponsiveness during chronic schistosomiasis...
  42. ncbi request reprint Innate, adaptive and regulatory responses in schistosomiasis: relationship to allergy
    Franca C Hartgers
    Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
    Chem Immunol Allergy 90:157-75. 2006
    ..Furthermore, the different mechanisms of immune hyporesponsiveness are depicted with emphasis on regulatory T cells. Finally, the relationship between downregulatory responses and allergy is discussed...
  43. doi request reprint Responses to malarial antigens are altered in helminth-infected children
    Franca C Hartgers
    Department of Parasitology, Leiden University Medical Centre, Leiden, The Netherlands
    J Infect Dis 199:1528-35. 2009
    ..These results indicate that the presence of helminth infection modulates the immune response to malarial parasites, making it more anti-inflammatory...
  44. pmc A longitudinal study of BCG vaccination in early childhood: the development of innate and adaptive immune responses
    Yenny Djuardi
    Department of Parasitology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia
    PLoS ONE 5:e14066. 2010
    ..Importantly, we observed no clear effects of BCG vaccination on innate immune responses in terms of early IL-10 or TNF-α production whereas some alterations in general adaptive immune responses to PHA were observed...
  45. doi request reprint Regulatory T cells in human geohelminth infection suppress immune responses to BCG and Plasmodium falciparum
    Linda J Wammes
    Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Immunol 40:437-42. 2010
    ..Geohelminth-induced immune modulation may have important consequences for co-endemic infections and vaccine trials...
  46. ncbi request reprint Helminths and dendritic cells: sensing and regulating via pattern recognition receptors, Th2 and Treg responses
    Bart Everts
    Department of Parasitology, Leiden University Medical Centre, ZA Leiden, The Netherlands
    Eur J Immunol 40:1525-37. 2010
    ..Here, we will discuss these new insights and will link them to the origin and importance of Th2 and regulatory immune responses with respect to the survival of both parasite and host...
  47. pmc Chronic helminth infections protect against allergic diseases by active regulatory processes
    Hermelijn H Smits
    Department of Parasitology, Leiden University Medical Center, Albinusdreef 2, Leiden, The Netherlands
    Curr Allergy Asthma Rep 10:3-12. 2010
    ..It is of great interest to define and characterize specific helminth molecules that have profound immunomodulatory capacities as targets for therapeutic application in the treatment or prophylaxis of allergic manifestations...
  48. ncbi request reprint Helminth infections: protection from atopic disorders
    Hermelijn H Smits
    Department of Parasitology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Curr Allergy Asthma Rep 5:42-50. 2005
    ..It would be interesting to define and characterize particular helminth molecules that have profound immunomodulatory capacities as a target for therapeutic application in the treatment or prophylaxis of allergic manifestations...
  49. pmc Oral polio vaccine influences the immune response to BCG vaccination. A natural experiment
    Erliyani Sartono
    Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 5:e10328. 2010
    ..We investigated the effect of OPV given simultaneously with BCG at birth on the immune response to BCG vaccine...
  50. ncbi request reprint Triggering of innate immune responses by schistosome egg glycolipids and their carbohydrate epitope GalNAc beta 1-4(Fuc alpha 1-2Fuc alpha 1-3)GlcNAc
    Desiree van der Kleij
    Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
    J Infect Dis 185:531-9. 2002
    ..The LDN-DF neoglycoconjugate was the most potent cytokine inducer, which indicates that this difucosylated glycan can act at the host-parasite interface and can trigger innate immune responses...
  51. ncbi request reprint Long-term treatment of intestinal helminths increases mite skin-test reactivity in Gabonese schoolchildren
    Anita H J van den Biggelaar
    Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
    J Infect Dis 189:892-900. 2004
    ..To show a direct link, prospective intervention studies are required...
  52. ncbi request reprint Control of inflammatory diseases by pathogens: lipids and the immune system
    Desiree van der Kleij
    Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Immunol 33:2953-63. 2003
    ..The overview focuses on the modulation of interactions between the antigen-presenting compartment and T cells to start an anti-inflammatory "program" with potential to regulate disease processes...
  53. doi request reprint Out of Africa: what can be learned from the studies of allergic disorders in Africa and Africans?
    Benedicta Baffoah Obeng
    Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
    Curr Opin Allergy Clin Immunol 8:391-7. 2008
    ..Allergic diseases have only recently gained serious attention in Africa. This review discusses recent studies that have focused on allergy among Africans and people of African ancestry...
  54. pmc Enhanced Toll-like receptor responsiveness associated with mitogen-activated protein kinase activation in Plasmodium falciparum-infected children
    Franca C Hartgers
    Department of Parasitology, Leiden University Medical Centre, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Infect Immun 76:5149-57. 2008
    ....
  55. ncbi request reprint Protective effect of Schistosoma mansoni infection on allergic airway inflammation depends on the intensity and chronicity of infection
    Hermelijn H Smits
    Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
    J Allergy Clin Immunol 120:932-40. 2007
    ..Population studies have suggested that chronic and intense helminth infections, in contrast to acute and mild helminth infections, might suppress allergic airway inflammation...
  56. ncbi request reprint Chronic helminth infections induce immunomodulation: consequences and mechanisms
    Elly van Riet
    Department of Parasitology, Leiden University Medical Centre, Leiden, The Netherlands
    Immunobiology 212:475-90. 2007
    ..New insights into these pathways could be useful to antagonize suppression and hence boost vaccine efficacy or to optimize suppression induced by helminth derived molecules and control inflammatory diseases...
  57. ncbi request reprint Chronic helminth infections modulate allergen-specific immune responses: Protection against development of allergic disorders?
    Hermelijn H Smits
    Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
    Ann Med 39:428-39. 2007
    ..Advantage should be taken from this knowledge to identify and select individual helminth-derived molecules that may harbor therapeutic potential against inflammatory diseases...
  58. pmc BCG stimulated dendritic cells induce an interleukin-10 producing T-cell population with no T helper 1 or T helper 2 bias in vitro
    Jeppe Madura Larsen
    Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
    Immunology 121:276-82. 2007
    ....
  59. doi request reprint Immune responses during helminth-malaria co-infection: a pilot study in Ghanaian school children
    Franca C Hartgers
    Department of Parasitology, Leiden University Medical Centre, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Parasitology 135:855-60. 2008
    ....
  60. ncbi request reprint Increased prevalence of intestinal helminth infection during pregnancy in a Sub-Saharan African community
    Ayola A Adegnika
    Albert Schweitzer Hospital Medical Research Unit, Lambarene, Gabon
    Wien Klin Wochenschr 119:712-6. 2007
    ..0 [1.4-5.9]). These data show a previously undescribed susceptibility pattern of pregnant women to intestinal helminth infection in a sub-Saharan African community...
  61. pmc Lower expression of TLR2 and SOCS-3 is associated with Schistosoma haematobium infection and with lower risk for allergic reactivity in children living in a rural area in Ghana
    Franca C Hartgers
    Department of Parasitology, Leiden University Medical Centre, Leiden, The Netherlands
    PLoS Negl Trop Dis 2:e227. 2008
    ..We have characterized the innate immune responses, at the molecular level, in children according to their helminth infection status and their atopic reactivity to allergens...
  62. pmc The immune response to schistosome antigens in formerly infected travelers
    Darius Soonawala
    Department of Infectious Diseases and Tropical Medicine, Leiden University Medical Center, Leiden, The Netherlands
    Am J Trop Med Hyg 84:43-7. 2011
    ..In conclusion, Schistosoma infection induced a memory immune response, and people who experienced KS tended to have a stronger immune response to schistosome antigens than their asymptomatic counterparts...
  63. ncbi request reprint Co-infection of helminths and malaria: modulation of the immune responses to malaria
    F C Hartgers
    Department of Parasitology, Leiden University Medical Centre, Leiden, The Netherlands
    Parasite Immunol 28:497-506. 2006
    ..Furthermore, the implications of helminth infection for the efficacy of malaria vaccines will be discussed...
  64. ncbi request reprint A novel host-parasite lipid cross-talk. Schistosomal lyso-phosphatidylserine activates toll-like receptor 2 and affects immune polarization
    Desiree van der Kleij
    Department of Parasitology, Leiden University Medical Center, The Netherlands
    J Biol Chem 277:48122-9. 2002
    ..Taken together, these findings provide evidence for a novel host-parasite interaction that may be central to long term survival of the parasite and limited host pathology with implications beyond parasitology...
  65. ncbi request reprint Responses to Toll-like receptor ligands in children living in areas where schistosome infections are endemic
    Desiree van der Kleij
    Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
    J Infect Dis 189:1044-51. 2004
    ..These results indicate that relentless exposure to pathogens can lead to altered responses to TLR ligands...
  66. ncbi request reprint Regulation of anti-filarial IgE by infection pressure
    A J Terhell
    Department of Parasitology, Leiden University Medical Centre, The Netherlands
    Parasitology 124:509-19. 2002
    ..Using a simple mathematical model, we illustrate how anti-filarial IgE increases with parasite antigen up to a threshold level, but levels off and becomes down-regulated after the threshold is exceeded...
  67. ncbi request reprint Microbial compounds selectively induce Th1 cell-promoting or Th2 cell-promoting dendritic cells in vitro with diverse th cell-polarizing signals
    Esther C de Jong
    Department of Cell Biology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 168:1704-9. 2002
    ..The data suggest that the molecular basis of Th1/Th2 polarization via DCs is unexpectedly diverse and is adapted to the nature of the microbial compounds...
  68. ncbi request reprint Production of interleukin 10 and transforming growth factor beta in concomitant allergy and autoimmunity
    Sanders K Chai
    Department of Occupational and Environmental Health Sciences, School of Public Health and Community Medicine, University of Washington, Seattle, Washington 98195 7234, USA
    Ann Allergy Asthma Immunol 94:279-85. 2005
    ..The regulatory cytokine production capacity of individuals with concomitant allergy and T(H)1-type autoimmunity may provide insight into the role of T-cell regulation in both disorders...
  69. ncbi request reprint Clustering of allergic outcomes within families and households in areas endemic for helminth infections
    Sitti Wahyuni
    Department of Parasitology, Hasanuddin University, Makassar, Indonesia
    Int Arch Allergy Immunol 136:356-64. 2005
    ..Although in industrialized countries clustering of allergic disorders within families has been frequently reported, such information is lacking from areas where helminth infections are endemic...
  70. ncbi request reprint Immune regulation by helminth parasites: cellular and molecular mechanisms
    Rick M Maizels
    Institute for Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK
    Nat Rev Immunol 3:733-44. 2003
    ..Long-lived parasites such as the helminths, however, are more remarkable for their ability to downregulate host immunity, protecting themselves from elimination and minimizing severe pathology in the host...
  71. ncbi request reprint Human IgE response to the Schistosoma haematobium 22.6 kDa antigen
    C M Fitzsimmons
    Department of Pathology, University of Cambridge, Cambridge, UK
    Parasite Immunol 26:371-6. 2004
    ..These results demonstrate that like related molecules in other species, Sh22.6 is a target for the human IgE response. The data also indicate that changes in the IgE response occur with age or with progressive exposure to key antigens...
  72. doi request reprint Placental malaria increases malaria risk in the first 30 months of life
    Norbert G Schwarz
    Medical Research Unit, Albert Schweitzer Hospital, Lambarene, Gabon, South Africa
    Clin Infect Dis 47:1017-25. 2008
    ..An additional consequence may be increased risk of malaria in early life, although the epidemiological evidence of this consequence is limited...
  73. ncbi request reprint Microscopic and sub-microscopic Plasmodium falciparum infection, but not inflammation caused by infection, is associated with low birth weight
    Ayola A Adegnika
    Medical Research Unit, Albert Schweitzer Hospital, Lambarene, Gabon
    Am J Trop Med Hyg 75:798-803. 2006
    ..This finding may have important operational implications and emphasizes the need for appropriate diagnostic methods in studies evaluating the outcome of pregnancy-associated malaria...
  74. ncbi request reprint Functions of the tegument of schistosomes: clues from the proteome and lipidome
    Jaap J van Hellemond
    Department Biochemistry and Cell Biology, Faculty of Veterinary Medicine and Institute of Biomembranes, Utrecht University, P O Box 80176, 3508 TD Utrecht, The Netherlands
    Int J Parasitol 36:691-9. 2006
    ..The tegumental proteome and lipidome, therefore, imply that many unknown molecular mechanisms are employed by schistosomes to survive within their host...
  75. ncbi request reprint Genetic variation in IL-10 is associated with atopic reactivity in Gabonese schoolchildren
    Anita H J van den Biggelaar
    J Allergy Clin Immunol 120:973-5. 2007
  76. ncbi request reprint Pregnancy-associated malaria affects toll-like receptor ligand-induced cytokine responses in cord blood
    Ayola A Adegnika
    Medical Research Unit, Albert Schweitzer Hospital, Lambarene, Gabon
    J Infect Dis 198:928-36. 2008
    ..In this context, the influence of the timing and/or duration of placental infection with Plasmodium falciparum are unknown, and changes to innate immune responses have not been studied extensively...
  77. ncbi request reprint Human bancroftian filariasis: immunological markers of morbidity and infection
    Ashok K Satapathy
    Division of Immunology, Regional Medical Research Centre Indian Council of Medical Research, Chandrasekharpur, Bhubaneswar 751 023, Orissa, India
    Microbes Infect 8:2414-23. 2006
    ..Since plasma levels of these cytokines are often determined by host genetics, studies on cytokine genetic polymorphisms could offer new insights into the relationship between infection and disease in human lymphatic filariasis...
  78. ncbi request reprint Comparison of an enzyme linked immunosorbent assay (ELISA) and a radioallergosorbent test (RAST) for detection of IgE antibodies to Brugia malayi
    Sitti Wahyuni
    Department of Parasitology, Hasanuddin University, Makassar, Indonesia
    Parasite Immunol 25:609-14. 2003
    ..In areas with low endemicity or where control programs are implemented, sera will have to be tested by RAST...
  79. ncbi request reprint Effect of high-dose vitamin A supplementation on the immune response to Bacille Calmette-Guerin vaccine
    Birgitte R Diness
    Bandim Health Project, INDEPTH Network, Bissau, Guinea Bissau
    Am J Clin Nutr 86:1152-9. 2007
    ..Bacille Calmette-Guérin (BCG) vaccine is given at birth in tuberculosis-endemic countries. Previous studies suggest that VAS may influence the immune response to vaccines...