P J van den Broek

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint How many infection control staff do we need in hospitals?
    P J van den Broek
    Department of Infectious Diseases, Leiden University Medical Centre, Leiden, The Netherlands
    J Hosp Infect 65:108-11. 2007
  2. ncbi request reprint [Staphylococcus aureus, a successful pathogen]
    P J van den Broek
    Leids Universitair Medisch Centrum, afd Infectieziekten, Postbus 9600, 2300 RC Leiden
    Ned Tijdschr Geneeskd 147:1045-8. 2003
  3. pmc Endemic and epidemic acinetobacter species in a university hospital: an 8-year survey
    P J van den Broek
    Department of Infectious Diseases, C5 P, P O Box 9600, 2300 RC Leiden, The Netherlands
    J Clin Microbiol 47:3593-9. 2009
  4. pmc Appropriate use of indwelling urethra catheters in hospitalized patients: results of a multicentre prevalence study
    Irálice A V Jansen
    Centre for Infectious Disease Control, National Institute for Public Health and the Environment RIVM, PO box 1 postbak 75, 3720 BA, Bilthoven, The Netherlands
    BMC Urol 12:25. 2012
  5. pmc An evidence-based recommendation on bed head elevation for mechanically ventilated patients
    Barbara S Niël-Weise
    Leiden University Medical Center, Dutch Working Party Infection Prevention, C7 130, Postbus 9600, 2300 RC Leiden, Germany
    Crit Care 15:R111. 2011
  6. pmc Cross-sectional study of availability and pharmaceutical quality of antibiotics requested with or without prescription (Over The Counter) in Surabaya, Indonesia
    Usman Hadi
    Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands
    BMC Infect Dis 10:203. 2010
  7. ncbi request reprint Epidemiology of multiple Acinetobacter outbreaks in The Netherlands during the period 1999-2001
    P J van den Broek
    Department of Infectious Diseases, Leiden University Medical Centre, Leiden, The Netherlands
    Clin Microbiol Infect 12:837-43. 2006
  8. ncbi request reprint [Meningococci infection by a bacteriophage with a virulence factor]
    P J van den Broek
    Leids Universitair Medisch Centrum, afd Infectieziekten, Postbus 9600, 2300 RC Leiden
    Ned Tijdschr Geneeskd 149:2600-2. 2005
  9. ncbi request reprint [Sterile gloves are necessary in minor surgery]
    Peterhans J van den Broek
    Leids Universitair Medisch Centrum, afd Infectieziekten, Leiden, The Netherlands
    Ned Tijdschr Geneeskd 155:A3341. 2011
  10. doi request reprint Can Escherichia coli be used as an indicator organism for transmission events in hospitals?
    P J van den Broek
    Department of Infectious Diseases, C5 P, Leiden University Medical Centre, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Eur J Clin Microbiol Infect Dis 28:169-73. 2009

Detail Information

Publications43

  1. ncbi request reprint How many infection control staff do we need in hospitals?
    P J van den Broek
    Department of Infectious Diseases, Leiden University Medical Centre, Leiden, The Netherlands
    J Hosp Infect 65:108-11. 2007
    ..This is one FTE ICP per 5000 admissions and one medical microbiologist or epidemiologist per 25000 admissions...
  2. ncbi request reprint [Staphylococcus aureus, a successful pathogen]
    P J van den Broek
    Leids Universitair Medisch Centrum, afd Infectieziekten, Postbus 9600, 2300 RC Leiden
    Ned Tijdschr Geneeskd 147:1045-8. 2003
    ..Its structure illustrates how well S. aureus can adapt itself and acquire properties of other microorganisms. This genetic knowledge may lead to new strategies to combat S. aureus...
  3. pmc Endemic and epidemic acinetobacter species in a university hospital: an 8-year survey
    P J van den Broek
    Department of Infectious Diseases, C5 P, P O Box 9600, 2300 RC Leiden, The Netherlands
    J Clin Microbiol 47:3593-9. 2009
    ..There was a borderline significant (P = 0.059) trend of decreasing susceptibility. A. baumannii was the Acinetobacter species causing the largest burden of multiple-antibiotic resistance and transmissions in the hospital...
  4. pmc Appropriate use of indwelling urethra catheters in hospitalized patients: results of a multicentre prevalence study
    Irálice A V Jansen
    Centre for Infectious Disease Control, National Institute for Public Health and the Environment RIVM, PO box 1 postbak 75, 3720 BA, Bilthoven, The Netherlands
    BMC Urol 12:25. 2012
    ..In this paper we describe the prevalence of IUCs, including their inappropriate use in the Netherlands. We also determine factors associated with inappropriate use of IUCs in hospitalized patients...
  5. pmc An evidence-based recommendation on bed head elevation for mechanically ventilated patients
    Barbara S Niël-Weise
    Leiden University Medical Center, Dutch Working Party Infection Prevention, C7 130, Postbus 9600, 2300 RC Leiden, Germany
    Crit Care 15:R111. 2011
    ..This recommendation, however, is not an evidence-based one...
  6. pmc Cross-sectional study of availability and pharmaceutical quality of antibiotics requested with or without prescription (Over The Counter) in Surabaya, Indonesia
    Usman Hadi
    Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands
    BMC Infect Dis 10:203. 2010
    ..The aim of this study was to explore a potential connection between resistance and substandard antibiotics sold in the area...
  7. ncbi request reprint Epidemiology of multiple Acinetobacter outbreaks in The Netherlands during the period 1999-2001
    P J van den Broek
    Department of Infectious Diseases, Leiden University Medical Centre, Leiden, The Netherlands
    Clin Microbiol Infect 12:837-43. 2006
    ..In all hospitals, a large panel of measures was required to bring the outbreak to an end. Extensive environmental sampling yielded numerous positive samples in most but not all hospitals...
  8. ncbi request reprint [Meningococci infection by a bacteriophage with a virulence factor]
    P J van den Broek
    Leids Universitair Medisch Centrum, afd Infectieziekten, Postbus 9600, 2300 RC Leiden
    Ned Tijdschr Geneeskd 149:2600-2. 2005
    ..However, the way this virulence factor was found is a nice example of unravelling the pathogenesis of infectious diseases in the genomic era...
  9. ncbi request reprint [Sterile gloves are necessary in minor surgery]
    Peterhans J van den Broek
    Leids Universitair Medisch Centrum, afd Infectieziekten, Leiden, The Netherlands
    Ned Tijdschr Geneeskd 155:A3341. 2011
    ..In conclusion, the available evidence is too limited to change the recommendation to use sterile gloves for minor surgery...
  10. doi request reprint Can Escherichia coli be used as an indicator organism for transmission events in hospitals?
    P J van den Broek
    Department of Infectious Diseases, C5 P, Leiden University Medical Centre, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Eur J Clin Microbiol Infect Dis 28:169-73. 2009
    ..This study identified a number of problems regarding the use of Escherichia coli as indicator organism for transmission events. The use of Escherichia coli for this purpose cannot be recommended at the moment...
  11. doi request reprint How much time should long-term care and geriatric rehabilitation facilities (nursing homes) spend on infection control?
    Peterhans J van den Broek
    Department of Infectious Diseases, Leiden University Medical Centre, Leiden, The Netherlands
    Am J Infect Control 38:723-5. 2010
    ..Such standards are not even available for long-term care and geriatric rehabilitation facilities (ie, nursing homes). This study addressed the question of how much time nursing homes should spend on infection control...
  12. pmc Urethral catheters: can we reduce use?
    Pieter J Van den Broek
    Leiden University Medical Centre, Department of Infectious Diseases, Leiden, The Netherlands
    BMC Urol 11:10. 2011
    ..Indwelling urinary catheters are the main cause of healthcare-associated urinary tract infections. It can be expected that reduction of the use of urinary catheters will lead to decreased numbers of urinary tract infection...
  13. ncbi request reprint [The Dutch College of General Practitioners' guideline on urinary tract infections: response from the viewpoint of internal medicine]
    P J van den Broek
    Leids Universitair Medisch Centrum, afd Infectieziekten, Postbus 9600, 2300 RC Leiden
    Ned Tijdschr Geneeskd 145:718-20. 2001
    ..In the CBO guideline amoxicillin-clavulanic acid is considered to be sufficiently safe for the treatment of pregnant women because most urinary tract infections occur after the first trimester...
  14. doi request reprint Multifactorial origin of high incidence of Serratia marcescens in a cardio-thoracic ICU: analysis of risk factors and epidemiological characteristics
    M G J de Boer
    Department of Infectious Diseases, Leiden University Medical Center, P O Box 9600, Leiden, The Netherlands
    J Infect 56:446-53. 2008
    ..A four-fold increase in the incidence of Serratia marcescens occurred in a cardio-thoracic ICU within a 13-month period. Clinical, epidemiological and molecular characteristics were analysed to elucidate the outbreak's origin...
  15. ncbi request reprint Preventing nosocomial infections: improving compliance with standard precautions in an Indonesian teaching hospital
    D O Duerink
    Department of Infectious Diseases, Leiden University Medical Centre, Leiden, The Netherlands
    J Hosp Infect 64:36-43. 2006
    ..Compliance with safe handling of needles improved slightly due to introduction of the one-handed method for safe recapping of used needles...
  16. ncbi request reprint Persistent Acinetobacter baumannii? Look inside your medical equipment
    A T Bernards
    Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands
    Infect Control Hosp Epidemiol 25:1002-4. 2004
    ..Removing dust from the machines and replacing all dust filters brought the outbreaks to an end...
  17. ncbi request reprint A tool to assess knowledge, attitude and behavior of Indonesian health care workers regarding infection control
    D O Duerink
    Department of Infectious Diseases, Leiden University Medical Centre, Leiden, The Netherlands
    Acta Med Indones 45:206-15. 2013
    ..to investigate knowledge, attitude and behaviour toward infection control in two teaching hospitals on the island of Java by means of a questionnaire and to evaluate the use of the questionnaire as a tool...
  18. ncbi request reprint Humidification policies for mechanically ventilated intensive care patients and prevention of ventilator-associated pneumonia: a systematic review of randomized controlled trials
    B S Niël-Weise
    Dutch Working Party on Infection Prevention, Leiden, The Netherlands
    J Hosp Infect 65:285-91. 2007
    ..This is due to the theoretical consideration that less condensate reduces colonization and subsequent risk of spread throughout an ICU when condensate is removed...
  19. doi request reprint Anti-infective-treated central venous catheters for total parenteral nutrition or chemotherapy: a systematic review
    B S Niël-Weise
    Leiden University Medical Center, Dutch Working Party on Infection Prevention, Leiden, The Netherlands
    J Hosp Infect 69:114-23. 2008
    ....
  20. ncbi request reprint Is there evidence for recommending needleless closed catheter access systems in guidelines? A systematic review of randomized controlled trials
    B S Niël-Weise
    Leiden University Medical Centre, Office of the Infection Prevention Working Party, Leiden, The Netherlands
    J Hosp Infect 62:406-13. 2006
    ..From the point of view of infection prevention, there are no objections to use these new systems. However, there is insufficient evidence at this stage to recommend the needleless closed vascular devices...
  21. ncbi request reprint Hair removal policies in clean surgery: systematic review of randomized, controlled trials
    B S Niël-Weise
    Dutch Working Party on Infection Prevention, Leiden, The Netherlands
    Infect Control Hosp Epidemiol 26:923-8. 2005
    ..To determine whether certain hair removal policies are better than others to prevent surgical-site infections in patients undergoing clean surgery...
  22. ncbi request reprint [Clostridium difficile ribotype 027, toxinotype III in The Netherlands]
    E J Kuijper
    Leids Universitair Medisch Centrum, Centrum voor Infectieziekten, Postbus 9600, 2300 RC Leiden
    Ned Tijdschr Geneeskd 149:2087-9. 2005
    ..Protocols for diagnostic investigations, prevention and control of outbreaks are available...
  23. ncbi request reprint Intracellular activity of trovafloxacin against Staphylococcus aureus
    P J van den Broek
    Leiden University Medical Centre, Department of Infectious Diseases, The Netherlands
    J Antimicrob Chemother 44:193-9. 1999
    ..aureus in cell-free medium and is not related to the cell-associated concentration. Intracellular conditions are not favourable for the antibacterial activity of trovafloxacin...
  24. ncbi request reprint Anti-infective-treated central venous catheters: a systematic review of randomized controlled trials
    B S Niël-Weise
    Dutch Working Party on Infection Prevention, PO Box 9600, 2300 RC Leiden, The Netherlands
    Intensive Care Med 33:2058-68. 2007
    ..This systematic review assesses the effect of anti-infective-treated central venous catheters (CVCs) on catheter-related bloodstream infection (CRBSI) in the acute care setting...
  25. ncbi request reprint Policies for endotracheal suctioning of patients receiving mechanical ventilation: a systematic review of randomized controlled trials
    B S Niël-Weise
    Dutch Working Party on Infection Prevention, Leiden University Medical Center, Leiden, The Netherlands
    Infect Control Hosp Epidemiol 28:531-6. 2007
    ....
  26. ncbi request reprint [Two guidelines on community-acquired pneumonia: both an important basis for individual policies]
    P J van den Broek
    Leids Universitair Medisch Centrum, afd Infectieziekten, C5 P, Postbus 9600, 2300 RC Leiden
    Ned Tijdschr Geneeskd 149:2492-4. 2005
    ..The antibiotics recommended in the guidelines differ. Clinicians should take notice of both guidelines and take the best from each to formulate their own personal approach to patients with community-acquired pneumonia...
  27. ncbi request reprint Surveillance of healthcare-associated infections in Indonesian hospitals
    D O Duerink
    Department of Infectious Diseases C5 P, Leiden University Medical Centre, P O Box 9600, 2300 RC Leiden, The Netherlands
    J Hosp Infect 62:219-29. 2006
    ..Efficiency can be improved by restricting the surveillance to include only those patients with invasive procedures. This can help to detect 90% of all infections while screening only 60% of patients...
  28. doi request reprint Systematic review and meta-analysis of antibiotic prophylaxis to prevent infections from chest drains in blunt and penetrating thoracic injuries
    A Bosman
    Department of Surgery Traumatology, Leiden University Medical Centre, Leiden, The Netherlands
    Br J Surg 99:506-13. 2012
    ..No consensus exists as to whether antibiotic prophylaxis in tube thoracostomy as primary treatment for traumatic chest injuries reduces the incidence of surgical-site and pleural cavity infections...
  29. pmc Yops of Yersinia enterocolitica inhibit receptor-dependent superoxide anion production by human granulocytes
    L G Visser
    Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    Infect Immun 67:1245-50. 1999
    ..These findings suggest that the specific targets for YopH are not present in f-MLP receptor-linked signal transduction and that other Yop-mediated mechanisms are involved...
  30. ncbi request reprint Can history and exam alone reliably predict pneumonia?
    A W Graffelman
    Leiden University Medical Center, Leiden, The Netherlands
    J Fam Pract 56:465-70. 2007
    ..Prediction rules based on clinical information have been developed to support the diagnosis of pneumonia and help limit the use of expensive diagnostic tests. However, these prediction rules need to be validated in the primary care setting...
  31. ncbi request reprint Is there evidence for recommending silver-coated urinary catheters in guidelines?
    B S Niël-Weise
    Working Party Infection Prevention, Leiden University Medical Center, Leiden, The Netherlands
    J Hosp Infect 52:81-7. 2002
    ....
  32. pmc Clinical pharmacokinetics of cefamandole and ceftazidime administered by continuous intravenous infusion
    J Berkhout
    Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    Antimicrob Agents Chemother 47:1862-6. 2003
    ..These formulas were tested with a group of subsequent patients and proved to be practical and fairly reliable. For some patients, a correction for a possible underestimation of the renal clearance at presentation might be required...
  33. ncbi request reprint Outbreak of nosocomial meningitis caused by Acinetobacter baumannii in neurosurgical patients
    M M Wroblewska
    Department of Medical Microbiology, Medical University in Warsaw, Poland
    J Hosp Infect 57:300-7. 2004
    ..baumannii into a neurosurgical unit is a severe risk factor for patients undergoing neurosurgical procedures. Genotypic typing methods are important for definitive identification of these strains in patients and their environment...
  34. ncbi request reprint Status of infection control policies and organisation in European hospitals, 2001: the ARPAC study
    M J Struelens
    Department of Microbiology, Erasme Hospital, and Infectious Diseases Epidemiology Unit, School of Public Health, Universite Libre de Bruxelles, Brussels, Belgium
    Clin Microbiol Infect 12:729-37. 2006
    ..Hand hygiene procedures were sub-standard in one-third of centres. Strengthening of IC policies in European hospitals should be a public health priority...
  35. ncbi request reprint [Optimising patient isolation due to methicllin-resistant Staphylococcus aureus]
    J A J W Kluytmans
    Amphia Ziekenhuis, Laboratorium voor Microbiologie en Infectiepreventie, 4800 RL Breda
    Ned Tijdschr Geneeskd 149:794-6. 2005
    ..The disadvantages of isolation are recognised and should be prevented as far as possible. New diagnostic and therapeutic developments can shorten the duration of isolation significantly, which will further improve the quality of care...
  36. ncbi request reprint Audit of antibiotic prescribing in two governmental teaching hospitals in Indonesia
    U Hadi
    Department of Internal Medicine, Dr Soetomo Hospital School of Medicine, Airlangga University, SBY, Indonesia
    Clin Microbiol Infect 14:698-707. 2008
    ..Agreement among assessors was low (kappa coefficients 0.13-0.14). Despite methodological limitations, recommendations could be made to address the need for improving diagnosis, treatment and drug delivery processes in this setting...
  37. doi request reprint Infection control measures to limit the spread of Clostridium difficile
    R P Vonberg
    Institute for Medical Microbiology and Hospital Epidemiology, Medical School Hannover, Hannover, Germany
    Clin Microbiol Infect 14:2-20. 2008
    ..Existing local protocols and practices for the control of C. difficile should be carefully reviewed and modified if necessary...
  38. doi request reprint Optimizing antibiotic usage in adults admitted with fever by a multifaceted intervention in an Indonesian governmental hospital
    Usman Hadi
    Department of Internal Medicine, Dr Soetomo Hospital and School of Medicine, Airlangga University, Surabaya, Indonesia
    Trop Med Int Health 13:888-99. 2008
    ..To optimize antimicrobial treatment of patients with fever upon admission to the department of internal medicine of Dr Soetomo Hospital in Surabaya, Indonesia...
  39. ncbi request reprint Transmission of Pseudomonas aeruginosa in children with cystic fibrosis attending summer camps in The Netherlands
    R W Brimicombe
    Department of Medical Microbiology, HagaZiekenhuis, 2545 CH The Hague, The Netherlands
    J Cyst Fibros 7:30-6. 2008
    ..The study aimed to establish the degree of transmission resulting in subsequent infection of P. aeruginosa among CF children (n=80) attending holiday camps in The Netherlands...
  40. ncbi request reprint [Optimisation of the antibiotic policy in the Netherlands. X. The SWAB guideline for antimicrobial treatment of complicated urinary tract infections]
    S E Geerlings
    Academisch Medisch Centrum Universiteit van Amsterdam, afd Infec tieziekten, Tropische Geneeskunde en Aids, Center for Infection and Immunity Amsterdam, Meibergdreef 9, 1005 AZ Amsterdam
    Ned Tijdschr Geneeskd 150:2370-6. 2006
    ....
  41. ncbi request reprint Genotypic diversity and antibiotic susceptibility of Acinetobacter baumannii isolates in a Bulgarian hospital
    R Dobrewski
    Department of Clinical Microbiology, Military Medical Academy, Sophia, Bulgaria
    Clin Microbiol Infect 12:1135-7. 2006
    ..The single isolate allocated to type 2 was identified to European clone I. All isolates were resistant to multiple antibiotics, but most retained susceptibility to tobramycin and colistin, and all except one were susceptible to imipenem...
  42. ncbi request reprint Management of a patient with Lassa fever to prevent transmission
    C M Swaan
    J Hosp Infect 55:234-5. 2003
  43. pmc Changes over time in risk factors for cardiovascular disease and use of lipid-lowering drugs in HIV-infected individuals and impact on myocardial infarction
    C A Sabin
    Dept of Primary Care and Population Sciences, Royal Free and UC Medical School, Rowland Hill St, London, NW3 2PF, United Kingdom
    Clin Infect Dis 46:1101-10. 2008
    ..We evaluated changes in risk factors for CVD and the use of lipid-lowering therapy in HIV-infected individuals and assessed the impact of any changes on the incidence of myocardial infarction...