J M Wit

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint Catch-up growth: definition, mechanisms, and models
    Jan Maarten Wit
    Department of Paediatrics, Leiden University Medical Center, Leiden, The Netherlands
    J Pediatr Endocrinol Metab 15:1229-41. 2002
  2. doi request reprint Personalized approach to growth hormone treatment: clinical use of growth prediction models
    J M Wit
    Department of Pediatrics, Leiden University Medical Center, NL 2300 Leiden, The Netherlands
    Horm Res Paediatr 79:257-70. 2013
  3. doi request reprint Role of insulin-like growth factors in growth, development and feeding
    Jan M Wit
    Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
    World Rev Nutr Diet 106:60-5. 2013
  4. doi request reprint Spectrum of insulin-like growth factor deficiency
    Jan M Wit
    Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
    Endocr Dev 23:30-41. 2012
  5. doi request reprint Aromatase inhibitors in pediatrics
    Jan M Wit
    Department of Pediatrics, J6S, Leiden University Medical Center, Albinusdreef 2, 2333ZA, P O Box 9600, 2300RC Leiden, The Netherlands
    Nat Rev Endocrinol 8:135-47. 2012
  6. ncbi request reprint Diagnosis and management of disorders of IGF-I synthesis and action
    J M Wit
    Department of Paediatrics, Leiden University Medical Center, Leiden, The Netherlands
    Pediatr Endocrinol Rev 9:538-40. 2011
  7. pmc The effect of family-based multidisciplinary cognitive behavioral treatment in children with obesity: study protocol for a randomized controlled trial
    Rimke C Vos
    Department of Pediatrics, Juliana Children s Hospital HagaHospital, The Hague, The Netherlands
    Trials 12:110. 2011
  8. pmc Referral patterns of children with poor growth in primary health care
    Floor K Grote
    Dept of Paediatrics, Leiden University Medical Center, Leiden, The Netherlands
    BMC Public Health 7:77. 2007
  9. pmc Screening rules for growth to detect celiac disease: a case-control simulation study
    Paula van Dommelen
    Dept of Statistics, TNO Quality of Life, Leiden, The Netherlands
    BMC Pediatr 8:35. 2008
  10. pmc Motives for choosing growth-enhancing hormone treatment in adolescents with idiopathic short stature: a questionnaire and structured interview study
    Hanneke Visser-van Balen
    Department of Pediatric Psychology, University Medical Center Utrecht, Wilhelmina Children s Hospital, P O Box 85090, 3508 AB Utrecht, The Netherlands
    BMC Pediatr 5:15. 2005

Detail Information

Publications124 found, 100 shown here

  1. ncbi request reprint Catch-up growth: definition, mechanisms, and models
    Jan Maarten Wit
    Department of Paediatrics, Leiden University Medical Center, Leiden, The Netherlands
    J Pediatr Endocrinol Metab 15:1229-41. 2002
    ....
  2. doi request reprint Personalized approach to growth hormone treatment: clinical use of growth prediction models
    J M Wit
    Department of Pediatrics, Leiden University Medical Center, NL 2300 Leiden, The Netherlands
    Horm Res Paediatr 79:257-70. 2013
    ..There is a need for user-friendly software programs to make prediction models easily available in the clinic...
  3. doi request reprint Role of insulin-like growth factors in growth, development and feeding
    Jan M Wit
    Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
    World Rev Nutr Diet 106:60-5. 2013
    ..Feeding disturbances in infants with IGF1 and IGF1R mutations suggest a role of IGF-1 signaling in regulatory brain centers...
  4. doi request reprint Spectrum of insulin-like growth factor deficiency
    Jan M Wit
    Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
    Endocr Dev 23:30-41. 2012
    ..IGFD can also have a digenic or oligogenic origin. The diagnostic yield of genetic testing in children with a height <-2.5 SDS and a serum IGF-1 <-2 appears sufficient to perform genetic tests for known candidate genes...
  5. doi request reprint Aromatase inhibitors in pediatrics
    Jan M Wit
    Department of Pediatrics, J6S, Leiden University Medical Center, Albinusdreef 2, 2333ZA, P O Box 9600, 2300RC Leiden, The Netherlands
    Nat Rev Endocrinol 8:135-47. 2012
    ....
  6. ncbi request reprint Diagnosis and management of disorders of IGF-I synthesis and action
    J M Wit
    Department of Paediatrics, Leiden University Medical Center, Leiden, The Netherlands
    Pediatr Endocrinol Rev 9:538-40. 2011
    ..Children with GHR defects, and presumably STAT5B and homozygous IGF1 defects, can be treated with rhlGF-I. Children with IGF1R defects and mild or heterozygous IGF1 defects respond to GH treatment...
  7. pmc The effect of family-based multidisciplinary cognitive behavioral treatment in children with obesity: study protocol for a randomized controlled trial
    Rimke C Vos
    Department of Pediatrics, Juliana Children s Hospital HagaHospital, The Hague, The Netherlands
    Trials 12:110. 2011
    ..The intervention aims to establish long-term weight reduction and stabilization, reduction of obesity-related health consequences and improvement of self-image by change of lifestyle and learning cognitive behavioral techniques...
  8. pmc Referral patterns of children with poor growth in primary health care
    Floor K Grote
    Dept of Paediatrics, Leiden University Medical Center, Leiden, The Netherlands
    BMC Public Health 7:77. 2007
    ..This resulted in guidelines for referral. In this study we evaluate the referral pattern of short stature in primary health care using these guidelines, comparing it with cut-off values mentioned by the WHO...
  9. pmc Screening rules for growth to detect celiac disease: a case-control simulation study
    Paula van Dommelen
    Dept of Statistics, TNO Quality of Life, Leiden, The Netherlands
    BMC Pediatr 8:35. 2008
    ..However, the effectiveness of slowed growth as a tool for identifying children with CD is unknown. Our aim is to study the diagnostic efficiency of several growth criteria used to detect CD children...
  10. pmc Motives for choosing growth-enhancing hormone treatment in adolescents with idiopathic short stature: a questionnaire and structured interview study
    Hanneke Visser-van Balen
    Department of Pediatric Psychology, University Medical Center Utrecht, Wilhelmina Children s Hospital, P O Box 85090, 3508 AB Utrecht, The Netherlands
    BMC Pediatr 5:15. 2005
    ..The aim of our study was to clarify the motives of adolescents and their parents when choosing to participate in a growth-enhancing trial combining growth hormone and puberty-delaying hormone treatment...
  11. pmc Catch-up growth up to ten years of age in children born very preterm or with very low birth weight
    Noël B B Knops
    Department of Paediatrics, Leiden University Medical Center, J6S, PO Box 2600, 2300 RC Leiden, The Netherlands
    BMC Pediatr 5:26. 2005
    ..Most studies report stunting in children born very preterm and/or small for gestational age. In this article we study the growth pattern of these children and aim to identify factors associated with postnatal catch-up growth...
  12. pmc The diagnostic work up of growth failure in secondary health care; an evaluation of consensus guidelines
    Floor K Grote
    Dept of Paediatrics, Leiden University Medical Center, Leiden, The Netherlands
    BMC Pediatr 8:21. 2008
    ..In the present paper we evaluate the diagnostic work-up in secondary health care according to existing consensus guidelines and study the frequency of underlying medical disorders...
  13. pmc Adenomatous polyposis coli-mediated control of beta-catenin is essential for both chondrogenic and osteogenic differentiation of skeletal precursors
    Razvan L Miclea
    Department of Tissue Regeneration, Institute for Biomedical Technology, University of Twente, Enschede, The Netherlands
    BMC Dev Biol 9:26. 2009
    ..Adenomatous polyposis coli (Apc) is a key controller of beta-catenin turnover by down-regulating intracellular levels of beta-catenin...
  14. ncbi request reprint Growth hormone (GH) treatment to final height in children with idiopathic short stature: evidence for a dose effect
    Jan M Wit
    Leiden University Medical Center, Leiden, The Netherlands
    J Pediatr 146:45-53. 2005
    ..2)...
  15. ncbi request reprint Optimizing growth hormone therapy in growth hormone deficient children: what to do in the absence of hard evidence? Commentary on Rachmiel et al.: Final height in children with idiopathic growth hormone deficiency treated with a fixed dose of recombinant
    J M Wit
    Department of Paediatrics, Leiden University Medical Center, Leiden, The Netherlands
    Horm Res 68:244-7. 2007
  16. ncbi request reprint Preterm growth restraint: a paradigm that unifies intrauterine growth retardation and preterm extrauterine growth retardation and has implications for the small-for-gestational-age indication in growth hormone therapy
    J M Wit
    Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
    Pediatrics 117:e793-5. 2006
  17. doi request reprint Idiopathic short stature: management and growth hormone treatment
    J M Wit
    Department of Pediatrics, Leiden University Medical Center, P O Box 9600, Leiden, Zuid Holland, The Netherlands
    Growth Horm IGF Res 18:111-35. 2008
    ..In case of a low predicted adult height at the onset of puberty, addition of a GnRH analogue can be considered. Although GH therapy appears safe, long-term monitoring is recommended...
  18. doi request reprint Idiopathic short stature: definition, epidemiology, and diagnostic evaluation
    J M Wit
    Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
    Growth Horm IGF Res 18:89-110. 2008
    ..ISS is the diagnostic group that remains after excluding known conditions in short children...
  19. ncbi request reprint European perspective on treatment approaches for growth failure
    Jan M Wit
    Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
    Pediatr Endocrinol Rev 5:862-8. 2008
  20. doi request reprint Genetic evaluation of short stature
    J M Wit
    Department of Paediatrics, J6S Leiden University Medical Center, Leiden, The Netherlands
    Best Pract Res Clin Endocrinol Metab 25:1-17. 2011
    ..If no obvious candidate gene can be determined, a whole genome approach can be taken to check for deletions, duplications and/or uniparental disomies...
  21. doi request reprint Endocrine regulation of longitudinal bone growth
    Jan M Wit
    Department of Paediatrics, Leiden University Medical Center, Leiden, The Netherlands
    Endocr Dev 21:30-41. 2011
    ..Finally, the paracrine-autocrine SHOX-BNP pathway and the related CNP-NPR2 pathway are also involved in growth, as very many other growth factors and their receptors and mediators...
  22. ncbi request reprint Benefit of postponing normal puberty for improving final height
    J M Wit
    Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Endocrinol 151:S41-5. 2004
    ..More data on long-term safety have to be collected before the combination of GH and GnRHa in children with idiopathic short stature should be considered for clinical use outside clinical trials...
  23. ncbi request reprint A variable degree of intrauterine and postnatal growth retardation in a family with a missense mutation in the insulin-like growth factor I receptor
    M J E Walenkamp
    Department of Pediatrics J6 S, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    J Clin Endocrinol Metab 91:3062-70. 2006
    ..The type 1 IGF-I receptor (IGF1R) mediates the biological functions of IGF-I. Binding of IGF-I to the IGF1R results in autophosphorylation of the intracellular beta-subunit and activation of intracellular signaling...
  24. ncbi request reprint A randomized controlled trial of three years growth hormone and gonadotropin-releasing hormone agonist treatment in children with idiopathic short stature and intrauterine growth retardation
    G A Kamp
    Department of Pediatrics, Leiden University Medical Center, Sophia Children's Hospital Rotterdam, The Netherlands
    J Clin Endocrinol Metab 86:2969-75. 2001
    ..This resulted in a considerable gain in predicted adult height, without demonstrable side effects. Final height results will provide the definite answer on the effectiveness of this combined treatment...
  25. ncbi request reprint Expression of estrogen receptors and enzymes involved in sex steroid metabolism in the rat tibia during sexual maturation
    B C J van der Eerden
    Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
    J Endocrinol 180:457-67. 2004
    ..This process may contribute to the beneficial effects of estrogen on bone mass accrual, possibly by intracrinology...
  26. doi request reprint Intelligence of very preterm or very low birthweight infants in young adulthood
    N Weisglas-Kuperus
    Division of Neonatology, Department of Pediatrics, Erasmus MC Sophia Children s Hospital, Dr Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands
    Arch Dis Child Fetal Neonatal Ed 94:F196-200. 2009
    ..To examine the effect of intrauterine and neonatal growth, prematurity and personal and environmental risk factors on intelligence in adulthood in survivors of the early neonatal intensive care era...
  27. doi request reprint The severe short stature in two siblings with a heterozygous IGF1 mutation is not caused by a dominant negative effect of the putative truncated protein
    H A van Duyvenvoorde
    Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
    Growth Horm IGF Res 21:44-50. 2011
    ..In this paper we describe the structural and functional characteristics of the putative truncated IGF-I protein...
  28. doi request reprint Antenatal glucocorticoid treatment is not associated with long-term metabolic risks in individuals born before 32 weeks of gestation
    M J J Finken
    Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
    Arch Dis Child Fetal Neonatal Ed 93:F442-7. 2008
    ..Findings from studies in humans on this topic are highly contradictory due to a number of methodological flaws, and renal function after glucocorticoid exposure has never been assessed...
  29. doi request reprint Health-related quality of life of very preterm infants at 1 year of age after two developmental care-based interventions
    S M van der Pal
    Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
    Child Care Health Dev 34:619-25. 2008
    ..The individualized approach of the NIDCAP was thought to further increase HRQoL...
  30. ncbi request reprint Mutations in the NSD1 gene in patients with Sotos syndrome associate with endocrine and paracrine alterations in the IGF system
    L de Boer
    Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Endocrinol 151:333-41. 2004
    ....
  31. ncbi request reprint Growth hormone (GH) secretion and response to GH therapy after total body irradiation and haematopoietic stem cell transplantation during childhood
    B Bakker
    Department of Paediatrics, Leiden University Medical Centre, Leiden, The Netherlands
    Clin Endocrinol (Oxf) 67:589-97. 2007
    ..In January 1997 we introduced a protocol for the treatment with GH of children with impaired growth after unfractionated total body irradiation (TBI). This study is an evaluation of that protocol...
  32. doi request reprint Short stature associated with a novel heterozygous mutation in the insulin-like growth factor 1 gene
    H A van Duyvenvoorde
    Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
    J Clin Endocrinol Metab 95:E363-7. 2010
    ..Homozygous IGF1 deletions or mutations lead to severe short stature, deafness, microcephaly, and mental retardation. Heterozygosity for an IGF-I defect may modestly decrease height and head circumference...
  33. doi request reprint High-dose GH treatment limited to the prepubertal period in young children with idiopathic short stature does not increase adult height
    S A van Gool
    Department of Pediatrics, Leiden University Medical Center, Postal Zone J6 S, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Eur J Endocrinol 162:653-60. 2010
    ..To assess the long-term effect of prepubertal high-dose GH treatment on growth in children with idiopathic short stature (ISS)...
  34. ncbi request reprint Developing evidence-based guidelines for referral for short stature
    F K Grote
    Department of Paediatrics, Leiden University Medical Center, Leiden, The Netherlands
    Arch Dis Child 93:212-7. 2008
    ..To establish evidence-based guidelines for growth monitoring on a population basis. Study..
  35. doi request reprint Homozygous and heterozygous expression of a novel mutation of the acid-labile subunit
    H A van Duyvenvoorde
    Departments of Paediatrics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Eur J Endocrinol 159:113-20. 2008
    ..Acid-labile subunit (ALS) deficiency due to homozygous inactivation of the ALS gene (IGFALS) is associated with moderate short stature, and in few cases pubertal delay. The clinical expression of heterozygosity is unknown...
  36. ncbi request reprint Evidence for genomic and nongenomic actions of estrogen in growth plate regulation in female and male rats at the onset of sexual maturation
    B C J van der Eerden
    Department of Pediatrics, Leiden University Medical Center, The Netherlands
    J Endocrinol 175:277-88. 2002
    ..There may be a role for nongenomic signaling in body weight gain, tibial length and growth plate width but genomic signaling prevails...
  37. doi request reprint No change in developmental outcome with incubator covers and nesting for very preterm infants in a randomised controlled trial
    C M Maguire
    Department of Pediatrics, Subdivision of Neonatology, Leiden University Medical Center, Leiden, The Netherlands
    Arch Dis Child Fetal Neonatal Ed 94:F92-7. 2009
    ..To investigate in a randomised controlled trial the effect of basic elements of developmental care (incubator covers and positioning aids) on growth and neurodevelopment in infants born at < 32 weeks...
  38. ncbi request reprint Pubertal development in The Netherlands 1965-1997
    D Mul
    Department of Paediatrics, Erasmus University Medical Centre Sophia Children s Hospital, Rotterdam, The Netherlands
    Pediatr Res 50:479-86. 2001
    ..In conclusion, in The Netherlands the age at onset of puberty or menarche has stabilized since 1980. Height, weight, and body mass index have a strong influence on the chance of menarche...
  39. ncbi request reprint Biochemical markers of growth hormone (GH) sensitivity in children with idiopathic short stature: individual capacity of IGF-I generation after high-dose GH treatment determines the growth response to GH
    G A Kamp
    Department of Pediatrics, Leiden University Medical Center, The Netherlands
    Clin Endocrinol (Oxf) 57:315-25. 2002
    ..To assess multiple dose-response relationships between three GH doses (1.5, 3.0 and 6.0 IU/m2) and nine different biochemical markers of GH sensitivity in a well-defined group of 17 children with idiopathic short stature (ISS)...
  40. ncbi request reprint Catch-up growth and endocrine changes in childhood celiac disease. Endocrine changes during catch-up growth
    B Boersma
    Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
    Horm Res 58:57-65. 2002
    ..Although several correlations between these endocrine alterations and auxological parameters were detected, it is questionable whether the endocrine changes are the driving force behind catch-up growth...
  41. doi request reprint Genetic analysis of short children with apparent growth hormone insensitivity
    J M Wit
    Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
    Horm Res Paediatr 77:320-33. 2012
    ..In short children, a low IGF-I and normal GH secretion may be associated with various monogenic causes, but their prevalence is unknown. We aimed at testing GH1, GHR, STAT5B, IGF1, and IGFALS in children with GH insensitivity. Subjects and..
  42. ncbi request reprint Psychosocial, cognitive, and motor functioning in patients with suspected Sotos syndrome: a comparison between patients with and without NSD1 gene alterations
    L de Boer
    Department of Paediatrics, Leiden University Medical Center, Leiden, The Netherlands
    Dev Med Child Neurol 48:582-8. 2006
    ....
  43. ncbi request reprint Genetic analysis of tall stature
    S G Kant
    Center for Human and Clinical Genetics, Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Horm Res 64:149-56. 2005
    ..The various possibilities are discussed and placed in a flowchart...
  44. doi request reprint Should blood gas analysis be part of the diagnostic workup of short children? Auxological data and blood gas analysis in children with renal tubular acidosis
    D Mul
    Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
    Horm Res Paediatr 74:351-7. 2010
    ..Renal tubular acidosis (RTA) is a rare cause of growth failure, therefore it is uncertain whether routine screening with blood gas analysis of short infants and children is cost-effective...
  45. pmc Nationwide age references for sitting height, leg length, and sitting height/height ratio, and their diagnostic value for disproportionate growth disorders
    A M Fredriks
    Department of Paediatrics, Leiden University Medical Center, Leiden, Netherlands
    Arch Dis Child 90:807-12. 2005
    ....
  46. ncbi request reprint Pubertal development and growth after total-body irradiation and bone marrow transplantation for haematological malignancies
    B Bakker
    Department of Paediatrics, Leiden University Medical Centre, The Netherlands
    Eur J Pediatr 159:31-7. 2000
    ..Decrease in height SDS was seen in the majority of patients and was positively correlated with male gender and lower age at the time of BMT...
  47. ncbi request reprint Parental experiences during the first period at the neonatal unit after two developmental care interventions
    S M van der Pal
    Department of Pediatrics, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Acta Paediatr 96:1611-6. 2007
    ....
  48. doi request reprint Growth of preterm born children
    A M Euser
    Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
    Horm Res 70:319-28. 2008
    ..In this review, we describe the growth of (very) preterm infants or (very) low-birth-weight infants from birth until adulthood...
  49. ncbi request reprint Is hypotension a major risk factor for neurological morbidity at term age in very preterm infants?
    S E Martens
    Department of Paediatrics, Leiden University Medical Center, J6 S PO Box 9600 2300 RC, Leiden, The Netherlands
    Early Hum Dev 75:79-89. 2003
    ..To investigate the influence of perinatal risk factors, especially hypotension, on neuromotor status at term in surviving preterm infants born before 32 weeks of gestation...
  50. ncbi request reprint Plasma insulin-like growth factors (IGFs), IGF-Binding proteins (IGFBPs), acid-labile subunit (ALS) and IGFBP-3 proteolysis in individuals with clinical characteristics of Sotos syndrome
    L de Boer
    Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
    J Pediatr Endocrinol Metab 17:615-27. 2004
    ..We investigated whether this syndrome is related to alterations in plasma insulin-like growth factors (IGFs), IGF-binding proteins (IGFBPs), acid-labile subunit (ALS) and serum IGFBP-3 proteolysis...
  51. ncbi request reprint Growth monitoring and diagnostic work-up of short stature: an international inventorization
    F K Grote
    Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
    J Pediatr Endocrinol Metab 18:1031-8. 2005
    ..Growth monitoring is almost universally performed, but few data are available on which referral criteria and diagnostic work-up are used worldwide for children with short stature...
  52. ncbi request reprint Disturbances of growth and endocrine function after busulphan-based conditioning for haematopoietic stem cell transplantation during infancy and childhood
    B Bakker
    Department of Pediatrics, J6 208, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Bone Marrow Transplant 33:1049-56. 2004
    ..We conclude that, besides gonadal and thyroid dysfunction, impaired growth and hyperparathyroidism often occur after Bu/Cy conditioning for SCT and that growth impairment may be the result of insufficient GH secretion...
  53. pmc High dose growth hormone treatment induces acceleration of skeletal maturation and an earlier onset of puberty in children with idiopathic short stature
    G A Kamp
    Department of Pediatrics, Leiden University Medical Center, Netherlands
    Arch Dis Child 87:215-20. 2002
    ..As it is unknown whether GH treatment during puberty adds to final height gain, we sought to improve the cost-benefit ratio, employing a study design with high dose GH treatment restricted to the prepubertal period...
  54. ncbi request reprint Development and psychometric evaluation of the TAPQOL: a health-related quality of life instrument for 1-5-year-old children
    M Fekkes
    Child Health Division, TNO Prevention and Health, Leiden University Medical Centre, Leiden, The Netherlands
    Qual Life Res 9:961-72. 2000
    ..This study shows that the TAPQOL is a reliable and valid parent's perception of HRQoL in preschool children. More research is needed to evaluate the psychometric performance of the TAPQOL in different clinical populations...
  55. ncbi request reprint Could cortisol explain the association between birth weight and cardiovascular disease in later life? A meta-analysis
    N van Montfoort
    Department of Clinical Epidemiology, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Eur J Endocrinol 153:811-7. 2005
    ..However, their findings were inconsistent. To quantitatively assess the overall association between birth weight and circulating cortisol level, we aimed to perform a meta-analysis of the published literature...
  56. ncbi request reprint Homozygous and heterozygous expression of a novel insulin-like growth factor-I mutation
    M J E Walenkamp
    Department of Pediatrics J6 S, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    J Clin Endocrinol Metab 90:2855-64. 2005
    ..Remarkably, IGF-I deficiency is relatively well tolerated during the subsequent four decades of adulthood. IGF-I haploinsufficiency results in subtle inhibition of intrauterine and postnatal growth...
  57. ncbi request reprint Height, weight, body mass index and pubertal development references for children of Moroccan origin in The Netherlands
    A M Fredriks
    Department of Paediatrics, Leiden University Medical Centre, Leiden, The Netherlands
    Acta Paediatr 93:817-24. 2004
    ..To provide growth and sexual maturation reference data for Moroccan children living in The Netherlands and to compare them with the reference data of children of Dutch origin...
  58. ncbi request reprint Health status development in a cohort of preterm children
    N C Theunissen
    Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
    J Pediatr 137:534-9. 2000
    ..To determine the impact of preterm birth on health status (HS) development at the ages of 5 and 10 years in a cohort of children born before term...
  59. doi request reprint Impact of the exon 3-deleted growth hormone (GH) receptor polymorphism on baseline height and the growth response to recombinant human GH therapy in GH-deficient (GHD) and non-GHD children with short stature: a systematic review and meta-analysis
    M J E Wassenaar
    Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    J Clin Endocrinol Metab 94:3721-30. 2009
    ..The exon-3 deleted GH receptor (GHR(d3)) polymorphism is associated with an increased growth response to recombinant human GH (rhGH) therapy in some, but not all, studies in GH-deficient (GHD) and non-GHD children with short stature...
  60. ncbi request reprint Growth hormone (GH) secretion in patients with an inactivating defect of the GH-releasing hormone (GHRH) receptor is pulsatile: evidence for a role for non-GHRH inputs into the generation of GH pulses
    F Roelfsema
    Department of Endocrinology and Metabolism, Leiden University Medical Center, 2333AA Leiden, The Netherlands
    J Clin Endocrinol Metab 86:2459-64. 2001
    ..In addition, we infer that effectual GHRH input controls the GH cell mass and the orderliness of the secretory process...
  61. ncbi request reprint Tall stature and duplication of the insulin-like growth factor I receptor gene
    S G Kant
    Department of Clinical Genetics, CHCG, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Med Genet 50:1-10. 2007
    ..Looking for a duplication of the 15qter region is still worth consideration in patients with tall stature and features of Sotos syndrome without an NSD1 alteration, especially when there is craniosynostosis or marked speech delay...
  62. ncbi request reprint Effect of x-irradiation on growth and the expression of parathyroid hormone-related peptide and Indian hedgehog in the tibial growth plate of the rat
    B Bakker
    Department of Paediatrics, Leiden University Medical Center, Leiden, The Netherlands
    Horm Res 59:35-41. 2003
    ..To study the effect of irradiation on the longitudinal growth and the expression of parathyroid hormone-related peptide (PTHrP) and Indian hedgehog (IHh) in tibial growth plates of rats...
  63. doi request reprint Inhibition of Gsk3β in cartilage induces osteoarthritic features through activation of the canonical Wnt signaling pathway
    R L Miclea
    Department of Pediatrics, Leiden University Medical Centre, Leiden, Netherlands
    Osteoarthritis Cartilage 19:1363-72. 2011
    ..In this study we wanted to further investigate the role of Gsk3β in cartilage maintenance...
  64. ncbi request reprint Dehydroepiandrosterone sulfate treatment for atrichia pubis
    J M Wit
    Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
    Horm Res 56:134-9. 2001
    ..To evaluate the efficacy of oral dehydroepiandrosterone sulfate (DHEAS) treatment for atrichia pubis in female adolescents...
  65. ncbi request reprint Sex steroid metabolism in the tibial growth plate of the rat
    B C J van der Eerden
    Department of Pediatrics, Leiden University Medical Center, The Netherlands
    Endocrinology 143:4048-55. 2002
    ..Our data suggest that intracrinology in the rat growth plate can occur and may be a major source of local sex steroid delivery...
  66. ncbi request reprint Preterm birth and later insulin resistance: effects of birth weight and postnatal growth in a population based longitudinal study from birth into adult life
    M J J Finken
    Department of Pediatrics, Leiden University Medical Center, P O Box 9600, 2300, RC Leiden, The Netherlands
    Diabetologia 49:478-85. 2006
    ....
  67. ncbi request reprint Genetic disorders in the growth hormone - insulin-like growth factor-I axis
    M J E Walenkamp
    Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
    Horm Res 66:221-30. 2006
    ..To help in this selection process, we developed flowcharts, based on the recently described patients, that can be used as guidelines in the diagnostic process of patients with severe short stature of unknown origin...
  68. pmc Longitudinal analysis of growth and puberty in 21-hydroxylase deficiency patients
    H J Van der Kamp
    Department of Paediatrics, Leiden University Medical Center, Leiden, Netherlands
    Arch Dis Child 87:139-44. 2002
    ..To evaluate growth from diagnosis until final height (FH) in 21-hydroxylase deficiency patients...
  69. ncbi request reprint Growth-reductive therapy in children with marfan syndrome
    L Rozendaal
    Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
    J Pediatr 147:674-9. 2005
    ..To determine the accuracy and precision of 2 height-prediction methods in Marfan syndrome and to assess the growth-reductive effect and side effects of sex hormone treatment...
  70. ncbi request reprint Genetic disorders in the GH IGF-I axis in mouse and man
    M J E Walenkamp
    Department of Pediatrics J6 S, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Eur J Endocrinol 157:S15-26. 2007
    ..Finally, the implications of a genetic defect in the GH-IGF-I axis for the patient and the therapeutic options will be discussed...
  71. ncbi request reprint Growth hormone therapy
    J M Wit
    Department of Paediatrics, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Best Pract Res Clin Endocrinol Metab 16:483-503. 2002
    ..33 mg/kg/week is 5-7 cm. GH is efficacious in short stature due to chronic renal failure and Prader-Willi syndrome. In other conditions insufficient data are available. There are few side-effects...
  72. ncbi request reprint Gender differences in expression of androgen receptor in tibial growth plate and metaphyseal bone of the rat
    B C J van der Eerden
    Department of Pediatrics, Leiden University Medical Center, The Netherlands
    Bone 30:891-6. 2002
    ....
  73. doi request reprint Social lifestyle, risk-taking behavior, and psychopathology in young adults born very preterm or with a very low birthweight
    Elysee T M Hille
    Leiden University Medical Center, Leiden, The Netherlands
    J Pediatr 152:793-800, 800.e1-4. 2008
    ..To assess social lifestyle, risk-taking behavior, and psychopathology in young adults born very preterm or with a very low birthweight...
  74. ncbi request reprint The estrogen receptor in the growth plate: implications for pubertal growth
    B C van der Eerden
    Department of Pediatrics, Leiden University Medical Center, The Netherlands
    J Pediatr Endocrinol Metab 14:1527-33. 2001
    ..With the recent development of knockout models for both estrogen receptors, attempts are being made to unravel the local actions of estrogen in order to characterize further their roles in the regulation of longitudinal growth...
  75. ncbi request reprint Radiographic evaluation of children with growth disorders
    S G Kant
    Center for Human and Clinical Genetics, Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Horm Res 68:310-5. 2007
    ..The combination of clinical and biochemical features and an appropriate skeletal survey can often lead to the correct diagnosis and/or guide the subsequent molecular analysis...
  76. pmc Short stature and the probability of coeliac disease, in the absence of gastrointestinal symptoms
    J C W van Rijn
    Department of Paediatrics, Leiden University Medical Center, Netherlands
    Arch Dis Child 89:882-3. 2004
  77. ncbi request reprint Clinicians' perspective on quality of life assessment in paediatric clinical practice
    R M Baars
    Department of Paediatrics, Leiden University Medical Centre, Leiden, The Netherlands
    Acta Paediatr 93:1356-62. 2004
    ..This study was undertaken to investigate paediatric clinicians' views on and use of quality of life (QoL) assessment in clinical practice...
  78. ncbi request reprint Final height gain by GH therapy in children with idiopathic short stature is dose dependent
    J M Wit
    Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
    J Clin Endocrinol Metab 87:604-11. 2002
    ..8 cm). We conclude that a GH dosage of 27 IU (9 mg)/m(2) x wk to prepubertal children with ISS leads to a mean FH gain of approximately 7 cm, whereas regimens starting on lower dosages are less efficacious...
  79. ncbi request reprint Genetic analysis of short stature
    S G Kant
    CHCG Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Horm Res 60:157-65. 2003
    ..Important options are UPD7 and the FGFR3, SHOX, GH1 and GHR genes. Furthermore, analysis of the IGF and IGF1R genes should be considered. We propose a flow chart for molecular analysis in short stature...
  80. ncbi request reprint Expression of estrogen receptor alpha and beta in the epiphyseal plate of the rat
    B C J van der Eerden
    Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
    Bone 30:478-85. 2002
    ..Furthermore, our data indicate that the absence of growth-plate closure in the rat cannot be explained by disappearance of ER alpha expression during sexual maturation per se...
  81. ncbi request reprint Skin fibroblasts of children with idiopathic short stature show an increased mitogenic response to IGF-I and secrete more IGFBP-3
    Gerdine A Kamp
    Department of Pediatrics, Leiden University Medical Center J6 204, PO Box 9600, 2300 RC Leiden, The Netherlands
    Clin Endocrinol (Oxf) 56:439-47. 2002
    ..Secondly, to investigate whether these cellular parameters can predict the growth response to GH treatment in children with ISS...
  82. pmc Adult height in patients with early onset of Crohn's disease
    N Alemzadeh
    Department of Gastroenterology Hepatology, Leiden University Medical Centre, Leiden, The Netherlands
    Gut 51:26-9. 2002
    ..Growth impairment during childhood and adolescence is a common problem faced by patients with an early onset of Crohn's disease...
  83. ncbi request reprint Behaviour at 2 years of age in very preterm infants (gestational age < 32 weeks)
    G M S J Stoelhorst
    Department of Paediatrics, Leiden University Medical Centre, The Hague, The Netherlands
    Acta Paediatr 92:595-601. 2003
    ..The objective of this study was to determine behavioural outcome and risk factors for abnormal behaviour at 2 y corrected age in very premature infants in a regionally defined, prospective cohort study...
  84. ncbi request reprint Adult height corrected for shrinking and secular trend
    R Niewenweg
    Department of Paediatrics, Leiden University Medical Center, Leiden, The Netherlands
    Ann Hum Biol 30:563-9. 2003
    ....
  85. ncbi request reprint In vivo and in vitro studies in a 46, XY phenotypically female infant with 17-ketosteroid reductase deficiency
    J M Wit
    Department of Pediatrics, University Hospital for Children and Youth, Het Wilhelmina Kinderziekenhuis, Utrecht, The Netherlands
    Horm Metab Res 20:367-74. 1988
    ..The activity of 3 beta-hydroxysteroid-dehydrogenase was slightly increased. The serial analysis of plasma androgens provides more insight in the natural history of 17-ketosteroid reductase...
  86. ncbi request reprint Is blood pressure increased 19 years after intrauterine growth restriction and preterm birth? A prospective follow-up study in The Netherlands
    Mandy G Keijzer-Veen
    Department of Pediatric Nephrology, Erasmus MC Sophia Children s Hospital, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Pediatrics 116:725-31. 2005
    ..To determine whether intrauterine growth restriction (IUGR) is a predisposing factor for high blood pressure (BP) in 19-year-olds who were born (very) preterm...
  87. ncbi request reprint Final height after transplantation in childhood
    Boudewijn Bakker
    Blood 106:2592-3; author reply 2593. 2005
  88. doi request reprint Single gene mutations causing SGA
    Marie J E Walenkamp
    Department of Paediatrics, J6 S, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, The Netherlands
    Best Pract Res Clin Endocrinol Metab 22:433-46. 2008
    ..The phenotype in relation to the genotype of the different disorders will be reviewed in this chapter...
  89. ncbi request reprint Psychosocial functioning of adolescents with idiopathic short stature or persistent short stature born small for gestational age during three years of combined growth hormone and gonadotropin-releasing hormone agonist treatment
    Hanneke Visser-van Balen
    Department of Pediatric Psychology, University Medical Center Utrecht, Wilhelmina Children s Hospital, The Netherlands
    Horm Res 64:77-87. 2005
    ....
  90. ncbi request reprint Safety of growth hormone treatment in pediatric patients with idiopathic short stature
    Charmian A Quigley
    Lilly Research Laboratories, D C 5015, Indianapolis, Indiana 46285, USA
    J Clin Endocrinol Metab 90:5188-96. 2005
    ..Recombinant human GH was approved by the United States Food and Drug Administration in 2003 for the treatment of idiopathic short stature (ISS). However, to date, the safety of GH in this patient population has not been rigorously studied...
  91. ncbi request reprint Associations between prenatal and infancy weight gain and BMI, fat mass, and fat distribution in young adulthood: a prospective cohort study in males and females born very preterm
    Anne M Euser
    Department of Clinical Epidemiology, Leiden University Medical Center, Netherlands
    Am J Clin Nutr 81:480-7. 2005
    ..Increasing evidence indicates that adult body composition is associated with prenatal and infancy weight gain, but the relative importance of different time periods has not been elucidated...
  92. ncbi request reprint Final height outcome after three years of growth hormone and gonadotropin-releasing hormone agonist treatment in short adolescents with relatively early puberty
    Sandy A van Gool
    Leiden University Medical Center, Department of Pediatrics, and Tergooi Hospital, Blaricum, The Netherlands
    J Clin Endocrinol Metab 92:1402-8. 2007
    ..Our objective was to assess final height (FH) and adverse effects of combined GH and GnRH agonist (GnRHa) treatment in short adolescents born small for gestational age or with normal birth size (idiopathic short stature)...
  93. ncbi request reprint Structural and functional characteristics of the Val44Met insulin-like growth factor I missense mutation: correlation with effects on growth and development
    Adam Denley
    School of Molecular and Biomedical Science, University of Adelaide, Adelaide, 5005 South Australia
    Mol Endocrinol 19:711-21. 2005
    ....
  94. ncbi request reprint Neonatal screening for congenital adrenal hyperplasia
    Hetty J van der Kamp
    Department of Paediatrics, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Endocrinol 151:U71-5. 2004
    ..Ongoing refinement of cut-off levels is needed to improve specificity and sensitivity...
  95. ncbi request reprint Cutoff levels of 17-alpha-hydroxyprogesterone in neonatal screening for congenital adrenal hyperplasia should be based on gestational age rather than on birth weight
    Hetty J van der Kamp
    Department of Pediatrics, H 3Q, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    J Clin Endocrinol Metab 90:3904-7. 2005
    ..We investigated which approach would result in the greatest specificity and sensitivity...
  96. ncbi request reprint The short stature homeodomain protein SHOX induces cellular growth arrest and apoptosis and is expressed in human growth plate chondrocytes
    Antonio Marchini
    Institute of Human Genetics, University of Heidelberg, Im Neuenheimer Feld 328, D 69120 Heidelberg, Germany
    J Biol Chem 279:37103-14. 2004
    ..This study provides the first insight into the biological function of SHOX as regulator of cellular proliferation and viability and relates these cellular events to the phenotypic consequences of SHOX deficiency...
  97. doi request reprint The views of young adults and their parents on hormone treatment for short stature in adolescence
    Hanneke Visser-van Balen
    Department of Pediatric Psychology, University Medical Center Utrecht, Wilhelmina Children s Hospital, Utrecht, The Netherlands
    Horm Res 69:172-9. 2008
    ....
  98. ncbi request reprint Auxological data in patients clinically suspected of Sotos syndrome with NSD1 gene alterations
    Lonneke de Boer
    Department of Paediatrics, Leiden University Medical Centre, Leiden, The Netherlands
    Acta Paediatr 94:1142-4. 2005
    ..The aim was to investigate which auxology parameters relate to NSD1+/- in patients clinically suspected of Sotos syndrome...
  99. ncbi request reprint Effect of growth hormone dose on bone maturation and puberty in children with idiopathic short stature
    Brenda J Crowe
    Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, USA
    J Clin Endocrinol Metab 91:169-75. 2006
    ..GH at 0.22 mg/kg.wk has been shown to have no effect on pubertal onset or pace, whereas GH at 0.5 mg/kg x wk has been shown to advance pubertal onset and bone maturation...
  100. ncbi request reprint Debate on the use of growth hormone in the treatment of children with idiopathic short stature (ISS) (Pro and Con)
    Alan D Rogol
    Department of Pediatricsm University of Virginia, Charlottesville, VA, USA
    Pediatr Endocrinol Rev 4:226-7. 2007
  101. ncbi request reprint Lipid profile and carotid intima-media thickness in a prospective cohort of very preterm subjects at age 19 years: effects of early growth and current body composition
    Martijn J J Finken
    Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
    Pediatr Res 59:604-9. 2006
    ..Attempts to reduce the CVD risk in this specific population should focus on weight reduction in young adulthood rather than on optimizing the early growth pattern...