C J H van de Velde

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. pmc Quality of life in relation to tamoxifen or exemestane treatment in postmenopausal breast cancer patients: a Tamoxifen Exemestane Adjuvant Multinational (TEAM) Trial side study
    J G H van Nes
    Department of Surgery, K6 R, Leiden University Medical Centre, P O Box 9600, 2300, RC, Leiden, The Netherlands
    Breast Cancer Res Treat 134:267-76. 2012
  2. pmc Surgical treatment for unexplained severe pain of the thyroid gland: report of three cases and concise review of the literature
    Jan van Schaik
    Department of Surgery, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Case Report Med 2011:349756. 2011
  3. pmc Validation study of the prognostic value of cyclin-dependent kinase (CDK)-based risk in Caucasian breast cancer patients
    J G H van Nes
    Department of Surgery, Leiden University Medical Centre, P O Box 9600, Leiden 2300 RC, The Netherlands
    Br J Cancer 100:494-500. 2009
  4. doi request reprint Experts reviews of the multidisciplinary consensus conference colon and rectal cancer 2012: science, opinions and experiences from the experts of surgery
    C J H van de Velde
    Department of Surgery, Leiden University Medical Center, The Netherlands Electronic address
    Eur J Surg Oncol 40:454-68. 2014
  5. ncbi request reprint EURECCA colorectal: multidisciplinary management: European consensus conference colon & rectum
    Cornelis J H Van De Velde
    EURECCA and CC3, European Cancer Organization, European Society of Surgical Oncology, Department of Surgery, Leiden University Medical Center, The Netherlands Electronic address
    Eur J Cancer 50:1.e1-1.e34. 2014
  6. pmc Short-course radiotherapy followed by neo-adjuvant chemotherapy in locally advanced rectal cancer--the RAPIDO trial
    Per J Nilsson
    Department of Molecular Medicine and Surgery, Karolinska Institutet and Center for Surgical Gastroenterology, Karolinska University Hospital, Solna P9 03, SE 171 76 Stockholm, Sweden
    BMC Cancer 13:279. 2013
  7. doi request reprint EURECCA colorectal: multidisciplinary mission statement on better care for patients with colon and rectal cancer in Europe
    Cornelis J H Van De Velde
    EURECCA and CC3, Executive Board of ECCO, Department of Surgery, Leiden University Medical Center, The Netherlands
    Eur J Cancer 49:2784-90. 2013
  8. doi request reprint Specific adverse events predict survival benefit in patients treated with tamoxifen or aromatase inhibitors: an international tamoxifen exemestane adjuvant multinational trial analysis
    Duveken B Y Fontein
    Leiden University Medical Center, Leiden, The Netherlands
    J Clin Oncol 31:2257-64. 2013
  9. pmc Elderly postmenopausal patients with breast cancer are at increased risk for distant recurrence: a tamoxifen exemestane adjuvant multinational study analysis
    Willemien van de Water
    Department of Surgical Oncology, Leiden University Medical Center, Albinusdreef 2, P O 9600, 2300 RC Leiden, The Netherlands
    Oncologist 18:8-13. 2013
  10. doi request reprint Quality assurance in rectal cancer treatment
    C J H van de Velde
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Dig Dis 30:126-31. 2012

Detail Information

Publications106 found, 100 shown here

  1. pmc Quality of life in relation to tamoxifen or exemestane treatment in postmenopausal breast cancer patients: a Tamoxifen Exemestane Adjuvant Multinational (TEAM) Trial side study
    J G H van Nes
    Department of Surgery, K6 R, Leiden University Medical Centre, P O Box 9600, 2300, RC, Leiden, The Netherlands
    Breast Cancer Res Treat 134:267-76. 2012
    ..Certain QoL issues are treatment- and/or time-specific and deserve attention by health care providers. There is a need for careful inquiry into QoL issues by those prescribing endocrine treatment to optimize QoL and treatment adherence...
  2. pmc Surgical treatment for unexplained severe pain of the thyroid gland: report of three cases and concise review of the literature
    Jan van Schaik
    Department of Surgery, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Case Report Med 2011:349756. 2011
    ..Surgical therapy is a successful final option in the treatment of unexplained painful thyroid and painful Hashimoto's thyroiditis...
  3. pmc Validation study of the prognostic value of cyclin-dependent kinase (CDK)-based risk in Caucasian breast cancer patients
    J G H van Nes
    Department of Surgery, Leiden University Medical Centre, P O Box 9600, Leiden 2300 RC, The Netherlands
    Br J Cancer 100:494-500. 2009
    ..CDK-based risk is a prognostic marker of distance recurrence of patients with early breast cancer. More validation would be warranted to use of CDK-based risk into clinical practice...
  4. doi request reprint Experts reviews of the multidisciplinary consensus conference colon and rectal cancer 2012: science, opinions and experiences from the experts of surgery
    C J H van de Velde
    Department of Surgery, Leiden University Medical Center, The Netherlands Electronic address
    Eur J Surg Oncol 40:454-68. 2014
    ..IV colorectal cancer, definitions of quality of surgery, transanal endoscopic microsurgery (TEM), laparoscopic colon and rectal surgery, preoperative radiotherapy and chemoradiotherapy, and how about functional outcome after surgery?..
  5. ncbi request reprint EURECCA colorectal: multidisciplinary management: European consensus conference colon & rectum
    Cornelis J H Van De Velde
    EURECCA and CC3, European Cancer Organization, European Society of Surgical Oncology, Department of Surgery, Leiden University Medical Center, The Netherlands Electronic address
    Eur J Cancer 50:1.e1-1.e34. 2014
    ..The expert panel consisted of representatives of European scientific organisations involved in cancer care of patients with colon and rectal cancer and representatives of national colorectal registries...
  6. pmc Short-course radiotherapy followed by neo-adjuvant chemotherapy in locally advanced rectal cancer--the RAPIDO trial
    Per J Nilsson
    Department of Molecular Medicine and Surgery, Karolinska Institutet and Center for Surgical Gastroenterology, Karolinska University Hospital, Solna P9 03, SE 171 76 Stockholm, Sweden
    BMC Cancer 13:279. 2013
    ..The concept of neo-adjuvant chemotherapy has been proven successful in gastric cancer, hepatic metastases from colorectal cancer and is currently tested in primary colon cancer...
  7. doi request reprint EURECCA colorectal: multidisciplinary mission statement on better care for patients with colon and rectal cancer in Europe
    Cornelis J H Van De Velde
    EURECCA and CC3, Executive Board of ECCO, Department of Surgery, Leiden University Medical Center, The Netherlands
    Eur J Cancer 49:2784-90. 2013
    ..The expert panel consisted of representatives of European scientific organisations involved in cancer care of patients with colon and rectal cancer and representatives of national colorectal registries...
  8. doi request reprint Specific adverse events predict survival benefit in patients treated with tamoxifen or aromatase inhibitors: an international tamoxifen exemestane adjuvant multinational trial analysis
    Duveken B Y Fontein
    Leiden University Medical Center, Leiden, The Netherlands
    J Clin Oncol 31:2257-64. 2013
    ....
  9. pmc Elderly postmenopausal patients with breast cancer are at increased risk for distant recurrence: a tamoxifen exemestane adjuvant multinational study analysis
    Willemien van de Water
    Department of Surgical Oncology, Leiden University Medical Center, Albinusdreef 2, P O 9600, 2300 RC Leiden, The Netherlands
    Oncologist 18:8-13. 2013
    ..The aim of this study was to assess the incidence of breast cancer recurrence (locoregional and distant), and contralateral breast cancer by age at diagnosis...
  10. doi request reprint Quality assurance in rectal cancer treatment
    C J H van de Velde
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Dig Dis 30:126-31. 2012
    ..Recently, it was shown that surgical variation is not only important for patients with rectal cancer, but also plays an important role for the outcome of patients with colon cancer...
  11. pmc Age determines the prognostic role of the cancer stem cell marker aldehyde dehydrogenase-1 in breast cancer
    J Sven D Mieog
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    BMC Cancer 12:42. 2012
    ..The purpose of this study was to compare the expression and the prognostic effect of the breast cancer stem cell marker aldehyde dehydrogenase-1 (ALDH1) in young and elderly breast cancer patients...
  12. pmc NKG2D ligand tumor expression and association with clinical outcome in early breast cancer patients: an observational study
    Esther M de Kruijf
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    BMC Cancer 12:24. 2012
    ..We examined tumor expression and prognostic effect of NKG2DL in breast cancer patients...
  13. doi request reprint Adjuvant tamoxifen and exemestane in early breast cancer (TEAM): a randomised phase 3 trial
    Cornelis J H Van De Velde
    Leiden University Medical Centre, Leiden, Netherlands
    Lancet 377:321-31. 2011
    ..We therefore compared the long-term effects of exemestane monotherapy with sequential treatment (tamoxifen followed by exemestane)...
  14. doi request reprint Switching from tamoxifen to aromatase inhibitors for adjuvant endocrine therapy in postmenopausal patients with early breast cancer
    C J H van de Velde
    Leiden University Medical Center, Department of Surgery, The Netherlands
    Cancer Treat Rev 36:54-62. 2010
    ..This paper reviews studies that have investigated a switch strategy with AIs and considers the implications of these data on treatment choice for postmenopausal patients with hormone receptor-positive breast cancer...
  15. pmc Impact of established prognostic factors and molecular subtype in very young breast cancer patients: pooled analysis of four EORTC randomized controlled trials
    Jos A van der Hage
    Division of Surgical Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Breast Cancer Res 13:R68. 2011
    ..The purpose of this study was to determine the prognostic value of established clinical and pathological prognostic factors in young breast cancer patients...
  16. pmc Efficacy of adjuvant chemotherapy according to hormone receptor status in young patients with breast cancer: a pooled analysis
    Jos A van der Hage
    Leiden University Medical Center, Department of Surgery, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Breast Cancer Res 9:R70. 2007
    ..Therefore, we studied the effect of adjuvant chemotherapy in young patients with breast cancer in relation to hormone receptor status...
  17. pmc The influence of micrometastases on prognosis and survival in stage I-II colon cancer patients: the EnrouteāŠ• Study
    Daniel J Lips
    Department of Surgery, Jeroen Bosch Hospital, Nieuwstraat 34, 5211 NL s Hertogenbosch, The Netherlands
    BMC Surg 11:11. 2011
    ..The purpose of the present study is to delineate the subset of pN0 patients with micrometastases (pN0(micro+)) and evaluate the benefits from adjuvant chemotherapy in pN0(micro+) CC patients...
  18. pmc Gastric cancers of Western European and African patients show different patterns of genomic instability
    Tineke E Buffart
    Dept of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    BMC Med Genomics 4:7. 2011
    ..We aim to study genomic instability patterns of gastric cancers obtained from patients from United Kingdom (UK) and South Africa (SA), in an attempt to support the African enigma hypothesis at the biological level...
  19. pmc Macrodissection versus microdissection of rectal carcinoma: minor influence of stroma cells to tumor cell gene expression profiles
    Elza C de Bruin
    Department of Clinical Oncology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    BMC Genomics 6:142. 2005
    ....
  20. pmc DNA copy number profiles of gastric cancer precursor lesions
    Tineke E Buffart
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    BMC Genomics 8:345. 2007
    ..e. intestinal-type and pyloric gland adenomas, would carry different patterns of DNA copy number changes, possibly reflecting distinct genetic pathways of gastric carcinogenesis in these two adenoma types...
  21. pmc Neo-adjuvant chemotherapy followed by surgery and chemotherapy or by surgery and chemoradiotherapy for patients with resectable gastric cancer (CRITICS)
    Johan L Dikken
    Department of Surgery, K6 R, Leiden University Medical Center, P O Box9600, 2300 RC Leiden, The Netherlands
    BMC Cancer 11:329. 2011
    ..This study aims to obtain an improved overall survival for patients treated with preoperative chemotherapy and surgery by incorporating radiotherapy concurrently with chemotherapy postoperatively...
  22. pmc High-resolution analysis of HLA class I alterations in colorectal cancer
    Jan Willem F Dierssen
    Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands
    BMC Cancer 6:233. 2006
    ..Distinct patterns of HLA surface expression might conceal different immune escape mechanisms employed by the tumors and are worth further study...
  23. pmc Integrating chromosomal aberrations and gene expression profiles to dissect rectal tumorigenesis
    Esther H Lips
    Department of Pathology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    BMC Cancer 8:314. 2008
    ..In order to find markers for tumor staging, we searched for candidate genes on these specific chromosomes...
  24. pmc Introduction of a breast cancer care programme including ultra short hospital stay in 4 early adopter centres: framework for an implementation study
    Mascha de Kok
    Department of Surgery, University Hospital Maastricht, Maastricht, The Netherlands
    BMC Cancer 7:117. 2007
    ..The ultra short stay programme and the applied implementation strategy will be evaluated from the economic perspective...
  25. pmc 2010 SSO John Wayne clinical research lecture: rectal cancer outcome improvements in Europe: population-based outcome registrations will conquer the world
    W van Gijn
    Department of Surgery, K6 R, Leiden University Medical Center, Leiden, The Netherlands
    Ann Surg Oncol 18:691-6. 2011
    ..To further improve outcomes and diminish variation, EURECCA will establish the basis for a strong, multidisciplinary, international audit structure that can be used as a template for similar projects worldwide...
  26. doi request reprint The survival gap between middle-aged and elderly colon cancer patients. Time trends in treatment and survival
    C B M van den Broek
    Department of Surgery, Leiden University Medical Centre, Albinusdreef 2, PO Box 9600 2300 RC, Leiden, The Netherlands
    Eur J Surg Oncol 37:904-12. 2011
    ....
  27. doi request reprint Patterns of care in Dutch postmenopausal patients with hormone-sensitive early breast cancer participating in the Tamoxifen Exemestane Adjuvant Multinational (TEAM) trial
    J G H van Nes
    Department of Surgery, Leiden University Medical Centre, Leiden, The Netherlands
    Ann Oncol 21:974-82. 2010
    ..As there was a nationwide participation in The Netherlands, we studied the variations in patterns of care in the Comprehensive Cancer Centre Regions (CCCRs) and compliance with national guidelines...
  28. doi request reprint An increasing use of defunctioning stomas after low anterior resection for rectal cancer. Is this the way to go?
    H S Snijders
    Leiden University Medical Centre, Leiden, Department of Surgery, The Netherlands
    Eur J Surg Oncol 39:715-20. 2013
    ..In this study, current use of defunctioning stomas was assessed and compared to the use of defunctioning stomas at the time of the TME-trial together with associated outcomes...
  29. doi request reprint Quality assurance in rectal cancer treatment in the Netherlands: a catch up compared to colon cancer treatment
    W van Gijn
    Department of Surgery, Leiden University Medical Center, K6 R, P O Box 9600, 2300 RC Leiden, The Netherlands
    Eur J Surg Oncol 36:340-4. 2010
    ..The aim of this study is to examine the effects of the structural changes in rectal cancer care on survival compared to colon cancer for patients treated before, during and after the TME trial...
  30. doi request reprint Risk factors for sexual dysfunction after rectal cancer treatment
    M M Lange
    Department of Surgery, Leiden University Medical Center, K6 R, P O Box 9600, 2300 RC Leiden, The Netherlands
    Eur J Cancer 45:1578-88. 2009
    ..Patients should be informed preoperatively, and education of surgeons in neuroanatomy may provide the key to the improvement of functional outcome...
  31. ncbi request reprint Neo-adjuvant chemotherapy for operable gastric cancer: long term results of the Dutch randomised FAMTX trial
    H H Hartgrink
    Department of Surgery, Leiden University Medical Centre, P O Box 9600, 2300 RC Leiden, The Netherlands
    Eur J Surg Oncol 30:643-9. 2004
    ..We performed a randomised trial with pre-operative FAMTX vs. surgery alone in order to evaluate the effect of pre-operative chemotherapy on resectability and survival...
  32. doi request reprint Isolated hepatic melphalan perfusion of colorectal liver metastases: outcome and prognostic factors in 154 patients
    L B J van Iersel
    Department of Clinical Oncology, Leiden University Medical Center, Leiden, The Netherlands
    Ann Oncol 19:1127-34. 2008
    ..The aim of this study was to identify prognostic factors for local and systemic failure after isolated hepatic perfusion (IHP) with 200 mg melphalan in patients with colorectal liver metastases...
  33. doi request reprint Tailored follow-up for early breast cancer patients: a prognostic index that predicts locoregional recurrence
    J G H van Nes
    Department of Surgery, Leiden University Medical Centre, K6 R, P O Box 9600, 2300 RC Leiden, The Netherlands
    Eur J Surg Oncol 36:617-24. 2010
    ..After the first year, the main goal is particularly to detect locoregional recurrences (LRR). Our aim was to develop a simple prognostic index to predict LRR to tailor the follow-up programme...
  34. ncbi request reprint Late side effects of short-course preoperative radiotherapy combined with total mesorectal excision for rectal cancer: increased bowel dysfunction in irradiated patients--a Dutch colorectal cancer group study
    K C M J Peeters
    Department of Surgery, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Clin Oncol 23:6199-206. 2005
    ..Also, hospital treatment was recorded for diseases possibly related to late side effects of rectal cancer treatment...
  35. ncbi request reprint Results of a national survey among Dutch surgeons treating patients with colorectal carcinoma. Current opinion about follow-up, treatment of metastasis, and reasons to revise follow-up practice
    I Grossmann
    Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Colorectal Dis 9:787-92. 2007
    ..The common clinical practice and opinion about follow-up for colorectal carcinoma, was evaluated by means of a survey among Dutch general surgeons...
  36. doi request reprint Postoperative complications and survival of elderly breast cancer patients: a FOCUS study analysis
    N A de Glas
    Department of Surgery, Leiden University Medical Center, P O Box 9600, Postzone K6 R, 2300 RC, Leiden, The Netherlands
    Breast Cancer Res Treat 138:561-9. 2013
    ..This suggests that postoperative complications in itself did not lead to higher relative mortality, but that the high relative mortality was most likely due to geriatric parameters such as comorbidity or poor physical function...
  37. pmc Clinical trial of combined radio- and fluorescence-guided sentinel lymph node biopsy in breast cancer
    B E Schaafsma
    Department of Surgery, Leiden University Medical Centre, Leiden, The Netherlands
    Br J Surg 100:1037-44. 2013
    ..The aim of this clinical trial was to evaluate and optimize a hybrid NIR fluorescence and radioactive tracer for SLN detection in patients with breast cancer...
  38. doi request reprint Patients' opinions on quality of care before and after implementation of a short stay programme following breast cancer surgery
    M De Kok
    Department of Surgery, Maastricht University Medical Centre, P Debeyelaan 25, Maastricht, The Netherlands
    Breast 19:404-9. 2010
    ....
  39. ncbi request reprint Explaining differences in attitude toward adjuvant chemotherapy between experienced and inexperienced breast cancer patients
    S J T Jansen
    Department of Medical Decision Making, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Clin Oncol 23:6623-30. 2005
    ..We used this theory to explore in what way the beliefs of experienced patients differed from those of inexperienced patients...
  40. ncbi request reprint Hepatic artery infusion of high-dose melphalan at reduced flow during isolated hepatic perfusion for the treatment of colorectal metastases confined to the liver: a clinical and pharmacologic evaluation
    L B J van Iersel
    Department of Clinical Oncology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Eur J Surg Oncol 33:874-81. 2007
    ..We believe that the low flow and pressure rates found in this study can result in reduced drug penetration of the tumour and thus limited tumour response...
  41. doi request reprint Surgery in metastatic breast cancer: patients with a favorable profile seem to have the most benefit from surgery
    Z M Rashaan
    Department of Surgery, Leiden University Medical Centre, P O Box 9600, 2300 RC Leiden, Netherlands
    Eur J Surg Oncol 38:52-6. 2012
    ..The aim of this study was to assess characteristics associated with surgical treatment and to determine the impact on survival in women with stage IV breast cancer...
  42. doi request reprint High non-compliance in the use of letrozole after 2.5 years of extended adjuvant endocrine therapy. Results from the IDEAL randomized trial
    D B Y Fontein
    Department of Surgical Oncology, Leiden University Medical Centre, Albinusdreef 2, 2333ZA Leiden, The Netherlands
    Eur J Surg Oncol 38:110-7. 2012
    ..The aim of this study was to investigate non-compliance to aromatase inhibitors and factors associated with early treatment discontinuation in the extended adjuvant setting...
  43. ncbi request reprint Extended lymph node dissection for gastric cancer: who may benefit? Final results of the randomized Dutch gastric cancer group trial
    H H Hartgrink
    Department of Surgery, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Clin Oncol 22:2069-77. 2004
    ..We have reviewed the results of our trial after follow-up of more than 10 years...
  44. doi request reprint The Dutch surgical colorectal audit
    N J van Leersum
    Leiden University Medical Center, Leiden, Department of Surgery, The Netherlands
    Eur J Surg Oncol 39:1063-70. 2013
    ..This article illustrates key elements of the DSCA and results of three years of auditing...
  45. pmc Dose optimization for near-infrared fluorescence sentinel lymph node mapping in patients with melanoma
    J R van der Vorst
    Department of Surgery, Leiden University Medical Center, Albinusdreef 2, 2300 RC Leiden, The Netherlands
    Br J Dermatol 168:93-8. 2013
    ..Near-infrared (NIR) fluorescence has been hypothesized to improve SLN mapping...
  46. doi request reprint Differences in outcomes of oesophageal and gastric cancer surgery across Europe
    J L Dikken
    Departments of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Br J Surg 100:83-94. 2013
    ..The present study was designed to evaluate differences in resection rates, outcomes and annual hospital volumes between these countries, and to analyse the relationship between hospital volume and outcomes...
  47. doi request reprint Adherence to treatment guidelines and survival in patients with early-stage breast cancer by age at diagnosis
    W van de Water
    Department of Surgical Oncology, Leiden University Medical Centre, Leiden, The Netherlands
    Br J Surg 99:813-20. 2012
    ..The aim of this study was to assess adherence to treatment guidelines by age at diagnosis, and to examine age-specific survival in relation to adherence to guidelines...
  48. ncbi request reprint How important is the opinion of significant others to cancer patients' adjuvant chemotherapy decision-making?
    A M Stiggelbout
    Department of Medical Decision Making, Leiden University Medical Center, P O Box 9600, 2300, Leiden, The Netherlands
    Support Care Cancer 15:319-25. 2007
    ..We surveyed patients with breast and colorectal cancer about the importance they assigned to the opinions of their significant others and assessed correlates of these importance scores...
  49. doi request reprint Breast cancer in elderly compared to younger patients in the Netherlands: stage at diagnosis, treatment and survival in 127,805 unselected patients
    E Bastiaannet
    Department of Surgery, Leiden University Medical Centre, Leiden, RC, The Netherlands
    Breast Cancer Res Treat 124:801-7. 2010
    ..In the future, specific geriatric screening tools are necessary to identify fit elderly patients who could receive more "aggressive" treatment while best supportive care should be given to frail elderly patients...
  50. ncbi request reprint Real-time intraoperative detection of breast cancer using near-infrared fluorescence imaging and Methylene Blue
    Q R J G Tummers
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Surg Oncol 40:850-8. 2014
    ....
  51. doi request reprint Influence of hospital type on outcomes after oesophageal and gastric cancer surgery
    J L Dikken
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Br J Surg 99:954-63. 2012
    ..The present study examined the distribution of oesophagectomies and gastrectomies between hospital types in the Netherlands, and the relationship between hospital type and outcome...
  52. ncbi request reprint Impact of locoregional treatment on the early-stage breast cancer patients: a retrospective analysis
    J A van der Hage
    Department of Surgery, D6 43, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Eur J Cancer 39:2192-9. 2003
    ..Adjuvant radiotherapy in mastectomised patients was associated with both a significantly superior locoregional control and overall survival. The effect of adjuvant radiotherapy was most profound in patients who had 1-3 positive nodes...
  53. ncbi request reprint Results of European pooled analysis of IORT-containing multimodality treatment for locally advanced rectal cancer: adjuvant chemotherapy prevents local recurrence rather than distant metastases
    M Kusters
    Department of Surgery, Catharina Hospital, Eindhoven, The Netherlands
    Ann Oncol 21:1279-84. 2010
    ..The purpose of this study is to analyze the pooled results of multimodality treatment of locally advanced rectal cancer (LARC) in four major treatment centers with particular expertise in intraoperative radiotherapy (IORT)...
  54. doi request reprint Urinary dysfunction after rectal cancer treatment is mainly caused by surgery
    M M Lange
    Department of Surgery, Leiden University Medical Centre, Leiden, The Netherlands
    Br J Surg 95:1020-8. 2008
    ..This study aimed to evaluate UD during 5 years after total mesorectal excision (TME) and to investigate the influence of preoperative radiotherapy (PRT) and surgical factors...
  55. ncbi request reprint Management of isolated nonresectable liver metastases in colorectal cancer patients: a case-control study of isolated hepatic perfusion with melphalan versus systemic chemotherapy
    L B J van Iersel
    Department of Clinical Oncology, Leiden University Medical Center, Leiden, The Netherlands
    Ann Oncol 21:1662-7. 2010
    ..To compare the median overall survival of patients with isolated nonresectable liver metastases in comparable groups of patients treated with either isolated hepatic perfusion (IHP) with melphalan or systemic chemotherapy...
  56. ncbi request reprint Diabetes in relation to breast cancer relapse and all-cause mortality in elderly breast cancer patients: a FOCUS study analysis
    M Kiderlen
    Department of Surgery, Leiden University Medical Center, Leiden
    Ann Oncol 24:3011-6. 2013
    ..The aim of this study was to assess the impact of diabetes on relapse-free period (RFP) and overall mortality in elderly breast cancer patients...
  57. ncbi request reprint The feasibility and reliability of sentinel node mapping in colorectal cancer
    F S Doekhie
    Department of Surgery K6 R, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Eur J Surg Oncol 31:854-62. 2005
    ..In this paper, studies on the feasibility and reliability of SNM in CRC are reviewed...
  58. doi request reprint Variations in locoregional therapy in postmenopausal patients with early breast cancer treated in different countries
    J G H van Nes
    Department of Surgery, Leiden University Medical Centre, Leiden, The Netherlands
    Br J Surg 97:671-9. 2010
    ..The large number of patients already recruited offered the opportunity to explore locoregional treatment practices between countries...
  59. doi request reprint Multicentre analysis of oncological and survival outcomes following anastomotic leakage after rectal cancer surgery
    M den Dulk
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Br J Surg 96:1066-75. 2009
    ....
  60. doi request reprint Prognostic significance of the tumor-stroma ratio: validation study in node-negative premenopausal breast cancer patients from the EORTC perioperative chemotherapy (POP) trial (10854)
    T J A Dekker
    Department of Surgery, Leiden University Medical Center, P O Box 9600 Albinusdreef, 2, 2300 RC, Leiden, The Netherlands
    Breast Cancer Res Treat 139:371-9. 2013
    ..038-4.669, P = 0.040). This study validates the prognostic value of the tumor-stroma ratio. This parameter can be easily assessed on HE slides and can be implemented next to pathological staging reports to determine patient prognosis...
  61. doi request reprint Age and the effect of physical activity on breast cancer survival: A systematic review
    D B Y Fontein
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Cancer Treat Rev 39:958-65. 2013
    ..In this population of cancer survivors it is therefore imperative to embark on research focused on improving physical functioning in the context of comorbidities and functional limitations...
  62. doi request reprint Relationship between specific adverse events and efficacy of exemestane therapy in early postmenopausal breast cancer patients
    D B Y Fontein
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Ann Oncol 23:3091-7. 2012
    ..Additionally, the relationship between hormone receptor expression and AEs was assessed...
  63. pmc Near-infrared fluorescence sentinel lymph node biopsy in vulvar cancer: a randomised comparison of lymphatic tracers
    B E Schaafsma
    Department of Surgery, Leiden University Medical Centre, Leiden, The Netherlands
    BJOG 120:758-64. 2013
    ..No significant difference was found between ICG:HSA and ICG alone. This trial confirms the feasibility of NIR fluorescence imaging for SLN mapping in vulvar cancer...
  64. doi request reprint Stability of preferences with regard to adjuvant chemotherapy: impact of treatment decision, experience and the passing of time
    S J T Jansen
    Department of Medical Decision Making, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Cancer Care (Engl) 17:74-83. 2008
    ..We conclude that the frequently observed discrepancy in treatment preferences between experienced and inexperienced patients seems to be an effect of the treatment decision and not of experience of the treatment...
  65. ncbi request reprint Prognostic relevance of occult tumour cells in lymph nodes in colorectal cancer
    F S Doekhie
    Department of Surgery K6 R, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Eur J Surg Oncol 32:253-8. 2006
    ..These high-risk patients are possibly identified by occult tumour cell (OTC) assessment in lymph nodes. In this paper, studies on the clinical relevance of OTC in lymph nodes are reviewed...
  66. ncbi request reprint Patterns of local recurrence in rectal cancer; a study of the Dutch TME trial
    M Kusters
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Surg Oncol 36:470-6. 2010
    ..In patients from the Dutch TME trial patterns of local recurrence (LR) in rectal cancer were studied. The purpose was to reconstruct the most likely mechanisms of LR and the effect of preoperative radiotherapy...
  67. doi request reprint Metastatic lymph node ratio in stage III rectal cancer; prognostic significance in addition to the 7th edition of the TNM classification
    J W T Dekker
    Department of Surgery, Leiden University Medical Center, Albinushof 2a, 2300 RC Leiden, The Netherlands
    Eur J Surg Oncol 36:1180-6. 2010
    ..This study assesses the prognostic capacity of the metastatic lymph node ratio (LNR) in addition to the new TNM classification...
  68. doi request reprint Volume and outcome in colorectal cancer surgery
    W van Gijn
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Surg Oncol 36:S55-63. 2010
    ..The objective of this review is to conduct a meta-analysis using the best evidence available on the volume-outcome relationship for colorectal cancer treatment...
  69. doi request reprint Improved survival after resectable non-cardia gastric cancer in The Netherlands: the importance of surgical training and quality control
    P Krijnen
    Leiden Cancer Registry, Comprehensive Cancer Centre West IKW, Leiden, The Netherlands
    Eur J Surg Oncol 35:715-20. 2009
    ..In a population-based study, we evaluated whether the survival of patients with resectable gastric cancer improved over time on a regional level...
  70. ncbi request reprint Common data items in seven European oesophagogastric cancer surgery registries: Towards a European Upper GI cancer audit (EURECCA Upper GI)
    W O de Steur
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Surg Oncol 40:325-9. 2014
    ..The aim of this study was to identify a core dataset of shared items in the different data registries which can be used for future collaboration between countries...
  71. doi request reprint Prevention of seroma formation after axillary dissection in breast cancer: a systematic review
    A J M van Bemmel
    Department of Surgery, Leiden University Medical Centre, The Netherlands
    Eur J Surg Oncol 37:829-35. 2011
    ..The aim of this paper is to provide a systematic review of studies and reports on risk factors and preventive measures. Surgery lies at the core of seroma formation; therefore focus will be placed on surgical ways of reducing seroma...
  72. pmc The impact of the perception of treatment choice on satisfaction with treatment, experienced chemotherapy burden and current quality of life
    S J T Jansen
    Department of Medical Decision Making, J10S, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Br J Cancer 91:56-61. 2004
    ..In cases when the decision to be treated or not has potential consequences for the chance of survival, patients' QoL may not be improved by the perception of having had a choice of treatment...
  73. ncbi request reprint Carcinoembryonic antigen (CEA) measurement during follow-up for rectal carcinoma is useful even if normal levels exist before surgery. A retrospective study of CEA values in the TME trial
    I Grossmann
    Department of Surgery, University Medical Center Groningen, University of Groningen, PO Box 30 000, 9700 RD Groningen, The Netherlands
    Eur J Surg Oncol 33:183-7. 2007
    ..One reason is the assumption that when a normal CEA value exists before curative resection of CRC, it will neither rise during follow-up. This study investigates this relationship...
  74. doi request reprint Expression of cell adhesion molecules and prognosis in breast cancer
    S Saadatmand
    Department of Surgery, Leiden University Medical Centre, Leiden, The Netherlands
    Br J Surg 100:252-60. 2013
    ..The prognostic value of tumour expression of N-cadherin, E-cadherin, carcinoembryonic antigen (CEA) and epithelial CAM (Ep-CAM) was evaluated in patients with breast cancer...
  75. doi request reprint The EURECCA project: Data items scored by European colorectal cancer audit registries
    W van Gijn
    Department of Surgery, Leiden University Medical Center, K6 R, PO Box 9600, 2300 RC Leiden, The Netherlands
    Eur J Surg Oncol 38:467-71. 2012
    ..The aim of this study is to compare the data items used by the nine registries participating in EURECCA to identify a core dataset and explore options for future research...
  76. ncbi request reprint Risk factors for faecal incontinence after rectal cancer treatment
    M M Lange
    Department of Surgery, Leiden University Medical Centre, Leiden, The Netherlands
    Br J Surg 94:1278-84. 2007
    ..Low anterior resection (LAR) may result in faecal incontinence. This study aimed to identify risk factors for long-term faecal incontinence after total mesorectal excision (TME) with or without preoperative radiotherapy (PRT)...
  77. pmc Clinical impact of MMP and TIMP gene polymorphisms in gastric cancer
    F J G M Kubben
    Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands
    Br J Cancer 95:744-51. 2006
    ..We conclude that MMP-related SNPs, especially MMP-7(-181A>G) and TIMP-2(303C>T), may be helpful in identifying gastric cancer patients with a poor clinical outcome...
  78. doi request reprint Patterns of local recurrence in rectal cancer: a single-center experience
    M Kusters
    Department of Surgery, Leiden University Medical Center, The Netherlands
    Ann Surg Oncol 16:289-96. 2009
    ..Bilateral LLND is more effective in reducing the chance of local recurrence than unilateral LLND. Either surgical approach, with or without LLND, requires reliable imaging during work-up...
  79. doi request reprint Localization of non-palpable breast cancer using a radiolabelled titanium seed
    Y E A van Riet
    Department of Surgery, Catharina Hospital, Eindhoven, The Netherlands
    Br J Surg 97:1240-5. 2010
    ..Use of an iodine-125-radiolabelled (I-125) seed for localization of non-palpable breast tumours could potentially prevent these problems...
  80. ncbi request reprint Missing forms and dropout in the TME quality of life substudy
    H Putter
    Department of Medical Statistics, Leiden University Medical Centre, Leiden, The Netherlands
    Qual Life Res 14:857-65. 2005
    ..We study patterns of dropout and evaluate the impact of missing forms in the TME QOL substudy...
  81. ncbi request reprint Isolated hepatic perfusion for the treatment of colorectal metastases confined to the liver: recent trends and perspectives
    J Rothbarth
    Department of Surgery, K6 R, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Eur J Cancer 40:1812-24. 2004
    ..The results of these studies show that high response rates and high survival rates can be achieved by IHP. In this article, the current status, recent developments and future perspectives of IHP are discussed...
  82. ncbi request reprint Radiation induces different changes in expression profiles of normal rectal tissue compared with rectal carcinoma
    I D Nagtegaal
    Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands
    Virchows Arch 446:127-35. 2005
    ..In the current study, we analyzed the effects of irradiation on gene expression in normal and tumor tissue of rectal cancer patients...
  83. ncbi request reprint Low Maruyama index surgery for gastric cancer: blinded reanalysis of the Dutch D1-D2 trial
    K C M J Peeters
    Department of Surgery, K6 R, Leiden University Medical Center, PO Box 9600, RC Leiden, 2300, The Netherlands
    World J Surg 29:1576-84. 2005
    ..A compelling dose-response effect reveals that the MI is a quantitative yardstick for assessing the adequacy of lymphadenectomy in gastric cancer...
  84. doi request reprint Variation in case-mix between hospitals treating colorectal cancer patients in the Netherlands
    N E Kolfschoten
    Leiden University Medical Centre, Dept of Surgery, The Netherlands
    Eur J Surg Oncol 37:956-63. 2011
    ....
  85. pmc Use of aspirin postdiagnosis improves survival for colon cancer patients
    E Bastiaannet
    Department of Surgery, Leiden University Medical Centre, The Netherlands
    Br J Cancer 106:1564-70. 2012
    ..Aim of the present observational population-based study was to assess the therapeutic effect on overall survival of aspirin/NSAIDs as adjuvant treatment used after the diagnosis of colorectal cancer patients...
  86. doi request reprint Professionals' opinion on follow-up in breast cancer patients; perceived purpose and influence of patients' risk factors
    M van Hezewijk
    Department of Radiation Oncology, Leiden University Medical Center, The Netherlands
    Eur J Surg Oncol 37:217-24. 2011
    ..The study focuses on current practice, purpose and perceived effects, and preferred frequency and duration of follow-up...
  87. ncbi request reprint Improved diagnosis and treatment of anastomotic leakage after colorectal surgery
    M den Dulk
    Department of Surgery, Haga Hospital, The Hague, The Netherlands
    Eur J Surg Oncol 35:420-6. 2009
    ..This study aimed at testing feasibility of a standardised postoperative surveillance protocol to reduce delay in the diagnosis of anastomotic leakage (AL) and, subsequently, mortality...
  88. ncbi request reprint Patients' needs and preferences in routine follow-up for early breast cancer; an evaluation of the changing role of the nurse practitioner
    M van Hezewijk
    Departments of Radiation Oncology, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Eur J Surg Oncol 37:765-73. 2011
    ..The aim of this study was to evaluate the effect of the introduction of nurse practitioners (NPs) in a breast cancer unit on patients' informational needs, preferences and attitude towards follow-up...
  89. ncbi request reprint Long-term survival with non-proportional hazards: results from the Dutch Gastric Cancer Trial
    H Putter
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Centre, University of Leiden, The Netherlands
    Stat Med 24:2807-21. 2005
    ..We illustrate a number of ways of dealing with survival data that do not obey the proportional hazards assumption, each of which can be easily implemented in standard statistical packages...
  90. pmc Loss of Ep-CAM (CO17-1A) expression predicts survival in patients with gastric cancer
    I Songun
    Department of Surgery, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Br J Cancer 92:1767-72. 2005
    ..Loss of Ep-CAM-expression identifies aggressive tumours especially in patients with stage I and II disease. This information may be helpful in selecting patients suitable for surgery or for additional treatment pre- or postoperatively...
  91. doi request reprint Combined expression of the non-receptor protein tyrosine kinases FAK and Src in primary colorectal cancer is associated with tumor recurrence and metastasis formation
    P de Heer
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Surg Oncol 34:1253-61. 2008
    ..The aim of the current study was to examine the expression of FAK, Src, and paxillin using immunohistochemistry in the context of disease progression and to evaluate its clinical significance as a prognostic factor...
  92. doi request reprint Origin of presacral local recurrence after rectal cancer treatment
    M Kusters
    Department of Surgery, Catharina Hospital, Eindhoven, The Netherlands
    Br J Surg 97:1582-7. 2010
    ....
  93. pmc Benefit from preoperative radiotherapy in rectal cancer treatment: disease-free patients' and oncologists' preferences
    A H Pieterse
    Department of Medical Decision Making, University Medical Center Leiden, Leiden, The Netherlands
    Br J Cancer 97:717-24. 2007
    ..Oncologists should adequately inform their patients about the risks and benefits of PRT, and elicit patient preferences regarding treatment outcomes...
  94. pmc Surgical treatment of early stage breast cancer in elderly: an international comparison
    M Kiderlen
    Department of Surgery, Leiden University Medical Center, PO Box 9600, 2300, RC, Leiden, The Netherlands
    Breast Cancer Res Treat 132:675-82. 2012
    ..Despite large treatment differences, survival does not seem to be affected in a major way...
  95. doi request reprint Combining process indicators to evaluate quality of care for surgical patients with colorectal cancer: are scores consistent with short-term outcome?
    N E Kolfschoten
    Department of Surgery, Leiden University Medical Center, PO Box 9600, Leiden 2300 RC, The Netherlands
    BMJ Qual Saf 21:481-9. 2012
    ..To determine if composite measures based on process indicators are consistent with short-term outcome indicators in surgical colorectal cancer care...
  96. ncbi request reprint The preferred treatment for young women with breast cancer--mastectomy versus breast conservation
    J G H van Nes
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Breast 15:S3-10. 2006
    ..A predictive model is needed for doctors and patients to facilitate this process...
  97. doi request reprint A systematic review and meta-analysis of the volume-outcome relationship in the surgical treatment of breast cancer. Are breast cancer patients better of with a high volume provider?
    G A Gooiker
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Surg Oncol 36:S27-35. 2010
    ....
  98. pmc Near-infrared fluorescence imaging in patients undergoing pancreaticoduodenectomy
    M Hutteman
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Eur Surg Res 47:90-7. 2011
    ..In this study, we explored the use of indocyanine green (ICG) for these applications and attempted to optimize injection timing and dose...
  99. ncbi request reprint The essentials of locoregional control in the treatment of gastric cancer
    M den Dulk
    Leiden University Medical Center, Department of Surgery, Leiden, The Netherlands
    Scand J Surg 95:236-42. 2006
    ....
  100. doi request reprint Socioeconomic differences in survival among breast cancer patients in the Netherlands not explained by tumor size
    E Bastiaannet
    Department of Surgery, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, The Netherlands
    Breast Cancer Res Treat 127:721-7. 2011
    ..Higher stage at diagnosis of patients with a lower SES only partly explains the decreased survival. Policies aimed at the reduction of socioeconomic health inequalities might be important to improve survival of breast cancer...