L A Trouw

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. pmc Anti-c1q autoantibodies, novel tests, and clinical consequences
    Michael Mahler
    INOVA Diagnostics, Inc San Diego, CA, USA
    Front Immunol 4:117. 2013
  2. pmc Genetic variants in the region of the C1q genes are associated with rheumatoid arthritis
    L A Trouw
    Department of Rheumatology, Leiden University Medical Center, The Netherlands
    Clin Exp Immunol 173:76-83. 2013
  3. pmc The major risk alleles of age-related macular degeneration (AMD) in CFH do not play a major role in rheumatoid arthritis (RA)
    L A Trouw
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Clin Exp Immunol 166:333-7. 2011
  4. pmc The fine specificity of IgM anti-citrullinated protein antibodies (ACPA) is different from that of IgG ACPA
    Parawee Suwannalai
    Department of Rheumatology, Leiden University Medical Center LUMC, PO Box 9600, NL 2300 RC Leiden, The Netherlands
    Arthritis Res Ther 13:R195. 2011
  5. doi request reprint Anti-cyclic citrullinated peptide antibodies from rheumatoid arthritis patients activate complement via both the classical and alternative pathways
    L A Trouw
    Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 60:1923-31. 2009
  6. pmc Glomerular deposition of C1q and anti-C1q antibodies in mice following injection of antimouse C1q antibodies
    L A Trouw
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Clin Exp Immunol 132:32-9. 2003
  7. pmc Anti-C1q autoantibodies in murine lupus nephritis
    L A Trouw
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Clin Exp Immunol 135:41-8. 2004
  8. ncbi request reprint A role for mannose-binding lectin dysfunction in generation of autoantibodies in systemic lupus erythematosus
    M A Seelen
    Department of Nephrology, C3P 29, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Rheumatology (Oxford) 44:111-9. 2005
  9. pmc Autoantibodies against mannose-binding lectin in systemic lupus erythematosus
    M A Seelen
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Clin Exp Immunol 134:335-43. 2003
  10. ncbi request reprint Immune deposition of C1q and anti-C1q antibodies in the kidney is dependent on the presence of glomerular IgG
    L A Trouw
    Department of Nephrology, D3 P 39 Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Mol Immunol 40:595-602. 2003

Collaborators

Detail Information

Publications23

  1. pmc Anti-c1q autoantibodies, novel tests, and clinical consequences
    Michael Mahler
    INOVA Diagnostics, Inc San Diego, CA, USA
    Front Immunol 4:117. 2013
    ..Such large-scale studies will reveal the true value of clinical testing for anti-C1q autoantibodies in several clinical conditions...
  2. pmc Genetic variants in the region of the C1q genes are associated with rheumatoid arthritis
    L A Trouw
    Department of Rheumatology, Leiden University Medical Center, The Netherlands
    Clin Exp Immunol 173:76-83. 2013
    ..Combined analysis, including integrated data from six GWAS studies, provides support for the genetic association. Genetic variants in C1q are correlated with C1q levels and may be a risk for the development of RA...
  3. pmc The major risk alleles of age-related macular degeneration (AMD) in CFH do not play a major role in rheumatoid arthritis (RA)
    L A Trouw
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Clin Exp Immunol 166:333-7. 2011
    ..In conclusion, the major risk alleles of AMD in CFH do not have a similar effect on developing RA...
  4. pmc The fine specificity of IgM anti-citrullinated protein antibodies (ACPA) is different from that of IgG ACPA
    Parawee Suwannalai
    Department of Rheumatology, Leiden University Medical Center LUMC, PO Box 9600, NL 2300 RC Leiden, The Netherlands
    Arthritis Res Ther 13:R195. 2011
    ..In this study, we analyzed whether a difference exists between the fine specificity of IgM versus IgG anti-citrullinated protein antibodies (ACPAs)...
  5. doi request reprint Anti-cyclic citrullinated peptide antibodies from rheumatoid arthritis patients activate complement via both the classical and alternative pathways
    L A Trouw
    Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 60:1923-31. 2009
    ..This study was undertaken to investigate whether human anti-cyclic citrullinated peptide (anti-CCP) antibodies activate the complement system in vitro and, if so, which pathways of complement activation are used...
  6. pmc Glomerular deposition of C1q and anti-C1q antibodies in mice following injection of antimouse C1q antibodies
    L A Trouw
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Clin Exp Immunol 132:32-9. 2003
    ..This deposition is stable for at least 2 weeks, causes complement activation, leucocyte influx and can lead to mild albuminuria...
  7. pmc Anti-C1q autoantibodies in murine lupus nephritis
    L A Trouw
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Clin Exp Immunol 135:41-8. 2004
    ..In conclusion, anti-C1q antibodies are already present in serum and immune deposits of the kidney early in life and therefore can play a role in nephritis during experimental SLE-like disease in mice...
  8. ncbi request reprint A role for mannose-binding lectin dysfunction in generation of autoantibodies in systemic lupus erythematosus
    M A Seelen
    Department of Nephrology, C3P 29, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Rheumatology (Oxford) 44:111-9. 2005
    ..To investigate the possible association of the mannose binding lectin (MBL) pathway of complement activation with different disease parameters and disease activity in patients with systemic lupus erythematosus (SLE)...
  9. pmc Autoantibodies against mannose-binding lectin in systemic lupus erythematosus
    M A Seelen
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Clin Exp Immunol 134:335-43. 2003
    ..We conclude that anti-MBL are present in sera from SLE patients and influence the functional activity of MBL...
  10. ncbi request reprint Immune deposition of C1q and anti-C1q antibodies in the kidney is dependent on the presence of glomerular IgG
    L A Trouw
    Department of Nephrology, D3 P 39 Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Mol Immunol 40:595-602. 2003
    ..Therefore we hypothesize that high and fluctuating levels of IgG as observed in patients with SLE may contribute to flares of renal inflammation in those patients with anti-C1q autoantibodies...
  11. doi request reprint Anti-citrullinated protein antibodies have a low avidity compared with antibodies against recall antigens
    P Suwannalai
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Ann Rheum Dis 70:373-9. 2011
    ..Nonetheless, the evolution of the ACPA response is still poorly understood and might intrinsically differ from the protective responses against pathogens...
  12. doi request reprint Low-avidity anticitrullinated protein antibodies (ACPA) are associated with a higher rate of joint destruction in rheumatoid arthritis
    Parawee Suwannalai
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Ann Rheum Dis 73:270-6. 2014
    ..Nonetheless, ACPA-avidity did vary between patients. As antibody mediated effects are influenced by antibody-avidity, we now investigated ACPA-avidity in relation to biological activity and clinical outcome...
  13. ncbi request reprint New biomarkers in rheumatoid arthritis
    A Willemze
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Neth J Med 70:392-9. 2012
    ..The development of biomarker-based disease activity scores might allow easy and frequent monitoring of patients to rapidly adjust treatment...
  14. doi request reprint Novel genetic association of the VTCN1 region with rheumatoid arthritis
    Nina A Daha
    Department of Rheumatology, Leiden University Medical Center, The Netherlands
    Ann Rheum Dis 71:567-71. 2012
    ..VTCN1 is known to play a pivotal role in regulation of the immune system and, in soluble form, has previously been associated with higher disease activity...
  15. doi request reprint Avidity maturation of anti-citrullinated protein antibodies in rheumatoid arthritis
    P Suwannalai
    Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 64:1323-8. 2012
    ....
  16. ncbi request reprint Autoantibodies to complement components
    L A Trouw
    Department of Nephrology, D3 P, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Mol Immunol 38:199-206. 2001
    ..In the present review, we describe autoantibodies against complement components and their subsequent effects...
  17. ncbi request reprint [The role of the complement system in the defence against infections and new ways of assessing the activation routes]
    M A Seelen
    Leids Universitair Medisch Centrum, afd Nierziekten, C3P 29, Albinusdreef 2, 2333 ZA Leiden
    Ned Tijdschr Geneeskd 148:2318-23. 2004
    ..A new ELISA assay has been developed to enable the assessment of the functional activity of the whole lectin pathway and to determine the classical and the alternative pathway functional activity in a simple uniform design...
  18. ncbi request reprint Diagnostic and prognostic significance of anti-C1q antibodies in systemic lupus erythematosus
    Marc A Seelen
    Department of Nephrology, Leiden University Medical Center, The Netherlands
    Curr Opin Nephrol Hypertens 12:619-24. 2003
    ..Anti-C1q autoantibodies are strongly associated with renal involvement in systemic lupus erythematosus. This study will review recent findings on the pathogenic role and clinical importance of anti-C1q antibodies in lupus nephritis...
  19. ncbi request reprint Specific inhibition of the classical complement pathway by C1q-binding peptides
    A Roos
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    J Immunol 167:7052-9. 2001
    ..We conclude that peptide 2J is a promising reagent for the development of a therapeutic inhibitor of the earliest step of the classical complement pathway, i.e., the binding of C1q to its target...
  20. doi request reprint A1.55 Development of antibodies specific for carbamylated protein precedes disease onset in MICE with collagen-induced arthritis
    M K Verheul
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Ann Rheum Dis 73:A23-4. 2014
    ..As no information is present on the molecular mechanisms underlying the break of tolerance and hence the induction of anti-CarP-responses, we analysed their appearance in the mouse collagen-induced arthritis (CIA) model...
  21. ncbi request reprint Complement and renal disease
    L A Trouw
    Department of Nephrology, D3 P 39, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Mol Immunol 40:125-34. 2003
    ..Current research provides clues on the role of individual complement components and activation pathways as well as possible modes of complement regulation in the management of renal disease...
  22. doi request reprint Autoimmunity in rheumatoid arthritis: different antigens--common principles
    L A Trouw
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Ann Rheum Dis 72:ii132-6. 2013
    ..In this review we will discuss novel insight into the immune responses directed against citrullinated and carbamylated proteins...
  23. ncbi request reprint Role of complement and complement regulators in the removal of apoptotic cells
    L A Trouw
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Mol Immunol 45:1199-207. 2008
    ..Although the complement system is also involved in inducing apoptosis in target cells, this review will focus on the role of complement in the clearance of apoptotic cells...