Peter Ac 't Hoen

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. ncbi Cell-type specific regulation of myostatin signaling
    Dwi U Kemaladewi
    Center for Human and Clinical Genetics, Leiden University Medical Center, Postzone S4 P, PO Box 9600, 2300RC, Leiden, The Netherlands
    FASEB J 26:1462-72. 2012
  2. ncbi Increased sensitivity of next generation sequencing-based expression profiling after globin reduction in human blood RNA
    Anastasios Mastrokolias
    Center for Human and Clinical Genetics, Leiden University Medical Center, Einthovenweg 20, 2333ZC, Leiden, The Netherlands
    BMC Genomics 13:28. 2012
  3. ncbi Phage display screening without repetitious selection rounds
    Peter A C 't Hoen
    Center for Human and Clinical Genetics and Leiden Genome Technology Center, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Anal Biochem 421:622-31. 2012
  4. ncbi Fluorescent labelling of cRNA for microarray applications
    Peter A C 't Hoen
    Center for Human and Clinical Genetics, Leiden University Medical Center, Wassenaarseweg 72, 2333 AL Leiden, The Netherlands
    Nucleic Acids Res 31:e20. 2003
  5. ncbi mRNA degradation controls differentiation state-dependent differences in transcript and splice variant abundance
    Peter A C 't Hoen
    Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Nucleic Acids Res 39:556-66. 2011
  6. ncbi Deep sequencing-based expression analysis shows major advances in robustness, resolution and inter-lab portability over five microarray platforms
    Peter A C 't Hoen
    The Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Nucleic Acids Res 36:e141. 2008
  7. ncbi Generation and characterization of transgenic mice with the full-length human DMD gene
    Peter A C 't Hoen
    Center for Human and Clinical Genetics, Leiden University Medical Center, Postal Zone S4 P, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Biol Chem 283:5899-907. 2008
  8. ncbi Gene expression profiling to monitor therapeutic and adverse effects of antisense therapies for Duchenne muscular dystrophy
    Peter A C 't Hoen
    Leiden University Medical Center, Center for Human and Clinical Genetics, Room S 04 003, Postbus 9600, 2300 RC Leiden, The Netherlands
    Pharmacogenomics 7:281-97. 2006
  9. ncbi Intensity-based analysis of two-colour microarrays enables efficient and flexible hybridization designs
    Peter A C 't Hoen
    Center for Human and Clinical Genetics, Leiden University Medical Center, The Netherlands
    Nucleic Acids Res 32:e41. 2004
  10. ncbi Deregulation of the ubiquitin-proteasome system is the predominant molecular pathology in OPMD animal models and patients
    Seyed Yahya Anvar
    Center for Human and Clinical Genetics, Leiden University Medical Center, P, O, Box 9600, 2300 RC Leiden, The Netherlands
    Skelet Muscle 1:15. 2011

Collaborators

  • Johan T den Dunnen
  • Annemieke Aartsma-Rus
  • Rolf Turk
  • Judith M Boer
  • Judith C T van Deutekom
  • Aurelie Goyenvalle
  • Kay E Davies
  • Helene H Thygesen
  • Willeke M C van Roon-Mom
  • A Seda Yilmaz-Elis
  • Gert Jan van Ommen
  • Anastasios Mastrokolias
  • Dwi U Kemaladewi
  • Seyed Yahya Anvar
  • S Yahya Anvar
  • Gertjan B van Ommen
  • Henk P J Buermans
  • Gert Jan B van Ommen
  • Yavuz Ariyurek
  • Paola Pedotti
  • Matthew S Hestand
  • Veronica Vinciotti
  • Cor Breukel
  • Huma Safdar
  • Bart Jm van Vlijmen
  • Sjef de Kimpe
  • J Sjef Verbeek
  • David J J de Gorter
  • Peter Ten Dijke
  • Willem M Hoogaars
  • Marc Snoeck
  • Barbara van der Sluijs
  • Vered Raz
  • Aymeric Chartier
  • Andrea Venema
  • Capucine Trollet
  • Martine Simonelig
  • Baziel van Engelen
  • John Vissing
  • Silvere M van der Maarel
  • George Dickson
  • Gertjan van Ommen
  • Allan Tucker
  • Michiel van Galen
  • Erno Vreugdenhil
  • Barry A Pepers
  • Renee X de Menezes
  • Michel P Villerius
  • Gertjan J B van Ommen
  • Geert J Schenk
  • Mattias de Hollander
  • Rolf Ham Vossen
  • Carola A C M Verwijmeren
  • Rowan Kuiper
  • Josephine C Dorsman
  • Emile J de Meijer
  • Xiaohui Liu

Detail Information

Publications19

  1. ncbi Cell-type specific regulation of myostatin signaling
    Dwi U Kemaladewi
    Center for Human and Clinical Genetics, Leiden University Medical Center, Postzone S4 P, PO Box 9600, 2300RC, Leiden, The Netherlands
    FASEB J 26:1462-72. 2012
    ..Together, our results identify a molecular mechanism that explains the cell-type specific aspects of signaling by myostatin and other TGF-β family members...
  2. ncbi Increased sensitivity of next generation sequencing-based expression profiling after globin reduction in human blood RNA
    Anastasios Mastrokolias
    Center for Human and Clinical Genetics, Leiden University Medical Center, Einthovenweg 20, 2333ZC, Leiden, The Netherlands
    BMC Genomics 13:28. 2012
    ..We have removed globin transcripts from 6 human whole blood RNA samples with a human globin reduction kit and compared them with the same non-reduced samples using deep Serial Analysis of Gene Expression...
  3. ncbi Phage display screening without repetitious selection rounds
    Peter A C 't Hoen
    Center for Human and Clinical Genetics and Leiden Genome Technology Center, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Anal Biochem 421:622-31. 2012
    ..We conclude that next generation sequencing can significantly empower phage display screenings by accelerating the finding of specific binders and restraining the number of false positive hits...
  4. ncbi Fluorescent labelling of cRNA for microarray applications
    Peter A C 't Hoen
    Center for Human and Clinical Genetics, Leiden University Medical Center, Wassenaarseweg 72, 2333 AL Leiden, The Netherlands
    Nucleic Acids Res 31:e20. 2003
    ..In conclusion, the currently developed method is an efficient, robust and inexpensive technique for fluorescent labelling of cRNA and allows sensitive detection of gene expression profiles on oligonucleotide microarrays...
  5. ncbi mRNA degradation controls differentiation state-dependent differences in transcript and splice variant abundance
    Peter A C 't Hoen
    Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Nucleic Acids Res 39:556-66. 2011
    ..In conclusion, control of stability and degradation emerge as important determinants for differential expression of mRNA transcripts and splice variants...
  6. ncbi Deep sequencing-based expression analysis shows major advances in robustness, resolution and inter-lab portability over five microarray platforms
    Peter A C 't Hoen
    The Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Nucleic Acids Res 36:e141. 2008
    ..We conclude that deep sequencing provides a major advance in robustness, comparability and richness of expression profiling data and is expected to boost collaborative, comparative and integrative genomics studies...
  7. ncbi Generation and characterization of transgenic mice with the full-length human DMD gene
    Peter A C 't Hoen
    Center for Human and Clinical Genetics, Leiden University Medical Center, Postal Zone S4 P, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Biol Chem 283:5899-907. 2008
    ..In addition, the hDMD mouse can be used to study the influence of the genomic context on deletion and recombination frequencies, genome stability, and gene expression regulation...
  8. ncbi Gene expression profiling to monitor therapeutic and adverse effects of antisense therapies for Duchenne muscular dystrophy
    Peter A C 't Hoen
    Leiden University Medical Center, Center for Human and Clinical Genetics, Room S 04 003, Postbus 9600, 2300 RC Leiden, The Netherlands
    Pharmacogenomics 7:281-97. 2006
    ....
  9. ncbi Intensity-based analysis of two-colour microarrays enables efficient and flexible hybridization designs
    Peter A C 't Hoen
    Center for Human and Clinical Genetics, Leiden University Medical Center, The Netherlands
    Nucleic Acids Res 32:e41. 2004
    ....
  10. ncbi Deregulation of the ubiquitin-proteasome system is the predominant molecular pathology in OPMD animal models and patients
    Seyed Yahya Anvar
    Center for Human and Clinical Genetics, Leiden University Medical Center, P, O, Box 9600, 2300 RC Leiden, The Netherlands
    Skelet Muscle 1:15. 2011
    ..We suggest that the natural decrease in proteasome expression and its activity during muscle aging contributes to the onset of the disease...
  11. ncbi Mutant huntingtin activates Nrf2-responsive genes and impairs dopamine synthesis in a PC12 model of Huntington's disease
    Willeke M C van Roon-Mom
    Center for Human and Clinical Genetics, Leiden, The Netherlands
    BMC Mol Biol 9:84. 2008
    ..mRNA changes were studied in an inducible PC12 model of Huntington's disease, before and after aggregates became visible, to identify groups of genes that could play a role in the early pathology of Huntington's disease...
  12. ncbi Gene expression variation between mouse inbred strains
    Rolf Turk
    Center for Human and Clinical Genetics, Leiden University Medical Center, Wassenaarseweg 72, 2333 AL Leiden, Nederland
    BMC Genomics 5:57. 2004
    ..In this study, we investigated the effect of genetic background on expression profiles. We analysed the transcriptome of mouse hindlimb muscle of five frequently used mouse inbred strains using spotted oligonucleotide microarrays...
  13. ncbi Muscle regeneration in dystrophin-deficient mdx mice studied by gene expression profiling
    R Turk
    Center for Human and Clinical Genetics, Leiden University Medical Center, Wassenaarseweg 72, 2333 AL Leiden, Nederland
    BMC Genomics 6:98. 2005
    ..To characterize the molecular processes associated with regeneration, we compared gene expression levels in hindlimb muscle tissue of mdx and control mice at 9 timepoints, ranging from 1-20 weeks of age...
  14. ncbi Can subtle changes in gene expression be consistently detected with different microarray platforms?
    Paola Pedotti
    Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    BMC Genomics 9:124. 2008
    ..Here we address the performance and the overlap in the detection of differentially expressed genes for five different microarray platforms in a challenging biological context where differences in gene expression are few and subtle...
  15. ncbi New methods for next generation sequencing based microRNA expression profiling
    Henk P J Buermans
    Center for Human and Clinical Genetics, Leiden University Medical Center, Einthovenweg 20, 2333 ZC Leiden, The Netherlands
    BMC Genomics 11:716. 2010
    ..A modification to the small-RNA expression kit (SREK, Ambion) library preparation method for the SOLiD sequencing platform is described to generate microRNA sequencing libraries that are compatible with the Illumina Genome Analyzer...
  16. ncbi The identification of informative genes from multiple datasets with increasing complexity
    S Yahya Anvar
    Center for Intelligent Data Analysis, School of Information Systems, Computing and Mathematics, Brunel University, Uxbridge, Middlesex, UB8 3PH, UK
    BMC Bioinformatics 11:32. 2010
    ....
  17. ncbi CORE_TF: a user-friendly interface to identify evolutionary conserved transcription factor binding sites in sets of co-regulated genes
    Matthew S Hestand
    The Center for Human and Clinical Genetics, Leiden University Medical Center, Postzone S4 0P, PO Box 9600, 2300 RC Leiden, The Netherlands
    BMC Bioinformatics 9:495. 2008
    ..Computational methods to reduce false positives are to look for over-representation of transcription factor binding sites in a set of similarly regulated promoters or to look for conservation in orthologous promoter alignments...
  18. ncbi Exploiting the full power of temporal gene expression profiling through a new statistical test: application to the analysis of muscular dystrophy data
    Veronica Vinciotti
    Department of Information Systems and Computing, Brunel University, Uxbridge UB8 3PH, UK
    BMC Bioinformatics 7:183. 2006
    ..A Hotelling T2-statistic is derived to detect the genes for which the parameters of these polynomials are significantly different from each other...
  19. ncbi Inhibition of IL-1 Signaling by Antisense Oligonucleotide-mediated Exon Skipping of IL-1 Receptor Accessory Protein (IL-1RAcP)
    A Seda Yilmaz-Elis
    Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Mol Ther Nucleic Acids 2:e66. 2013
    ..Molecular Therapy - Nucleic Acids (2013) 2, e66; doi:10.1038/mtna.2012.58; published online 22 January 2013...