Hans C van Houwelingen

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint Advanced methods in meta-analysis: multivariate approach and meta-regression
    Hans C van Houwelingen
    Department of Medical Statistics, Leiden University Medical Center, P O Box 9604, 2300 RC Leiden, The Netherlands
    Stat Med 21:589-624. 2002
  2. ncbi request reprint Cross-validated Cox regression on microarray gene expression data
    Hans C van Houwelingen
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, P O Box 9604, 2300 RC Leiden, The Netherlands
    Stat Med 25:3201-16. 2006
  3. ncbi request reprint Interim analysis on survival data: its potential bias and how to repair it
    Hans C van Houwelingen
    Department of Medical Statistics, Leiden University Medical Center, RC Leiden, The Netherlands
    Stat Med 24:2823-35. 2005
  4. pmc Prolonged conservative treatment or 'early' surgery in sciatica caused by a lumbar disc herniation: rationale and design of a randomized trial [ISRCT 26872154]
    Wilco C Peul
    Department of Neurosurgery, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    BMC Musculoskelet Disord 6:8. 2005
  5. pmc Multivariate random effects meta-analysis of diagnostic tests with multiple thresholds
    Taye H Hamza
    Department of Biostatistics, Erasmus MC Erasmus University Medical Center, Rotterdam, The Netherlands
    BMC Med Res Methodol 9:73. 2009
  6. pmc The comparative analysis of statistics, based on the likelihood ratio criterion, in the automated annotation problem
    Andrey M Leontovich
    Belozersky Institute of Physico Chemical Biology, Moscow State University, Moscow 119899, Russia
    BMC Bioinformatics 9:31. 2008
  7. ncbi request reprint Evaluation of diagnostic NOTCH3 immunostaining in CADASIL
    Saskia A J Lesnik Oberstein
    Department of Clinical Genetics, K5 R, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Acta Neuropathol 106:107-11. 2003
  8. ncbi request reprint A fast routine for fitting Cox models with time varying effects of the covariates
    Aris Perperoglou
    Leiden University Medical Center, Department of Medical Statistics and Bio informatics, P O Box 9604, 2300 RC, Leiden, The Netherlands
    Comput Methods Programs Biomed 81:154-61. 2006
  9. ncbi request reprint Myocardial infarction in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)
    Saskia A J Lesnik Oberstein
    Department of Clinical Genetics, Leiden University Medical Center, The Netherlands
    Medicine (Baltimore) 82:251-6. 2003
  10. ncbi request reprint Microarray data analysis: a hierarchical T-test to handle heteroscedasticity
    Renee X de Menezes
    Department of Medical Statistics, Leiden University Medical Center, PO Box 9604, 2300 RC Leiden, The Netherlands
    Appl Bioinformatics 3:229-35. 2004

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Advanced methods in meta-analysis: multivariate approach and meta-regression
    Hans C van Houwelingen
    Department of Medical Statistics, Leiden University Medical Center, P O Box 9604, 2300 RC Leiden, The Netherlands
    Stat Med 21:589-624. 2002
    ..All analyses that use approximate likelihood can be carried out by standard software. We demonstrate how the models can be fitted using SAS Proc Mixed...
  2. ncbi request reprint Cross-validated Cox regression on microarray gene expression data
    Hans C van Houwelingen
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, P O Box 9604, 2300 RC Leiden, The Netherlands
    Stat Med 25:3201-16. 2006
    ..The main aim of this paper it to show how generally accepted biostatistical procedures can be employed to analyse high-dimensional data...
  3. ncbi request reprint Interim analysis on survival data: its potential bias and how to repair it
    Hans C van Houwelingen
    Department of Medical Statistics, Leiden University Medical Center, RC Leiden, The Netherlands
    Stat Med 24:2823-35. 2005
    ..The consequences for design and analysis are discussed and some practical recommendations are given...
  4. pmc Prolonged conservative treatment or 'early' surgery in sciatica caused by a lumbar disc herniation: rationale and design of a randomized trial [ISRCT 26872154]
    Wilco C Peul
    Department of Neurosurgery, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    BMC Musculoskelet Disord 6:8. 2005
    ..The design of a randomized multicenter trial is presented on the effectiveness of a prolonged conservative treatment strategy compared with surgery in patients with persisting intense sciatica (lumbosacral radicular syndrome)...
  5. pmc Multivariate random effects meta-analysis of diagnostic tests with multiple thresholds
    Taye H Hamza
    Department of Biostatistics, Erasmus MC Erasmus University Medical Center, Rotterdam, The Netherlands
    BMC Med Res Methodol 9:73. 2009
    ..However, this approach does not fully exploit the data...
  6. pmc The comparative analysis of statistics, based on the likelihood ratio criterion, in the automated annotation problem
    Andrey M Leontovich
    Belozersky Institute of Physico Chemical Biology, Moscow State University, Moscow 119899, Russia
    BMC Bioinformatics 9:31. 2008
    ..This paper discusses the problem of automated annotation. It is a continuation of the previous work on the A4-algorithm (Adaptive algorithm of automated annotation) developed by Leontovich and others...
  7. ncbi request reprint Evaluation of diagnostic NOTCH3 immunostaining in CADASIL
    Saskia A J Lesnik Oberstein
    Department of Clinical Genetics, K5 R, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Acta Neuropathol 106:107-11. 2003
    ..Confirmation by DNA analysis is requisite for positive results, and when there exists high clinical suspicion, also for negative results...
  8. ncbi request reprint A fast routine for fitting Cox models with time varying effects of the covariates
    Aris Perperoglou
    Leiden University Medical Center, Department of Medical Statistics and Bio informatics, P O Box 9604, 2300 RC, Leiden, The Netherlands
    Comput Methods Programs Biomed 81:154-61. 2006
    ..For larger data sets our algorithm was several times faster, and was able to handle larger data sets then SAS and R...
  9. ncbi request reprint Myocardial infarction in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)
    Saskia A J Lesnik Oberstein
    Department of Clinical Genetics, Leiden University Medical Center, The Netherlands
    Medicine (Baltimore) 82:251-6. 2003
    ..To our knowledge, this is the first study showing that NOTCH3 mutation carriers may be at increased risk of early acute myocardial infarction, expanding CADASIL disease expression beyond the central nervous system to include the heart...
  10. ncbi request reprint Microarray data analysis: a hierarchical T-test to handle heteroscedasticity
    Renee X de Menezes
    Department of Medical Statistics, Leiden University Medical Center, PO Box 9604, 2300 RC Leiden, The Netherlands
    Appl Bioinformatics 3:229-35. 2004
    ..This approach can be extended to cases where there are more than two groups...
  11. doi request reprint Dealing with heterogeneity between cohorts in genomewide SNP association studies
    Jeremie J Lebrec
    Leiden University Medical Center, The Netherlands
    Stat Appl Genet Mol Biol 9:Article 8. 2010
    ..Our new testing strategy has the potential to detect them while maintaining sensitivity to variants with homogeneous effects...
  12. pmc Assessment of global phase uncertainty in case-control studies
    Hae Won Uh
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands
    BMC Genet 10:54. 2009
    ..All three methods are designed for single populations; they can be applied in cases only, controls only or the whole data. Therefore they are not necessarily optimal for haplotype testing in case-control studies...
  13. pmc How to quantify information loss due to phase ambiguity in haplotype case-control studies
    Hae Won Uh
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands
    BMC Genet 6:S108. 2005
    ..We determined which individuals were responsible for the information loss, and calculated how much information could be gained when the ambiguous individuals could be resolved by adding additional parental information...
  14. ncbi request reprint A relaxation of the gamma frailty (Burr) model
    Aris Perperoglou
    Leiden University Medical Center, University of Leiden, PO Box 9604, 2300 RC, The Netherlands
    Stat Med 25:4253-66. 2006
    ..We show that the relaxed Burr model serves as a good approximation to the Burr model when the frailty is constant, and furthermore it gives better results when the frailty is time dependent...
  15. doi request reprint Vertical modeling: a pattern mixture approach for competing risks modeling
    M A Nicolaie
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Stat Med 29:1190-205. 2010
    ..We illustrate our methods using data of 8966 leukemia patients from the European Group for Blood and Marrow Transplantation...
  16. doi request reprint Reduced-rank proportional hazards regression and simulation-based prediction for multi-state models
    Marta Fiocco
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, P O Box 9604, 2300 RC, Leiden, The Netherlands
    Stat Med 27:4340-58. 2008
    ..We use data from the European Group for Blood and Marrow Transplantation to illustrate our techniques...
  17. pmc A simple method for co-segregation analysis to evaluate the pathogenicity of unclassified variants; BRCA1 and BRCA2 as an example
    Leila Mohammadi
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands
    BMC Cancer 9:211. 2009
    ..Statistical methods have been described in literature but these methods are not always easy to apply in a diagnostic setting...
  18. pmc Dynamic predicting by landmarking as an alternative for multi-state modeling: an application to acute lymphoid leukemia data
    Hans C van Houwelingen
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Post Zone S5 P, P O Box 9600, Leiden, 2300 RC, The Netherlands
    Lifetime Data Anal 14:447-63. 2008
    ..The landmark methodology does not need complex modeling and leads to easy prediction rules. On the other hand, it does not give the insight in the biological processes as obtained for the multi-state model...
  19. ncbi request reprint Testing association of a pathway with survival using gene expression data
    Jelle J Goeman
    Department of Medical Statistics, Leiden University Medical Center, The Netherlands
    Bioinformatics 21:1950-7. 2005
    ..A recent surge of interest in survival as the primary clinical endpoint of microarray studies has called for an extension of the Global Test methodology to survival...
  20. ncbi request reprint Approaches in modelling long-term survival: an application to breast cancer
    Aris Perperoglou
    Leiden University Medical Center, University of Leiden, P O Box 9604, 2300 RC, The Netherlands
    Stat Med 26:2666-85. 2007
    ..We comment on the differences and similarities among the models and evaluate their performance using survival and hazard plots, Brier scores and pseudo-observations...
  21. ncbi request reprint Reduced-rank hazard regression for modelling non-proportional hazards
    Aris Perperoglou
    Department of Medical Statistics, Leiden University Medical Center, University of Leiden, P O Box 9604, 2300 RC, Leiden, The Netherlands
    Stat Med 25:2831-45. 2006
    ..We illustrate these models with an application to ovarian cancer patients...
  22. ncbi request reprint Assessing genetic effects in survival data by correlating martingale residuals with an application to age at onset of Huntington disease
    Claire M A Wintrebert
    Department of Medical Statistics, Leiden University Medical Centre, P O Box 9604, Leiden, 2300 RC, The Netherlands
    Stat Med 25:3190-200. 2006
    ..6 for relatives that share 50 per cent of their genes (sib-pairs and parent-child) and about 0.3 for relatives that share 25 per cent of their genes (grandparent-grandchild, uncle/aunt-niece/nephew)...
  23. doi request reprint Combining matched and unmatched control groups in case-control studies
    Saskia le Cessie
    Department of Medical Statistics and Bioinformatics, S5 P, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Am J Epidemiol 168:1204-10. 2008
    ....
  24. pmc Influence of genotyping error in linkage mapping for complex traits--an analytic study
    Jeremie J P Lebrec
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Postzone S 05 P, PO Box 9600 2300 RC Leiden, The Netherlands
    BMC Genet 9:57. 2008
    ..The influence of genotyping error on selective designs for continuous traits has not been assessed yet...
  25. ncbi request reprint Translation, adaptation and validation of the Shoulder Rating Questionnaire (SRQ) into the Dutch language
    Henricus M Vermeulen
    Department of Physical Therapy, Leiden University Medical Center, Leiden, The Netherlands
    Clin Rehabil 19:300-11. 2005
    ..To translate and adapt the original English version of the Shoulder Rating Questionnaire (SRQ) into the Dutch language (SRQ-DLV) and evaluate its internal consistency, reliability, validity and responsiveness to clinical changes...
  26. ncbi request reprint Predicting kidney graft failure using time-dependent renal function covariates
    Mattheus H J de Bruijne
    Department of Medical Statistics, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands
    J Clin Epidemiol 56:448-55. 2003
    ..This study illustrates that the prediction of late graft failure could be improved significantly by using time-dependent renal function covariates...
  27. ncbi request reprint A global test for groups of genes: testing association with a clinical outcome
    Jelle J Goeman
    Department of Medical Statistics, Leiden University Medical Center, P O Box 9604, 2300 RC Leiden, The Netherlands
    Bioinformatics 20:93-9. 2004
    ..Groups of genes may be any size from a single gene to all genes on the chip (e.g. known pathways, specific areas of the genome or clusters from a cluster analysis)...
  28. ncbi request reprint A regression model with unexplained residuals was preferred in the analysis of the fetal origins of adult diseases hypothesis
    Mandy G Keijzer-Veen
    Department of Clinical Epidemiology, Leiden University Medical Center, The Netherlands
    J Clin Epidemiol 58:1320-4. 2005
    ....
  29. ncbi request reprint Surgery versus prolonged conservative treatment for sciatica
    Wilco C Peul
    Department of Neurosurgery, Leiden University Medical Center, Leiden, The Netherlands
    N Engl J Med 356:2245-56. 2007
    ..Lumbar-disk surgery often is performed in patients who have sciatica that does not resolve within 6 weeks, but the optimal timing of surgery is not known...
  30. pmc A new score statistic to test for association given linkage in affected sibling pair-control designs
    Jeanine J Houwing Duistermaat
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Postzone S 5 P, PO Box 9600, 2300 RC, Leiden, The Netherlands
    BMC Proc 1:S39. 2007
    ..We conclude that for the GAW15 data the new method performs well and that methods that use the linkage information may be more efficient than standard comparisons of genotypes in cases and controls...
  31. pmc Adjusting for sex and anti-CCP levels in linkage analysis of rheumatoid arthritis
    Jeremie J P Lebrec
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, P, O, Box 9604, 2300 RC Leiden, The Netherlands
    BMC Proc 1:S75. 2007
    ..Comparison of the unadjusted and the anti-CCP-adjusted analyses identifies persisting peaks mapping to regions that can be attributed to a 'dimension' of RA independent of anti-CCP...
  32. ncbi request reprint MR imaging: effectiveness and costs at triage of patients with nonacute knee symptoms
    Patrice W J Vincken
    Department of Radiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, and Department of Radiology, MCH Westeinde Hospital, The Hague, The Netherlands
    Radiology 242:85-93. 2007
    ....
  33. pmc Model selection based on logistic regression in a highly correlated candidate gene region
    Hae Won Uh
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands
    BMC Proc 1:S114. 2007
    ..We also evaluate model selection in terms of average prediction error across nine replicates. We conclude that for the Genetic Analysis Workshop 15 (GAW15) data, the newly developed Bayesian selection method performs well...
  34. ncbi request reprint Incipient CADASIL
    Saskia A J Lesnik Oberstein
    Department of Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Arch Neurol 60:707-12. 2003
    ..Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is caused by mutations in the NOTCH3 gene. Knowledge of disease expression in young adult NOTCH3 mutation carriers (MCs) is limited...
  35. pmc Integration of gene ontology pathways with North American Rheumatoid Arthritis Consortium genome-wide association data via linear modeling
    Jérémie Jp Lebrec
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, P, O, Box 9604, 2300 RC Leiden, The Netherlands
    BMC Proc 3:S94. 2009
    ..Using case-control study data from the North American Rheumatoid Arthritis Consortium and gene annotation data from the Gene Ontology, we illustrate how the method can be used to prioritize candidate genes for further investigation...
  36. ncbi request reprint Technology assessment of saline contrast hysterosonography
    Cornelis D de Kroon
    Department of Gynecology, Leiden University Medical Center, The Netherlands
    Am J Obstet Gynecol 188:945-9. 2003
    ..The purpose of our study was to evaluate to which extent saline contrast hysterosonography (SCHS) is able to replace diagnostic hysteroscopy in uterine cavity evaluation in women suspected of intrauterine abnormalities...
  37. ncbi request reprint An index for renal outcome in ANCA-associated glomerulonephritis
    Clarissa E Vergunst
    Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Kidney Dis 41:532-8. 2003
    ....
  38. doi request reprint Sensitivity analysis of state-transition models: how to deal with a large number of inputs
    Hans C van Houwelingen
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, University of Leiden, Leiden, The Netherlands
    Comput Biol Med 41:838-42. 2011
    ..This should not to be read as a lack of validity of the method, but it shows that any sensitivity method cannot be automated in a form that runs without expert guidance on the ranges...