Jan J G M Verschuuren

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint Available treatment options for the management of Lambert-Eaton myasthenic syndrome
    Jan J G M Verschuuren
    Leiden University Medical Centre, Department of Neurology, PO Box 9600, 2300 RC Leiden, Leiden, The Netherlands
    Expert Opin Pharmacother 7:1323-36. 2006
  2. pmc Effect of enzyme therapy and prognostic factors in 69 adults with Pompe disease: an open-label single-center study
    Juna M de Vries
    Department of Neurology and Center for Lysosomal and Metabolic Diseases, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Orphanet J Rare Dis 7:73. 2012
  3. doi request reprint Pathophysiology of myasthenia gravis with antibodies to the acetylcholine receptor, muscle-specific kinase and low-density lipoprotein receptor-related protein 4
    Jan J G M Verschuuren
    Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands
    Autoimmun Rev 12:918-23. 2013
  4. doi request reprint Muscle-specific kinase myasthenia gravis IgG4 autoantibodies cause severe neuromuscular junction dysfunction in mice
    Rinse Klooster
    Department of Human Genetics, Medical Genetics Centre, Leiden University Medical Centre, Leiden, The Netherlands
    Brain 135:1081-101. 2012
  5. doi request reprint Clinical aspects of myasthenia explained
    Jan J G M Verschuuren
    Department of Neurology, Leiden University Medical Center LUMC, Leiden, The Netherlands
    Autoimmunity 43:344-52. 2010
  6. pmc The effect of plasma from muscle-specific tyrosine kinase myasthenia patients on regenerating endplates
    W Pascale Ter Beek
    Neurophysiology Section, Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands
    Am J Pathol 175:1536-44. 2009
  7. doi request reprint Clinical Dutch-English Lambert-Eaton Myasthenic syndrome (LEMS) tumor association prediction score accurately predicts small-cell lung cancer in the LEMS
    Maarten J Titulaer
    Leiden University Medical Center, Leiden, The Netherlands
    J Clin Oncol 29:902-8. 2011
  8. doi request reprint Pre- and postsynaptic neuromuscular junction abnormalities in musk myasthenia
    Erik H Niks
    Department of Neurology, Leiden University Medical Center, K5Q 114, P O Box 9600, 2300 RC Leiden, The Netherlands
    Muscle Nerve 42:283-8. 2010
  9. pmc AChR deficiency due to epsilon-subunit mutations: two common mutations in the Netherlands
    Catharina G Faber
    Department of Neurology, Maastricht University Medical Centre, PO Box 5800, 6202 AZ, Maastricht, The Netherlands
    J Neurol 256:1719-23. 2009
  10. doi request reprint SOX antibodies in small-cell lung cancer and Lambert-Eaton myasthenic syndrome: frequency and relation with survival
    Maarten J Titulaer
    Department of Neurology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Clin Oncol 27:4260-7. 2009

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Available treatment options for the management of Lambert-Eaton myasthenic syndrome
    Jan J G M Verschuuren
    Leiden University Medical Centre, Department of Neurology, PO Box 9600, 2300 RC Leiden, Leiden, The Netherlands
    Expert Opin Pharmacother 7:1323-36. 2006
    ..Chemotherapy has successfully ameliorated the course of disease in Lambert-Eaton myasthenic syndrome patients with an underlying tumour...
  2. pmc Effect of enzyme therapy and prognostic factors in 69 adults with Pompe disease: an open-label single-center study
    Juna M de Vries
    Department of Neurology and Center for Lysosomal and Metabolic Diseases, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Orphanet J Rare Dis 7:73. 2012
    ..We investigated whether it alters the course of disease, and also identified potential prognostic factors...
  3. doi request reprint Pathophysiology of myasthenia gravis with antibodies to the acetylcholine receptor, muscle-specific kinase and low-density lipoprotein receptor-related protein 4
    Jan J G M Verschuuren
    Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands
    Autoimmun Rev 12:918-23. 2013
    ..Further studies into the specific pathophysiological pathways of the several MG subforms might help to develop new, more antigen specific, therapies...
  4. doi request reprint Muscle-specific kinase myasthenia gravis IgG4 autoantibodies cause severe neuromuscular junction dysfunction in mice
    Rinse Klooster
    Department of Human Genetics, Medical Genetics Centre, Leiden University Medical Centre, Leiden, The Netherlands
    Brain 135:1081-101. 2012
    ....
  5. doi request reprint Clinical aspects of myasthenia explained
    Jan J G M Verschuuren
    Department of Neurology, Leiden University Medical Center LUMC, Leiden, The Netherlands
    Autoimmunity 43:344-52. 2010
    ..Myasthenic phenotypes can be classified according to the basic aetiological mechanisms or divided depending on the clinical phenotype...
  6. pmc The effect of plasma from muscle-specific tyrosine kinase myasthenia patients on regenerating endplates
    W Pascale Ter Beek
    Neurophysiology Section, Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands
    Am J Pathol 175:1536-44. 2009
    ..Our results suggest that anti-MuSK antibodies influence the activity of MuSK molecules without reducing their number, thereby diminishing the size of the endplate and affecting the functioning of AChRs...
  7. doi request reprint Clinical Dutch-English Lambert-Eaton Myasthenic syndrome (LEMS) tumor association prediction score accurately predicts small-cell lung cancer in the LEMS
    Maarten J Titulaer
    Leiden University Medical Center, Leiden, The Netherlands
    J Clin Oncol 29:902-8. 2011
    ..In view of its profound impact on therapy and survival, we developed and validated a score to identify the presence of SCLC early in the course of LEMS...
  8. doi request reprint Pre- and postsynaptic neuromuscular junction abnormalities in musk myasthenia
    Erik H Niks
    Department of Neurology, Leiden University Medical Center, K5Q 114, P O Box 9600, 2300 RC Leiden, The Netherlands
    Muscle Nerve 42:283-8. 2010
    ..Results suggest that anti-MuSK antibodies reduce the stability of muscle-nerve contact...
  9. pmc AChR deficiency due to epsilon-subunit mutations: two common mutations in the Netherlands
    Catharina G Faber
    Department of Neurology, Maastricht University Medical Centre, PO Box 5800, 6202 AZ, Maastricht, The Netherlands
    J Neurol 256:1719-23. 2009
    ....
  10. doi request reprint SOX antibodies in small-cell lung cancer and Lambert-Eaton myasthenic syndrome: frequency and relation with survival
    Maarten J Titulaer
    Department of Neurology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Clin Oncol 27:4260-7. 2009
    ..Clinical outcome with respect to SOX antibodies was evaluated, as the SOX-related antitumor immune response might help to control the tumor growth...
  11. doi request reprint Screening for small-cell lung cancer: a follow-up study of patients with Lambert-Eaton myasthenic syndrome
    Maarten J Titulaer
    Department of Neurology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Clin Oncol 26:4276-81. 2008
    ..We evaluated screening to optimize screening strategy for SCLC. It is important to detect these tumors early in newly diagnosed patients with LEMS to offer optimal patient treatment...
  12. pmc Epidemiology of myasthenia gravis with anti-muscle specific kinase antibodies in The Netherlands
    Erik H Niks
    Department of Neurology, J3 R 166, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Neurol Neurosurg Psychiatry 78:417-8. 2007
    ..Nationwide, 35 patients with MuSK myasthenia gravis were identified, yielding a prevalence of 1.9 per million (95% confidence interval (CI) 1.22 to 2.59) and an annual incidence 0.10 per million person-years (95% CI 0.06 to 0.14)...
  13. ncbi request reprint Severely impaired neuromuscular synaptic transmission causes muscle weakness in the Cacna1a-mutant mouse rolling Nagoya
    Simon Kaja
    Department of Neurology and Clinical Neurophysiology, Leiden University Medical Centre, Leiden, The Netherlands
    Eur J Neurosci 25:2009-20. 2007
    ..Taken together, our studies indicate that the gait abnormality of RN mice is due to a combination of ataxia and muscle weakness and that RN models aspects of the NMJ dysfunction in LEMS...
  14. ncbi request reprint P/Q-type calcium channel antibodies, Lambert-Eaton myasthenic syndrome and survival in small cell lung cancer
    Paul W Wirtz
    Department of Neurology, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    J Neuroimmunol 164:161-5. 2005
    ..In both series, only patients with LEMS had a remarkably long survival, whereas presence of the antibodies without LEMS did not result in a better prognosis...
  15. pmc Clinical features and predictors for disease natural progression in adults with Pompe disease: a nationwide prospective observational study
    Nadine A M E van der Beek
    Department of Neurology, Center for Lysosomal and Metabolic Diseases, Erasmus MC University Medical Center, s Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands
    Orphanet J Rare Dis 7:88. 2012
    ..Furthermore, we defined the natural disease course and identified prognostic factors for disease progression...
  16. doi request reprint SOX1 antibodies in Lambert-Eaton myasthenic syndrome and screening for small cell lung carcinoma
    Alexander F Lipka
    Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands
    Ann N Y Acad Sci 1275:70-7. 2012
    ..This prediction model has provided for a simple clinical tool to indicate the presence of SCLC early in the course of the disease. The DELTA-P score can be used to guide tumor screening in individual patients...
  17. doi request reprint IgG fc N-glycosylation changes in Lambert-Eaton myasthenic syndrome and myasthenia gravis
    Maurice H J Selman
    Biomolecular Mass Spectrometry Unit, Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
    J Proteome Res 10:143-52. 2011
    ..Interestingly, LEMS patients below 50 years showed elevated levels of bisecting N-acetylglucosamine on IgG1 and IgG2, demonstrating for the first time the link of changes in the level of bisecting N-acetylglucosamine with disease...
  18. doi request reprint A 12-year follow-up in sporadic inclusion body myositis: an end stage with major disabilities
    Fieke M Cox
    Department of Neurology, Leiden University Medical Centre, 2300 RC Leiden, The Netherlands
    Brain 134:3167-75. 2011
    ..Sporadic inclusion body myositis is a chronic progressive disorder, leading to major disabilities at the end stage of the disease due to extensive muscle weakness...
  19. doi request reprint Prednisone 10 days on/10 days off in patients with Duchenne muscular dystrophy
    Chiara S M Straathof
    Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands
    J Neurol 256:768-73. 2009
    ..Our data suggest that prednisone 10 on/10 off has relatively few side effects and extends the ambulant phase by 1 year compared to historical controls...
  20. ncbi request reprint Trigeminal autonomic cephalgias due to structural lesions: a review of 31 cases
    Irene Favier
    Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands
    Arch Neurol 64:25-31. 2007
    ..We found that even typical TACs can be caused by an underlying lesion. Clinical warning signs and symptoms are relatively rare. We recommend neuroimaging in all patients with a TAC or TAC-like syndrome...
  21. doi request reprint Differentiation of hereditary spastic paraparesis from primary lateral sclerosis in sporadic adult-onset upper motor neuron syndromes
    Frans Brugman
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Arch Neurol 66:509-14. 2009
    ..Differentiation between these diseases is important for genetic counseling and prognostication...
  22. ncbi request reprint HLA and smoking in prediction and prognosis of small cell lung cancer in autoimmune Lambert-Eaton myasthenic syndrome
    Paul W Wirtz
    Department of Neurology, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    J Neuroimmunol 159:230-7. 2005
    ..Moreover, negativity for HLA-B8 combined with smoking behavior points more strongly to an underlying SCLC and predicts a worse prognosis in SCLC-LEMS patients...
  23. doi request reprint Paraneoplastic syndromes of the neuromuscular junction: therapeutic options in myasthenia gravis, lambert-eaton myasthenic syndrome, and neuromyotonia
    Agnes van Sonderen
    Department of Neurology, Haga Hospital, The Hague, The Netherlands
    Curr Treat Options Neurol 15:224-39. 2013
    ..Plasma exchange or intravenous immunoglobulin is indicated in severe neuromyotonia and in patients with neuromyotonia combined with central nervous system symptoms, a clinical picture known as Morvan's syndrome...
  24. doi request reprint Lambert-Eaton myasthenic syndrome: tumor versus nontumor forms
    Maarten J Titulaer
    Department of Neurology, K5 Q, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Ann N Y Acad Sci 1132:129-34. 2008
    ..We summarize the literature and present data from our Dutch cohort of 104 LEMS patients to compare the clinical and laboratory characteristics of tumor and nontumor related LEMS patients...
  25. ncbi request reprint Inclusion body myositis. Clinical features and clinical course of the disease in 64 patients
    Umesh A Badrising
    Dept of Neurology, Leiden University Medical Centre, Leiden, The Netherlands
    J Neurol 252:1448-54. 2005
    ..IBM has a unique distribution of muscle weakness. Ankylotic contractures are common. We feel that their joint impact on daily functioning is characteristic for the disease...
  26. pmc Myasthenia gravis thymus: complement vulnerability of epithelial and myoid cells, complement attack on them, and correlations with autoantibody status
    Maria I Leite
    Department of Clinical Neurology, University of Oxford, Oxford, United Kingdom
    Am J Pathol 171:893-905. 2007
    ..Remarkably, the similar changes place many apparent AChR-seronegative patients in the same spectrum as the AChR-seropositive patients...
  27. doi request reprint Re: Lambert-Eaton myasthenic syndrome with pure ocular weakness
    Maarten J Titulaer
    Neurology 70:86; author reply 86-7. 2008