Research Topics
Genomes and GenesSpecies | C van KootenSummaryAffiliation: Leiden University Country: The Netherlands Publications
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Detail Information
Publications
Blockade of costimulatory pathways of T-cell activation: the solution to acute and chronic rejection?C van Kooten
Department of Nephrology, Leiden University Medical Center, The Netherlands
Curr Opin Nephrol Hypertens 8:675-80. 1999..On the basis of the extensive tissue distribution of CD40, it is likely that the CD40/CD40L system plays a much broader role...- CD40-CD40 ligandC van Kooten
Department of Nephrology, Leiden University Medical Center, The Netherlands
J Leukoc Biol 67:2-17. 2000.... - Presence of a population of CD20+, CD38- B lymphocytes with defective proliferative responsiveness in the synovial compartment of patients with rheumatoid arthritisC C Reparon-Schuijt
Leiden University Medical Center, The Netherlands
Arthritis Rheum 44:2029-37. 2001..The capacity of these cells to respond to activation by the production of Ig supports the notion that these cells might serve as Ig-producing effector cells and, as such, play a role in the pathophysiology of RA... - Interleukin-17 and CD40-ligand synergistically enhance cytokine and chemokine production by renal epithelial cellsA M Woltman
Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
J Am Soc Nephrol 11:2044-55. 2000..These data suggest an important role for T cells in renal allograft rejection by acting on parenchymal cells via both soluble mediators and direct cellular contact... - Secretion of anti-citrulline-containing peptide antibody by B lymphocytes in rheumatoid arthritisC C Reparon-Schuijt
Leiden University Medical Center, The Netherlands
Arthritis Rheum 44:41-7. 2001..The local presence of anti-CCP-secreting cells in the inflamed joints provides evidence for an antigen-driven maturation of CCP-specific B cells at the site of inflammation in RA... 
Anti-C1q autoantibodies in murine lupus nephritisL A Trouw
Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
Clin Exp Immunol 135:41-8. 2004..In conclusion, anti-C1q antibodies are already present in serum and immune deposits of the kidney early in life and therefore can play a role in nephritis during experimental SLE-like disease in mice...- Possible role for CD40-CD40L in the regulation of interstitial infiltration in the kidneyC van Kooten
Department of Nephrology, Leiden University Hospital, The Netherlands
Kidney Int 51:711-21. 1997..These data suggest that CD40L-CD40 interactions between infiltrating activated T cells and PTEC might be an important factor in the regulation of interstitial infiltration within the kidney... 
Mannan-binding lectin mediates renal ischemia/reperfusion injury independent of complement activationP van der Pol
Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
Am J Transplant 12:877-87. 2012..Taken together, these data reveal a crucial role for MBL in the early pathophysiology of renal IRI and identify MBL as a novel therapeutic target in kidney transplantation...- Synergistic effect of interleukin-1 and CD40L on the activation of human renal tubular epithelial cellsC van Kooten
Department of Nephrology, Leiden University, The Netherlands
Kidney Int 56:41-51. 1999..We studied this regulation in more detail by combined treatment with CD40 ligand and the proinflammatory cytokine interleukin-1 (IL-1) in vitro... - Secretory immunoglobulin A (IgA) responses in IgA nephropathy patients after mucosal immunization, as part of a polymeric IgA responseJ W Eijgenraam
Department of Nephrology, Leiden University Medical Centre, Leiden, The Netherlands
Clin Exp Immunol 152:227-32. 2008..No differences between IgAN patients and controls were detected, suggesting that the size distribution of antigen-specific IgA in the circulation is not disturbed specifically in IgAN patients... - Rapamycin induces apoptosis in monocyte- and CD34-derived dendritic cells but not in monocytes and macrophagesA M Woltman
Department of Nephrology, Leiden University Medical Center, The Netherlands
Blood 98:174-80. 2001..The fact that Rapa exerts a specific effect on DCs but not on monocytes and macrophages might contribute to the unique actions of Rapa in the prevention of allograft rejection and other immune responses... - Immunological function of tubular epithelial cells: the functional implications of CD40 expressionC van Kooten
Department of Nephrology, Leiden University Medical Center, Leiden, The
Exp Nephrol 8:203-7. 2000..In the present review we will discuss the potential implications of CD40-CD40L interactions for the activation of TECs and its immunological function... - Immune deposition of C1q and anti-C1q antibodies in the kidney is dependent on the presence of glomerular IgGL A Trouw
Department of Nephrology, D3 P 39 Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
Mol Immunol 40:595-602. 2003..Therefore we hypothesize that high and fluctuating levels of IgG as observed in patients with SLE may contribute to flares of renal inflammation in those patients with anti-C1q autoantibodies... - Calcineurin inhibitors affect B cell antibody responses indirectly by interfering with T cell helpS Heidt
Department of Immunohaematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
Clin Exp Immunol 159:199-207. 2010..Furthermore, our studies support the necessity of intervening in T cell helper function to attenuate humoral responses... - Quantification of dendritic cell subsets in human renal tissue under normal and pathological conditionsA M Woltman
Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
Kidney Int 71:1001-8. 2007..In conclusion, we show that human kidneys contain a dense network of myeloid and plasmacytoid DCs and provide the tools for phenotyping and enumeration of these cells to better understand interindividual differences in immune responses... - Tubular epithelial cells: A critical cell type in the regulation of renal inflammatory processesC van Kooten
Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
Exp Nephrol 7:429-37. 1999..In the present review we will outline the capacity of TECs to produce inflammatory mediators and discuss the different mechanisms involved in the regulation of production of these mediators... - Functions of CD40 on B cells, dendritic cells and other cellsC van Kooten
Department of Nephrology, Leiden University Hospital, 1 C3P, Albinusdreef 2, 2333 AA, Leiden, The Netherlands
Curr Opin Immunol 9:330-7. 1997..Finally, the critical role of CD40-CD40L interactions in the development of various disease states has been fully appreciated... - Pancreas allograft biopsies with positive c4d staining and anti-donor antibodies related to worse outcome for patientsH de Kort
Department of Pathology, Leiden University Medical Center, The Netherlands
Am J Transplant 10:1660-7. 2010..Hence, C4d should be used as an additional marker in combination with DSA in the evaluation of pancreas transplant biopsies... - Glucocorticoids transform CD40-triggering of dendritic cells into an alternative activation pathway resulting in antigen-presenting cells that secrete IL-10D Rea
Department of Immunohematology and Blood Bank and the Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
Blood 95:3162-7. 2000..Collectively, our results demonstrate that DEX profoundly modulates CD40-dependent DC activation and suggest that the resulting alternatively activated DCs can be exploited for suppression of unwanted T-cell responses in vivo... - IgA1 glycosylation in IgA nephropathy: as sweet as it can beJ W Eijgenraam
Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
Kidney Int 73:1106-8. 2008..As only a small fraction of IgA in IgAN patients is abnormally glycosylated, it is probable that a more detailed molecular analysis at the single cell level is required to unravel the cause of this abnormality... - Role of tubular cells in progressive renal diseaseC van Kooten
Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
Kidney Blood Press Res 22:53-61. 1999.... - Maturation-resistant dendritic cells induce hyporesponsiveness in alloreactive CD45RA+ and CD45RO+ T-cell populationsA M Woltman
Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
Am J Transplant 6:2580-91. 2006..The finding that also alloreactive memory T cells can be regulated supports the rationale of cell-based therapies to obtain allograft-specific tolerance in transplant recipients... - Ultraviolet-A (UVA-1) radiation suppresses immunoglobulin production of activated B lymphocytes in vitroM C A Polderman
Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands
Clin Exp Immunol 145:528-34. 2006..Both effects may be responsible for the observed improvement of disease activity in SLE patients... - Underglycosylation of IgA in IgA nephropathy: more than a diagnostic marker?A Roos
Department of Clinical Chemistry, Leiden University Medical Center, Leiden, The Netherlands
Kidney Int 71:1089-91. 2007..Further studies on the nature, production, regulation, and cellular and molecular interactions of this undergalactosylated IgA may facilitate disease diagnosis and provide further insight into the pathogenesis of this important disease... - Cytokine cross-talk between tubular epithelial cells and interstitial immunocompetent cellsC van Kooten
Department of Nephrology, Leiden University Medical Center, The Netherlands
Curr Opin Nephrol Hypertens 10:55-9. 2001..Interfering in this cross-talk between tubular epithelial cells and infiltrating cells might provide new options for therapeutic intervention... - A pathogenic role for secretory IgA in IgA nephropathyB D Oortwijn
Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
Kidney Int 69:1131-8. 2006..Furthermore, we showed that SIgA is accumulated in the glomeruli of an IgAN patient. These data suggest an important role for SIgA in the pathogenesis of IgAN... - Proteinase 3 interacts with a 111-kD membrane molecule of human umbilical vein endothelial cellsM E Taekema-Roelvink
Department of Nephrology, Leiden University Medical Center, The Netherlands
J Am Soc Nephrol 11:640-8. 2000..It is hypothesized that PR3, either released systemically or locally at inflammatory sites following activation of primed polymorphonuclear neutrophils, may lead to endothelial cell injury and activation of endothelial cells... - Randomized trial of short-course high-dose erythropoietin in donation after cardiac death kidney transplant recipientsZ Aydin
Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
Am J Transplant 12:1793-800. 2012..8 vs. placebo 78.7%, p = 1.00). Epoetin treatment significantly increased the risk of thrombotic events at 1 month and 1 year (Epoetin 24.4% vs. placebo 6.4%, p = 0.02)... - Glomerular deposition of C1q and anti-C1q antibodies in mice following injection of antimouse C1q antibodiesL A Trouw
Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
Clin Exp Immunol 132:32-9. 2003..This deposition is stable for at least 2 weeks, causes complement activation, leucocyte influx and can lead to mild albuminuria... - Polyreactivity of human IgG Fc-binding phage antibodies constructed from synovial fluid CD38+ B cells of patients with rheumatoid arthritisW J E Van Esch
Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
J Autoimmun 19:241-50. 2002.... - Isolation, culture, characterization and use of human renal tubular epithelial cellsC van Kooten
Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
J Nephrol 14:204-10. 2001..The present paper provides an overview of the isolation, culture and characterization of tubular epithelial cells, with a main emphasis on cells from human origin... - Differential requirements for induction of total immunoglobulin and physiological rheumatoid factor production by human peripheral blood B cellsW J van Esch
Department of Rheumatology, Leiden University Medical Centre, Leiden, The Netherlands
Clin Exp Immunol 123:496-504. 2001..Together, these results indicate that conditions for the induction of total Ig and physiological RFs are different... - CD40 ligation enhances IL-15 production by tubular epithelial cellsM Weiler
Department of Nephrology, Soroka University Medical Center, Ben-Gurion University of the Negev, Faculty of Health Sciences, Beer-Sheva, Israel
J Am Soc Nephrol 12:80-7. 2001..Each signal alone induces IL-15 in similar magnitudes, and both signals are additive. Because IL-15 is a major T-cell activator, this interaction may contribute to graft rejection... - A soluble form of TRAP (CD40 ligand) is rapidly released after T cell activationD Graf
Robert Koch Institute, Berlin, Germany
Eur J Immunol 25:1749-54. 1995..Like other members of the TNF superfamily (e.g. TNF-alpha, Fas/APO-1 ligand), TRAP thus has the potential to be biologically active not only in a transmembrane form but also as a soluble molecule... - The CD40 antigen and its ligandJ Banchereau
Schering Plough, Laboratory for Immunological Research, Dardilly, France
Annu Rev Immunol 12:881-922. 1994.... - Human IgG Fc-binding phage antibodies constructed from synovial fluid CD38+ B cells of patients with rheumatoid arthritis show the imprints of an antigen-dependent process of somatic hypermutation and clonal selectionW J E Van Esch
Department of Rheumatology, Leiden University Medical Centre, Leiden, The Netherlands
Clin Exp Immunol 131:364-76. 2003....