Miranda M C van Beers

Summary

Affiliation: Leiden University
Country: The Netherlands

Publications

  1. doi request reprint Hybrid transgenic immune tolerant mouse model for assessing the breaking of B cell tolerance by human interferon beta
    Miranda M C van Beers
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    J Immunol Methods 352:32-7. 2010
  2. pmc Aggregated recombinant human interferon Beta induces antibodies but no memory in immune-tolerant transgenic mice
    Miranda M C van Beers
    Department of Pharmaceutics Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, Utrecht, The Netherlands
    Pharm Res 27:1812-24. 2010
  3. doi request reprint Antibody response against Betaferon® in immune tolerant mice: involvement of marginal zone B-cells and CD4+ T-cells and apparent lack of immunological memory
    Melody Sauerborn
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, Universiteitsweg 99, Utrecht, 3584 CG, The Netherlands
    J Clin Immunol 33:255-63. 2013
  4. doi request reprint Immunogenicity of recombinant human interferon beta interacting with particles of glass, metal, and polystyrene
    Miranda M C van Beers
    Division of Drug Delivery Technology, Leiden Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands
    J Pharm Sci 101:187-99. 2012
  5. doi request reprint On the role of aggregates in the immunogenicity of recombinant human interferon beta in patients with multiple sclerosis
    Miranda M C van Beers
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, Utrecht, The Netherlands
    J Interferon Cytokine Res 30:767-75. 2010

Detail Information

Publications5

  1. doi request reprint Hybrid transgenic immune tolerant mouse model for assessing the breaking of B cell tolerance by human interferon beta
    Miranda M C van Beers
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    J Immunol Methods 352:32-7. 2010
    ..This suggests that pegylation did not affect the potential of rhIFNbeta-1a to break B cell tolerance...
  2. pmc Aggregated recombinant human interferon Beta induces antibodies but no memory in immune-tolerant transgenic mice
    Miranda M C van Beers
    Department of Pharmaceutics Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, Utrecht, The Netherlands
    Pharm Res 27:1812-24. 2010
    ..To study the influence of protein aggregation on the immunogenicity of recombinant human interferon beta (rhIFNbeta) in wild-type mice and transgenic, immune-tolerant mice, and to evaluate the induction of immunological memory...
  3. doi request reprint Antibody response against Betaferon® in immune tolerant mice: involvement of marginal zone B-cells and CD4+ T-cells and apparent lack of immunological memory
    Melody Sauerborn
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, Universiteitsweg 99, Utrecht, 3584 CG, The Netherlands
    J Clin Immunol 33:255-63. 2013
    ..The apparent absence of immunological memory indicates a CD4+ T-cell independent (Tind) immune response underlying ADA formation against Betaferon®. This hypothesis was tested...
  4. doi request reprint Immunogenicity of recombinant human interferon beta interacting with particles of glass, metal, and polystyrene
    Miranda M C van Beers
    Division of Drug Delivery Technology, Leiden Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands
    J Pharm Sci 101:187-99. 2012
    ..The protein fraction adsorbed on stainless steel particles was responsible for this. In conclusion, rhIFNβ-1a adsorbs to common hydrophilic surface materials, possibly increasing the immunogenicity of the protein...
  5. doi request reprint On the role of aggregates in the immunogenicity of recombinant human interferon beta in patients with multiple sclerosis
    Miranda M C van Beers
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, Utrecht, The Netherlands
    J Interferon Cytokine Res 30:767-75. 2010
    ..Here, we summarize the different factors influencing the immunogenicity of rhIFN-β in patients with multiple sclerosis and discuss the role played by rhIFN-β aggregates...