Affiliation: Leiden University Medical Center
Country: The Netherlands
- The PWWP domain: a potential protein-protein interaction domain in nuclear proteins influencing differentiation?I Stec
MGC Department of Human and Clinical Genetics, Leiden University Medical Center, Wassenaarseweg 72, 2333 AL, Leiden, The Netherlands
FEBS Lett 473:1-5. 2000..Due to its position, the composition of amino acids close to the PWWP motif and the pattern of other domains present, we hypothesize that the domain is involved in protein-protein interactions...
- A partial BRCA1 sequence homology mapping to 4q28I Stec
Department of Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
Cytogenet Cell Genet 94:26-9. 2001..BLAST-searches, RT-PCR and RACE-experiments have been unable to provide evidence that BRCA1-h is part of an expressed gene...
- WHSC1L1, on human chromosome 8p11.2, closely resembles WHSC1 and maps to a duplicated region shared with 4p16.3I Stec
MGC Department of Human Genetics and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
Genomics 76:5-8. 2001..Rearrangements of 8p are frequently found in human cancer, including breast cancer. These characteristics indicate that WHSC1L1 might have a role in embryonic development and, when disregulated, in cancer development...
- WHSC1, a 90 kb SET domain-containing gene, expressed in early development and homologous to a Drosophila dysmorphy gene maps in the Wolf-Hirschhorn syndrome critical region and is fused to IgH in t(4;14) multiple myelomaI Stec
MGC Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
Hum Mol Genet 7:1071-82. 1998..3;q32.3) translocations recently described in multiple myelomas, at least three breakpoints merge the IgH and WHSC1 genes, potentially causing fusion proteins replacing WHSC1 exons 1-4 by the IgH 5'-VDJ moiety...