Haico van Attikum
Affiliation: Leiden University Medical Center
Country: The Netherlands
Pfeiffer A, Luijsterburg M, Acs K, Wiegant W, Helfricht A, Herzog L, et al
. Ataxin-3 consolidates the MDC1-dependent DNA double-strand break response by counteracting the SUMO-targeted ubiquitin ligase RNF4. EMBO J. 2017;36:1066-1083 pubmed publisher
..We propose that the opposing activities of RNF4 and ataxin-3 consolidate robust MDC1-dependent signaling and repair of DSBs. ..
Typas D, Luijsterburg M, Wiegant W, Diakatou M, Helfricht A, Thijssen P, et al
. The de-ubiquitylating enzymes USP26 and USP37 regulate homologous recombination by counteracting RAP80. Nucleic Acids Res. 2015;43:6919-33 pubmed publisher
..These findings reveal a novel ubiquitin-dependent mechanism that regulates distinct BRCA1-containing complexes for efficient repair of DSBs by HR. ..
Pines A, Dijk M, Makowski M, Meulenbroek E, Vrouwe M, van der Weegen Y, et al
. TRiC controls transcription resumption after UV damage by regulating Cockayne syndrome protein A. Nat Commun. 2018;9:1040 pubmed publisher
..Thus, we uncover CSA as a TRiC substrate and reveal that TRiC regulates CSA-dependent TC-NER and the development of CS. ..
van Attikum H, Gasser S. Crosstalk between histone modifications during the DNA damage response. Trends Cell Biol. 2009;19:207-17 pubmed publisher
..These collectively regulate DSB repair and checkpoint arrest, avoiding genomic instability and oncogenic transformation in higher eukaryotes. ..
Luijsterburg M, de Krijger I, Wiegant W, Shah R, Smeenk G, de Groot A, et al
. PARP1 Links CHD2-Mediated Chromatin Expansion and H3.3 Deposition to DNA Repair by Non-homologous End-Joining. Mol Cell. 2016;61:547-562 pubmed publisher
..Together, these findings reveal a PARP1-dependent process that couples ATP-dependent chromatin remodeling with histone variant deposition at DSBs to facilitate NHEJ and safeguard genomic stability. ..
Spruijt C, Luijsterburg M, Menafra R, Lindeboom R, Jansen P, Edupuganti R, et al
. ZMYND8 Co-localizes with NuRD on Target Genes and Regulates Poly(ADP-Ribose)-Dependent Recruitment of GATAD2A/NuRD to Sites of DNA Damage. Cell Rep. 2016;17:783-798 pubmed publisher
..Thus, these results show that a specific substoichiometric interaction with a NuRD subunit paralogue provides unique functionality to distinct NuRD subcomplexes. ..
Rother M, van Attikum H. DNA repair goes hip-hop: SMARCA and CHD chromatin remodellers join the break dance. Philos Trans R Soc Lond B Biol Sci. 2017;372: pubmed publisher
..This article is part of the themed issue 'Chromatin modifiers and remodellers in DNA repair and signalling'. ..