Hans C van Houwelingen

..All analyses that use approximate likelihood can be carried out by standard software. We demonstrate how the models can be fitted using SAS Proc Mixed...

..The main aim of this paper it to show how generally accepted biostatistical procedures can be employed to analyse high-dimensional data...

..The consequences for design and analysis are discussed and some practical recommendations are given...

..The design of a randomized multicenter trial is presented on the effectiveness of a prolonged conservative treatment strategy compared with surgery in patients with persisting intense sciatica (lumbosacral radicular syndrome)...

..However, this approach does not fully exploit the data...

..This paper discusses the problem of automated annotation. It is a continuation of the previous work on the A4-algorithm (Adaptive algorithm of automated annotation) developed by Leontovich and others...

..Confirmation by DNA analysis is requisite for positive results, and when there exists high clinical suspicion, also for negative results...

..For larger data sets our algorithm was several times faster, and was able to handle larger data sets then SAS and R...

..To our knowledge, this is the first study showing that NOTCH3 mutation carriers may be at increased risk of early acute myocardial infarction, expanding CADASIL disease expression beyond the central nervous system to include the heart...

..This approach can be extended to cases where there are more than two groups...

..Our new testing strategy has the potential to detect them while maintaining sensitivity to variants with homogeneous effects...

..All three methods are designed for single populations; they can be applied in cases only, controls only or the whole data. Therefore they are not necessarily optimal for haplotype testing in case-control studies...

..We determined which individuals were responsible for the information loss, and calculated how much information could be gained when the ambiguous individuals could be resolved by adding additional parental information...

..We show that the relaxed Burr model serves as a good approximation to the Burr model when the frailty is constant, and furthermore it gives better results when the frailty is time dependent...

..We illustrate our methods using data of 8966 leukemia patients from the European Group for Blood and Marrow Transplantation...

..We use data from the European Group for Blood and Marrow Transplantation to illustrate our techniques...

..Statistical methods have been described in literature but these methods are not always easy to apply in a diagnostic setting...

..The landmark methodology does not need complex modeling and leads to easy prediction rules. On the other hand, it does not give the insight in the biological processes as obtained for the multi-state model...

..A recent surge of interest in survival as the primary clinical endpoint of microarray studies has called for an extension of the Global Test methodology to survival...

..We comment on the differences and similarities among the models and evaluate their performance using survival and hazard plots, Brier scores and pseudo-observations...

..We illustrate these models with an application to ovarian cancer patients...

..6 for relatives that share 50 per cent of their genes (sib-pairs and parent-child) and about 0.3 for relatives that share 25 per cent of their genes (grandparent-grandchild, uncle/aunt-niece/nephew)...

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..The influence of genotyping error on selective designs for continuous traits has not been assessed yet...

..To translate and adapt the original English version of the Shoulder Rating Questionnaire (SRQ) into the Dutch language (SRQ-DLV) and evaluate its internal consistency, reliability, validity and responsiveness to clinical changes...

..This study illustrates that the prediction of late graft failure could be improved significantly by using time-dependent renal function covariates...

..Groups of genes may be any size from a single gene to all genes on the chip (e.g. known pathways, specific areas of the genome or clusters from a cluster analysis)...

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..Lumbar-disk surgery often is performed in patients who have sciatica that does not resolve within 6 weeks, but the optimal timing of surgery is not known...

..We conclude that for the GAW15 data the new method performs well and that methods that use the linkage information may be more efficient than standard comparisons of genotypes in cases and controls...

..Comparison of the unadjusted and the anti-CCP-adjusted analyses identifies persisting peaks mapping to regions that can be attributed to a 'dimension' of RA independent of anti-CCP...

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..We also evaluate model selection in terms of average prediction error across nine replicates. We conclude that for the Genetic Analysis Workshop 15 (GAW15) data, the newly developed Bayesian selection method performs well...

..Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is caused by mutations in the NOTCH3 gene. Knowledge of disease expression in young adult NOTCH3 mutation carriers (MCs) is limited...

..Using case-control study data from the North American Rheumatoid Arthritis Consortium and gene annotation data from the Gene Ontology, we illustrate how the method can be used to prioritize candidate genes for further investigation...

..Our study showed that diagnostic hysteroscopy can be restricted to inconclusive or failed SCHS...

..72 (if fibrinoid necrosis present) - 0.42* (age). CONCLUSION: The index created with results from this study provides an indication of renal outcome in patients diagnosed with ANCA-associated glomerulonephritis...

..This should not to be read as a lack of validity of the method, but it shows that any sensitivity method cannot be automated in a form that runs without expert guidance on the ranges...