Esther van de Vosse

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. ncbi Leprosy bacillus triggers the wrong cells
    Tom H M Ottenhoff
    Dept Immunohematology and Blood Transfusion, Leiden University Medical Center, The Netherlands
    Int J Lepr Other Mycobact Dis 73:208-10. 2005
  2. ncbi Distribution of CFTR variations in an Indonesian enteric fever cohort
    Esther van de Vosse
    Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    Clin Infect Dis 50:1231-7. 2010
  3. doi IL-23 modulates CD56+/CD3- NK cell and CD56+/CD3+ NK-like T cell function differentially from IL-12
    Diederik van de Wetering
    Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    Int Immunol 21:145-53. 2009
  4. pmc Salmonella induced IL-23 and IL-1beta allow for IL-12 production by monocytes and Mphi1 through induction of IFN-gamma in CD56 NK/NK-like T cells
    Diederik van de Wetering
    Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 4:e8396. 2009
  5. pmc The R156H variation in IL-12Rβ1 is not a mutation
    Esther van de Vosse
    Department of Infectious Diseases, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands
    Ital J Pediatr 39:12. 2013
  6. pmc A genome wide association study of pulmonary tuberculosis susceptibility in Indonesians
    Eileen Png
    Human Genetics, Genome Institute of Singapore, 60 Biopolis Street, Singapore
    BMC Med Genet 13:5. 2012
  7. ncbi Genetic deficiencies of innate immune signalling in human infectious disease
    Esther van de Vosse
    Department of Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands
    Lancet Infect Dis 9:688-98. 2009
  8. pmc Severe congenital neutropenia in a multigenerational family with a novel neutrophil elastase (ELANE) mutation
    Esther van de Vosse
    Department of Infectious Diseases, C5 P, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands
    Ann Hematol 90:151-8. 2011
  9. doi Antisense-mediated exon skipping to correct IL-12Rbeta1 deficiency in T cells
    Esther van de Vosse
    Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    Blood 113:4548-55. 2009
  10. doi Mycobacterium bovis BCG-itis and cervical lymphadenitis due to Salmonella enteritidis in a patient with complete interleukin-12/-23 receptor beta1 deficiency
    E Van de Vosse
    Department of Infectious Diseases, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands
    Infection 38:128-30. 2010

Detail Information

Publications90

  1. ncbi Leprosy bacillus triggers the wrong cells
    Tom H M Ottenhoff
    Dept Immunohematology and Blood Transfusion, Leiden University Medical Center, The Netherlands
    Int J Lepr Other Mycobact Dis 73:208-10. 2005
  2. ncbi Distribution of CFTR variations in an Indonesian enteric fever cohort
    Esther van de Vosse
    Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    Clin Infect Dis 50:1231-7. 2010
    ..We recently found a microsatellite polymorphism in the CFTR gene, IVS8CA, to be associated with susceptibility to enteric fever in a case-control study in Indonesia...
  3. doi IL-23 modulates CD56+/CD3- NK cell and CD56+/CD3+ NK-like T cell function differentially from IL-12
    Diederik van de Wetering
    Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    Int Immunol 21:145-53. 2009
    ....
  4. pmc Salmonella induced IL-23 and IL-1beta allow for IL-12 production by monocytes and Mphi1 through induction of IFN-gamma in CD56 NK/NK-like T cells
    Diederik van de Wetering
    Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 4:e8396. 2009
    ..Interleukin (IL)-12 and IL-23 are thought to be the key cytokines required for initiating a type-1 cytokine immune response to Mycobacteria and Salmonellae. The relative contribution of IL-23 and IL-12 to this process is uncertain...
  5. pmc The R156H variation in IL-12Rβ1 is not a mutation
    Esther van de Vosse
    Department of Infectious Diseases, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands
    Ital J Pediatr 39:12. 2013
    ..respond to argue that the amino acid substitution, R156H described in the described case exerts a summatory effect, as a genetic cofactor, along with an additional and still unidentified molecular alteration of the same pathway...
  6. pmc A genome wide association study of pulmonary tuberculosis susceptibility in Indonesians
    Eileen Png
    Human Genetics, Genome Institute of Singapore, 60 Biopolis Street, Singapore
    BMC Med Genet 13:5. 2012
    ..In order to identify additional targets in genetically dissimilar populations, and to enhance our understanding of this disease, we performed a multi-stage GWAS in a Southeast Asian cohort from Indonesia...
  7. ncbi Genetic deficiencies of innate immune signalling in human infectious disease
    Esther van de Vosse
    Department of Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands
    Lancet Infect Dis 9:688-98. 2009
    ..Whereas a few patients might have autoantibodies against type-1 cytokines, others might harbour mutations in new genes and pathways that still need to be identified...
  8. pmc Severe congenital neutropenia in a multigenerational family with a novel neutrophil elastase (ELANE) mutation
    Esther van de Vosse
    Department of Infectious Diseases, C5 P, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands
    Ann Hematol 90:151-8. 2011
    ..None of these patients developed leukaemia. This is the first truly multigenerational family with mutations in ELANE as unambiguous cause of severe congenital neutropenia SCN...
  9. doi Antisense-mediated exon skipping to correct IL-12Rbeta1 deficiency in T cells
    Esther van de Vosse
    Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    Blood 113:4548-55. 2009
    ..We demonstrated that T cells can be highly efficiently transduced with AONs and are amenable to antisense-mediated exon skipping. Furthermore, we showed that exon skipping (partly) corrects the IL-12Rbeta1 deficiency in patients' cells...
  10. doi Mycobacterium bovis BCG-itis and cervical lymphadenitis due to Salmonella enteritidis in a patient with complete interleukin-12/-23 receptor beta1 deficiency
    E Van de Vosse
    Department of Infectious Diseases, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands
    Infection 38:128-30. 2010
    ..This mutation abrogated IL-12/IL-23Rbeta1 cell-surface expression and resulted in complete lack of T cell responsiveness to both IL-12 and IL-23...
  11. ncbi A novel mutation in NCF1 in an adult CGD patient with a liver abscess as first presentation
    Esther van de Vosse
    Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    J Hum Genet 54:313-6. 2009
    ..837delC, and one conversion in NCF1, resulting in the complete absence of the p47(phox) component of the NADPH-oxidase complex. This p47(phox)-deficient CGD patient had the highest age at diagnosis reported thus far...
  12. ncbi Susceptibility to typhoid fever is associated with a polymorphism in the cystic fibrosis transmembrane conductance regulator (CFTR)
    Esther van de Vosse
    Department of Infectious Diseases, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands
    Hum Genet 118:138-40. 2005
    ..We found an association between genotypes in CFTR and susceptibility to typhoid fever (OR=2.6). These analyses suggest that the role CFTR plays in vitro in S. typhi infection is also important for infection in the human population...
  13. ncbi Molecular complementation of IL-12Rbeta1 deficiency reveals functional differences between IL-12Rbeta1 alleles including partial IL-12Rbeta1 deficiency
    Esther van de Vosse
    Department of Infectious Diseases, Leiden University Medical Center, The Netherlands
    Hum Mol Genet 14:3847-55. 2005
    ..The QMG allele was found to be a higher IL-12 responder allele compared with the RTR allele. These results have implications for understanding IL-12R/IL-23R structure-function and the role of IL-12R/IL-23R in human disease...
  14. ncbi Targets of anticytokine therapy and the risk of infections in humans and mice
    Esther van de Vosse
    Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    Curr Opin Rheumatol 19:626-35. 2007
    ..Naturally occurring or manipulated genetic defects of tumor necrosis factor, interleukins-1, -6, -12, and -15, and interferon-gamma are examined for their increased susceptibility to, or protection from, infection...
  15. ncbi Human host genetic factors in mycobacterial and Salmonella infection: lessons from single gene disorders in IL-12/IL-23-dependent signaling that affect innate and adaptive immunity
    Esther van de Vosse
    Department of Infectious Diseases, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Microbes Infect 8:1167-73. 2006
    ..Alternative IL-12/IL-23-dependent, interferon-gamma-independent pathways of immunity to intracellular bacteria are also discussed...
  16. doi Nontuberculous mycobacterial cervicofacial lymphadenitis in children from the multicenter, randomized, controlled trial in The Netherlands: relevance of polymorphisms in candidate host immunity genes
    Margje H Haverkamp
    Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    Int J Pediatr Otorhinolaryngol 74:752-4. 2010
    ..We studied 22 polymorphisms in relevant candidate genes, some related to periodontitis, in children with NTM lymphadenitis. We also tested for the most common mutation in IFNGR1...
  17. ncbi Control of human host immunity to mycobacteria
    Tom H M Ottenhoff
    Department Immunohematology and Blood Transfusion, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Tuberculosis (Edinb) 85:53-64. 2005
    ..These new findings will be discussed since they provide further insights into the role of type-1 cytokines in immunity to mycobacteria, including M. tuberculosis...
  18. ncbi Polymorphisms in proinflammatory genes and susceptibility to typhoid fever and paratyphoid fever
    Soegianto Ali
    Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    J Interferon Cytokine Res 27:271-9. 2007
    ....
  19. ncbi Human genetics of intracellular infectious diseases: molecular and cellular immunity against mycobacteria and salmonellae
    Esther van de Vosse
    Department of Infectious Diseases, Leiden University Medical Centre, Leiden, Netherlands
    Lancet Infect Dis 4:739-49. 2004
    ..New findings discussed in this review provide further and sometimes surprising insights into the role of type 1 cytokines, and into the unexpected heterogeneity seen in these syndromes...
  20. ncbi IL-23 and IL-12 responses in activated human T cells retrovirally transduced with IL-23 receptor variants
    Roelof A de Paus
    Department of Infectious Diseases, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Mol Immunol 45:3889-95. 2008
    ..In conclusion, the reported association between R381Q and P310L variants of the IL-23R and autoimmune diseases does not depend on differences in functional activity between wild-type and R381Q and P310L variants of the IL-23R...
  21. ncbi Genetic variations in the interleukin-12/interleukin-23 receptor (beta1) chain, and implications for IL-12 and IL-23 receptor structure and function
    Esther van de Vosse
    Department of Infectious Diseases, Leiden University Medical Center LUMC, Leiden, The Netherlands
    Immunogenetics 54:817-29. 2003
    ..Based on these analyses, we propose an integrated model of IL-12Rbeta1 structure and function. This significantly enhances our molecular understanding of the human IL-12 and IL-23 systems...
  22. doi The influence of influenza virus infections on the development of tuberculosis
    Roelof A de Paus
    Department of Infectious Diseases, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Tuberculosis (Edinb) 93:338-42. 2013
    ..We conclude that in an endemic country like Indonesia, an influenza virus infection is not a major determinant for developing clinically manifest tuberculosis...
  23. doi Differential expression and function of human IL-12Rβ2 polymorphic variants
    Roelof A de Paus
    Department of Infectious Diseases, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Mol Immunol 56:380-9. 2013
    ..Two of these are relatively common in some populations and may be used in future association studies to reveal a role for IL-12 in infectious and/or immune related diseases. ..
  24. doi Pulmonary Mycobacterium abscessus: a canary in the cystic fibrosis coalmine
    Margje H Haverkamp
    Department of Infectious Diseases, Leiden University Medical Center, Albinusdreef 2, Leiden, The Netherlands
    J Infect 64:609-12. 2012
    ..The forme fruste of CF should be considered in the analysis of host factors predisposing for PNTM...
  25. doi IFN-α cannot substitute lack of IFN-γ responsiveness in cells of an IFN-γR1 deficient patient
    Diederik van de Wetering
    Department of Infectious Diseases, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands
    Clin Immunol 138:282-90. 2011
    ....
  26. pmc Genome-wide expression profiling identifies type 1 interferon response pathways in active tuberculosis
    Tom H M Ottenhoff
    Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 7:e45839. 2012
    ....
  27. ncbi Psoriasis is not associated with IL-12p70/IL-12p40 production and IL12B promoter polymorphism
    Nicolle H R Litjens
    Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    J Invest Dermatol 122:923-6. 2004
    ..Together, psoriasis is not associated with a promoter polymorphism in the IL12B gene nor with the production of IL-12p70 by LPS-stimulated blood cells...
  28. doi Inhibition of the type I immune responses of human monocytes by IFN-α and IFN-β
    Roelof A de Paus
    Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    Cytokine 61:645-55. 2013
    ..Our findings indicate that IFN-α/β play a significant role in the immunopathogenesis of bacterial infections, for example Mycobacterium tuberculosis infection...
  29. doi Functional analysis of naturally occurring amino acid substitutions in human IFN-gammaR1
    Diederik van de Wetering
    Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    Mol Immunol 47:1023-30. 2010
    ..The other variants are deleterious mutations with V61E, V61Q, Y66C, C77F, C77Y and C85Y leading to complete IFN-gammaR1 deficiency, while V63G and I87T lead to partial IFN-gammaR1 deficiency...
  30. ncbi Severe Mycobacterium bovis BCG infections in a large series of novel IL-12 receptor beta1 deficient patients and evidence for the existence of partial IL-12 receptor beta1 deficiency
    Elgin G R Lichtenauer-Kaligis
    Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Immunol 33:59-69. 2003
    ..Collectively, our findings indicate that idiopathic, unusually severe infections due to M. bovis BCG can be caused by complete as well as partial IL-12Rbeta1 deficiency...
  31. pmc Influence of polymorphisms in innate immunity genes on susceptibility to invasive aspergillosis after stem cell transplantation
    Mark G J de Boer
    Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 6:e18403. 2011
    ....
  32. ncbi Nontuberculous mycobacterial infections in children with inborn errors of the immune system
    Margje H Haverkamp
    Department of Infectious Diseases, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands Electronic address
    J Infect 68:S134-50. 2014
    ..Furthermore, it is likely that many new candidate genes and pathways crucial for mycobacterial immunity will be identified. ..
  33. ncbi Heredity versus environment in tuberculosis in twins: the 1950s United Kingdom Prophit Survey Simonds and Comstock revisited
    Ellen A van der Eijk
    Department of Infectious Diseases, C5 P, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Am J Respir Crit Care Med 176:1281-8. 2007
    ..His analysis did not take into account strong imbalance of variables within subgroups, underestimating possible confounding effects of environmental factors...
  34. ncbi IL-12Rβ1 deficiency: mutation update and description of the IL12RB1 variation database
    Esther van de Vosse
    Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    Hum Mutat 34:1329-39. 2013
    ..All these variants have been deposited in the online IL12RB1 variation database (www.LOVD.nl/IL12RB1). In this article, we review the function of IL-12Rβ1 and molecular genetics of human IL12RB1. ..
  35. pmc Dynamic changes in pro- and anti-inflammatory cytokine profiles and gamma interferon receptor signaling integrity correlate with tuberculosis disease activity and response to curative treatment
    Edhyana Sahiratmadja
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Infect Immun 75:820-9. 2007
    ..The depression of both IFN-gamma production and IFN-gammaR signaling may synergize in contributing to defective host control in active TB...
  36. doi Cutaneous leukocytoclastic vasculitis due to Salmonella enteritidis in a child with interleukin-12 receptor beta-1 deficiency
    Serkan Filiz
    Department of Pediatric Allergy and Immunology, Akdeniz University School of Medicine, Antalya, TurkeyDepartment of Pediatric Hematology, Akdeniz University School of Medicine, Antalya, TurkeyDepartment of Pathology, Akdeniz University School of Medicine, Antalya, TurkeyDepartment of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    Pediatr Dermatol 31:236-40. 2014
    ..Here we report a case of an IL-12Rβ1 deficiency with cutaneous leukocytoclastic vasculitis due to Salmonella enteritidis. ..
  37. ncbi Correlating interleukin-12 stimulated interferon-γ production and the absence of ectodermal dysplasia and anhidrosis (EDA) in patients with mutations in NF-κB essential modulator (NEMO)
    Margje H Haverkamp
    Department of Infectious Diseases, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands
    J Clin Immunol 34:436-43. 2014
    ..We compared cytokine production by NEMO-ID patients with and without EDA...
  38. ncbi Intact IFN-γR1 expression and function distinguishes Langerhans cell histiocytosis from mendelian susceptibility to mycobacterial disease
    Willemijn T Quispel
    Immunology Laboratory, Willem Alexander Children s Hospital, Leiden University Medical Center, Leiden, The Netherlands
    J Clin Immunol 34:84-93. 2014
    ..We hypothesized that similar defects might underlie the pathogenesis of LCH...
  39. ncbi Two patients with complete defects in interferon gamma receptor-dependent signaling
    Jeroen G Noordzij
    Department of Immunology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    J Clin Immunol 27:490-6. 2007
    ..Protein expression and interferon-gamma dependent signaling were not detectable...
  40. ncbi Detection of Mycobacterium leprae infection employing a combinatorial approach of anti-45 kDa and modified anti-PGL-I antibody detection assays
    Om Parkash
    J Med Microbiol 56:1129-30. 2007
  41. pmc Discrepancy between Mycobacterium tuberculosis-specific gamma interferon release assays using short and prolonged in vitro incubation
    Eliane M S Leyten
    Department of Infectious Diseases, C5P, Leiden University Medical Center, RC Leiden, The Netherlands
    Clin Vaccine Immunol 14:880-5. 2007
    ....
  42. pmc Lack of immune responses to Mycobacterium tuberculosis DosR regulon proteins following Mycobacterium bovis BCG vaccination
    May Young Lin
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Infect Immun 75:3523-30. 2007
    ..tuberculosis infection, our findings support the development of vaccination strategies incorporating DosR regulon antigens to complement and improve the current BCG vaccine...
  43. ncbi Mycobacterium paratuberculosis is recognized by Toll-like receptors and NOD2
    Gerben Ferwerda
    Department of Internal Medicine and Nijmegen University Center for Infectious Diseases, Radboud University Nijmegen Medical Center, Geert Grooteplein Zuid 8, 6525 GA Nijmegen, The Netherlands
    J Leukoc Biol 82:1011-8. 2007
    ..paratuberculosis. These results demonstrate that TLR2, TLR4, and NOD2 are involved in the recognition of M. paratuberculosis by the innate immune system...
  44. pmc Assessment of cross-reactivity between Mycobacterium bovis and M. kansasii ESAT-6 and CFP-10 at the T-cell epitope level
    H Martin Vordermeier
    TB Research Group, Department of Statutory and Exotic Bacterial Diseases, Veterinary Laboratories Agency, Woodham Lane, New Haw, Addlestone KT15 3NB, United Kingdom
    Clin Vaccine Immunol 14:1203-9. 2007
    ....
  45. ncbi Serological heterogeneity against various Mycobacterium leprae antigens and its use in serodiagnosis of leprosy patients
    Om Parkash
    J Med Microbiol 56:1259-61. 2007
  46. pmc Innate immunity to Mycobacterium tuberculosis
    Reinout van Crevel
    Department of Internal Medicine, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Clin Microbiol Rev 15:294-309. 2002
    ..tuberculosis. These basic mechanisms augment our understanding of disease pathogenesis and clinical course and will be of help in designing adjunctive treatment strategies...
  47. pmc A user-friendly, highly sensitive assay to detect the IFN-gamma secretion by T cells
    Paul L A M Corstjens
    Leiden University Medical Center, Department of Molecular Cell Biology, Leiden, The Netherlands
    Clin Biochem 41:440-4. 2008
    ..Development of a user-friendly test alternative to ELISA-based assays to detect IFN-gamma by in vitro cultured peripheral blood mononuclear cells (PBMC) stimulated with pathogen-derived antigens...
  48. pmc Characterization of two heparan sulphate-binding sites in the mycobacterial adhesin Hlp
    Michelle I Portugal
    Laboratório de Microbiologia Celular, Instituto Oswaldo Cruz, FIOCRUZ, Av, Brasil 4365, Manguinhos, Rio de Janeiro, RJ 21045 900, Brazil
    BMC Microbiol 8:75. 2008
    ..In the present study, nuclear magnetic resonance (NMR) was used to map the binding site(s) of Hlp to heparan sulfate and identify the nature of the amino acid residues directly involved in this interaction...
  49. pmc Influenza virus vaccination induces interleukin-12/23 receptor beta 1 (IL-12/23R beta 1)-independent production of gamma interferon (IFN-gamma) and humoral immunity in patients with genetic deficiencies in IL-12/23R beta 1 or IFN-gamma receptor I
    Tjitske De Boer
    Department of Infectious Diseases, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Clin Vaccine Immunol 15:1171-5. 2008
    ..In conclusion, influenza virus vaccination induces IL-12/23-independent IFN-gamma production by T cells and can result in sufficient humoral protection in both IL-12/23R beta 1- and pIFN-gamma RI-deficient individuals...
  50. ncbi Human anti-inflammatory macrophages induce Foxp3+ GITR+ CD25+ regulatory T cells, which suppress via membrane-bound TGFbeta-1
    Nigel D L Savage
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    J Immunol 181:2220-6. 2008
    ....
  51. pmc Rational combination of peptides derived from different Mycobacterium leprae proteins improves sensitivity for immunodiagnosis of M. leprae infection
    Annemieke Geluk
    Department of Infectious Diseases Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Clin Vaccine Immunol 15:522-33. 2008
    ..Thus, this study provides the first evidence for the possibility of immunodiagnostics for leprosy based on mixtures of peptides recognized in the context of different HLA alleles...
  52. ncbi Association of polymorphisms in IL-12/IFN-gamma pathway genes with susceptibility to pulmonary tuberculosis in Indonesia
    Edhyana Sahiratmadja
    Eijkman Institute for Molecular Biology, Jakarta, Indonesia
    Tuberculosis (Edinb) 87:303-11. 2007
    ..03; OR=0.6). This new finding supports the role that IL-23-of which IL12B encodes a subunit--plays in generation of memory T cells...
  53. ncbi Human deficiencies in type-1 cytokine receptors reveal the essential role of type-1 cytokines in immunity to intracellular bacteria
    Tom H M Ottenhoff
    Dept of Immunohematology and Blood Transfusion, Leiden University Medical Center, Building 1, E3 Q, P O Box 9600, 2300 RC Leiden, The Netherlands
    Adv Exp Med Biol 531:279-94. 2003
    ..These findings are summarized, discussed and placed in a broader context in relation to protective immune mechanisms and disease susceptibility...
  54. pmc PPE protein (Rv3873) from DNA segment RD1 of Mycobacterium tuberculosis: strong recognition of both specific T-cell epitopes and epitopes conserved within the PPE family
    Limei Meng Okkels
    Department of Infectious Disease Immunology, Statens Serum Institut, DK 2300 Copenhagen, Denmark
    Infect Immun 71:6116-23. 2003
    ..The immunodominant epitope (residues 118 to 135) for both TB patients and BCG-vaccinated individuals was found to be highly conserved among a large number of PPE family members...
  55. ncbi IL-12 receptor deficiency revisited: IL-23-mediated signaling is also impaired in human genetic IL-12 receptor beta1 deficiency
    Marieke A Hoeve
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Immunol 33:3393-7. 2003
    ..The syndrome caused by IL-12Rbeta1-deficiency thus needs to be reinterpreted as resulting from defective IL-12-as well as IL-23-mediated immunity...
  56. ncbi Mapping immune reactivity toward Rv2653 and Rv2654: two novel low-molecular-mass antigens found specifically in the Mycobacterium tuberculosis complex
    Claus Aagaard
    Department of Infectious Disease Immunology, Statens Serum Institute, Copenhagen, Denmark
    J Infect Dis 189:812-9. 2004
    ..Rv2654 is a strongly recognized T cell antigen that is highly specific for TB and has potential as a novel cell-mediated immunity-based TB diagnostic agent...
  57. ncbi Pulmonary delivery of chitosan-DNA nanoparticles enhances the immunogenicity of a DNA vaccine encoding HLA-A*0201-restricted T-cell epitopes of Mycobacterium tuberculosis
    Maytal Bivas-Benita
    Leiden Amsterdam Center for Drug Research, Division of Pharmaceutical Technology, PO Box 9502, 2300 RA Leiden, The Netherlands
    Vaccine 22:1609-15. 2004
    ....
  58. pmc Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteria
    Frank A W Verreck
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, Albinusdreef 2, NL 2333 ZA, Leiden, The Netherlands
    Proc Natl Acad Sci U S A 101:4560-5. 2004
    ..Mphi heterogeneity thus may be an important determinant of immunity and disease outcome in intracellular bacterial infection...
  59. ncbi Induction of in vivo functional Db-restricted cytolytic T cell activity against a putative phosphate transport receptor of Mycobacterium tuberculosis
    Marta Romano
    Laboratory of Mycobacterial Immunology, Pasteur Institute of Brussels, Brussels, Belgium
    J Immunol 172:6913-21. 2004
    ..These results highlight the potential of DNA vaccination for the induction and characterization of CD4(+) and particularly CD8(+) T cell responses against mycobacterial Ags...
  60. ncbi Single nucleotide polymorphisms (SNPs) at -238 and -308 positions in the TNFalpha promoter: clinical and bacteriological evaluation in leprosy
    Patrícia R Vanderborght
    Leprosy Laboratory, Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, Brazil
    Int J Lepr Other Mycobact Dis 72:143-8. 2004
    ....
  61. ncbi Interferon-gamma production in response to M. tuberculosis antigens in TB patients in Indonesia
    Yanri W Subronto
    Dept of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Adv Exp Med Biol 531:249-60. 2003
  62. ncbi Innate immunity to Mycobacterium tuberculosis
    Reinout van Crevel
    Dept of Internal Medicine, University Medical Center Nijmegen, The Netherlands
    Adv Exp Med Biol 531:241-7. 2003
  63. ncbi Human host defense and cytokines in mycobacterial infectious diseases: interleukin-18 cannot compensate for genetic defects in the interleukin-12 system
    Frank A W Verreck
    Clin Infect Dis 35:210-2. 2002
  64. ncbi Genetics, cytokines and human infectious disease: lessons from weakly pathogenic mycobacteria and salmonellae
    Tom H M Ottenhoff
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Nat Genet 32:97-105. 2002
    ..Ten syndromes have thus far been identified. Recent insights in genetically controlled host defense and susceptibility to mycobacterial disease are discussed...
  65. pmc Epitope mapping of the immunodominant antigen TB10.4 and the two homologous proteins TB10.3 and TB12.9, which constitute a subfamily of the esat-6 gene family
    Rikke Louise Vinther Skjøt
    Department of TB Immunology, Statens Serum Institute, Copenhagen, Denmark
    Infect Immun 70:5446-53. 2002
    ..4 stimulated the largest responses, but epitopes unique to both TB10.3 and TB12.9 were found. The relevance of the findings for TB vaccine development and as a potential mechanism for immune evasion is discussed...
  66. ncbi Divergent role for TNF-alpha in IFN-gamma-induced killing of Toxoplasma gondii and Salmonella typhimurium contributes to selective susceptibility of patients with partial IFN-gamma receptor 1 deficiency
    Riny Janssen
    Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    J Immunol 169:3900-7. 2002
    ..We propose that the divergent role of TNF-alpha in IFN-gamma-induced killing of T. gondii and S. typhimurium may at least partially explain the highly selective susceptibility of patients...
  67. pmc T-cell responses to the Mycobacterium tuberculosis-specific antigen ESAT-6 in Brazilian tuberculosis patients
    Fernando L L Cardoso
    Leprosy Laboratory, Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, Brazil
    Infect Immun 70:6707-14. 2002
    ..tuberculosis infection in an area of TB endemicity...
  68. ncbi Role of tumor necrosis factor-alpha and interleukin-10 promoter gene polymorphisms in leprosy
    Adalberto R Santos
    Leprosy Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil
    J Infect Dis 186:1687-91. 2002
    ..These data indicate that a relationship exists between TNF-alpha and IL-10 promoter polymorphisms and the development of PB leprosy...
  69. ncbi Tuberculin skin testing and in vitro T cell responses to ESAT-6 and culture filtrate protein 10 after infection with Mycobacterium marinum or M. kansasii
    Sandra M Arend
    Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    J Infect Dis 186:1797-807. 2002
    ..ELISA and ELISPOT yielded comparable results, as did whole antigen and peptides (P<.0001). These results may be relevant for the development of novel assays for diagnosis of tuberculosis...
  70. ncbi Kinetics of T cell-activation molecules in response to Mycobacterium tuberculosis antigens
    Paulo R Z Antas
    Laboratório de Hanseníase, Instituto Oswaldo Cruz, FIOCRUZ, 21045 900 Rio de Janeiro, RJ, Brasil
    Mem Inst Oswaldo Cruz 97:1097-9. 2002
    ....
  71. ncbi Interleukin (IL)-12 and IL-23 are key cytokines for immunity against Salmonella in humans
    Calman MacLennan
    Medical Research Council Centre for Immune Regulation, Division of Immunity and Infection, University of Birmingham, Birmingham, Alabama, USA
    J Infect Dis 190:1755-7. 2004
    ..Investigation of the IL-12/IL-23-IFN- gamma axis should be considered in patients with invasive salmonella disease...
  72. ncbi Study of the antibody response against Mycobacterium tuberculosis antigens in Warao Amerindian children in Venezuela
    Z Araujo
    Catedra de Immunologia, Escuela de Medicina José María Vargas, Facultad de Medicina, Universidad Central de Venezuela, Apartado 4043, Caracas 1010A, Venezuela
    Mem Inst Oswaldo Cruz 99:517-24. 2004
    ....
  73. ncbi Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells
    Marieke A Hoeve
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Immunol 36:661-70. 2006
    ....
  74. ncbi Introduction: new susceptibility genes in mycobacterial infectious diseases
    Tom H M Ottenhoff
    Microbes Infect 8:1117-8. 2006
  75. pmc Use of enzyme-linked immunospot assay with Mycobacterium tuberculosis-specific peptides for diagnosis of recent infection with M. tuberculosis after accidental laboratory exposure
    Eliane M S Leyten
    Department of Infectious Diseases, C5P, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    J Clin Microbiol 44:1197-201. 2006
    ..6, and TB7.7 for the diagnosis of latent infection. In particular, positive responses to peptides 2 to 6 of TB37.6 were observed exclusively in recently infected persons...
  76. ncbi HLA and leprosy in the pre and postgenomic eras
    Annemieke Geluk
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center
    Hum Immunol 67:439-45. 2006
    ..Thus current state-of-the-art HLA immunogenetics can provide new tools for specific diagnosis of M. leprae infection, which can impact our understanding of leprosy transmission and can lead to improved intervention...
  77. ncbi Human T-cell responses to 25 novel antigens encoded by genes of the dormancy regulon of Mycobacterium tuberculosis
    Eliane M S Leyten
    Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    Microbes Infect 8:2052-60. 2006
    ..Particularly strong IFN-gamma responses to latency antigens were observed in latently infected individuals, suggesting that immune responses against these antigens may contribute to controlling latent M. tuberculosis infection...
  78. pmc Immunogenicity of eight dormancy regulon-encoded proteins of Mycobacterium tuberculosis in DNA-vaccinated and tuberculosis-infected mice
    Virginie Roupie
    Mycobacterial Immunology, WIV Pasteur Institute Brussels, 642 Engelandstraat, B1180 Brussels, Belgium
    Infect Immun 75:941-9. 2007
    ..These findings have implications for proof-of-concept studies in mice mimicking tuberculosis (TB) latency models and their extrapolation to humans for potential new vaccination strategies against TB...
  79. pmc T-cell recognition of the HspX protein of Mycobacterium tuberculosis correlates with latent M. tuberculosis infection but not with M. bovis BCG vaccination
    Annemieke Geluk
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Infect Immun 75:2914-21. 2007
    ..Thus, we suggest that subunit vaccines incorporating HspX and/or other latency antigens, as well as recombinant BCG strains expressing latency antigens need to be considered as new vaccines against TB...
  80. pmc Recognition of stage-specific mycobacterial antigens differentiates between acute and latent infections with Mycobacterium tuberculosis
    Abebech Demissie
    Armauer Hansen Research Institute, Addis Ababa, Ethiopia
    Clin Vaccine Immunol 13:179-86. 2006
    ....
  81. ncbi Presentation of interleukin-12/-23 receptor beta1 deficiency with various clinical symptoms of Salmonella infections
    Ozden Sanal
    Immunology Division, Hacettepe University Children s Hospital, Ankara, Turkey
    J Clin Immunol 26:1-6. 2006
    ..IL-12/IL-23p40/IL-12R/IL-23Rbeta1 deficiency seem to be underdiagnosed in patients with salmonellosis, and since such patients need prolonged therapy, diagnosis is important...
  82. ncbi Phenotypic and functional characterization of CD4 T cells expressing killer Ig-like receptors
    Jeroen van Bergen
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    J Immunol 173:6719-26. 2004
    ..Together, our data indicate that KIR-expressing CD4 T cells are predominantly HLA class II-restricted effector memory Th1 cells, and that a significant, previously unrecognized fraction of effector memory Th1 cells expresses KIR...
  83. pmc Epstein-Barr virus gp42 is posttranslationally modified to produce soluble gp42 that mediates HLA class II immune evasion
    Maaike E Ressing
    Department of Medical Microbiology, Leiden University Medical Center, Bldg 1 E4, P P O Box 9600, 2300 RC Leiden, The Netherlands
    J Virol 79:841-52. 2005
    ..These results imply that soluble gp42 is generated during EBV lytic infection and could contribute to undetected virus production by mediating evasion from T-cell immunity...
  84. ncbi Expression of FOXP3 mRNA is not confined to CD4+CD25+ T regulatory cells in humans
    Mary E Morgan
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Hum Immunol 66:13-20. 2005
    ..These results indicate that FOXP3 expression in humans, unlike mice, may not be specific for cells with a regulatory phenotype and may be only a consequence of activation status...
  85. ncbi Evaluation of vaccines in the EU TB Vaccine Cluster using a guinea pig aerosol infection model of tuberculosis
    Ann Williams
    Health Protection Agency, Porton Down, Salisbury SP4 OJG, UK
    Tuberculosis (Edinb) 85:29-38. 2005
    ..A relatively high aerosol-challenge dose and evaluation over a protracted time post-challenge allowed superior protection over BCG to be demonstrated by BCG boosted with MVA and fowl pox vectors expressing Ag85A...
  86. pmc ESAT-6/CFP-10 fusion protein and peptides for optimal diagnosis of mycobacterium tuberculosis infection by ex vivo enzyme-linked immunospot assay in the Gambia
    Philip C Hill
    Tuberculosis Division, Bacterial Diseases Programme, Medical Research Council Unit, MRC Labs, P O Box 273, Banjul, The Gambia
    J Clin Microbiol 43:2070-4. 2005
    ..007). A fusion protein of ESAT-6 and CFP-10 is equivalent to overlapping peptides for the diagnosis of latent M. tuberculosis infection. Use of a combination of peptides and fusion protein offers improved sensitivity...
  87. pmc Postgenomic approach to identify novel Mycobacterium leprae antigens with potential to improve immunodiagnosis of infection
    Annemieke Geluk
    Department of Immunohematology and Blood Transfusion, LUMC PO Box 9600, 2300 RC Leiden, The Netherlands
    Infect Immun 73:5636-44. 2005
    ..leprae-exposed individuals. These proteins may provide new tools to develop tests for specific diagnosis of M. leprae infection and may enhance our understanding of leprosy and its transmission...
  88. ncbi Monokine induced by interferon gamma and IFN-gamma response to a fusion protein of Mycobacterium tuberculosis ESAT-6 and CFP-10 in Brazilian tuberculosis patients
    Clarice Abramo
    Laboratory of Immunology, Department of Parasitology, Microbiology and Immunology, Biological Sciences Institute, Federal University of Juiz de Fora, 36036 330 Juiz de Fora, Brazil
    Microbes Infect 8:45-51. 2006
    ..tuberculosis-specific antigens ESAT-6/CFP-10. These results point to MIG as a potential novel biomarker that may be helpful in assessing downstream responses induced by IFN-gamma in TB...
  89. ncbi Phenotypic and functional profiling of human proinflammatory type-1 and anti-inflammatory type-2 macrophages in response to microbial antigens and IFN-gamma- and CD40L-mediated costimulation
    Frank A W Verreck
    LUMC, Albinusdreef 2, Leiden NL 2333 ZA, The Netherlands
    J Leukoc Biol 79:285-93. 2006
    ..This is likely to be relevant for host-pathogen interactions in chronic bacterial infections and provides a model for dissecting pro- and anti-inflammatory cascades...
  90. pmc Identification and characterization of the ESAT-6 homologue of Mycobacterium leprae and T-cell cross-reactivity with Mycobacterium tuberculosis
    Annemieke Geluk
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Infect Immun 70:2544-8. 2002
    ..Moreover, our results suggest that there is significant cross-reactivity between T-ESAT-6 and L-ESAT-6, which has implications for the use of ESAT-6 as tool for diagnosis of leprosy and TB in areas where both diseases are endemic...