Rudi Gj Westendorp

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint Telomere length in white blood cells is not associated with morbidity or mortality in the oldest old: a population-based study
    Carmen M Martin-Ruiz
    Henry Wellcome Biogerontology Research Laboratory, University of Newcastle, Newcastle upon Tyne, UK
    Aging Cell 4:287-90. 2005
  2. pmc Cytomegalovirus seropositivity is associated with glucose regulation in the oldest old. Results from the Leiden 85-plus Study
    Sijia Chen
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, The Netherlands
    Immun Ageing 9:18. 2012
  3. pmc The effect of chronological age on the inflammatory response of human fibroblasts
    Juliane Wolf
    Immunology Division, Institute for Biomedical Aging Research, Austrian Academy of Sciences, Rennweg 10, 6020 Innsbruck, Austria
    Exp Gerontol 47:749-53. 2012
  4. pmc Regenerative potential of human muscle stem cells in chronic inflammation
    Bouke J Duijnisveld
    Department of Orthopaedics, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Arthritis Res Ther 13:R207. 2011
  5. pmc Common CFTR gene variants influence body composition and survival in rural Ghana
    Maris Kuningas
    Department of Gerontology and Geriatrics, Leiden University Medical Center LUMC, C2 R, PO Box 9600, 2300 RC Leiden, The Netherlands
    Hum Genet 127:201-6. 2010
  6. pmc Replication of LDL GWAs hits in PROSPER/PHASE as validation for future (pharmaco)genetic analyses
    Stella Trompet
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    BMC Med Genet 12:131. 2011
  7. pmc Diagnostic accuracy of plasma NT-proBNP levels for excluding cardiac abnormalities in the very elderly
    Bert Vaes
    Department of General Practice, Universite Catholique de Louvain, Avenue Mounier 53, bte 5360, 1200 Brussels, Belgium
    BMC Geriatr 10:85. 2010
  8. pmc Impact of valvular heart disease on activities of daily living of nonagenarians: the Leiden 85-plus study a population based study
    Thomas van Bemmel
    Departments of Gerontology and Geriatrics, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    BMC Geriatr 10:17. 2010
  9. pmc Subnormal vitamin B12 concentrations and anaemia in older people: a systematic review
    Wendy P J den Elzen
    Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands
    BMC Geriatr 10:42. 2010
  10. ncbi request reprint [Reforming the healthcare for older patients with co-morbidity]
    R G J Westendorp
    Leids Universitair Medisch Centrum, afd Ouderengeneeskunde, Postbus 9600, 2300 RC Leiden
    Ned Tijdschr Geneeskd 151:1973-4. 2007

Detail Information

Publications102 found, 100 shown here

  1. ncbi request reprint Telomere length in white blood cells is not associated with morbidity or mortality in the oldest old: a population-based study
    Carmen M Martin-Ruiz
    Henry Wellcome Biogerontology Research Laboratory, University of Newcastle, Newcastle upon Tyne, UK
    Aging Cell 4:287-90. 2005
    ..We conclude that blood monocyte telomere length is not a predictive indicator for age-related morbidity and mortality at ages over 85 years, possibly because of a high degree of telomere length instability in this group...
  2. pmc Cytomegalovirus seropositivity is associated with glucose regulation in the oldest old. Results from the Leiden 85-plus Study
    Sijia Chen
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, The Netherlands
    Immun Ageing 9:18. 2012
    ..abstract:..
  3. pmc The effect of chronological age on the inflammatory response of human fibroblasts
    Juliane Wolf
    Immunology Division, Institute for Biomedical Aging Research, Austrian Academy of Sciences, Rennweg 10, 6020 Innsbruck, Austria
    Exp Gerontol 47:749-53. 2012
    ..It may thus contribute to age-related inflammatory processes, referred to as 'inflamm-aging'...
  4. pmc Regenerative potential of human muscle stem cells in chronic inflammation
    Bouke J Duijnisveld
    Department of Orthopaedics, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Arthritis Res Ther 13:R207. 2011
    ..The aim of this study was to define the role of chronic inflammation on the regenerative potential of satellite cells in human muscle...
  5. pmc Common CFTR gene variants influence body composition and survival in rural Ghana
    Maris Kuningas
    Department of Gerontology and Geriatrics, Leiden University Medical Center LUMC, C2 R, PO Box 9600, 2300 RC Leiden, The Netherlands
    Hum Genet 127:201-6. 2010
    ..In conclusion, we identified common haplotypes in the CFTR gene that influence survival and body composition in the population at large with no evidence for heterozygote advantage...
  6. pmc Replication of LDL GWAs hits in PROSPER/PHASE as validation for future (pharmaco)genetic analyses
    Stella Trompet
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    BMC Med Genet 12:131. 2011
    ..In this report we first describe the rationale of the PROSPER/PHASE project and second show that the PROSPER/PHASE study can be used to study pharmacogenetics in the elderly...
  7. pmc Diagnostic accuracy of plasma NT-proBNP levels for excluding cardiac abnormalities in the very elderly
    Bert Vaes
    Department of General Practice, Universite Catholique de Louvain, Avenue Mounier 53, bte 5360, 1200 Brussels, Belgium
    BMC Geriatr 10:85. 2010
    ....
  8. pmc Impact of valvular heart disease on activities of daily living of nonagenarians: the Leiden 85-plus study a population based study
    Thomas van Bemmel
    Departments of Gerontology and Geriatrics, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    BMC Geriatr 10:17. 2010
    ..Nested within the Leiden 85-plus study, a population based follow-up study of the oldest old, a sample of 81 nonagenarians was recruited...
  9. pmc Subnormal vitamin B12 concentrations and anaemia in older people: a systematic review
    Wendy P J den Elzen
    Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands
    BMC Geriatr 10:42. 2010
    ..The aim of this systematic review was to evaluate the association between subnormal vitamin B12 concentrations and anaemia in older people...
  10. ncbi request reprint [Reforming the healthcare for older patients with co-morbidity]
    R G J Westendorp
    Leids Universitair Medisch Centrum, afd Ouderengeneeskunde, Postbus 9600, 2300 RC Leiden
    Ned Tijdschr Geneeskd 151:1973-4. 2007
    ..This observation indicates a necessity to reform the Dutch healthcare system to better meet the complex needs of older people...
  11. ncbi request reprint Regulation of human life histories: the role of the inflammatory host response
    David Van Bodegom
    Department of Geriatrics and Gerontology, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Ann N Y Acad Sci 1100:84-97. 2007
    ....
  12. ncbi request reprint What is healthy aging in the 21st century?
    Rudi G J Westendorp
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, Netherlands
    Am J Clin Nutr 83:404S-409S. 2006
    ..Increasing our understanding of the aging process and applying available interventions will help to protect and preserve healthy aging...
  13. doi request reprint Nonagenarian siblings and their offspring display lower risk of mortality and morbidity than sporadic nonagenarians: The Leiden Longevity Study
    Rudi G J Westendorp
    Department of Gerontology and Geriatrics, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Am Geriatr Soc 57:1634-7. 2009
    ....
  14. pmc Adverse environmental conditions influence age-related innate immune responsiveness
    Linda May
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    Immun Ageing 6:7. 2009
    ..CONCLUSION-: We conclude that the decline in innate cytokine responses is an intrinsic ageing phenomenon, while pathogen exposure and/or selective survival drive pro-inflammatory responses under adverse living conditions...
  15. pmc Are we becoming less disposable?
    Rudi G J Westendorp
    Leiden University Medical Center, The Netherlands
    EMBO Rep 5:2-6. 2004
  16. ncbi request reprint Leiden research program on ageing
    Rudi G J Westendorp
    Section of Gerontology and Geriatrics, Department of General Internal Medicine C2 R, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Exp Gerontol 37:609-14. 2002
    ....
  17. ncbi request reprint Genetic variants in the glucocorticoid receptor gene (NR3C1) and cardiovascular disease risk. The Leiden 85-plus Study
    Maris Kuningas
    Department of Gerontology and Geriatrics C2 R, Leiden University Medical Center LUMC, PO Box 9600, 2300 RC, Leiden, The Netherlands
    Biogerontology 7:231-8. 2006
    ..We conclude that, in spite the effect of the ER22/23EK and N363S SNPs on metabolism, these polymorphisms together with the BclI SNP, do not affect the risks of cardiovascular disease and survival at old age...
  18. ncbi request reprint Homocysteine, vitamin B-12, and folic acid and the risk of cognitive decline in old age: the Leiden 85-Plus study
    Simon P Mooijaart
    Departments of Gerontology and Geriatrics and Clinical Chemistry, Leiden University Medical Center, Leiden, Netherlands
    Am J Clin Nutr 82:866-71. 2005
    ..High concentrations of homocysteine and low concentrations of vitamin B-12 and folic acid are frequently observed in subjects with dementia...
  19. pmc Selection for genetic variation inducing pro-inflammatory responses under adverse environmental conditions in a Ghanaian population
    Maris Kuningas
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 4:e7795. 2009
    ..Pro-inflammatory host responses that are deleterious later in life may originate from evolutionary selection for genetic variation mediating resistance to infectious diseases under adverse environmental conditions...
  20. ncbi request reprint Low production capacity of interleukin-10 associates with the metabolic syndrome and type 2 diabetes : the Leiden 85-Plus Study
    Eric van Exel
    Section of Gerontology and Geriatrics, Department of General Internal Medicine, Leiden University Medical Center, The Netherlands
    Diabetes 51:1088-92. 2002
    ..These findings showed that low IL-10 production capacity (i.e., a pro-inflammatory response) is associated with the metabolic syndrome and type 2 diabetes...
  21. doi request reprint Rapid flow cytometric method for measuring senescence associated beta-galactosidase activity in human fibroblasts
    Gerard Noppe
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden 2300 RC, The Netherlands
    Cytometry A 75:910-6. 2009
    ..004 and P = 0.635 respectively). We found the modified flow cytometric method measuring SA-beta-gal activity superior in discriminating between degrees of senescence in different populations of fibroblasts...
  22. ncbi request reprint Inflammation and interleukin-1 signaling network contribute to depressive symptoms but not cognitive decline in old age
    Anita H J van den Biggelaar
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    Exp Gerontol 42:693-701. 2007
    ..A high innate IL-1ra to IL-1beta production capacity reflects a better ability to neutralize inflammation and may therefore protect against depressive symptoms...
  23. ncbi request reprint Serum calcium and cognitive function in old age
    Miranda T Schram
    Department of Gerontology and Geriatrics, Leiden University Medical Centre, Leiden, The Netherlands
    J Am Geriatr Soc 55:1786-92. 2007
    ..To determine whether serum calcium is associated with cognitive function in elderly individuals in the general population...
  24. ncbi request reprint Neuropsychological correlates of MRI measures in the continuum of cognitive decline at old age
    Wiesje M van der Flier
    Department of Neurology and Alzheimer Center, VU Medical Center, Leiden, The Netherlands
    Dement Geriatr Cogn Disord 20:82-8. 2005
    ..To investigate the independent associations between medial temporal lobe atrophy and white matter hyperintensities (WMH) and cognitive functions in the elderly...
  25. ncbi request reprint Common chronic diseases and general impairments as determinants of walking disability in the oldest-old population
    Annetje Bootsma-van der Wiel
    Departent of General Internal Medicine, Leiden University Medical Center, The Netherlands
    J Am Geriatr Soc 50:1405-10. 2002
    ..Walking disability affects older people's autonomy and well-being. We investigated the relative effect of common chronic diseases and general impairments on walking disability in the general oldest-old population...
  26. ncbi request reprint A common variant of the methylenetetrahydrofolate reductase gene (1p36) is associated with an increased risk of cancer
    Bastiaan T Heijmans
    Molecular Epidemiology Section, Department of Medical Statistics and Bioinformatics, Leiden University Medical Centre, 2300 RA Leiden, The Netherlands
    Cancer Res 63:1249-53. 2003
    ..The mechanism underlying this association might involve genomic instability as a result of insufficient methylation of genomic DNA...
  27. doi request reprint Genetic variation in pentraxin (PTX) 3 gene associates with PTX3 production and fertility in women
    Linda May
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    Biol Reprod 82:299-304. 2010
    ..003) and higher fertility (P = 0.043). The results reported here provide the first evidence, based on protein production and analysis of polymorphisms, that the long pentraxin PTX3 plays a role in female fertility in humans...
  28. ncbi request reprint Memory complaints in patients with normal cognition are associated with smaller hippocampal volumes
    Wiesje M van der Flier
    Department of Neurology, J3R 43 Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    J Neurol 251:671-5. 2004
    ..These preliminary results suggest that memory complaints may reflect minimal brain deficits associated with impending dementia, depression or a combination of both disorders...
  29. pmc Human insulin/IGF-1 and familial longevity at middle age
    Maarten P Rozing
    Department of Gerontology and Geriatrics, Leiden University Medical Center, 2300 RC, Leiden, The Netherlands
    Aging (Albany NY) 1:714-22. 2009
    ....
  30. ncbi request reprint Prospective study of the effect of blood pressure on renal function in old age: the Leiden 85-Plus Study
    Thomas van Bemmel
    Department of Gerontology and Geriatrics, C2 R, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Am Soc Nephrol 17:2561-6. 2006
    ..08]; P < 0.001). In the oldest individual, high BP is not associated with renal function. In contrast, low DBP is associated with an accelerated decline of renal function. The clinical implications of these findings have to be studied...
  31. doi request reprint Patterns of muscle strength loss with age in the general population and patients with a chronic inflammatory state
    Karel G M Beenakker
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    Ageing Res Rev 9:431-6. 2010
    ..Handgrip strength was used as a proxy for overall muscle strength...
  32. ncbi request reprint Nitric oxide mediates hypoxia-induced cerebral vasodilation in humans
    Annette H M Van Mil
    Department of General Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    J Appl Physiol 92:962-6. 2002
    ..05 for both). Use of phase-contrast magnetic resonance imaging shows that hypoxia-induced cerebral vasodilatation in humans is mediated by NO...
  33. ncbi request reprint Impact of genetic variations in the WRN gene on age related pathologies and mortality
    Maris Kuningas
    Department of Gerontology and Geriatrics C2 R, Leiden University Medical Center LUMC, P O Box 9600, 2300 RC Leiden, The Netherlands
    Mech Ageing Dev 127:307-13. 2006
    ..In conclusion, the i1-C/T, L1074F and C1367R polymorphisms in the WRN gene do not influence the aging-trajectories and survival in the population at large...
  34. ncbi request reprint Variation in the SHC1 gene and longevity in humans
    Simon P Mooijaart
    Section of Gerontology and Geriatrics, Department of General Internal Medicine, Leiden University Medical Center, P O Box 9503, RC Leiden 2300, The Netherlands
    Exp Gerontol 39:263-8. 2004
    ..Low valine allele frequency resulted, however, in low power to detect statistical significance. These data suggest that an association between the Met(410)Val polymorphism and longevity in humans may exist...
  35. ncbi request reprint Effect of smoking and sun on the aging skin
    Cornelis Kennedy
    Department of Dermatology, Leiden University Medical Center, The Netherlands
    J Invest Dermatol 120:548-54. 2003
    ..In contrast to elastosis, telangiectasia may not be a good marker of the aging skin, specifically not in women...
  36. ncbi request reprint Lack of effect of pravastatin on cerebral blood flow or parenchymal volume loss in elderly at risk for vascular disease
    V Hester ten Dam
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    Stroke 36:1633-6. 2005
    ..We examined the effect of 40 mg pravastatin on the decline in CBF and brain volume in a subset of elderly subjects participating in the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER) trial...
  37. ncbi request reprint Association between high-density lipoprotein and cognitive impairment in the oldest old
    Eric van Exel
    Section of Gerontology and Geriatrics, Department of General Internal Medicine, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Ann Neurol 51:716-21. 2002
    ..At least part of the association between high-density lipoprotein cholesterol and cognitive function is independent of atherosclerotic disease...
  38. ncbi request reprint Plasma apolipoprotein CI protects against mortality from infection in old age
    Jimmy F P Berbee
    Department of Biomedical Research, TNO Quality of Life, Gaubius Laboratory, Leiden, The Netherlands
    J Gerontol A Biol Sci Med Sci 63:122-6. 2008
    ..63; 95% CI, 0.44-0.90; p =.013), whereas for HDL cholesterol significance was lost. We conclude that high apoCI levels are associated with reduced mortality from infection, in line with experimental evidence in rodents...
  39. doi request reprint Relation between replicative senescence of human fibroblasts and life history characteristics
    Andrea B Maier
    Leiden University Medical Centre, Department of Gerontology and Geriatrics, 2300 RC Leiden, The Netherlands
    Ageing Res Rev 8:237-43. 2009
    ..018) indicating that publication bias is at play. We conclude that, except for premature ageing syndromes, replicative capacity of fibroblasts in vitro does not mirror key characteristics of human life histories...
  40. doi request reprint Influence of the TP53 codon 72 polymorphism on the cellular responses to X-irradiation in fibroblasts from nonagenarians
    P Martijn den Reijer
    Department of Gerontology and Geriatrics, Leiden University Medical Centre, RC Leiden, The Netherlands
    Mech Ageing Dev 129:175-82. 2008
    ..029) at 3 days after irradiation. Possibly, these differences in cellular responses to stress between the TP53 codon 72 genotypes contribute to the differences in cancer incidence and longevity observed earlier for these genotypes...
  41. pmc Effect of anemia and comorbidity on functional status and mortality in old age: results from the Leiden 85-plus Study
    Wendy P J den Elzen
    Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands
    CMAJ 181:151-7. 2009
    ..There is limited insight into the attributable effect of anemia and comorbidity on functional status and mortality in old age...
  42. ncbi request reprint SIRT1 gene, age-related diseases, and mortality: the Leiden 85-plus study
    Maris Kuningas
    Department of Gerontology and Geriatrics C2 R, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Gerontol A Biol Sci Med Sci 62:960-5. 2007
    ..In conclusion, our results indicate a role for SIRT1 in cognitive functioning, but the role in life span remains to be elucidated...
  43. doi request reprint EEG markers of future cognitive performance in the elderly
    Karin van der Hiele
    Department of Neurology Neuropsychology section, Leiden University Medical Center, Leiden, The Netherlands
    J Clin Neurophysiol 25:83-9. 2008
    ..Although the "cognition only" model showed similar predictive power, the EEG provided significant additional value. The added value of EEG registration in the diagnostic work-up of dementia should be further assessed in larger samples...
  44. doi request reprint Pravastatin and cognitive function in the elderly. Results of the PROSPER study
    Stella Trompet
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    J Neurol 257:85-90. 2010
    ..05). Pravastatin treatment in old age did not affect cognitive decline during a 3 year follow-up period. Employing statin therapy in the elderly in an attempt to prevent cognitive decline therefore seems to be futile...
  45. pmc Polymorphisms in TLR4 and TLR2 genes, cytokine production and survival in rural Ghana
    Linda May
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Hum Genet 18:490-5. 2010
    ..In conclusion, we demonstrate that genetic variation within the TLR4 gene influences cytokine production capacity, but in an endemic area does not influence the susceptibility to malaria infection or mortality...
  46. doi request reprint Relation between maximum replicative capacity and oxidative stress-induced responses in human skin fibroblasts in vitro
    Pim Dekker
    Department of Gerontology and Geriatrics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    J Gerontol A Biol Sci Med Sci 66:45-50. 2011
    ..07). Summarizing, fibroblast strains with a higher maximum replicative capacity have longer telomeres, are less prone to go into stress-induced cellular senescence, and more prone to die after stress...
  47. pmc Genome-wide association study (GWAS)-identified disease risk alleles do not compromise human longevity
    Marian Beekman
    Molecular Epidemiology, Leiden University Medical Center, 2300 RC, Leiden, The Netherlands
    Proc Natl Acad Sci U S A 107:18046-9. 2010
    ..Longevity in this study population is not compromised by the cumulative effect of this set of risk alleles for common disease...
  48. doi request reprint Cognitive decline precedes late-life longitudinal changes in vascular risk factors
    Peter van Vliet
    Department of Gerontology and Geriatrics C2 R, Leiden University Medical Center, RC, Leiden, The Netherlands
    J Neurol Neurosurg Psychiatry 81:1028-32. 2010
    ..It is unclear whether declines in these vascular risk factors are preceded by declines in cognitive function or vice versa...
  49. pmc Associations between total cerebral blood flow and age related changes of the brain
    Adriaan C G M van Es
    Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 5:e9825. 2010
    ....
  50. doi request reprint Handgrip strength as a predictor of functional, psychological and social health. A prospective population-based study among the oldest old
    Diana G Taekema
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    Age Ageing 39:331-7. 2010
    ..Muscle strength measurements could be useful as part of a clinical evaluation of oldest old patients to determine who are most at risk of accelerated decline in the near future...
  51. doi request reprint Dynamics of traditional metabolic risk factors associate with specific causes of death in old age
    Peter van Vliet
    Department of Gerontology and Geriatrics C2 R, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands
    J Gerontol A Biol Sci Med Sci 65:488-94. 2010
    ..With increasing age, these risk factors are prone to change over time. It is unclear whether dynamics of these traditional metabolic risk factors in late life associate with mortality and whether they occur in concert with each other...
  52. doi request reprint White blood cell count and C-reactive protein are independent predictors of mortality in the oldest old
    Jorien M Willems
    Department of Gerontology and Geriatrics, C 2 R, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Gerontol A Biol Sci Med Sci 65:764-8. 2010
    ..We assessed the independent predictive value of WBC count and CRP levels in relation to mortality, both vascular and nonvascular, in very old participants...
  53. doi request reprint Favorable glucose tolerance and lower prevalence of metabolic syndrome in offspring without diabetes mellitus of nonagenarian siblings: the Leiden longevity study
    Maarten P Rozing
    Gerontology and Geriatrics, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands
    J Am Geriatr Soc 58:564-9. 2010
    ..To explore measures of metabolic syndrome and glucose metabolism in families with exceptional longevity...
  54. doi request reprint Apolipoprotein e genotype, plasma cholesterol, and cancer: a Mendelian randomization study
    Stella Trompet
    Department of Gerontology and Geriatrics, C 2 R Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Am J Epidemiol 170:1415-21. 2009
    ..86, 95% CI: 0.50, 1.47) or cancer mortality (HR = 0.70, 95% CI: 0.30, 1.60) compared with ApoE4 carriers. These findings suggest that low cholesterol levels are not causally related to increased cancer risk...
  55. pmc Effect of erythropoietin levels on mortality in old age: the Leiden 85-plus Study
    Wendy P J den Elzen
    Department of Public Health and Primary Care, Leiden University Medical Center, The Netherlands
    CMAJ 182:1953-8. 2010
    ..We investigated the prognostic value of elevated erythropoietin levels on mortality among very elderly people in the general population...
  56. ncbi request reprint Complement Factor H polymorphism Y402H associates with inflammation, visual acuity, and cardiovascular mortality in the elderly population at large
    Simon P Mooijaart
    Department of Gerontology and Geriatrics, C 2 R Leiden University Medical Center, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Exp Gerontol 42:1116-22. 2007
    ..Visual impairment identifies elderly with an increased risk of cardiovascular disease...
  57. ncbi request reprint Thyroid status, disability and cognitive function, and survival in old age
    Jacobijn Gussekloo
    Section of Gerontology and Geriatrics, Department of General Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands
    JAMA 292:2591-9. 2004
    ..Despite the equivocal outcomes of randomized controlled trials, general clinical opinion favors screening and treatment of elderly individuals with subclinical thyroid disorders...
  58. ncbi request reprint Persistence of high-replicative capacity in cultured fibroblasts from nonagenarians
    Andrea B Maier
    Department of Gerontology and Geriatrics, Leiden University Medical Centerm PO BOX 9600, 2300 RC Leiden, The Netherlands
    Aging Cell 6:27-33. 2007
    ..These results cast further doubt on the association between in vitro growth characteristics of fibroblast cultures and the length of human lifespan...
  59. ncbi request reprint Shuttling between species for pathways of lifespan regulation: a central role for the vitellogenin gene family?
    Bernd W Brandt
    Section of Molecular Epidemiology, Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, The Netherlands
    Bioessays 27:339-46. 2005
    ..Here, the vitellogenin family emerges as a potential key connection between lipid metabolism and the insulin/IGF-1 signalling pathway...
  60. pmc Lipoprotein particle profiles mark familial and sporadic human longevity
    Bastiaan T Heijmans
    Department of Molecular Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands
    PLoS Med 3:e495. 2006
    ..Here, we investigate whether this observation can be confirmed for familial longevity in an outbred European population and whether it can be extended to sporadic longevity in the general population...
  61. ncbi request reprint Mental performance in old age dependent on cortisol and genetic variance in the mineralocorticoid and glucocorticoid receptors
    Maris Kuningas
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    Neuropsychopharmacology 32:1295-301. 2007
    ..In contrast, these genetic variants in the MR and GR genes do not influence cognitive functioning in old age...
  62. ncbi request reprint Beta-galactosidase activity as a biomarker of replicative senescence during the course of human fibroblast cultures
    Andrea B Maier
    Department of Gerontology and Geriatrics, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Ann N Y Acad Sci 1100:323-32. 2007
    ..Thus, our results support beta-galactosidase activity as a reliable biomarker for the course of replicative senescence, if used under defined standardized conditions...
  63. pmc ApoE plasma levels and risk of cardiovascular mortality in old age
    Simon P Mooijaart
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, Netherlands
    PLoS Med 3:e176. 2006
    ..Whereas the isoforms have been associated with cardiovascular disease, the relation between plasma apoE levels and cardiovascular disease is unknown...
  64. ncbi request reprint Association between chronic diseases and disability in elderly subjects with low and high income: the Leiden 85-plus Study
    Annetje Bootsma-van der Wiel
    Department of Gerontology and Geriatrics, Leiden University Medical Center, The Netherlands
    Eur J Public Health 15:494-7. 2005
    ..Disability in activities of daily living (ADL) might be more prevalent among elderly with low income due to higher prevalence of chronic diseases and impairments, as well as stronger associations of these factors with ADL-disability...
  65. ncbi request reprint Inflammation underlying cardiovascular mortality is a late consequence of evolutionary programming
    Anita H J van den Biggelaar
    Department of General Internal Medicine, Section Gerontology and Geriatrics, Leiden University Medical Center, C2 R, Albinusdreef 2, P O Box 9600, 2300 RC Leiden, The Netherlands
    FASEB J 18:1022-4. 2004
    ..77; 95% CI: 0.68-0.88), while a positive association with IL-10 was found (RR = 1.22; 95% CI: 1.05-1.41). We suggest that cardiovascular mortality is a late consequence of evolutionary programming for a pro-inflammatory response...
  66. ncbi request reprint Sensory impairment and cognitive functioning in oldest-old subjects: the Leiden 85+ Study
    Jacobijn Gussekloo
    Department of Gerontology and Geriatrics, C 2 R, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Am J Geriatr Psychiatry 13:781-6. 2005
    ..Because studies on the association of sensory impairment (both hearing and visual impairment) and cognitive functioning in elderly persons yielded conflicting results, the authors explored this association within the Leiden 85+ Study...
  67. ncbi request reprint Presence of human papillomavirus DNA in plucked eyebrow hairs is associated with a history of cutaneous squamous cell carcinoma
    Linda Struijk
    Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    J Invest Dermatol 121:1531-5. 2003
    ....
  68. ncbi request reprint The 15-item Geriatric Depression Scale (GDS-15) detects changes in depressive symptoms after a major negative life event. The Leiden 85-plus Study
    David J Vinkers
    Section of Gerontology and Geriatrics, Department of General Internal Medicine, Leiden University Medical Center, The Netherlands
    Int J Geriatr Psychiatry 19:80-4. 2004
    ..The 15-item Geriatric Depression Scale (GDS-15) is a widely used screening instrument for depressive symptoms in the elderly, but its ability to detect alterations in depressive symptoms over time has not been established...
  69. ncbi request reprint High innate production capacity of tumor necrosis factor-alpha and decline of handgrip strength in old age
    Diana G Taekema
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    Mech Ageing Dev 128:517-21. 2007
    ..Within a population-based prospective follow up study of elderly people aged 85 years we show that a high innate production capacity of TNF-alpha precedes a steeper decline in muscle strength over time...
  70. ncbi request reprint Late-onset dementia: structural brain damage and total cerebral blood flow
    Aart Spilt
    Department of Radiology, General Internal Medicine and Neurology, Leiden University Medical Center, Albinusdreef, C2 S, 2333 ZA Leiden, The Netherlands
    Radiology 236:990-5. 2005
    ..To prospectively compare indicators of structural brain damage and total cerebral blood flow in patients with late-onset dementia, subjects of the same age with optimal cognitive function, and young subjects...
  71. ncbi request reprint Association of APOE epsilon2/epsilon3/epsilon4 and promoter gene variants with dementia but not cardiovascular mortality in old age
    Bastiaan T Heijmans
    Gaubius Laboratory, TNO Prevention and Health, Leiden, The Netherlands
    Am J Med Genet 107:201-8. 2002
    ..Furthermore, they emphasize that variation at the APOE locus has a higher impact on the risk of dementia than on the risk of cardiovascular disease in old age...
  72. ncbi request reprint Lymphocyte count and mortality risk in older persons. The Leiden 85-Plus Study
    Gerbrand J Izaks
    Section of Gerontology and Geriatrics, Department of General Internal, Medicine, Leiden University Medical Center, Leiden, The Netherlands
    J Am Geriatr Soc 51:1461-5. 2003
    ..To investigate whether a low peripheral blood lymphocyte count is associated with increased mortality risk in older persons and to determine whether this association could be ascribed to ill health...
  73. doi request reprint Genetic variation in PCAF, a key mediator in epigenetics, is associated with reduced vascular morbidity and mortality: evidence for a new concept from three independent prospective studies
    Douwe Pons
    Department of Cardiology, Leiden University Medical Center, RC Leiden, The Netherlands
    Heart 97:143-50. 2011
    ....
  74. pmc Homocysteine and familial longevity: the Leiden Longevity Study
    Carolien A Wijsman
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 6:e17543. 2011
    ..63). The results suggest that homocysteine metabolism is not likely to predict familial longevity...
  75. doi request reprint Circulating levels of IGF1 are associated with muscle strength in middle-aged- and oldest-old women
    Diana G Taekema
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Endocrinol 164:189-96. 2011
    ..We studied the relationship between circulating levels of IGF1, its binding protein 3 (IGFBP3), and handgrip strength and physical performance in middle-aged- and oldest-old subjects...
  76. ncbi request reprint Colony formation and colony size do not reflect the onset of replicative senescence in human fibroblasts
    Andrea B Maier
    Leiden University Medical Center, Department of Gerontology and Geriatrics, Leiden, The Netherlands
    J Gerontol A Biol Sci Med Sci 63:655-9. 2008
    ..The number of cells within the colonies was modestly correlated to the growth speed of the mass cultures. We conclude that the colony formation assay does not reflect the onset of replicative senescence in human fibroblasts...
  77. pmc Effects of a web-based intervention on physical activity and metabolism in older adults: randomized controlled trial
    Carolien A Wijsman
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, Netherlands
    J Med Internet Res 15:e233. 2013
    ..The potential of Web-assisted interventions for increasing physical activity and improving metabolism in older individuals holds great promise but to our knowledge it has not been studied...
  78. doi request reprint Pharmacogenetics of statins: achievements, whole-genome analyses and future perspectives
    Iris Postmus
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    Pharmacogenomics 13:831-40. 2012
    ..Moreover, we describe the PHASE study, an EU-funded GWA study that will investigate the genetic variation responsible for the variation in response to pravastatin in a large randomized clinical trial...
  79. doi request reprint Increased amygdalar and hippocampal volumes in elderly obese individuals with or at risk of cardiovascular disease
    Ralph L Widya
    Departments of Radiology, Leiden University Medical Center, Leiden, Netherlands
    Am J Clin Nutr 93:1190-5. 2011
    ..The basal ganglia, hippocampus, and thalamus are involved in the regulation of human feeding behavior. Recent studies have shown that obesity [body mass index (BMI; in kg/m(2)) > 30] is associated with loss of gray and white matter...
  80. doi request reprint Performance of Cockcroft-Gault, MDRD, and CKD-EPI in estimating prevalence of renal function and predicting survival in the oldest old
    Jorien M Willems
    Department of Gerontology and Geriatrics, C 2 R, Leiden University Medical Center, PO Box 9600, 2300, RC, Leiden, The Netherlands
    BMC Geriatr 13:113. 2013
    ..Furthermore, we assessed prevalence of eGFR in a population-based sample of 85 year olds and investigated the performance of these eGFRs in predicting mortality in the oldest old...
  81. ncbi request reprint Liver X receptor alpha associates with human life span
    Simon P Mooijaart
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    J Gerontol A Biol Sci Med Sci 62:343-9. 2007
    ..018), and higher levels of triglycerides (p =.041). Genetic variation in the gene coding for the LXRalpha (NR1H3) associates with human life span...
  82. ncbi request reprint Plasma levels of apolipoprotein E and risk of stroke in old age
    Peter van Vliet
    Department of Gerontology and Geriatrics C2 R, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands
    Ann N Y Acad Sci 1100:140-7. 2007
    ..440). In conclusion, in old age, except for epsilon2-allele carriers, high plasma apoE levels are associated with a higher risk of stroke, independent of APOE genotype, plasma levels of lipids, and other cardiovascular risk factors...
  83. doi request reprint Genes encoding longevity: from model organisms to humans
    Maris Kuningas
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    Aging Cell 7:270-80. 2008
    ..In conclusion, although the study of model organisms has revealed potential candidate genetic mechanisms determining aging and lifespan, to what extent they explain variation in human populations is still uncertain...
  84. ncbi request reprint MMSE scores correlate with local ventricular enlargement in the spectrum from cognitively normal to Alzheimer disease
    Luca Ferrarini
    Division of Image Processing, Leiden University Medical Center, Leiden, The Netherlands
    Neuroimage 39:1832-8. 2008
    ..The extent of atrophy showed no significant correlations. In conclusion, the MMSE scores correlate with localized depth of atrophy in well-defined periventricular structures...
  85. ncbi request reprint Plasma levels of apolipoprotein E and cognitive function in old age
    Simon P Mooijaart
    Department of Gerontology and Geriatrics C2 R, Leiden University Medical Center, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Ann N Y Acad Sci 1100:148-61. 2007
    ..We conclude that in old age, in non-epsilon2-allele carriers, high plasma apoE levels are associated with cognitive impairments, independent of genotype, cardiovascular risk factors, and stroke...
  86. ncbi request reprint Association between apolipoprotein E4 and cognitive decline in elderly adults
    Chris J Packard
    Department of Vascular Biochemistry, University of Glasgow, Glasgow, Scotland
    J Am Geriatr Soc 55:1777-85. 2007
    ..To determine the influence of apolipoprotein E on cognitive decline in a cohort of elderly men and women...
  87. ncbi request reprint Evidence for non-random distribution of Fcgamma receptor genotype combinations
    W Ludo van der Pol
    Department of Immunology, Laboratory for Immunotherapy, KC 02 085 2, University Medical Center Utrecht, Lundlaan 6, 3584 EA Utrecht, The Netherlands
    Immunogenetics 55:240-6. 2003
    ..00001). This study provides important information for the interpretation of studies reporting associations of FcgammaR alleles with disease, and underscores the apparent differences in FcgammaR heterogeneity between ethnic groups...
  88. ncbi request reprint Magnetization transfer imaging in normal aging, mild cognitive impairment, and Alzheimer's disease
    Wiesje M van der Flier
    Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands
    Ann Neurol 52:62-7. 2002
    ..Moreover, structural changes also were observed in MCI patients, indicating that widespread brain damage can be demonstrated before patients are clinically demented...
  89. doi request reprint Measuring cognitive function with age: the influence of selection by health and survival
    Sjoerd M Euser
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlandes
    Epidemiology 19:440-7. 2008
    ..Research into the pathophysiology of age-associated cognitive function and decline requires a valid estimate of cognitive function. However, this estimation can be grossly influenced by a selective loss to follow-up...
  90. ncbi request reprint Insulin/Insulin-like growth factor-1 signaling and cognitive function in humans
    Sjoerd M Euser
    Department of Gerontology and Geriatrics, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands
    J Gerontol A Biol Sci Med Sci 63:907-10. 2008
    ..010). The IIS6 score was not associated with change in cognitive function. In addition to old age survival, genetically reduced IIS seems to be beneficial for cognitive function in women...
  91. ncbi request reprint In a population-based prospective study, no association between high blood pressure and mortality after age 85 years
    Thomas van Bemmel
    Department of Gerontology and Geriatrics, C2 R, Leiden University Medical Centre, Leiden, The Netherlands
    J Hypertens 24:287-92. 2006
    ..To study the impact of a history of hypertension and current blood pressure on mortality in the oldest old...
  92. ncbi request reprint Chromosome 4q25, microsomal transfer protein gene, and human longevity: novel data and a meta-analysis of association studies
    Marian Beekman
    Section of Molecular Epidemiology, Department of General Internal Medicine, Leiden University Medical Center, P O Box 9503, 2300 RA Leiden, The Netherlands
    J Gerontol A Biol Sci Med Sci 61:355-62. 2006
    ..Meta-analyses of all previous studies implied that the association in U.S. Caucasians may have its source in admixture of the U.S. control population rather than in the genetic effect of the locus on exceptional longevity...
  93. ncbi request reprint Human cytokine response to ex vivo amyloid-beta stimulation is mediated by genetic factors
    Danielle Posthuma
    Department of Biological Psychology, Vrije Universiteit Amsterdam, The Netherlands
    Twin Res Hum Genet 8:132-7. 2005
    ..We conclude that genes influencing amyloid-beta-induced cytokine response may provide clues to the progression of AD pathology...
  94. ncbi request reprint Reduced insulin/IGF-1 signalling and human longevity
    Diana van Heemst
    Section of Gerontology and Geriatrics, Department of General Internal Medicine, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, The Netherlands
    Aging Cell 4:79-85. 2005
    ..This effect was stronger for the GH1 SNP than for variation in the conserved IIS genes that were found to affect longevity in model organisms...
  95. ncbi request reprint Seasonal mood variation in the elderly: the Leiden 85-plus study
    Anton J M de Craen
    Department of General Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    Int J Geriatr Psychiatry 20:269-73. 2005
    ..The influence of seasonal changes on mood and behaviour is called seasonality. The prevalence of seasonality in elderly subjects is unknown...
  96. ncbi request reprint Haplotypes in the human Foxo1a and Foxo3a genes; impact on disease and mortality at old age
    Maris Kuningas
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Hum Genet 15:294-301. 2007
    ..036) and 1.19-fold increased risk for cardiovascular mortality (P=0.052). In conclusion, this study shows that genetic variation in evolutionarily conserved Foxo1a and Foxo3a genes influences lifespan in our study population...
  97. ncbi request reprint What are the effects of maternal and pre-adult environments on ageing in humans, and are there lessons from animal models?
    Paul M Brakefield
    Institute of Biology, Leiden University, PO Box 9516, 2300 RA Leiden, The Netherlands
    Mech Ageing Dev 126:431-8. 2005
    ....
  98. ncbi request reprint In an observational study elderly patients had an increased risk of falling due to home hazards
    Thomas van Bemmel
    Section of Gerontology and Geriatrics, Department of General Internal Medicine, C1 R, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Clin Epidemiol 58:63-7. 2005
    ..The objective of this study was to explore the relationship between home hazards and the incidence of falls in the oldest old population...
  99. ncbi request reprint Meta-analysis of nonsteroidal antiinflammatory drug use and risk of dementia
    Anton J M de Craen
    Section of Gerontology and Geriatrics, Department of General Internal Medicine, Leiden University Medical Center, P O Box 9600, Leiden 2300 RC, The Netherlands
    Am J Epidemiol 161:114-20. 2005
    ....
  100. pmc Endothelium-dependent NO-mediated vasodilation in humans is attenuated by peripheral alpa1-adrenoceptor activation
    Adriaan M Kamper
    Department of Gerontology, Leiden University Medical Center, Leiden, The Netherlands
    Vasc Health Risk Manag 1:251-6. 2005
    ..The aim of the present study was to examine the effect of alpha1- and alpha2-adrenoceptor activation on nitric oxide-mediated vasodilation...
  101. ncbi request reprint Impaired innate immunity predicts frailty in old age. The Leiden 85-plus study
    Anita H J van den Biggelaar
    Department of General Internal Medicine, Section Gerontology and Geriatrics, Leiden University Medical Center, C2 R, Albinusdreef 2, P O Box 9600, 2300 RC Leiden, The Netherlands
    Exp Gerontol 39:1407-14. 2004
    ..We conclude that a malfunctioning innate immune response predicts frailty in old age and is under specific (immuno-) genetic control...