Gabri van der Pluijm

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint Bone morphogenetic protein 7 inhibits tumor growth of human uveal melanoma in vivo
    Irene Notting
    Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands
    Invest Ophthalmol Vis Sci 48:4882-9. 2007
  2. doi request reprint Epithelial plasticity, cancer stem cells and bone metastasis formation
    Gabri van der Pluijm
    Leiden University Medical Center, Department of Urology J3 100, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Bone 48:37-43. 2011
  3. pmc The aldehyde dehydrogenase enzyme 7A1 is functionally involved in prostate cancer bone metastasis
    Christel van den Hoogen
    Department of Urology, Leiden University Medical Centre, The Netherlands
    Clin Exp Metastasis 28:615-25. 2011
  4. pmc Urokinase-receptor/integrin complexes are functionally involved in adhesion and progression of human breast cancer in vivo
    G van der Pluijm
    Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands
    Am J Pathol 159:971-82. 2001
  5. pmc In vitro and in vivo endochondral bone formation models allow identification of anti-angiogenic compounds
    Gabri van der Pluijm
    Department of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Pathol 163:157-63. 2003
  6. ncbi request reprint Interference with the microenvironmental support impairs the de novo formation of bone metastases in vivo
    Gabri van der Pluijm
    Department of Endocrinology, Leiden University Medical Center, Leiden, Netherlands
    Cancer Res 65:7682-90. 2005
  7. ncbi request reprint High aldehyde dehydrogenase activity identifies tumor-initiating and metastasis-initiating cells in human prostate cancer
    Christel van den Hoogen
    Department of Urology, Leiden University Medical Center, Leiden, The Netherlands
    Cancer Res 70:5163-73. 2010
  8. ncbi request reprint Bone morphogenetic protein 7 in the development and treatment of bone metastases from breast cancer
    Jeroen T Buijs
    Department of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands
    Cancer Res 67:8742-51. 2007
  9. doi request reprint Inhibition of bone resorption and growth of breast cancer in the bone microenvironment
    Jeroen T Buijs
    Department of Endocrinology, Leiden University Medical Center, C4 R, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Bone 44:380-6. 2009
  10. pmc BMP7, a putative regulator of epithelial homeostasis in the human prostate, is a potent inhibitor of prostate cancer bone metastasis in vivo
    Jeroen T Buijs
    Department of Urology, Leiden University Medical Center, J3 100, P O Box 9600, 2300 RC Leiden, The Netherlands
    Am J Pathol 171:1047-57. 2007

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Bone morphogenetic protein 7 inhibits tumor growth of human uveal melanoma in vivo
    Irene Notting
    Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands
    Invest Ophthalmol Vis Sci 48:4882-9. 2007
    ....
  2. doi request reprint Epithelial plasticity, cancer stem cells and bone metastasis formation
    Gabri van der Pluijm
    Leiden University Medical Center, Department of Urology J3 100, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Bone 48:37-43. 2011
    ....
  3. pmc The aldehyde dehydrogenase enzyme 7A1 is functionally involved in prostate cancer bone metastasis
    Christel van den Hoogen
    Department of Urology, Leiden University Medical Centre, The Netherlands
    Clin Exp Metastasis 28:615-25. 2011
    ..Our findings show, for the first time, that the ALDH7A1 enzyme is functionally involved in the formation of bone metastases and that the effect appeared dependent on the microenvironment, i.e., bone versus prostate...
  4. pmc Urokinase-receptor/integrin complexes are functionally involved in adhesion and progression of human breast cancer in vivo
    G van der Pluijm
    Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands
    Am J Pathol 159:971-82. 2001
    ..Our findings strongly suggest that adhesive and proteolytic events are tightly associated in metastatic breast cancer cells and that functional integrin-uPAR complexes are involved in tumor progression in vivo...
  5. pmc In vitro and in vivo endochondral bone formation models allow identification of anti-angiogenic compounds
    Gabri van der Pluijm
    Department of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Pathol 163:157-63. 2003
    ....
  6. ncbi request reprint Interference with the microenvironmental support impairs the de novo formation of bone metastases in vivo
    Gabri van der Pluijm
    Department of Endocrinology, Leiden University Medical Center, Leiden, Netherlands
    Cancer Res 65:7682-90. 2005
    ..Inhibition of bone turnover may represent a useful adjuvant therapy especially for cancer patients at risk to develop bone metastasis...
  7. ncbi request reprint High aldehyde dehydrogenase activity identifies tumor-initiating and metastasis-initiating cells in human prostate cancer
    Christel van den Hoogen
    Department of Urology, Leiden University Medical Center, Leiden, The Netherlands
    Cancer Res 70:5163-73. 2010
    ..Our findings suggest that ALDH-based viable cell sorting can be used to identify and characterize tumor-initiating and, more importantly perhaps, metastasis-initiating cells in human prostate cancer...
  8. ncbi request reprint Bone morphogenetic protein 7 in the development and treatment of bone metastases from breast cancer
    Jeroen T Buijs
    Department of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands
    Cancer Res 67:8742-51. 2007
    ..Because exogenous BMP7 can still counteract the breast cancer growth at the primary site and in bone, BMP7 may represent a novel therapeutic molecule for repression of local and bone metastatic growth of breast cancer...
  9. doi request reprint Inhibition of bone resorption and growth of breast cancer in the bone microenvironment
    Jeroen T Buijs
    Department of Endocrinology, Leiden University Medical Center, C4 R, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Bone 44:380-6. 2009
    ..However, interference with the bone micro-environmental growth support could still be of therapeutic relevance when given to patients early in the course of bone metastatic disease...
  10. pmc BMP7, a putative regulator of epithelial homeostasis in the human prostate, is a potent inhibitor of prostate cancer bone metastasis in vivo
    Jeroen T Buijs
    Department of Urology, Leiden University Medical Center, J3 100, P O Box 9600, 2300 RC Leiden, The Netherlands
    Am J Pathol 171:1047-57. 2007
    ..Thus, BMP7 can still counteract the epithelial-to-mesenchymal transition process in the metastatic tumor, positioning BMP7 as a novel therapeutic molecule for treatment of metastatic bone disease...
  11. pmc BMP-7 inhibits TGF-β-induced invasion of breast cancer cells through inhibition of integrin β(3) expression
    Hildegonda P H Naber
    Department of Molecular Cell Biology and Centre for Biomedical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Cell Oncol (Dordr) 35:19-28. 2012
    ..In breast cancer, high levels of TGF-β are associated with poor outcome, whereas inhibition of TGF-β-signaling reduces metastasis. In contrast, BMP-7 inhibits bone metastasis of breast cancer cells...
  12. pmc Targeting of α(v)-integrins in stem/progenitor cells and supportive microenvironment impairs bone metastasis in human prostate cancer
    Geertje van der Horst
    Department of Urology, Leiden University Medical Centre, Leiden, The Netherlands
    Neoplasia 13:516-25. 2011
    ....
  13. ncbi request reprint Advances in optical imaging and novel model systems for cancer metastasis research
    Nico V Henriquez
    Department of Endocrinology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands
    Clin Exp Metastasis 24:699-705. 2007
    ....
  14. ncbi request reprint The tumor suppressor Smad4 is required for transforming growth factor beta-induced epithelial to mesenchymal transition and bone metastasis of breast cancer cells
    Martine Deckers
    Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
    Cancer Res 66:2202-9. 2006
    ..Taken together, our results show that Smad4 plays an important role in both tumor suppression and progression of breast cancer cells...
  15. pmc Integrin αv expression is required for the acquisition of a metastatic stem/progenitor cell phenotype in human prostate cancer
    Christel van den Hoogen
    Department of Urology, Leiden University Medical Centre, Leiden, The Netherlands
    Am J Pathol 179:2559-68. 2011
    ....
  16. ncbi request reprint TGF-beta and BMP7 interactions in tumour progression and bone metastasis
    Jeroen T Buijs
    Department of Endocrinology, Leiden University Medical Centre, Leiden, The Netherlands
    Clin Exp Metastasis 24:609-17. 2007
    ..For instance, the tumour-stroma interactions occurring in the tissue of cancer origin, including epithelium-to-mesenchyme transition (EMT), bear similarities with the role of bone matrix-derived TGF-beta in skeletal metastasis formation...
  17. doi request reprint Osteotropic cancers: from primary tumor to bone
    Jeroen T Buijs
    Department of Urology, Leiden University Medical Center, Leiden, The Netherlands
    Cancer Lett 273:177-93. 2009
    ..For this reason, this review uses the 'seed and soil' hypothesis as a template to discuss novel insight and developments in the bone metastasis field...
  18. ncbi request reprint Bone morphogenetic proteins and its receptors; therapeutic targets in cancer progression and bone metastasis?
    Jeroen T Buijs
    Dept of Urology, Leiden University Medical Center, Albinusdreef 2, PO Box 9600, 2300 RC, Leiden, The Netherlands
    Curr Pharm Des 16:1291-300. 2010
    ..Especially in the last decade, studies have focused on the role of several BMPs in osteotropic cancers. In this review, the role of BMPs, particularly that of BMP7, in breast and prostate cancer will be discussed...
  19. doi request reprint Real-time cancer cell tracking by bioluminescence in a preclinical model of human bladder cancer growth and metastasis
    Geertje van der Horst
    Department of Urology, Leiden University Medical Center, Leiden, The Netherlands
    Eur Urol 60:337-43. 2011
    ..Molecular imaging of cancer growth and metastasis in preclinical models provides the essential link between cell-based experiments and clinical translation...
  20. ncbi request reprint Functional imaging of multidrug resistance in an orthotopic model of osteosarcoma using 99mTc-sestamibi
    Célia M F Gomes
    Department of Radiology, Section of Nuclear Medicine, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Nucl Med Mol Imaging 34:1793-803. 2007
    ..The purpose of this work was the development of an orthotopic model of osteosarcoma based on luciferase-expressing tumour cells for the in vivo imaging of multidrug resistance (MDR) with (99m)Tc-sestamibi...
  21. ncbi request reprint Dissociation of angiogenesis and osteoclastogenesis during endochondral bone formation in neonatal mice
    Martine M L Deckers
    Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, The Netherlands
    J Bone Miner Res 17:998-1007. 2002
    ..On the other hand, our results confirm that bisphosphonates can be used safely in the treatment of disorders that affect the growing skeleton, such as in juvenile osteoporosis...
  22. doi request reprint Bone morphogenetic protein 7: a broad-spectrum growth factor with multiple target therapeutic potency
    Mariëtte R Boon
    Department of General Internal Medicine, Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands
    Cytokine Growth Factor Rev 22:221-9. 2011
    ..Furthermore, the therapeutic potential of BMP7 in these disease states is discussed...
  23. doi request reprint Epithelial plasticity, cancer stem cells, and the tumor-supportive stroma in bladder carcinoma
    Geertje van der Horst
    Department of Urology, Leiden University Medical Center, Leiden, The Netherlands
    Mol Cancer Res 10:995-1009. 2012
    ..The potential implications for the development of novel bladder cancer therapy will be discussed...
  24. doi request reprint Preclinical imaging of the cellular and molecular events in the multistep process of bone metastasis
    Geertje van der Horst
    Department of Urology, Leiden University Medical Center, J3 100, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Future Oncol 8:415-30. 2012
    ..The outcome of these experimental studies will facilitate clinical cancer research by improving the detection of cancer cell invasion, metastasis and therapy response...
  25. doi request reprint Multimodal imaging and treatment of bone metastasis
    Eric L Kaijzel
    Department of Endocrinology, Leiden University Medical Center, Albinusdreef 2, Leiden, The Netherlands
    Clin Exp Metastasis 26:371-9. 2009
    ..In this paper, we discuss the use of optical imaging strategies--either alone or in combination with CT--to study intrabone tumor growth, tumor progression and to monitor efficacy of therapeutic agents in metastatic bone disease...
  26. ncbi request reprint Whole-body optical imaging in animal models to assess cancer development and progression
    Eric L Kaijzel
    Departments of Endocrinology and Metabolic Diseases and Urology, Leiden University Medical Center, Leiden, The Netherlands
    Clin Cancer Res 13:3490-7. 2007
    ..Finally, we discuss the translation of one optical imaging modality, near-IR fluorescence, from animal validation studies to applications in the clinic related to cancer management...
  27. ncbi request reprint Whole-body bioluminescent imaging of human uveal melanoma in a new mouse model of local tumor growth and metastasis
    Irene C Notting
    Department of Ophthalmology, Leiden University Medical Center, Albinusdreef 2, 2300 RC Leiden, The Netherlands
    Invest Ophthalmol Vis Sci 46:1581-7. 2005
    ..Therefore, the development of novel anticancer strategies is urgent, and more sensitive and less invasive methods of detecting and monitoring in vivo tumor growth and metastatic disease in cancer models are needed...
  28. pmc Transition of healthy to diseased synovial tissue in rheumatoid arthritis is associated with gain of mesenchymal/fibrotic characteristics
    Marjan M C Steenvoorden
    Department of Rheumatology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Arthritis Res Ther 8:R165. 2006
    ..Therefore, BMP-7 may represent a promising agent to counteract the transition imposed on synoviocytes in the RA joint...
  29. ncbi request reprint Celecoxib enhances doxorubicin-induced cytotoxicity in MDA-MB231 cells by NF-kappaB-mediated increase of intracellular doxorubicin accumulation
    Jens van Wijngaarden
    Department of Endocrinology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Eur J Cancer 43:433-42. 2007
    ....
  30. ncbi request reprint Endothelial network formed with human dermal microvascular endothelial cells in autologous multicellular skin substitutes
    Maria Ponec
    Department of Dermatology, Leiden University Medical Center, 9503, 2300, RA Leiden, The Netherlands
    Angiogenesis 7:295-305. 2004
    ..The potential development of biodegradable, biocompatible material suitable for these purposes is a great challenge for future research...
  31. pmc BMP7 activates brown adipose tissue and reduces diet-induced obesity only at subthermoneutrality
    Mariëtte R Boon
    Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 8:e74083. 2013
    ..We aimed to elucidate the role of sympathetic activation in the effect of BMP7 on BAT by treating mice with BMP7 at varying ambient temperature, and assessed the therapeutic potential of BMP7 in combating obesity...
  32. ncbi request reprint Radium-223 chloride: Extending life in prostate cancer patients by treating bone metastases
    Michel D Wissing
    Authors Affiliations Departments of Clinical Oncology, Radiology, and Urology, Leiden University Medical Centre, Leiden, The Netherlands
    Clin Cancer Res 19:5822-7. 2013
    ..Further studies are required to optimize its dosing and to confirm its efficacy and safety in cancer patients...
  33. doi request reprint The TGF-β/Smad pathway induces breast cancer cell invasion through the up-regulation of matrix metalloproteinase 2 and 9 in a spheroid invasion model system
    Eliza Wiercinska
    Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
    Breast Cancer Res Treat 128:657-66. 2011
    ..This collagen-embedded spheroid system therefore offers a valuable screening model for TGF-β/Smad- and MMP2- and MMP9-dependent breast cancer invasion...
  34. doi request reprint Preclinical models that illuminate the bone metastasis cascade
    Geertje van der Horst
    Department of Urology, Leiden University Medical Centre, Leiden, The Netherlands
    Recent Results Cancer Res 192:1-31. 2012
    ..Advances in experimental and clinical imaging will-in the long run-result in significant improvements in diagnosis, tumor localization, enhanced drug delivery and treatment...
  35. doi request reprint Liposomal nanomedicines in the treatment of prostate cancer
    Jan Kroon
    Department of Urology, Leiden University Medical Center, Leiden, The Netherlands Department of Targeted Therapeutics, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands Electronic address
    Cancer Treat Rev 40:578-84. 2014
    ..In this review, we provide an overview of the (pre)clinical studies that focus on liposomal drug delivery in prostate carcinoma. ..