C van Kooten

Summary

Affiliation: Leiden University
Country: The Netherlands

Publications

  1. ncbi request reprint Blockade of costimulatory pathways of T-cell activation: the solution to acute and chronic rejection?
    C van Kooten
    Department of Nephrology, Leiden University Medical Center, The Netherlands
    Curr Opin Nephrol Hypertens 8:675-80. 1999
  2. ncbi request reprint CD40-CD40 ligand
    C van Kooten
    Department of Nephrology, Leiden University Medical Center, The Netherlands
    J Leukoc Biol 67:2-17. 2000
  3. ncbi request reprint Presence of a population of CD20+, CD38- B lymphocytes with defective proliferative responsiveness in the synovial compartment of patients with rheumatoid arthritis
    C C Reparon-Schuijt
    Leiden University Medical Center, The Netherlands
    Arthritis Rheum 44:2029-37. 2001
  4. ncbi request reprint Interleukin-17 and CD40-ligand synergistically enhance cytokine and chemokine production by renal epithelial cells
    A M Woltman
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    J Am Soc Nephrol 11:2044-55. 2000
  5. ncbi request reprint Secretion of anti-citrulline-containing peptide antibody by B lymphocytes in rheumatoid arthritis
    C C Reparon-Schuijt
    Leiden University Medical Center, The Netherlands
    Arthritis Rheum 44:41-7. 2001
  6. pmc Anti-C1q autoantibodies in murine lupus nephritis
    L A Trouw
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Clin Exp Immunol 135:41-8. 2004
  7. ncbi request reprint Possible role for CD40-CD40L in the regulation of interstitial infiltration in the kidney
    C van Kooten
    Department of Nephrology, Leiden University Hospital, The Netherlands
    Kidney Int 51:711-21. 1997
  8. doi request reprint Mannan-binding lectin mediates renal ischemia/reperfusion injury independent of complement activation
    P van der Pol
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Transplant 12:877-87. 2012
  9. ncbi request reprint Synergistic effect of interleukin-1 and CD40L on the activation of human renal tubular epithelial cells
    C van Kooten
    Department of Nephrology, Leiden University, The Netherlands
    Kidney Int 56:41-51. 1999
  10. pmc Secretory immunoglobulin A (IgA) responses in IgA nephropathy patients after mucosal immunization, as part of a polymeric IgA response
    J W Eijgenraam
    Department of Nephrology, Leiden University Medical Centre, Leiden, The Netherlands
    Clin Exp Immunol 152:227-32. 2008

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Blockade of costimulatory pathways of T-cell activation: the solution to acute and chronic rejection?
    C van Kooten
    Department of Nephrology, Leiden University Medical Center, The Netherlands
    Curr Opin Nephrol Hypertens 8:675-80. 1999
    ..On the basis of the extensive tissue distribution of CD40, it is likely that the CD40/CD40L system plays a much broader role...
  2. ncbi request reprint CD40-CD40 ligand
    C van Kooten
    Department of Nephrology, Leiden University Medical Center, The Netherlands
    J Leukoc Biol 67:2-17. 2000
    ....
  3. ncbi request reprint Presence of a population of CD20+, CD38- B lymphocytes with defective proliferative responsiveness in the synovial compartment of patients with rheumatoid arthritis
    C C Reparon-Schuijt
    Leiden University Medical Center, The Netherlands
    Arthritis Rheum 44:2029-37. 2001
    ..The capacity of these cells to respond to activation by the production of Ig supports the notion that these cells might serve as Ig-producing effector cells and, as such, play a role in the pathophysiology of RA...
  4. ncbi request reprint Interleukin-17 and CD40-ligand synergistically enhance cytokine and chemokine production by renal epithelial cells
    A M Woltman
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    J Am Soc Nephrol 11:2044-55. 2000
    ..These data suggest an important role for T cells in renal allograft rejection by acting on parenchymal cells via both soluble mediators and direct cellular contact...
  5. ncbi request reprint Secretion of anti-citrulline-containing peptide antibody by B lymphocytes in rheumatoid arthritis
    C C Reparon-Schuijt
    Leiden University Medical Center, The Netherlands
    Arthritis Rheum 44:41-7. 2001
    ..The local presence of anti-CCP-secreting cells in the inflamed joints provides evidence for an antigen-driven maturation of CCP-specific B cells at the site of inflammation in RA...
  6. pmc Anti-C1q autoantibodies in murine lupus nephritis
    L A Trouw
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Clin Exp Immunol 135:41-8. 2004
    ..In conclusion, anti-C1q antibodies are already present in serum and immune deposits of the kidney early in life and therefore can play a role in nephritis during experimental SLE-like disease in mice...
  7. ncbi request reprint Possible role for CD40-CD40L in the regulation of interstitial infiltration in the kidney
    C van Kooten
    Department of Nephrology, Leiden University Hospital, The Netherlands
    Kidney Int 51:711-21. 1997
    ..These data suggest that CD40L-CD40 interactions between infiltrating activated T cells and PTEC might be an important factor in the regulation of interstitial infiltration within the kidney...
  8. doi request reprint Mannan-binding lectin mediates renal ischemia/reperfusion injury independent of complement activation
    P van der Pol
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Transplant 12:877-87. 2012
    ..Taken together, these data reveal a crucial role for MBL in the early pathophysiology of renal IRI and identify MBL as a novel therapeutic target in kidney transplantation...
  9. ncbi request reprint Synergistic effect of interleukin-1 and CD40L on the activation of human renal tubular epithelial cells
    C van Kooten
    Department of Nephrology, Leiden University, The Netherlands
    Kidney Int 56:41-51. 1999
    ..We studied this regulation in more detail by combined treatment with CD40 ligand and the proinflammatory cytokine interleukin-1 (IL-1) in vitro...
  10. pmc Secretory immunoglobulin A (IgA) responses in IgA nephropathy patients after mucosal immunization, as part of a polymeric IgA response
    J W Eijgenraam
    Department of Nephrology, Leiden University Medical Centre, Leiden, The Netherlands
    Clin Exp Immunol 152:227-32. 2008
    ..No differences between IgAN patients and controls were detected, suggesting that the size distribution of antigen-specific IgA in the circulation is not disturbed specifically in IgAN patients...
  11. ncbi request reprint Rapamycin induces apoptosis in monocyte- and CD34-derived dendritic cells but not in monocytes and macrophages
    A M Woltman
    Department of Nephrology, Leiden University Medical Center, The Netherlands
    Blood 98:174-80. 2001
    ..The fact that Rapa exerts a specific effect on DCs but not on monocytes and macrophages might contribute to the unique actions of Rapa in the prevention of allograft rejection and other immune responses...
  12. ncbi request reprint Immunological function of tubular epithelial cells: the functional implications of CD40 expression
    C van Kooten
    Department of Nephrology, Leiden University Medical Center, Leiden, The
    Exp Nephrol 8:203-7. 2000
    ..In the present review we will discuss the potential implications of CD40-CD40L interactions for the activation of TECs and its immunological function...
  13. ncbi request reprint Immune deposition of C1q and anti-C1q antibodies in the kidney is dependent on the presence of glomerular IgG
    L A Trouw
    Department of Nephrology, D3 P 39 Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Mol Immunol 40:595-602. 2003
    ..Therefore we hypothesize that high and fluctuating levels of IgG as observed in patients with SLE may contribute to flares of renal inflammation in those patients with anti-C1q autoantibodies...
  14. pmc Calcineurin inhibitors affect B cell antibody responses indirectly by interfering with T cell help
    S Heidt
    Department of Immunohaematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Clin Exp Immunol 159:199-207. 2010
    ..Furthermore, our studies support the necessity of intervening in T cell helper function to attenuate humoral responses...
  15. ncbi request reprint Quantification of dendritic cell subsets in human renal tissue under normal and pathological conditions
    A M Woltman
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Kidney Int 71:1001-8. 2007
    ..In conclusion, we show that human kidneys contain a dense network of myeloid and plasmacytoid DCs and provide the tools for phenotyping and enumeration of these cells to better understand interindividual differences in immune responses...
  16. ncbi request reprint Tubular epithelial cells: A critical cell type in the regulation of renal inflammatory processes
    C van Kooten
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Exp Nephrol 7:429-37. 1999
    ..In the present review we will outline the capacity of TECs to produce inflammatory mediators and discuss the different mechanisms involved in the regulation of production of these mediators...
  17. ncbi request reprint Functions of CD40 on B cells, dendritic cells and other cells
    C van Kooten
    Department of Nephrology, Leiden University Hospital, 1 C3P, Albinusdreef 2, 2333 AA, Leiden, The Netherlands
    Curr Opin Immunol 9:330-7. 1997
    ..Finally, the critical role of CD40-CD40L interactions in the development of various disease states has been fully appreciated...
  18. ncbi request reprint Pancreas allograft biopsies with positive c4d staining and anti-donor antibodies related to worse outcome for patients
    H de Kort
    Department of Pathology, Leiden University Medical Center, The Netherlands
    Am J Transplant 10:1660-7. 2010
    ..Hence, C4d should be used as an additional marker in combination with DSA in the evaluation of pancreas transplant biopsies...
  19. ncbi request reprint Glucocorticoids transform CD40-triggering of dendritic cells into an alternative activation pathway resulting in antigen-presenting cells that secrete IL-10
    D Rea
    Department of Immunohematology and Blood Bank and the Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Blood 95:3162-7. 2000
    ..Collectively, our results demonstrate that DEX profoundly modulates CD40-dependent DC activation and suggest that the resulting alternatively activated DCs can be exploited for suppression of unwanted T-cell responses in vivo...
  20. doi request reprint IgA1 glycosylation in IgA nephropathy: as sweet as it can be
    J W Eijgenraam
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Kidney Int 73:1106-8. 2008
    ..As only a small fraction of IgA in IgAN patients is abnormally glycosylated, it is probable that a more detailed molecular analysis at the single cell level is required to unravel the cause of this abnormality...
  21. ncbi request reprint Role of tubular cells in progressive renal disease
    C van Kooten
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Kidney Blood Press Res 22:53-61. 1999
    ....
  22. ncbi request reprint Maturation-resistant dendritic cells induce hyporesponsiveness in alloreactive CD45RA+ and CD45RO+ T-cell populations
    A M Woltman
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Transplant 6:2580-91. 2006
    ..The finding that also alloreactive memory T cells can be regulated supports the rationale of cell-based therapies to obtain allograft-specific tolerance in transplant recipients...
  23. pmc Ultraviolet-A (UVA-1) radiation suppresses immunoglobulin production of activated B lymphocytes in vitro
    M C A Polderman
    Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands
    Clin Exp Immunol 145:528-34. 2006
    ..Both effects may be responsible for the observed improvement of disease activity in SLE patients...
  24. ncbi request reprint Underglycosylation of IgA in IgA nephropathy: more than a diagnostic marker?
    A Roos
    Department of Clinical Chemistry, Leiden University Medical Center, Leiden, The Netherlands
    Kidney Int 71:1089-91. 2007
    ..Further studies on the nature, production, regulation, and cellular and molecular interactions of this undergalactosylated IgA may facilitate disease diagnosis and provide further insight into the pathogenesis of this important disease...
  25. ncbi request reprint Cytokine cross-talk between tubular epithelial cells and interstitial immunocompetent cells
    C van Kooten
    Department of Nephrology, Leiden University Medical Center, The Netherlands
    Curr Opin Nephrol Hypertens 10:55-9. 2001
    ..Interfering in this cross-talk between tubular epithelial cells and infiltrating cells might provide new options for therapeutic intervention...
  26. doi request reprint Randomized trial of short-course high-dose erythropoietin in donation after cardiac death kidney transplant recipients
    Z Aydin
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Transplant 12:1793-800. 2012
    ..8 vs. placebo 78.7%, p = 1.00). Epoetin treatment significantly increased the risk of thrombotic events at 1 month and 1 year (Epoetin 24.4% vs. placebo 6.4%, p = 0.02)...
  27. ncbi request reprint A pathogenic role for secretory IgA in IgA nephropathy
    B D Oortwijn
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Kidney Int 69:1131-8. 2006
    ..Furthermore, we showed that SIgA is accumulated in the glomeruli of an IgAN patient. These data suggest an important role for SIgA in the pathogenesis of IgAN...
  28. ncbi request reprint Proteinase 3 interacts with a 111-kD membrane molecule of human umbilical vein endothelial cells
    M E Taekema-Roelvink
    Department of Nephrology, Leiden University Medical Center, The Netherlands
    J Am Soc Nephrol 11:640-8. 2000
    ..It is hypothesized that PR3, either released systemically or locally at inflammatory sites following activation of primed polymorphonuclear neutrophils, may lead to endothelial cell injury and activation of endothelial cells...
  29. pmc Glomerular deposition of C1q and anti-C1q antibodies in mice following injection of antimouse C1q antibodies
    L A Trouw
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Clin Exp Immunol 132:32-9. 2003
    ..This deposition is stable for at least 2 weeks, causes complement activation, leucocyte influx and can lead to mild albuminuria...
  30. ncbi request reprint Polyreactivity of human IgG Fc-binding phage antibodies constructed from synovial fluid CD38+ B cells of patients with rheumatoid arthritis
    W J E Van Esch
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    J Autoimmun 19:241-50. 2002
    ....
  31. ncbi request reprint Isolation, culture, characterization and use of human renal tubular epithelial cells
    C van Kooten
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    J Nephrol 14:204-10. 2001
    ..The present paper provides an overview of the isolation, culture and characterization of tubular epithelial cells, with a main emphasis on cells from human origin...
  32. pmc Differential requirements for induction of total immunoglobulin and physiological rheumatoid factor production by human peripheral blood B cells
    W J van Esch
    Department of Rheumatology, Leiden University Medical Centre, Leiden, The Netherlands
    Clin Exp Immunol 123:496-504. 2001
    ..Together, these results indicate that conditions for the induction of total Ig and physiological RFs are different...
  33. ncbi request reprint CD40 ligation enhances IL-15 production by tubular epithelial cells
    M Weiler
    Department of Nephrology, Soroka University Medical Center, Ben-Gurion University of the Negev, Faculty of Health Sciences, Beer-Sheva, Israel
    J Am Soc Nephrol 12:80-7. 2001
    ..Each signal alone induces IL-15 in similar magnitudes, and both signals are additive. Because IL-15 is a major T-cell activator, this interaction may contribute to graft rejection...
  34. ncbi request reprint A soluble form of TRAP (CD40 ligand) is rapidly released after T cell activation
    D Graf
    Robert Koch Institute, Berlin, Germany
    Eur J Immunol 25:1749-54. 1995
    ..Like other members of the TNF superfamily (e.g. TNF-alpha, Fas/APO-1 ligand), TRAP thus has the potential to be biologically active not only in a transmembrane form but also as a soluble molecule...
  35. ncbi request reprint The CD40 antigen and its ligand
    J Banchereau
    Schering Plough, Laboratory for Immunological Research, Dardilly, France
    Annu Rev Immunol 12:881-922. 1994
    ....
  36. pmc Human IgG Fc-binding phage antibodies constructed from synovial fluid CD38+ B cells of patients with rheumatoid arthritis show the imprints of an antigen-dependent process of somatic hypermutation and clonal selection
    W J E Van Esch
    Department of Rheumatology, Leiden University Medical Centre, Leiden, The Netherlands
    Clin Exp Immunol 131:364-76. 2003
    ....