Jan P Vandenbroucke

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint The history of confounding
    Jan P Vandenbroucke
    Leiden University Medical Centre
    Soz Praventivmed 47:216-24. 2002
  2. ncbi request reprint Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): explanation and elaboration
    Jan P Vandenbroucke
    Leiden University Medical Center, Leiden, The Netherlands
    Ann Intern Med 147:W163-94. 2007
  3. doi request reprint Case-control studies: basic concepts
    Jan P Vandenbroucke
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Int J Epidemiol 41:1480-9. 2012
  4. pmc Incidence rates in dynamic populations
    Jan P Vandenbroucke
    Department of Clinical Epidemiology, Leiden University Medical Center, RC Leiden, The Netherlands
    Int J Epidemiol 41:1472-9. 2012
  5. pmc Trends in total cholesterol screening and in prescribing lipid-lowering drugs in general practice in the period 1994-2003
    Stefaan Bartholomeeusen
    Department of General Practice, Katholieke Universiteit Leuven, Kapucijnenvoer 33, Leuven, Belgium
    BMC Fam Pract 9:39. 2008
  6. ncbi request reprint [The N-of-1 trial: the ideal study design that is underused]
    J P Vandenbroucke
    Leids Universitair Medisch Centrum, afd Klinische Epidemiologie, Postbus 9600, 2300 RC Leiden
    Ned Tijdschr Geneeskd 150:2794-5. 2006
  7. ncbi request reprint The 1855 cholera epidemic in Ferrara: lessons from old data reanalysed with modern means
    Jan P Vandenbroucke
    Department of Clinical Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands
    Eur J Epidemiol 18:599-602. 2003
  8. ncbi request reprint [Breast cancer and the use of the hormones around the menopause]
    J P Vandenbroucke
    afd Klinische Epidemiologie, Leids Universitair Medisch Centrum, Postbus 9600, 2300 RC Leiden
    Ned Tijdschr Geneeskd 147:1829-34. 2003
  9. ncbi request reprint Alvan Feinstein and the art of consulting: how to define a research question
    Jan P Vandenbroucke
    Department of Clinical Epidemioloy, Leiden University Medical Centre, C9 P 2300 RC Leiden, The Netherlands
    J Clin Epidemiol 55:1176-7. 2002
  10. ncbi request reprint Commentary: the HRT story: vindication of old epidemiological theory
    Jan P Vandenbroucke
    Department of Clinical Epidemioloy, Leiden University Medical Centre, Bldg 1 C9 P, 2300 RC Leiden, The Netherlands
    Int J Epidemiol 33:456-7. 2004

Detail Information

Publications99

  1. ncbi request reprint The history of confounding
    Jan P Vandenbroucke
    Leiden University Medical Centre
    Soz Praventivmed 47:216-24. 2002
    ..The problems of confounding present their old challenges again in recent applications to genetic epidemiology...
  2. ncbi request reprint Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): explanation and elaboration
    Jan P Vandenbroucke
    Leiden University Medical Center, Leiden, The Netherlands
    Ann Intern Med 147:W163-94. 2007
    ..Examples of useful flow diagrams are also included. The STROBE Statement, this document, and the associated Web site (www.strobe-statement.org) should be helpful resources to improve reporting of observational research...
  3. doi request reprint Case-control studies: basic concepts
    Jan P Vandenbroucke
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Int J Epidemiol 41:1480-9. 2012
    ..Our focus is on case-control studies of disease incidence ('incident case-control studies'); we will not consider the situation of case-control studies of prevalent disease, which are published much less frequently...
  4. pmc Incidence rates in dynamic populations
    Jan P Vandenbroucke
    Department of Clinical Epidemiology, Leiden University Medical Center, RC Leiden, The Netherlands
    Int J Epidemiol 41:1472-9. 2012
    ..The first part will consider incidence rates in dynamic populations, and how they can best be taught in basic, intermediate and advanced courses. The second part will briefly explain how and why incidence rates are calculated in cohorts...
  5. pmc Trends in total cholesterol screening and in prescribing lipid-lowering drugs in general practice in the period 1994-2003
    Stefaan Bartholomeeusen
    Department of General Practice, Katholieke Universiteit Leuven, Kapucijnenvoer 33, Leuven, Belgium
    BMC Fam Pract 9:39. 2008
    ..Guidelines for treatment have been adopted. We investigated the consequences on the practice of GPs screening cholesterol levels and on the timing of starting statin prescription...
  6. ncbi request reprint [The N-of-1 trial: the ideal study design that is underused]
    J P Vandenbroucke
    Leids Universitair Medisch Centrum, afd Klinische Epidemiologie, Postbus 9600, 2300 RC Leiden
    Ned Tijdschr Geneeskd 150:2794-5. 2006
    ..Even so, the N-of-1 trial is the ultimate form of verification in, for example, the individualisation of treatment. For this reason, this form of study might be used more often...
  7. ncbi request reprint The 1855 cholera epidemic in Ferrara: lessons from old data reanalysed with modern means
    Jan P Vandenbroucke
    Department of Clinical Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands
    Eur J Epidemiol 18:599-602. 2003
  8. ncbi request reprint [Breast cancer and the use of the hormones around the menopause]
    J P Vandenbroucke
    afd Klinische Epidemiologie, Leids Universitair Medisch Centrum, Postbus 9600, 2300 RC Leiden
    Ned Tijdschr Geneeskd 147:1829-34. 2003
    ..Long-term preventative use, as happens in practice, is not indicated due to the risk of relatively serious side effects...
  9. ncbi request reprint Alvan Feinstein and the art of consulting: how to define a research question
    Jan P Vandenbroucke
    Department of Clinical Epidemioloy, Leiden University Medical Centre, C9 P 2300 RC Leiden, The Netherlands
    J Clin Epidemiol 55:1176-7. 2002
    ..In this paper, the author reminisces about how he learned and tried to apply those principles...
  10. ncbi request reprint Commentary: the HRT story: vindication of old epidemiological theory
    Jan P Vandenbroucke
    Department of Clinical Epidemioloy, Leiden University Medical Centre, Bldg 1 C9 P, 2300 RC Leiden, The Netherlands
    Int J Epidemiol 33:456-7. 2004
  11. ncbi request reprint [The importance of case reports as compared to evidence-based medicine and molecular explanation]
    J P Vandenbroucke
    Leids Universitair Medisch Centrum, afd Klinische Epidemiologie, Postbus 9600, 2300 RC Leiden
    Ned Tijdschr Geneeskd 146:1699-703. 2002
    ..Moreover, they can also provide convincing clinical evidence. Finally, a well-written case report must clearly state what is already known and what the case report adds to this...
  12. ncbi request reprint Alternative treatments in reproductive medicine. The vexing problem of 'seemingly impeccable trials...'
    Jan P Vandenbroucke
    Department of Clinical Epidemiology, Leiden University Medical Center, C9 P, P O Box 9600, 2300 RC Leiden, The Netherlands
    Hum Reprod 17:2228-9. 2002
    ..The role of editors and readers might be different: while editors might be under some obligation to publish 'seemingly impeccable trials', readers are not obliged to accept the findings...
  13. pmc Observational research, randomised trials, and two views of medical science
    Jan P Vandenbroucke
    Royal Netherlands Academy of Arts and Sciences, and Department of Clinical Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands
    PLoS Med 5:e67. 2008
  14. ncbi request reprint Homoeopathy and "the growth of truth"
    Jan P Vandenbroucke
    Department of Clinical Epidemiology, Leiden University Medical Centre, 2300 RC Leiden, Netherlands
    Lancet 366:691-2. 2005
  15. ncbi request reprint [The N-of-1 trial: the ideal study design that is underused]
    J P Vandenbroucke
    Leids Universitair Medisch Centrum
    Ned Tijdschr Tandheelkd 114:260-2. 2007
    ..Even so, the N-of-1 trial is the ultimate form of verification in, for example, the individualisation of treatment. For this reason, this form of study might be used more often...
  16. pmc What is the best evidence for determining harms of medical treatment?
    Jan P Vandenbroucke
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    CMAJ 174:645-6. 2006
  17. ncbi request reprint [Levels of evidence are insufficient]
    J P Vandenbroucke
    Leids Universitair Medisch Centrum, afd Klinische Epidemiologie, C9 P, Postbus 9600, 2300 RC Leiden
    Ned Tijdschr Geneeskd 150:2485. 2006
    ..In most instances of non-therapeutic research, observational data are more useful. Evaluating all medical knowledge on the basis of a single hierarchy of level of evidence is therefore seriously flawed...
  18. ncbi request reprint When are observational studies as credible as randomised trials?
    Jan P Vandenbroucke
    Department of Clinical Epidemioloy, Leiden University Medical Centre, Bldg 1 C9 P, 2300 RC Leiden, Netherlands
    Lancet 363:1728-31. 2004
  19. ncbi request reprint The making of STROBE
    Jan P Vandenbroucke
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Epidemiology 18:797-9. 2007
    ....
  20. ncbi request reprint [No prior informed consent required for 'no-risk' scientific research]
    J P Vandenbroucke
    Leids Universitair Medisch Centrum, afd Klinische Epidemiologie, Leiden
    Ned Tijdschr Geneeskd 150:616. 2006
    ....
  21. pmc Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): explanation and elaboration
    Jan P Vandenbroucke
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    PLoS Med 4:e297. 2007
    ..Examples of useful flow diagrams are also included. The STROBE Statement, this document, and the associated Web site (http://www.strobe-statement.org/) should be helpful resources to improve reporting of observational research...
  22. ncbi request reprint Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): explanation and elaboration
    Jan P Vandenbroucke
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Epidemiology 18:805-35. 2007
    ..Examples of useful flow diagrams are also included. The STROBE Statement, this document, and the associated web site (http://www.strobe-statement.org) should be helpful resources to improve reporting of observational research...
  23. doi request reprint Perinatal outcome, health, growth, and medical care utilization of 5- to 8-year-old intracytoplasmic sperm injection singletons
    Marjolein Knoester
    Department of Pediatrics, Neonatal Center, Leiden University Medical Center, Leiden, The Netherlands
    Fertil Steril 89:1133-46. 2008
    ..To evaluate short- and long-term health in intracytoplasmic sperm injection (ICSI) singletons...
  24. doi request reprint Use of glucocorticoids and risk of venous thromboembolism: a nationwide population-based case-control study
    Sigrun A Johannesdottir
    Department of Clinical Epidemiology, Institute of Clinical Medicine, Aarhus University Hospital, Aarhus N, The Netherlands
    JAMA Intern Med 173:743-52. 2013
    ..Because the prevalence of glucocorticoid use and the incidence of VTE are high, an increased risk of VTE associated with glucocorticoid use would have important implications...
  25. ncbi request reprint Cognitive development of singletons born after intracytoplasmic sperm injection compared with in vitro fertilization and natural conception
    Marjolein Knoester
    Department of Pediatrics, Neonatal Center, Leiden University Medical Center, Leiden, The Netherlands
    Fertil Steril 90:289-96. 2008
    ..To investigate cognitive development of singletons conceived by intracytoplasmic sperm injection (ICSI) at 5-8 years of age...
  26. doi request reprint [Strengthening the reporting of observational studies in epidemiology (STROBE): explanation and elaboration]
    Jan P Vandenbroucke
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Gac Sanit 23:158. 2009
    ..Examples of useful flow diagrams are also included. The STROBE Statement, this document, and the associated Web site (http://www.strobe-statement.org/) should be helpful resources to improve reporting of observational research...
  27. doi request reprint Reporting of noninferiority trials was incomplete in trial registries
    Olaf M Dekkers
    Department of Clinical Epidemiology, Leiden University Medical Centre, Albinusdreef 2, 2300 RC Leiden, The Netherlands
    J Clin Epidemiol 64:1034-8. 2011
    ..To examine the registration of noninferiority trials, with a focus on the reporting of study design and noninferiority margins...
  28. doi request reprint Multisystem morbidity and mortality in Cushing's syndrome: a cohort study
    Olaf M Dekkers
    Department of Clinical Epidemiology, Leiden University Medical Centre, Leiden 2300RC, The Netherlands
    J Clin Endocrinol Metab 98:2277-84. 2013
    ..Cushing's syndrome (CS) is associated with hypercoagulability, insulin resistance, hypertension, bone loss, and immunosuppression. To date, no adequately large cohort study has been performed to assess the multisystem effects of CS...
  29. doi request reprint Quantification of bias in direct effects estimates due to different types of measurement error in the mediator
    Saskia le Cessie
    Departments of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Epidemiology 23:551-60. 2012
    ....
  30. doi request reprint Distinguishing case series from cohort studies
    Olaf M Dekkers
    Leiden University Medical Center, The Netherlands
    Ann Intern Med 156:37-40. 2012
    ..Whereas a cohort study, in principle, enables the calculation of an absolute risk or a rate for the outcome, such a calculation is not possible in a case series...
  31. doi request reprint Myocardial infarction occurs with a similar 24 h pattern in the 4G/5G versions of plasminogen activator inhibitor-1
    Sandrin C Bergheanu
    Department of Cardiology, Leiden University Medical Center, The Netherlands
    Chronobiol Int 26:637-52. 2009
    ..Our findings show that 24 h variation of cardiac risk is not more pronounced among the 4G4G genotype of PAI-1...
  32. pmc Health risks encountered by Dutch medical students during an elective in the tropics and the quality and comprehensiveness of pre-and post-travel care
    Elhadi Sharafeldin
    Department of Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands
    BMC Med Educ 10:89. 2010
    ..To improve pre-and post-travel care, we assessed the health risks and the quality and comprehensiveness of pre-and post-travel care in a cohort of Dutch medical students returning form an elective abroad...
  33. doi request reprint A solution to the problem of studying blood donor-related risk factors when patients have received multiple transfusions
    Rutger A Middelburg
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Transfusion 50:1959-66. 2010
    ..We encountered this problem when studying transfusion-related acute lung injury (TRALI) and describe four methods to overcome this problem...
  34. ncbi request reprint ACE I/D polymorphism is associated with mortality in a cohort study of patients starting with dialysis
    Femke van der Sman-de Beer
    Department of Clinical Epidemiology, Leiden University Medical Center, The Netherlands
    Kidney Int 68:2237-43. 2005
    ..In dialysis patients, only a few follow-up studies have addressed the relationship between the insertion/deletion (I/D) polymorphism in the angiotensin-converting enzyme (ACE) gene and mortality, but the available data are contradictory...
  35. pmc The risk for breast cancer is not evidently increased in women with hyperprolactinemia
    O M Dekkers
    Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Pituitary 13:195-8. 2010
    ..The uncertainty about the exact risk that is due to the relatively low number of breast cancer cases, should be overcome by pooling results in a future meta-analysis...
  36. ncbi request reprint Oral contraceptives, hormone replacement therapy and thrombosis
    F R Rosendaal
    Department of Hematology, Leiden University Medical Center, The Netherlands
    Thromb Haemost 86:112-23. 2001
    ..First results are emerging that specific subgroups of women, with prothrombotic or other abnormalities, may be at risk, especially during the first years of use of hormone substitution...
  37. ncbi request reprint Female hormones and thrombosis
    F R Rosendaal
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 22:201-10. 2002
    ..The risk becomes very high in women with a previous venous thrombosis. Randomized trials have not confirmed a beneficial effect of postmenopausal hormones on the occurrence of myocardial infarction...
  38. ncbi request reprint Increased end-stage diabetic nephropathy in Indo-Asian immigrants living in the Netherlands
    P K Chandie Shaw
    Department of Nephrology, C3 P, Leiden University Medical Center, Leiden, The Netherlands
    Diabetologia 45:337-41. 2002
    ..We aimed to investigate the risk of end-stage diabetic nephropathy due to Type II (non-insulin-dependent) diabetes mellitus in Indo-Asian immigrants from Surinam...
  39. ncbi request reprint Mortality in acromegaly: a metaanalysis
    O M Dekkers
    Department of Endocrinology and Metabolic Diseases C4 R, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Clin Endocrinol Metab 93:61-7. 2008
    ..For this reason, it is not formally established whether mortality in acromegaly is different from the general population...
  40. ncbi request reprint [Epoetin-induced pure red-cell aplasia]
    A V Kharagjitsingh
    Leids Universitair Medisch Centrum, afd Klinische Epidemiologie, Postbus 9600, 2300 RC Leiden
    Ned Tijdschr Geneeskd 148:2550-3. 2004
    ..This complication should be considered in every patient treated with epoetin who experiences unexplained transfusion-dependent anaemia...
  41. doi request reprint How to assess the external validity of therapeutic trials: a conceptual approach
    O M Dekkers
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Int J Epidemiol 39:89-94. 2010
    ..External validity of study results is an important issue from a clinical point of view. From a methodological point of view, however, the concept of external validity is more complex than it seems to be at first glance...
  42. ncbi request reprint [Generalizability of therapeutic trials]
    O M Dekkers
    Leids Universitair Medisch Centrum, afd Klinische Epidemiologie, Post bus 9600, 2300 RC Leiden
    Ned Tijdschr Geneeskd 151:2203-6. 2007
    ..In exceptional cases the external validity can involve patients that would have been excluded in the original study...
  43. doi request reprint Relationship between venous and arterial thrombosis: a review of the literature from a causal perspective
    Willem M Lijfering
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Semin Thromb Hemost 37:885-96. 2011
    ..In addition, we comment on the effect of statin use on the occurrence of both arterial and venous thrombosis. The possible clinical implications of these findings are discussed...
  44. doi request reprint Efficacy of experimental treatments compared with standard treatments in non-inferiority trials: a meta-analysis of randomized controlled trials
    Darius Soonawala
    Department of Clinical Epidemiology, Leiden University Medical Centre, RC Leiden, The Netherlands
    Int J Epidemiol 39:1567-81. 2010
    ..In order to test this hypothesis we performed a meta-analysis of non-inferiority trials to assess the average effect of experimental treatments compared with standard treatments...
  45. pmc The venous thrombotic risk of oral contraceptives, effects of oestrogen dose and progestogen type: results of the MEGA case-control study
    A Van Hylckama Vlieg
    Department of Clinical Epidemiology, Leiden University Medical Center, C7 P, PO Box 9600, NL 2300 RC Leiden, Netherlands
    BMJ 339:b2921. 2009
    ..To assess the thrombotic risk associated with oral contraceptive use with a focus on dose of oestrogen and type of progestogen of oral contraceptives available in the Netherlands...
  46. ncbi request reprint An association between cartilaginous tumours and breast cancer in the national pathology registration in The Netherlands points towards a possible genetic trait
    A E Odink
    Department of Pathology, Leiden University Medical Centre, Leiden, The Netherlands
    J Pathol 193:190-2. 2001
    ..e. 51 years versus 60.9 years. The association of breast cancer and cartilaginous tumours and the early age of onset of breast cancer in these patients may suggest a genetic trait...
  47. ncbi request reprint Estimated age- and sex-specific incidence and prevalence of dopamine agonist-treated hyperprolactinemia
    M Kars
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    J Clin Endocrinol Metab 94:2729-34. 2009
    ..Few data exist on sex- and age-specific incidence and prevalence of idiopathic hyperprolactinemia and prolactinomas...
  48. pmc Female donors and transfusion-related acute lung injury: A case-referent study from the International TRALI Unisex Research Group
    Rutger A Middelburg
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Transfusion 50:2447-54. 2010
    ..We aimed to examine the relation between female donors and the occurrence of TRALI...
  49. ncbi request reprint An outbreak of Pneumocystis jiroveci pneumonia with 1 predominant genotype among renal transplant recipients: interhuman transmission or a common environmental source?
    Mark G J de Boer
    Department of Infectious Diseases, Centre for Infectious Diseases, Leiden University Medical Centre, Leiden, The Netherlands
    Clin Infect Dis 44:1143-9. 2007
    ..Clinical, epidemiological, and molecular data were analyzed to trace the outbreak's origin...
  50. ncbi request reprint Serum troponin T concentration as a predictor of mortality in hemodialysis and peritoneal dialysis patients
    Bas Havekes
    Department of Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands
    Am J Kidney Dis 47:823-9. 2006
    ..Although it is known that troponin T is an independent risk factor in dialysis patients as well, its prognostic value when measured routinely in clinical practice, particularly in addition to other risk indicators, is unclear...
  51. ncbi request reprint In defense of case reports and case series
    J P Vandenbroucke
    Leiden University Hospital Medical Center, Leiden, The Netherlands
    Ann Intern Med 134:330-4. 2001
    ..At the same time, good case reporting demands a clear focus to make explicit to the audience why a particular observation is important in the context of existing knowledge...
  52. ncbi request reprint [Financing medical research in the Netherlands: start taking care of the future now]
    J P Vandenbroucke
    Leids Universitair Medisch Centrum, afd Klinische Epidemiologie, Postbus 9600, 2300 RC Leiden
    Ned Tijdschr Geneeskd 146:1348-52. 2002
    ..New investments should primarily be in direct government financing and in augmentation of streams of money via Medical and Health Research Councils...
  53. ncbi request reprint [Causality: risk factors and interventions]
    Olaf M Dekkers
    Leids Universitair Medisch Centrum, afd Klinische Epidemiologie, Leiden, The Netherlands
    Ned Tijdschr Geneeskd 157:A5882. 2013
    ..A second problem is that risk factors cannot always easily be translated into interventions. This applies to factors that cannot be changed (e.g. gender) or that can have multiple causes themselves (e.g. obesity)...
  54. ncbi request reprint Clinical predictors of alloimmunization after red blood cell transfusion
    Martijn P Bauer
    Department of Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands
    Transfusion 47:2066-71. 2007
    ..Development of new red blood cell (RBC) alloantibodies (alloimmunization) is one of the most frequent adverse reactions after an RBC transfusion. Few studies have investigated clinical risk factors for alloimmunization...
  55. ncbi request reprint In an observational study elderly patients had an increased risk of falling due to home hazards
    Thomas van Bemmel
    Section of Gerontology and Geriatrics, Department of General Internal Medicine, C1 R, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Clin Epidemiol 58:63-7. 2005
    ..The objective of this study was to explore the relationship between home hazards and the incidence of falls in the oldest old population...
  56. ncbi request reprint Matched follow-up study of 5-8 year old ICSI-singletons: comparison of their neuromotor development to IVF and naturally conceived singletons
    Marjolein Knoester
    Department of Paediatrics, Neonatal Center, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Hum Reprod 22:1638-46. 2007
    ..Intracytoplasmic sperm injection (ICSI) is an invasive technique of artificial reproduction. We investigated the effect of ICSI on neuromotor development in 5-8 year old singletons...
  57. ncbi request reprint Thrombophilia, clinical factors, and recurrent venous thrombotic events
    Sverre C Christiansen
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    JAMA 293:2352-61. 2005
    ..The potential benefit of screening for thrombophilia with respect to prophylactic strategies and duration of anticoagulant treatment is not yet known...
  58. ncbi request reprint Sick leave as a predictor of job loss in patients with chronic arthritis
    Petronella D M de Buck
    Department of Rheumatology C1 R, Leiden University Medical Center, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Int Arch Occup Environ Health 80:160-70. 2006
    ..To study the occurrence and duration of sick leave as potential risk factors for permanent job loss after 24 months among 112 individuals with chronic arthritis and a disease related problem at work...
  59. ncbi request reprint Association between body mass index and mortality is similar in the hemodialysis population and the general population at high age and equal duration of follow-up
    Renée de Mutsert
    Leiden University Medical Center, Department of Clinical Epidemiology, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Am Soc Nephrol 18:967-74. 2007
    ..The clinical implication of this study is that to improve survival in the hemodialysis population, more attention should be paid to patients who are underweight instead of overweight...
  60. ncbi request reprint A comparative study of atypical and melanocytic naevi on the tropical island Curaçao and in The Netherlands
    M B Crijns
    Department of Dermatology, University Hospital, Leiden, The Netherlands
    Melanoma Res 5:161-7. 1995
    ..We found a generation-dependent difference in the expression of AN among White inhabitants of The Netherlands and on Curaçao, with a higher prevalence of AN in the younger generation...
  61. ncbi request reprint Preemptive versus Non-preemptive simultaneous pancreas-kidney transplantation: a single-center, long-term, follow-up study
    Menno T Pruijm
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Transplantation 81:1119-24. 2006
    ..We studied the effect of preemptive transplantation on patient survival, cardiovascular endpoints, and graft survival, as compared with non-preemptive transplantation...
  62. ncbi request reprint Heredity versus environment in tuberculosis in twins: the 1950s United Kingdom Prophit Survey Simonds and Comstock revisited
    Ellen A van der Eijk
    Department of Infectious Diseases, C5 P, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Am J Respir Crit Care Med 176:1281-8. 2007
    ..His analysis did not take into account strong imbalance of variables within subgroups, underestimating possible confounding effects of environmental factors...
  63. ncbi request reprint Survival of patients with epilepsy: an estimate of the mortality risk
    Darian P Shackleton
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Epilepsia 43:445-50. 2002
    ..To investigate the extent and causes of the differences in mortality found in studies on mortality in epilepsy based on a quantitative review of the literature...
  64. ncbi request reprint A regression model with unexplained residuals was preferred in the analysis of the fetal origins of adult diseases hypothesis
    Mandy G Keijzer-Veen
    Department of Clinical Epidemiology, Leiden University Medical Center, The Netherlands
    J Clin Epidemiol 58:1320-4. 2005
    ....
  65. ncbi request reprint Hereditary antithrombin deficiency: heterogeneity of the molecular basis and mortality in Dutch families
    H H van Boven
    Department of Clinical Epidemiology, University Hospital, Leiden, The Netherlands
    Blood 84:4209-13. 1994
    ..We suggest that the longevity is not affected by molecular defects in the antithrombin gene and hypothesize that differences in mortality or natural history between families most likely result from other (genetic) risk factors...
  66. ncbi request reprint Alternative medicine: a "mirror image" for scientific reasoning in conventional medicine
    J P Vandenbroucke
    Department of Clinical Epidemiology, Leiden University Medical Center, Building 1, PO Box 9600, 2300 RC Leiden, The Netherlands
    Ann Intern Med 135:507-13. 2001
    ..It does not lead to complete and uncontrollable subjectivity because discernment between rivaling explanations is still possible through argument and counterargument...
  67. ncbi request reprint [From pill to pill: oral contraception, venous thrombosis and coagulation disorders]
    J P Vandenbroucke
    Departement Klinische Epidemiologie, Leids Universitair Medisch Centrum, PO Box 9600, 2300 RC Leiden, Nederland
    Verh K Acad Geneeskd Belg 63:243-52; discussion 252-5. 2001
    ..The developments were accelerated by the finding that "third generation oral contraceptives" are associated with a higher risk of venous thrombosis. The lecture describes these new scientific insights...
  68. pmc Experience with multiple control groups in a large population-based case-control study on genetic and environmental risk factors
    E R Pomp
    Department of Clinical Epidemiology, C7 P, Leiden University Medical Center, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Eur J Epidemiol 25:459-66. 2010
    ..Our experience with the intricacies of dealing with two control groups may be useful to others when thinking about an optimal research design or the best statistical approach...
  69. ncbi request reprint Antipsychotic medication and venous thrombosis
    R Thomassen
    Department of Psychiatry, Leiden University Medical Center, The Netherlands
    Br J Psychiatry 179:63-6. 2001
    ..Recent epidemiological studies of good methodological quality have confirmed these findings. CONCLUSIONS: Venous thrombosis appears to be associated with the use of antipsychotic drugs in psychiatric patients...
  70. ncbi request reprint The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies
    Erik von Elm
    Institute of Social and Preventive Medicine ISPM, University of Bern, Bern, Switzerland
    Lancet 370:1453-7. 2007
    ..We hope that the STROBE statement will contribute to improving the quality of reporting of observational studies..
  71. ncbi request reprint Case-control and two-gate designs in diagnostic accuracy studies
    Anne W S Rutjes
    Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Clin Chem 51:1335-41. 2005
    ..Such case-control designs are intuitively appealing, but they have also been criticized for leading to inflated estimates of accuracy...
  72. ncbi request reprint Factor V Leiden and venous thromboembolism
    Jan P Vandenbroucke
    Ann Intern Med 141:484. 2004
  73. pmc Assessing the quality of research
    Paul Glasziou
    Department of Primary Health Care, University of Oxford, Oxford OX3 7LF
    BMJ 328:39-41. 2004
  74. ncbi request reprint Continuing controversies over "risks and rates"--more than a century after William Farr's "On prognosis"
    Jan P Vandenbroucke
    Soz Praventivmed 48:216-8. 2003
  75. ncbi request reprint [The Strengthening the Reporting of Observational Studies in Epidemiology [STROBE] statement: guidelines for reporting observational studies]
    Erik von Elm
    Institute of Social and Preventive Medicine ISPM, University of Bern, Berna, Switzerland
    Gac Sanit 22:144-50. 2008
    ..We hope that the STROBE statement will contribute to improving the quality of reporting of observational studies...
  76. ncbi request reprint [The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies]
    Erik von Elm
    Institute of Social and Preventive Medicine ISPM, University of Bern, Berna, Suiza
    Rev Esp Salud Publica 82:251-9. 2008
    ..We hope that the STROBE statement will contribute to improving the quality of reporting of observational studies...
  77. ncbi request reprint Incidence of recombinant erythropoietin (EPO) hyporesponse, EPO-associated antibodies, and pure red cell aplasia in dialysis patients
    Aantje V Kharagjitsingh
    Department of Internal Medicine, Medical Center Haaglanden, Westeinde, Den Haag, The Netherlands
    Kidney Int 68:1215-22. 2005
    ..The objectives of this study were to determine the incidence and causes of recombinant EPO hyporesponse, of antibodies to EPO in patients on dialysis, and to relate the detection of anti-EPO antibodies to the presence of PRCA...
  78. pmc The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies
    Erik von Elm
    Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland
    Bull World Health Organ 85:867-72. 2007
    ..We hope that the STROBE Statement will contribute to improving the quality of reporting of observational studies...
  79. pmc Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies
    Erik von Elm
    Institute of Social and Preventive Medicine, University of Bern, Finkenhubelweg 11, CH 3012 Bern, Switzerland
    BMJ 335:806-8. 2007
  80. ncbi request reprint The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies
    Erik von Elm
    Institute of Social and Preventive Medicine ISPM, University of Bern, Bern, Switzerland
    Epidemiology 18:800-4. 2007
    ..We hope that the STROBE Statement will contribute to improving the quality of reporting of observational studies...
  81. pmc The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies
    Erik von Elm
    Institute of Social and Preventive Medicine ISPM, University of Bern, Bern, Switzerland
    PLoS Med 4:e296. 2007
    ..We hope that the STROBE Statement will contribute to improving the quality of reporting of observational studies...
  82. ncbi request reprint The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies
    Erik von Elm
    Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland
    Ann Intern Med 147:573-7. 2007
    ..annals.org and on the Web sites of PLoS Medicine and Epidemiology. We hope that the STROBE Statement will contribute to improving the quality of reporting of observational studies...
  83. doi request reprint The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies
    Erik von Elm
    Institute of Social and Preventive Medicine, University of Bern, 3012 Bern, Switzerland
    J Clin Epidemiol 61:344-9. 2008
    ..We hope that the STROBE Statement will contribute to improving the quality of reporting of observational studies...
  84. ncbi request reprint Re: "quality of reporting of observational longitudinal research"
    Erik von Elm
    Am J Epidemiol 162:1032-3; author reply 1033. 2005
  85. ncbi request reprint Bortezomib in multiple myeloma
    Jan P Vandenbroucke
    N Engl J Med 353:1297-8; author reply 1297-8. 2005
  86. ncbi request reprint Commentary: strengthening the reporting of observational epidemiology the STROBE statement
    Matthias Egger
    Int J Epidemiol 36:948-50. 2007
  87. ncbi request reprint The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies
    Erik von Elm
    Institute of Social and Preventive Medicine ISPM, University of Bern, Finkenhubelweg 11, CH 3012 Bern, Switzerland
    Prev Med 45:247-51. 2007
    ..We hope that the STROBE Statement will contribute to improving the quality of reporting of observational studies...
  88. ncbi request reprint Determinants of methicillin-resistant Staphylococcus aureus carriage in nursing homes
    Carl Suetens
    Scientific Institute of Public Health, Department of Epidemiology, Brussels, Belgium
    Age Ageing 36:327-30. 2007
  89. ncbi request reprint Oral contraceptives and the risk of myocardial infarction
    Jan P Vandenbroucke
    N Engl J Med 346:1826-9; author reply 1826-9. 2002
  90. ncbi request reprint Do editors live up to the Sept 10, 2001, expectations?
    Jan P Vandenbroucke
    Lancet 360:1605-6; author reply 1606. 2002
  91. ncbi request reprint Re: Oral contraceptives and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers
    Geertruida H de Bock
    J Natl Cancer Inst 95:1011-2; author reply 1012-3. 2003
  92. ncbi request reprint Analytic approaches to observational studies with treatment selection bias
    Jan P Vandenbroucke
    JAMA 297:2077-8; auhor reply 2078. 2007
  93. ncbi request reprint Overweight, obesity, and mortality
    Cathelijne W Y Appels
    N Engl J Med 355:2699; author reply 2700-1. 2006
  94. ncbi request reprint Population screening for single genes that codetermine common diseases in adulthood had limited effects
    Steven W J Lamberts
    Department of Medicine, Erasmus Medical Center, 40 Molenwaterplein, 3015 GD Rotterdam, The Netherlands
    J Clin Epidemiol 59:358-64. 2006
    ..Chances, shortcomings, and practical aspects of population screening were considered...
  95. pmc Benefits and harms of drug treatments
    Jan P Vandenbroucke
    BMJ 329:2-3. 2004
  96. pmc One-time general consent for research on biological samples: opt out system for patients is optimal and endorsed in many countries
    Jan Willem W Coebergh
    BMJ 332:665. 2006
  97. doi request reprint What do case-control studies estimate? Survey of methods and assumptions in published case-control research
    Mirjam J Knol
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Am J Epidemiol 168:1073-81. 2008
    ..At present, investigators conducting case-control studies rarely discuss what their odds ratios estimate...
  98. doi request reprint Opportunities for enhancing the FDA guidance on pharmacovigilance
    Bruce M Psaty
    Cardiovascular Health Research Unit, Department of Medicine, University of Washington and Center for Health Studies, Group Health, Seattle, WA 98101, USA
    JAMA 300:952-4. 2008
  99. pmc Balancing benefits and harms in health care: observational data on harm should complement systematic reviews of benefit
    Jan P Vandenbroucke
    BMJ 327:750. 2003