I Stec

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint The PWWP domain: a potential protein-protein interaction domain in nuclear proteins influencing differentiation?
    I Stec
    MGC Department of Human and Clinical Genetics, Leiden University Medical Center, Wassenaarseweg 72, 2333 AL, Leiden, The Netherlands
    FEBS Lett 473:1-5. 2000
  2. ncbi request reprint A partial BRCA1 sequence homology mapping to 4q28
    I Stec
    Department of Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Cytogenet Cell Genet 94:26-9. 2001
  3. ncbi request reprint WHSC1L1, on human chromosome 8p11.2, closely resembles WHSC1 and maps to a duplicated region shared with 4p16.3
    I Stec
    MGC Department of Human Genetics and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Genomics 76:5-8. 2001
  4. ncbi request reprint WHSC1, a 90 kb SET domain-containing gene, expressed in early development and homologous to a Drosophila dysmorphy gene maps in the Wolf-Hirschhorn syndrome critical region and is fused to IgH in t(4;14) multiple myeloma
    I Stec
    MGC Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Hum Mol Genet 7:1071-82. 1998

Detail Information

Publications4

  1. ncbi request reprint The PWWP domain: a potential protein-protein interaction domain in nuclear proteins influencing differentiation?
    I Stec
    MGC Department of Human and Clinical Genetics, Leiden University Medical Center, Wassenaarseweg 72, 2333 AL, Leiden, The Netherlands
    FEBS Lett 473:1-5. 2000
    ..Due to its position, the composition of amino acids close to the PWWP motif and the pattern of other domains present, we hypothesize that the domain is involved in protein-protein interactions...
  2. ncbi request reprint A partial BRCA1 sequence homology mapping to 4q28
    I Stec
    Department of Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Cytogenet Cell Genet 94:26-9. 2001
    ..BLAST-searches, RT-PCR and RACE-experiments have been unable to provide evidence that BRCA1-h is part of an expressed gene...
  3. ncbi request reprint WHSC1L1, on human chromosome 8p11.2, closely resembles WHSC1 and maps to a duplicated region shared with 4p16.3
    I Stec
    MGC Department of Human Genetics and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Genomics 76:5-8. 2001
    ..Rearrangements of 8p are frequently found in human cancer, including breast cancer. These characteristics indicate that WHSC1L1 might have a role in embryonic development and, when disregulated, in cancer development...
  4. ncbi request reprint WHSC1, a 90 kb SET domain-containing gene, expressed in early development and homologous to a Drosophila dysmorphy gene maps in the Wolf-Hirschhorn syndrome critical region and is fused to IgH in t(4;14) multiple myeloma
    I Stec
    MGC Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Hum Mol Genet 7:1071-82. 1998
    ..3;q32.3) translocations recently described in multiple myelomas, at least three breakpoints merge the IgH and WHSC1 genes, potentially causing fusion proteins replacing WHSC1 exons 1-4 by the IgH 5'-VDJ moiety...