Jeroen van Bergen
Affiliation: Leiden University Medical Center
Country: The Netherlands
van Bergen J, Thompson A, Haasnoot G, Roodnat J, de Fijter J, Claas F, et al
. KIR-ligand mismatches are associated with reduced long-term graft survival in HLA-compatible kidney transplantation. Am J Transplant. 2011;11:1959-64 pubmed publisher
..This finding constitutes the first indication that alloreactive NK cells may thwart the success of HLA-compatible kidney transplantations, and suggests that suppression of NK-cell activity can improve the survival of such kidney grafts. ..
van Bergen J, Thompson A, Retiere C, Trowsdale J, Koning F. Cutting edge: killer Ig-like receptors mediate "missing self" recognition in vivo. J Immunol. 2009;182:2569-72 pubmed publisher
..Hence, the KIR transgene mediated "missing self" recognition in vivo. We anticipate that this KIR and HLA transgenic mouse will help shed light on KIR and HLA effects in disease and transplantation. ..
van Bergen J, Thompson A, van Pel M, RetiÃ¨re C, Salvatori D, Raulet D, et al
. HLA reduces killer cell Ig-like receptor expression level and frequency in a humanized mouse model. J Immunol. 2013;190:2880-5 pubmed publisher
..In line with these findings, both transgene-encoded KIR and endogenous NKG2A contributed to the rejection of cells lacking HLA-Cw3. These findings support the idea that HLA influences the human KIR repertoire. ..