Annette H M van der Helm-van Mil

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint Immunoglobulin A multiple myeloma presenting with Henoch-Schönlein purpura associated with reduced sialylation of IgA1
    Annette H M van der Helm-van Mil
    Department of General Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands
    Br J Haematol 122:915-7. 2003
  2. pmc Aspects of early arthritis. Definition of disease states in early arthritis: remission versus minimal disease activity
    Annette H M van der Helm-van Mil
    Department of Rheumatology, Leiden University Medical Center, The Netherlands
    Arthritis Res Ther 8:216. 2006
  3. ncbi request reprint [Early recognition of rheumatoid arthritis]
    Annette H M van der Helm-van Mil
    Leids Universitair Medisch Centrum, afd Reumatologie, Leiden, The Netherlands
    Ned Tijdschr Geneeskd 155:A2902. 2011
  4. doi request reprint Genetic variants in the prediction of rheumatoid arthritis
    Annette H M van der Helm-van Mil
    Leiden University Medical Center, Department of Rheumatology, Leiden, The Netherlands
    Ann Rheum Dis 69:1694-6. 2010
  5. ncbi request reprint A prediction rule for disease outcome in patients with recent-onset undifferentiated arthritis: how to guide individual treatment decisions
    Annette H M van der Helm-van Mil
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 56:433-40. 2007
  6. ncbi request reprint Emerging patterns of risk factor make-up enable subclassification of rheumatoid arthritis
    Annette H M van der Helm-van Mil
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 56:1728-35. 2007
  7. doi request reprint How to avoid phenotypic misclassification in using joint destruction as an outcome measure for rheumatoid arthritis?
    Annette H M van der Helm-van Mil
    Department of Rheumatology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Rheumatology (Oxford) 49:1429-35. 2010
  8. pmc Advances in the genetics of rheumatoid arthritis point to subclassification into distinct disease subsets
    Annette H M van der Helm-van Mil
    Department of Rheumatology, Leiden University Medical Center, PO Box 9600, 2300RC Leiden, The Netherlands
    Arthritis Res Ther 10:205. 2008
  9. doi request reprint Validation of a prediction rule for disease outcome in patients with recent-onset undifferentiated arthritis: moving toward individualized treatment decision-making
    Annette H M van der Helm-van Mil
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 58:2241-7. 2008
  10. ncbi request reprint Acute rheumatic fever and poststreptococcal reactive arthritis reconsidered
    Annette H M van der Helm-van Mil
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Curr Opin Rheumatol 22:437-42. 2010

Detail Information

Publications55

  1. ncbi request reprint Immunoglobulin A multiple myeloma presenting with Henoch-Schönlein purpura associated with reduced sialylation of IgA1
    Annette H M van der Helm-van Mil
    Department of General Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands
    Br J Haematol 122:915-7. 2003
    ..IgA multiple myeloma, secreting IgA1 molecules with decreased sialylation, presenting with a Henoch-Schönlein purpura-like syndrome was diagnosed...
  2. pmc Aspects of early arthritis. Definition of disease states in early arthritis: remission versus minimal disease activity
    Annette H M van der Helm-van Mil
    Department of Rheumatology, Leiden University Medical Center, The Netherlands
    Arthritis Res Ther 8:216. 2006
    ..These definitions of remission refer to different disease states; therefore, we propose that the term remission is reserved for patients that are not treated with antirheumatic drugs...
  3. ncbi request reprint [Early recognition of rheumatoid arthritis]
    Annette H M van der Helm-van Mil
    Leids Universitair Medisch Centrum, afd Reumatologie, Leiden, The Netherlands
    Ned Tijdschr Geneeskd 155:A2902. 2011
    ..Early recognition of arthritis and RA is mandatory for early treatment of RA and improvement of the prospects of RA patients...
  4. doi request reprint Genetic variants in the prediction of rheumatoid arthritis
    Annette H M van der Helm-van Mil
    Leiden University Medical Center, Department of Rheumatology, Leiden, The Netherlands
    Ann Rheum Dis 69:1694-6. 2010
    ....
  5. ncbi request reprint A prediction rule for disease outcome in patients with recent-onset undifferentiated arthritis: how to guide individual treatment decisions
    Annette H M van der Helm-van Mil
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 56:433-40. 2007
    ..However, 40-50% of patients with UA experience spontaneous remission. Thus, adequate decision-making regarding treatment of patients with early UA requires identification of those patients in whom RA will develop...
  6. ncbi request reprint Emerging patterns of risk factor make-up enable subclassification of rheumatoid arthritis
    Annette H M van der Helm-van Mil
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 56:1728-35. 2007
  7. doi request reprint How to avoid phenotypic misclassification in using joint destruction as an outcome measure for rheumatoid arthritis?
    Annette H M van der Helm-van Mil
    Department of Rheumatology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Rheumatology (Oxford) 49:1429-35. 2010
    ....
  8. pmc Advances in the genetics of rheumatoid arthritis point to subclassification into distinct disease subsets
    Annette H M van der Helm-van Mil
    Department of Rheumatology, Leiden University Medical Center, PO Box 9600, 2300RC Leiden, The Netherlands
    Arthritis Res Ther 10:205. 2008
    ..Additionally, although being scarcely explored, genetic variants affecting the severity of disease course are discussed...
  9. doi request reprint Validation of a prediction rule for disease outcome in patients with recent-onset undifferentiated arthritis: moving toward individualized treatment decision-making
    Annette H M van der Helm-van Mil
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 58:2241-7. 2008
    ..Recently, a prediction rule was developed to estimate the chance of progression to RA in individual patients presenting with UA. This study investigates the accuracy of this prediction rule in independent cohorts of patients with UA...
  10. ncbi request reprint Acute rheumatic fever and poststreptococcal reactive arthritis reconsidered
    Annette H M van der Helm-van Mil
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Curr Opin Rheumatol 22:437-42. 2010
    ..Therefore, this review explores similarities and dissimilarities in initial symptoms and signs, disease course and underlying pathophysiologic mechanisms...
  11. ncbi request reprint The HLA-DRB1 shared epitope alleles are primarily a risk factor for anti-cyclic citrullinated peptide antibodies and are not an independent risk factor for development of rheumatoid arthritis
    Annette H M van der Helm-van Mil
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 54:1117-21. 2006
    ..We therefore determined the influence of the SE alleles and anti-CCP antibodies on the progression from recent-onset undifferentiated arthritis (UA) to RA...
  12. ncbi request reprint Hypernatremia from a hunger strike as a cause of osmotic myelinolysis
    Annette H M van der Helm-van Mil
    Department of Intensive Care, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Neurology 64:574-5. 2005
  13. pmc Antibodies to citrullinated proteins and differences in clinical progression of rheumatoid arthritis
    Annette H M van der Helm-van Mil
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Res Ther 7:R949-58. 2005
    ..In conclusion, the phenotype of RA patients with or without anti-CCP antibodies is similar with respect to clinical presentation but differs with respect to disease course...
  14. ncbi request reprint No association between tumour necrosis factor receptor type 2 gene polymorphism and rheumatoid arthritis severity: a comparison of the extremes of phenotypes
    A H M van der Helm-van Mil
    Department of Rheumatology, C4 R, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Rheumatology (Oxford) 43:1232-4. 2004
    ..To assess the association between the tumour necrosis factor receptor 2 (TNFR2) 196 M/R single-nucleotide polymorphism and rheumatoid arthritis (RA) severity by taking advantage of the extremes of phenotype that exist in arthritis...
  15. ncbi request reprint An independent role of protective HLA class II alleles in rheumatoid arthritis severity and susceptibility
    Annette H M van der Helm-van Mil
    Department of Rheumatology, Leiden University Medical Center, RC Leiden, The Netherlands
    Arthritis Rheum 52:2637-44. 2005
    ....
  16. doi request reprint Quantitative heritability of anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis
    Diane Van der Woude
    Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 60:916-23. 2009
    ....
  17. pmc TRAF1/C5 polymorphism is not associated with increased mortality in rheumatoid arthritis: two large longitudinal studies
    Jessica A B van Nies
    Department of Rheumatology, Leiden University Medical Centre, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Arthritis Res Ther 12:R38. 2010
    ..As TRAF1/C5 associated mortality may not be restricted to RA, we also studied a large cohort of non-RA patients...
  18. ncbi request reprint The HLA-DRB1 shared epitope alleles differ in the interaction with smoking and predisposition to antibodies to cyclic citrullinated peptide
    Annette H M van der Helm-van Mil
    Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 56:425-32. 2007
    ....
  19. pmc Association of a single-nucleotide polymorphism in CD40 with the rate of joint destruction in rheumatoid arthritis
    Michael P M van der Linden
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 60:2242-7. 2009
    ..The purpose of this study was to investigate whether these newly described genetic regions are associated with the rate of joint destruction...
  20. doi request reprint The ACPA recognition profile and subgrouping of ACPA-positive RA patients
    Annemiek Willemze
    Department of Rheumatology, Leiden University Medical Center, The Netherlands
    Ann Rheum Dis 71:268-74. 2012
    ..Here, the authors investigated whether specific epitope recognition allows the identification of specific RA subgroups and whether it is associated with clinical features of RA...
  21. doi request reprint Value of anti-modified citrullinated vimentin and third-generation anti-cyclic citrullinated peptide compared with second-generation anti-cyclic citrullinated peptide and rheumatoid factor in predicting disease outcome in undifferentiated arthritis and rh
    Michael P M van der Linden
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 60:2232-41. 2009
    ....
  22. ncbi request reprint Refining the complex rheumatoid arthritis phenotype based on specificity of the HLA-DRB1 shared epitope for antibodies to citrullinated proteins
    Tom W J Huizinga
    Department of Rheumatology C4R, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Arthritis Rheum 52:3433-8. 2005
    ..We undertook this study to make the first comparison of SE allele frequencies in the healthy population with those in RA patients who do or do not harbor anti-CCP antibodies...
  23. doi request reprint Sustained drug-free remission in rheumatoid arthritis after DAS-driven or non-DAS-driven therapy: a comparison of two cohort studies
    Diane Van der Woude
    Department of Rheumatology, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Rheumatology (Oxford) 51:1120-8. 2012
    ..To compare the prevalence of and predictors for sustained drug-free remission in two cohorts of patients with recent-onset RA treated with DAS-driven therapy or non-DAS-driven therapy...
  24. doi request reprint Prevalence of and predictive factors for sustained disease-modifying antirheumatic drug-free remission in rheumatoid arthritis: results from two large early arthritis cohorts
    Diane Van der Woude
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 60:2262-71. 2009
    ....
  25. ncbi request reprint Association of HLA-DR3 with anti-cyclic citrullinated peptide antibody-negative rheumatoid arthritis
    Kirsten N Verpoort
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 52:3058-62. 2005
    ..We undertook this study to investigate whether anti-CCP-negative RA is associated with other HLA-DRB1 alleles...
  26. ncbi request reprint Serum pyridinoline levels and prediction of severity of joint destruction in rheumatoid arthritis
    Annemarie Krabben
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    J Rheumatol 40:1303-6. 2013
    ..We evaluated the predictive value of serum pyridinoline levels for joint destruction, both at baseline for longterm prediction and during the disease course for near-term prediction...
  27. doi request reprint Long-term impact of delay in assessment of patients with early arthritis
    Michael P M van der Linden
    Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 62:3537-46. 2010
    ..Patient characteristics associated with components of delay (by the patient, by the general practitioner [GP], and overall) were assessed...
  28. pmc Protective effect of noninherited maternal HLA-DR antigens on rheumatoid arthritis development
    Anouk L Feitsma
    Departments of Immunohematology and Blood Transfusion and Rheumatology, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands
    Proc Natl Acad Sci U S A 104:19966-70. 2007
    ..25; P = 0.003). These data show a protective NIMA-effect in a human autoimmune disease and indicate that a DERAA-positive mother can transfer protection against RA to her DERAA-negative child...
  29. ncbi request reprint Defining erosive disease typical of RA in the light of the ACR/EULAR 2010 criteria for rheumatoid arthritis; results of the data driven phase
    Rachel Knevel
    Correspondence to Dr Annette H M van der Helm van Mil, Department of Rheumatology, Leiden University Medical Center, P O Box 9600, Leiden 2300RC, The Netherlands
    Ann Rheum Dis 72:590-5. 2013
    ..RA-specific erosiveness however has not been defined yet. This study reports the results of the data driven phase of a European League Against Rheumatism (EULAR) taskforce aiming to define RA-specific erosiveness...
  30. doi request reprint Predicting arthritis outcomes--what can be learned from the Leiden Early Arthritis Clinic?
    Diederik P C de Rooy
    Department of Rheumatology, Leiden University Medical Center, C1 46, PO Box 9600, 2300 RC, Leiden, The Netherlands
    Rheumatology (Oxford) 50:93-100. 2011
    ..In early undifferentiated arthritis (UA), prediction of the development of RA is crucial, and in case of RA predicting the severity of the disease course may guide individualized treatment decisions...
  31. doi request reprint Distinct ACPA fine specificities, formed under the influence of HLA shared epitope alleles, have no effect on radiographic joint damage in rheumatoid arthritis
    Hans Ulrich Scherer
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Ann Rheum Dis 70:1461-4. 2011
    ..The authors investigated whether ACPA fine specificities, which are formed under the influence of SE alleles, associate with the extent of radiographic joint damage...
  32. doi request reprint Improved early identification of arthritis: evaluating the efficacy of Early Arthritis Recognition Clinics
    Jessica A B van Nies
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Ann Rheum Dis 72:1295-301. 2013
    ..In order to reduce delay of GPs in identifying early arthritis, we initiated an Early Arthritis Recognition Clinic (EARC)...
  33. doi request reprint Reasons for medical help-seeking behaviour of patients with recent-onset arthralgia
    Jessica A B van Nies
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Ann Rheum Dis 72:1302-7. 2013
    ..Patient delay in seeking medical help may cause suboptimal use of the therapeutic window in rheumatoid arthritis. We aimed to assess the motivations and the urgency with which patients with arthralgia seek medical help...
  34. doi request reprint Risk of rheumatoid arthritis development in patients with unclassified arthritis according to the 2010 ACR/EULAR criteria for rheumatoid arthritis
    Annemarie Krabben
    Department of Rheumatology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Rheumatology (Oxford) 52:1265-70. 2013
    ..Here we studied this frequency in other cohorts and evaluated the prognostic accuracy of ACPA and the Leiden prediction rule in 2010 UA patients...
  35. pmc An evaluation of molecular and clinical remission in rheumatoid arthritis by assessing radiographic progression
    Annette H M van der Helm-van Mil
    Leiden University Medical Center, Leiden, The Netherlands
    Rheumatology (Oxford) 52:839-46. 2013
    ..To determine whether molecular remission defined by a multi-biomarker disease activity (MBDA) score predicts a reduced risk of joint damage progression, and whether the MBDA score can augment existing classifications of remission...
  36. pmc Autoantibodies recognizing carbamylated proteins are present in sera of patients with rheumatoid arthritis and predict joint damage
    Jing Shi
    Department of Rheumatology, Leiden University Medical Center, 2300 RC, Leiden, The Netherlands
    Proc Natl Acad Sci U S A 108:17372-7. 2011
    ..These antibodies are predictive for a more severe clinical course in ACPA-negative RA-patients, indicating that anti-CarP antibodies are a unique and relevant serological marker for ACPA-negative RA...
  37. ncbi request reprint The ACPA isotype profile reflects long-term radiographic progression in rheumatoid arthritis
    Diane Van der Woude
    Department of Rheumatology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Ann Rheum Dis 69:1110-6. 2010
    ..The ACPA response has been shown to consist of various isotypes, but the consequences of differences in isotype distribution have not been extensively investigated...
  38. doi request reprint Repair of joint erosions in rheumatoid arthritis: prevalence and patient characteristics in a large inception cohort
    Michael P M van der Linden
    Department of Rheumatology, Leiden University Medical Centre, Leiden, The Netherlands
    Ann Rheum Dis 69:727-9. 2010
    ..Joint destruction in rheumatoid arthritis (RA) was until recently seen as an irreversible state. Lately, it was found that repair of bone erosions occurs; however, little is known about its prevalence...
  39. doi request reprint MRI of hand and foot joints of patients with anticitrullinated peptide antibody positive arthralgia without clinical arthritis
    Annemarie Krabben
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Ann Rheum Dis 72:1540-4. 2013
    ..Whether local inflammation occurs in the preclinical phase is unknown. Therefore, we studied the small joints of ACPA positive arthralgia patients for local subclinical inflammation...
  40. pmc A candidate gene approach identifies the TRAF1/C5 region as a risk factor for rheumatoid arthritis
    Fina A S Kurreeman
    Department of Rheumatology, Leiden University Medical Centre, Leiden, The Netherlands
    PLoS Med 4:e278. 2007
    ..We therefore aimed to investigate whether this locus would play a role in RA...
  41. doi request reprint Patients with early arthritis consume less alcohol than controls, regardless of the type of arthritis
    Annekoos L Huidekoper
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Rheumatology (Oxford) 52:1701-7. 2013
    ..To assess whether alcohol consumption affects long-term disease outcome, we also investigated its association with radiographic progression and sustained drug-free remission in RA...
  42. ncbi request reprint EULAR definition of erosive disease in light of the 2010 ACR/EULAR rheumatoid arthritis classification criteria
    Desiree van der Heijde
    Department of Rheumatology, Leiden University Medical Center, PO Box 9600, Leiden 2300 RC, The Netherlands
    Ann Rheum Dis 72:479-81. 2013
    ..A highly specific definition for erosive disease has thus been formulated...
  43. ncbi request reprint Invasiveness of fibroblast-like synoviocytes is an individual patient characteristic associated with the rate of joint destruction in patients with rheumatoid arthritis
    Tanja C A Tolboom
    Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 52:1999-2002. 2005
    ..This study was undertaken to investigate the association of these in vitro characteristics with disease characteristics in patients with RA...
  44. doi request reprint Genetic studies on components of the Wnt signalling pathway and the severity of joint destruction in rheumatoid arthritis
    Diederik P C de Rooy
    Department of Rheumatology, Leiden University Medical Center, PO Box 9600, Leiden 2300 RC, The Netherlands
    Ann Rheum Dis 72:769-75. 2013
    ..Dickkopf-1 (Dkk-1) and sclerostin (Sost) are negative regulators and lipoprotein receptor-related protein-5 (LRP-5) and Kremen-1 are transmembrane receptors involved in this pathway...
  45. doi request reprint Genetic predisposition of the severity of joint destruction in rheumatoid arthritis: a population-based study
    Rachel Knevel
    Department of Rheumatology, Leiden University Medical Center, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Ann Rheum Dis 71:707-9. 2012
    ..The evaluation of the heritability of the severity of RA is basic to further studies on genetic factors. A study was undertaken to determine whether joint destruction is heritable...
  46. pmc Can anti-cyclic citrullinated peptide antibody-negative RA be subdivided into clinical subphenotypes?
    Diederik P C de Rooy
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Res Ther 13:R180. 2011
    ..We aimed to evaluate the validity of this notion and explored whether clinical subphenotypes can be discerned within anti-CCP-negative RA...
  47. doi request reprint Loss of metacarpal bone density predicts RA development in recent-onset arthritis
    Diederik P C de Rooy
    Department of Rheumatology, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Rheumatology (Oxford) 51:1037-41. 2012
    ..We determined the ability of radiographic BMD loss to predict RA development and arthritis persistency in patients with early undifferentiated arthritis (UA)...
  48. pmc The prognostic value of baseline erosions in undifferentiated arthritis
    Mohamed M Thabet
    Department of Rheumatology, Leiden University Medical Center, Albinusdreef 2, Leiden, PO Box 9600, 2300RC, The Netherlands
    Arthritis Res Ther 11:R155. 2009
    ..This study evaluates the predictive value of erosive joints for the disease outcome in UA as measured by RA development and disease persistency...
  49. doi request reprint Improved treatment strategies reduce the increased mortality risk in early RA patients
    Jessica A B van Nies
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Rheumatology (Oxford) 49:2210-6. 2010
    ..We investigated whether this change in treatment corresponds to reversal of excess mortality by studying a large inception cohort of early RA patients exposed to different treatment strategies...
  50. doi request reprint A two-stage mixed-effects model approach for gene-set analyses in candidate gene studies
    Roula Tsonaka
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Postzone S5 P, PO Box 9600, 2300, RC, Leiden, The Netherlands
    Stat Med 31:1190-202. 2012
    ..The advantage of this approach is its broad applicability because it can be used for any phenotypic outcome and any genetic model and can be implemented with standard statistical software...
  51. ncbi request reprint Variation in radiologic joint destruction in rheumatoid arthritis differs between monozygotic and dizygotic twins and pairs of unrelated patients
    Annette H M van der Helm-van Mil
    Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 54:2028-30. 2006
  52. ncbi request reprint Understanding the genetic contribution to rheumatoid arthritis
    Annette H M van der Helm-van Mil
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Curr Opin Rheumatol 17:299-304. 2005
    ..Technical and methodologic progress has fueled the advances in this field...
  53. doi request reprint A1.29 In rheumatoid arthritis, smoking is not primarily associated with anti-citrullinaged protein antibodies, but with the presence of several autoantibodies
    Ammar Muhammad
    Leiden University Medical Center, Leiden, The Netherlands
    Ann Rheum Dis 73:A12. 2014
    ..We therefore investigated whether smoking is specifically associated with ACPA-positive RA, or with autoantibody-positive RA in general...
  54. ncbi request reprint [Mucocutaneous abnormalities in Chlamydia trachomatis-induced reactive arthritis]
    Koen D Quint
    Leids Universitair Medisch Centrum, afd Dermatologie, Leiden, The Netherlands
    Ned Tijdschr Geneeskd 154:A1614. 2010
    ..It is important that the patient's partner is tested at the same time and if necessary treated simultaneously to prevent reinfection...
  55. ncbi request reprint The 2010 ACR/EULAR criteria for rheumatoid arthritis: do they affect the classification or diagnosis of rheumatoid arthritis?
    Annette H M van der Helm-van Mil
    Correspondence to Annette H M van der Helm van Mil, Department of Rheumatology, Leiden University Medical Center, PO Box 9600, Leiden 2300RC, The Netherlands
    Ann Rheum Dis 71:1596-8. 2012
    ..Not fulfilling the criteria, in contrast, does not rule out RA in these individuals...