Research Topics
Genomes and Genes | Jan J G M VerschuurenSummaryAffiliation: Leiden University Medical Center Country: The Netherlands Publications
| Collaborators
|
Detail Information
Publications
Available treatment options for the management of Lambert-Eaton myasthenic syndromeJan J G M Verschuuren
Leiden University Medical Centre, Department of Neurology, PO Box 9600, 2300 RC Leiden, Leiden, The Netherlands
Expert Opin Pharmacother 7:1323-36. 2006..Chemotherapy has successfully ameliorated the course of disease in Lambert-Eaton myasthenic syndrome patients with an underlying tumour...
Muscle-specific kinase myasthenia gravis IgG4 autoantibodies cause severe neuromuscular junction dysfunction in miceRinse Klooster
Department of Human Genetics, Medical Genetics Centre, Leiden University Medical Centre, Leiden, The Netherlands
Brain 135:1081-101. 2012....- Clinical aspects of myasthenia explainedJan J G M Verschuuren
Department of Neurology, Leiden University Medical Center LUMC, Leiden, The Netherlands
Autoimmunity 43:344-52. 2010..Myasthenic phenotypes can be classified according to the basic aetiological mechanisms or divided depending on the clinical phenotype... - Clinical Dutch-English Lambert-Eaton Myasthenic syndrome (LEMS) tumor association prediction score accurately predicts small-cell lung cancer in the LEMSMaarten J Titulaer
Leiden University Medical Center, Leiden, The Netherlands
J Clin Oncol 29:902-8. 2011..In view of its profound impact on therapy and survival, we developed and validated a score to identify the presence of SCLC early in the course of LEMS... - Pre- and postsynaptic neuromuscular junction abnormalities in musk myastheniaErik H Niks
Department of Neurology, Leiden University Medical Center, K5Q 114, P O Box 9600, 2300 RC Leiden, The Netherlands
Muscle Nerve 42:283-8. 2010..Results suggest that anti-MuSK antibodies reduce the stability of muscle-nerve contact... 
The effect of plasma from muscle-specific tyrosine kinase myasthenia patients on regenerating endplatesW Pascale Ter Beek
Neurophysiology Section, Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands
Am J Pathol 175:1536-44. 2009..Our results suggest that anti-MuSK antibodies influence the activity of MuSK molecules without reducing their number, thereby diminishing the size of the endplate and affecting the functioning of AChRs...- SOX antibodies in small-cell lung cancer and Lambert-Eaton myasthenic syndrome: frequency and relation with survivalMaarten J Titulaer
Department of Neurology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
J Clin Oncol 27:4260-7. 2009..Clinical outcome with respect to SOX antibodies was evaluated, as the SOX-related antitumor immune response might help to control the tumor growth... - AChR deficiency due to epsilon-subunit mutations: two common mutations in the NetherlandsCatharina G Faber
Department of Neurology, Maastricht University Medical Centre, PO Box 5800, 6202 AZ, Maastricht, The Netherlands
J Neurol 256:1719-23. 2009.... - Screening for small-cell lung cancer: a follow-up study of patients with Lambert-Eaton myasthenic syndromeMaarten J Titulaer
Department of Neurology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
J Clin Oncol 26:4276-81. 2008..We evaluated screening to optimize screening strategy for SCLC. It is important to detect these tumors early in newly diagnosed patients with LEMS to offer optimal patient treatment... - P/Q-type calcium channel antibodies, Lambert-Eaton myasthenic syndrome and survival in small cell lung cancerPaul W Wirtz
Department of Neurology, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
J Neuroimmunol 164:161-5. 2005..In both series, only patients with LEMS had a remarkably long survival, whereas presence of the antibodies without LEMS did not result in a better prognosis... - A 12-year follow-up in sporadic inclusion body myositis: an end stage with major disabilitiesFieke M Cox
Department of Neurology, Leiden University Medical Centre, 2300 RC Leiden, The Netherlands
Brain 134:3167-75. 2011..Sporadic inclusion body myositis is a chronic progressive disorder, leading to major disabilities at the end stage of the disease due to extensive muscle weakness... - Epidemiology of myasthenia gravis with anti-muscle specific kinase antibodies in The NetherlandsErik H Niks
Department of Neurology, J3 R 166, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, The Netherlands
J Neurol Neurosurg Psychiatry 78:417-8. 2007..Nationwide, 35 patients with MuSK myasthenia gravis were identified, yielding a prevalence of 1.9 per million (95% confidence interval (CI) 1.22 to 2.59) and an annual incidence 0.10 per million person-years (95% CI 0.06 to 0.14)... - IgG fc N-glycosylation changes in Lambert-Eaton myasthenic syndrome and myasthenia gravisMaurice H J Selman
Biomolecular Mass Spectrometry Unit, Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
J Proteome Res 10:143-52. 2011..Interestingly, LEMS patients below 50 years showed elevated levels of bisecting N-acetylglucosamine on IgG1 and IgG2, demonstrating for the first time the link of changes in the level of bisecting N-acetylglucosamine with disease... - Severely impaired neuromuscular synaptic transmission causes muscle weakness in the Cacna1a-mutant mouse rolling NagoyaSimon Kaja
Department of Neurology and Clinical Neurophysiology, Leiden University Medical Centre, Leiden, The Netherlands
Eur J Neurosci 25:2009-20. 2007..Taken together, our studies indicate that the gait abnormality of RN mice is due to a combination of ataxia and muscle weakness and that RN models aspects of the NMJ dysfunction in LEMS... - Prednisone 10 days on/10 days off in patients with Duchenne muscular dystrophyChiara S M Straathof
Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands
J Neurol 256:768-73. 2009..Our data suggest that prednisone 10 on/10 off has relatively few side effects and extends the ambulant phase by 1 year compared to historical controls... - Trigeminal autonomic cephalgias due to structural lesions: a review of 31 casesIrene Favier
Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands
Arch Neurol 64:25-31. 2007..We found that even typical TACs can be caused by an underlying lesion. Clinical warning signs and symptoms are relatively rare. We recommend neuroimaging in all patients with a TAC or TAC-like syndrome... - Clinical features and predictors for disease natural progression in adults with Pompe disease: a nationwide prospective observational studyNadine A M E van der Beek
Department of Neurology, Center for Lysosomal and Metabolic Diseases, Erasmus MC University Medical Center, s Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands
Orphanet J Rare Dis 7:88. 2012..Furthermore, we defined the natural disease course and identified prognostic factors for disease progression... - SOX1 antibodies in Lambert-Eaton myasthenic syndrome and screening for small cell lung carcinomaAlexander F Lipka
Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands
Ann N Y Acad Sci 1275:70-7. 2012..This prediction model has provided for a simple clinical tool to indicate the presence of SCLC early in the course of the disease. The DELTA-P score can be used to guide tumor screening in individual patients... - Differentiation of hereditary spastic paraparesis from primary lateral sclerosis in sporadic adult-onset upper motor neuron syndromesFrans Brugman
Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
Arch Neurol 66:509-14. 2009..Differentiation between these diseases is important for genetic counseling and prognostication... - HLA and smoking in prediction and prognosis of small cell lung cancer in autoimmune Lambert-Eaton myasthenic syndromePaul W Wirtz
Department of Neurology, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
J Neuroimmunol 159:230-7. 2005..Moreover, negativity for HLA-B8 combined with smoking behavior points more strongly to an underlying SCLC and predicts a worse prognosis in SCLC-LEMS patients... - Paraneoplastic syndromes of the neuromuscular junction: therapeutic options in myasthenia gravis, lambert-eaton myasthenic syndrome, and neuromyotoniaAgnes van Sonderen
Department of Neurology, Haga Hospital, The Hague, The Netherlands
Curr Treat Options Neurol 15:224-39. 2013..Plasma exchange or intravenous immunoglobulin is indicated in severe neuromyotonia and in patients with neuromyotonia combined with central nervous system symptoms, a clinical picture known as Morvan's syndrome... - Lambert-Eaton myasthenic syndrome: tumor versus nontumor formsMaarten J Titulaer
Department of Neurology, K5 Q, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
Ann N Y Acad Sci 1132:129-34. 2008..We summarize the literature and present data from our Dutch cohort of 104 LEMS patients to compare the clinical and laboratory characteristics of tumor and nontumor related LEMS patients... - Inclusion body myositis. Clinical features and clinical course of the disease in 64 patientsUmesh A Badrising
Dept of Neurology, Leiden University Medical Centre, Leiden, The Netherlands
J Neurol 252:1448-54. 2005..IBM has a unique distribution of muscle weakness. Ankylotic contractures are common. We feel that their joint impact on daily functioning is characteristic for the disease... - Re: Lambert-Eaton myasthenic syndrome with pure ocular weaknessMaarten J Titulaer
Neurology 70:86; author reply 86-7. 2008 - Myasthenia gravis thymus: complement vulnerability of epithelial and myoid cells, complement attack on them, and correlations with autoantibody statusMaria I Leite
Department of Clinical Neurology, University of Oxford, Oxford, United Kingdom
Am J Pathol 171:893-905. 2007..Remarkably, the similar changes place many apparent AChR-seronegative patients in the same spectrum as the AChR-seropositive patients...