Christi J van Asperen

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint Possible consequences of applying guidelines to healthy women with a family history of breast cancer
    C J van Asperen
    Center for Human and Clinical Genetics, Department of Clinical Genetics, Leiden University Medical Center, The Netherlands
    Eur J Hum Genet 11:633-6. 2003
  2. ncbi request reprint Risk estimation for healthy women from breast cancer families: new insights and new strategies
    Christi J van Asperen
    Center of Human and Clinical Genetics, Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Cancer Epidemiol Biomarkers Prev 13:87-93. 2004
  3. pmc Exploring the link between MORF4L1 and risk of breast cancer
    Griselda Martrat
    Translational Research Laboratory, Catalan Institute of Oncology, Bellvitge Institute for Biomedical Research IDIBELL, Gran Via 199, L Hospitalet del Llobregat 08908, Spain
    Breast Cancer Res 13:R40. 2011
  4. pmc Genomewide high-density SNP linkage analysis of non-BRCA1/2 breast cancer families identifies various candidate regions and has greater power than microsatellite studies
    Anna Gonzalez-Neira
    Genotyping Unit, CeGen, Human Cancer Genetics Programme, Spanish National Cancer Centre, Spain
    BMC Genomics 8:299. 2007
  5. doi request reprint Opening the psychological black box in genetic counseling. The psychological impact of DNA testing is predicted by the counselees' perception, the medical impact by the pathogenic or uninformative BRCA1/2-result
    Joël Vos
    Department of Clinical Genetics, Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Psychooncology 21:29-42. 2012
  6. doi request reprint Exploring the short-term impact of DNA-testing in breast cancer patients: the counselees' perception matters, but the actual BRCA1/2 result does not
    Joël Vos
    Department of Clinical Genetics, Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Patient Educ Couns 86:239-51. 2012
  7. ncbi request reprint Prognostic factors for hereditary cancer distress six months after BRCA1/2 or HNPCC genetic susceptibility testing
    Iris van Oostrom
    Department of Clinical Genetics, Erasmus MC, University Medical Center Rotterdam, Westzeedijk 112 114, 3016 AH, Rotterdam, The Netherlands
    Eur J Cancer 43:71-7. 2007
  8. ncbi request reprint What's the message? Interpretation of an uninformative BRCA1/2 test result for women at risk of familial breast cancer
    Sandra van Dijk
    Department of Medical Decision Making, Leiden University Medical Center, Leiden, The Netherlands
    Genet Med 7:239-45. 2005
  9. doi request reprint Family communication matters: the impact of telling relatives about unclassified variants and uninformative DNA-test results
    Joël Vos
    Department of Clinical Genetics, Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Genet Med 13:333-41. 2011
  10. ncbi request reprint Clinical characteristics affect the impact of an uninformative DNA test result: the course of worry and distress experienced by women who apply for genetic testing for breast cancer
    Sandra van Dijk
    Department of Medical Decision making and Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    J Clin Oncol 24:3672-7. 2006

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Possible consequences of applying guidelines to healthy women with a family history of breast cancer
    C J van Asperen
    Center for Human and Clinical Genetics, Department of Clinical Genetics, Leiden University Medical Center, The Netherlands
    Eur J Hum Genet 11:633-6. 2003
    ..These guidelines, however, are arbitrary and only limited data are available on the efficacy of this surveillance for high-risk healthy women...
  2. ncbi request reprint Risk estimation for healthy women from breast cancer families: new insights and new strategies
    Christi J van Asperen
    Center of Human and Clinical Genetics, Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Cancer Epidemiol Biomarkers Prev 13:87-93. 2004
    ..This extension might offer a good alternative for breast cancer risk estimation in clinical practice...
  3. pmc Exploring the link between MORF4L1 and risk of breast cancer
    Griselda Martrat
    Translational Research Laboratory, Catalan Institute of Oncology, Bellvitge Institute for Biomedical Research IDIBELL, Gran Via 199, L Hospitalet del Llobregat 08908, Spain
    Breast Cancer Res 13:R40. 2011
    ..To gain deeper insight into this pathway and its influence on cancer risk, we searched for novel components through protein physical interaction screens...
  4. pmc Genomewide high-density SNP linkage analysis of non-BRCA1/2 breast cancer families identifies various candidate regions and has greater power than microsatellite studies
    Anna Gonzalez-Neira
    Genotyping Unit, CeGen, Human Cancer Genetics Programme, Spanish National Cancer Centre, Spain
    BMC Genomics 8:299. 2007
    ....
  5. doi request reprint Opening the psychological black box in genetic counseling. The psychological impact of DNA testing is predicted by the counselees' perception, the medical impact by the pathogenic or uninformative BRCA1/2-result
    Joël Vos
    Department of Clinical Genetics, Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Psychooncology 21:29-42. 2012
    ..In this study, we aimed at quantifying the effect that perception has in genetic counseling for hereditary breast/ovarian cancer...
  6. doi request reprint Exploring the short-term impact of DNA-testing in breast cancer patients: the counselees' perception matters, but the actual BRCA1/2 result does not
    Joël Vos
    Department of Clinical Genetics, Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Patient Educ Couns 86:239-51. 2012
    ..These studies were criticized for their small range of predictors, mediators, outcomes and contextual factors. We studied the short-term impact of DNA-testing with an extended model...
  7. ncbi request reprint Prognostic factors for hereditary cancer distress six months after BRCA1/2 or HNPCC genetic susceptibility testing
    Iris van Oostrom
    Department of Clinical Genetics, Erasmus MC, University Medical Center Rotterdam, Westzeedijk 112 114, 3016 AH, Rotterdam, The Netherlands
    Eur J Cancer 43:71-7. 2007
    ..Individuals who may benefit from additional support may be identified before result disclosure using a short instrument assessing the relevant aspects...
  8. ncbi request reprint What's the message? Interpretation of an uninformative BRCA1/2 test result for women at risk of familial breast cancer
    Sandra van Dijk
    Department of Medical Decision Making, Leiden University Medical Center, Leiden, The Netherlands
    Genet Med 7:239-45. 2005
    ....
  9. doi request reprint Family communication matters: the impact of telling relatives about unclassified variants and uninformative DNA-test results
    Joël Vos
    Department of Clinical Genetics, Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Genet Med 13:333-41. 2011
    ....
  10. ncbi request reprint Clinical characteristics affect the impact of an uninformative DNA test result: the course of worry and distress experienced by women who apply for genetic testing for breast cancer
    Sandra van Dijk
    Department of Medical Decision making and Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    J Clin Oncol 24:3672-7. 2006
    ..Moreover, the clinical heterogeneity within this group has not yet been considered. This study provides prospective data about the course of cancer-specific worry and distress for different groups of test applicants...
  11. pmc A method to assess the clinical significance of unclassified variants in the BRCA1 and BRCA2 genes based on cancer family history
    Encarna B Gomez Garcia
    Department of Clinical Genetics, University Hospital Maastricht, Maastricht, The Netherlands
    Breast Cancer Res 11:R8. 2009
    ..The aim of the present study was to identify which is the best combination of clinical parameters that can predict whether a UV is deleterious, to be used for the classification of UVs...
  12. doi request reprint A counselee-oriented perspective on risk communication in genetic counseling: explaining the inaccuracy of the counselees' risk perception shortly after BRCA1/2 test result disclosure
    Joël Vos
    Department of Clinical Genetics, Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Genet Med 13:800-11. 2011
    ..These predictors reflect the personal meaning of genetic risks and are expected to explain/mediate the impact of genetic counseling on risk-perception-accuracy...
  13. ncbi request reprint The common sense model of self-regulation and psychological adjustment to predictive genetic testing: a prospective study
    Iris van Oostrom
    Department of Clinical Genetics, Erasmus MC, University Medical Center Rotterdam, The Netherlands
    Psychooncology 16:1121-9. 2007
    ..Identifying unhelpful representations and cognitive restructuring may be appropriate interventions to help distressed individuals undergoing genetic susceptibility testing for a BRCA1/2 or a HNPCC-related mutation...
  14. pmc A whisper-game perspective on the family communication of DNA-test results: a retrospective study on the communication process of BRCA1/2-test results between proband and relatives
    Joël Vos
    Department of Clinical Genetics, Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Fam Cancer 10:87-96. 2011
    ..More attention is required for how probands disseminate information to relatives. Genetic-counsellors may help by supporting the probands in communicating to relatives, e.g. by providing clear summary letters for relatives...
  15. pmc Exome sequencing of germline DNA from non-BRCA1/2 familial breast cancer cases selected on the basis of aCGH tumor profiling
    Florentine S Hilbers
    Department of Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands
    PLoS ONE 8:e55734. 2013
    ..Our data also support the emerging view that non-BRCA1/2 hereditary breast cancer families have a very heterogeneous genetic basis...
  16. doi request reprint Disentangling the Babylonian speech confusion in genetic counseling: an analysis of the reliability and validity of the nomenclature for BRCA1/2 DNA-test results other than pathogenic
    Joël Vos
    Department of Clinical Genetics, Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Genet Med 11:742-9. 2009
    ..Therefore, we conducted a theoretical and empirical analysis of the terms most frequently used in articles between 2002 and 2007 for BRCA 1/2-test results other than pathogenic...
  17. ncbi request reprint A prospective study of the impact of genetic susceptibility testing for BRCA1/2 or HNPCC on family relationships
    Iris van Oostrom
    Department of Clinical Genetics, Erasmus MC, University Medical Center Rotterdam, Westzeedijk 114, 3016 AH Rotterdam, The Netherlands
    Psychooncology 16:320-8. 2007
    ..Open communication between relatives should be stimulated because a lack of open communication may be an important determinant of familial adverse effects...
  18. pmc MUTYH gene variants and breast cancer in a Dutch case–control study
    Astrid A Out
    Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Breast Cancer Res Treat 134:219-27. 2012
    ..This extensive case–control study could not confirm previously reported associations of MUTYH variants with BC, although it was too small to exclude subtle effects on BC susceptibility...
  19. doi request reprint Putting it all behind: long-term psychological impact of an inconclusive DNA test result for breast cancer
    Sandra van Dijk
    Department of Medical Psychology, Leiden University Medical Center, Leiden, The Netherlands
    Genet Med 10:745-50. 2008
    ..We assessed the influence of beliefs women held about their inconclusive DNA-result on psychological well-being and whether women had been able to put the period of DNA testing behind them...
  20. doi request reprint Genome-wide linkage scan in Dutch hereditary non-BRCA1/2 breast cancer families identifies 9q21-22 as a putative breast cancer susceptibility locus
    Rogier A Oldenburg
    Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Genes Chromosomes Cancer 47:947-56. 2008
    ..001). Five candidate genes were selected from the region around D9S167 and their coding regions subjected to direct sequence analysis in 16 probands. No clear pathogenic mutations were found in any of these genes...
  21. pmc A simple method for co-segregation analysis to evaluate the pathogenicity of unclassified variants; BRCA1 and BRCA2 as an example
    Leila Mohammadi
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands
    BMC Cancer 9:211. 2009
    ..Statistical methods have been described in literature but these methods are not always easy to apply in a diagnostic setting...
  22. ncbi request reprint Prediction of BRCA1/2 mutation status in patients with ovarian cancer from a hospital-based cohort
    Catharina E Jacobi
    Departments of Medical Decision Making, Leiden University Medical Center, Leiden, The Netherlands
    Genet Med 9:173-9. 2007
    ..To describe patient, tumor, and family histories of cancer in a hospital-based cohort of patients with ovarian cancer and to identify the predictive value of these characteristics for (non)carrying a BRCA1 or BRCA2 mutation...
  23. doi request reprint Rare variants in XRCC2 as breast cancer susceptibility alleles
    Florentine S Hilbers
    Department of Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands
    J Med Genet 49:618-20. 2012
    ..However, the breast cancer risk associated with these variants needs further evaluation...
  24. doi request reprint Intronic variants in BRCA1 and BRCA2 that affect RNA splicing can be reliably selected by splice-site prediction programs
    Maaike P G Vreeswijk
    Center for Human and Clinical Genetics, Leiden University Medical Center LUMC, Leiden, The Netherlands
    Hum Mutat 30:107-14. 2009
    ..In four cases (2.5%) a false-positive prediction was observed. For DNA diagnostic laboratories, these programs are therefore very useful to select intronic variants that are likely to affect RNA splicing for further analysis...
  25. pmc Clinical correlates of low-risk variants in FGFR2, TNRC9, MAP3K1, LSP1 and 8q24 in a Dutch cohort of incident breast cancer cases
    Petra E A Huijts
    Department of Clinical Genetics, K5 R, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Breast Cancer Res 9:R78. 2007
    ..Seven SNPs in five genomic loci were recently found to confer a mildly increased risk of breast cancer...
  26. ncbi request reprint Variants of uncertain clinical significance as a result of BRCA1/2 testing: impact of an ambiguous breast cancer risk message
    Sandra van Dijk
    Department of Medical Decision Making, Leiden University Medical Center, Leiden, The Netherlands
    Genet Test 8:235-9. 2004
    ..03). They were very comparable to women who received an inconclusive result on all post-disclosure measures. Our results suggest that discussing a VUCS result in genetic counseling does not give rise for concern...
  27. doi request reprint The counselees' self-reported request for psychological help in genetic counseling for hereditary breast/ovarian cancer: not only psychopathology matters
    Joël Vos
    Department of Clinical Genetics, Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Psychooncology 22:902-10. 2013
    ..g., surgery decisions), genetics-specific needs (e.g., feeling vulnerable/stigmatized), and existential concerns (e.g., meaning in life)...
  28. doi request reprint Genetic counseling does not fulfill the counselees' need for certainty in hereditary breast/ovarian cancer families: an explorative assessment
    Joël Vos
    Department of Clinical Genetics, Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Psychooncology 22:1167-76. 2013
    ..e., level of fulfillment of NfC) regarding the specific domains of DNA test result, heredity and cancer. We also examined relationships of NfC-PC with coping styles and distress...
  29. pmc Allele-specific regulation of FGFR2 expression is cell type-dependent and may increase breast cancer risk through a paracrine stimulus involving FGF10
    Petra E A Huijts
    Department of Clinical Genetics, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Breast Cancer Res 13:R72. 2011
    ..Allele-specific regulation of FGFR2 mRNA expression has been reported previously, but the molecular basis for the association of these variants with breast cancer has remained elusive to date...
  30. doi request reprint Variants of uncertain significance in BRCA1 and BRCA2 assessment of in silico analysis and a proposal for communication in genetic counselling
    Setareh Moghadasi
    Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    J Med Genet 50:74-9. 2013
    ..Our aims were to investigate the utility of in silico characteristics in the classification of VUS and whether initial VUS classifications justify differences in communication protocols during counselling...
  31. doi request reprint Differences and similarities in breast cancer risk assessment models in clinical practice: which model to choose?
    Catharina E Jacobi
    Department of Medical Decision Making, Leiden University Medical Center, Leiden, The Netherlands
    Breast Cancer Res Treat 115:381-90. 2009
    ..When models include personal risk factors, surveillance thresholds have to be reformulated. For current clinical practice, the Tyrer-Cuzick Model and the BOADICEA Model seem good choices...
  32. ncbi request reprint The CHEK2*1100delC variant acts as a breast cancer risk modifier in non-BRCA1/BRCA2 multiple-case families
    Rogier A Oldenburg
    Centre for Human and Clinical Genetics, Leiden University Medical Centre, Leiden, The Netherlands
    Cancer Res 63:8153-7. 2003
    ..Our results support a model in which CHEK2*1100delC interacts with an as yet unknown gene (or genes) to increase breast cancer risk...
  33. ncbi request reprint Feeling at risk: how women interpret their familial breast cancer risk
    Sandra van Dijk
    Department of Medical Decision Making, Leiden University Medical Center, Leiden, The Netherlands
    Am J Med Genet A 131:42-9. 2004
    ..These beliefs that women hold about their risk status, and concomitant levels of stress should play a prominent role in genetic counseling...