Frank J T Staal

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. doi request reprint Tales of the unexpected: tcf1 functions as a tumor suppressor for leukemias
    Frank J T Staal
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands Electronic address
    Immunity 37:761-3. 2012
  2. doi request reprint Stem cell self-renewal: lessons from bone marrow, gut and iPS toward clinical applications
    F J T Staal
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Leukemia 25:1095-102. 2011
  3. ncbi request reprint Wnt signaling in hematopoiesis: crucial factors for self-renewal, proliferation, and cell fate decisions
    Frank J T Staal
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    J Cell Biochem 109:844-9. 2010
  4. doi request reprint Genome-wide expression analysis of paired diagnosis-relapse samples in ALL indicates involvement of pathways related to DNA replication, cell cycle and DNA repair, independent of immune phenotype
    F J T Staal
    Department of Immunology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Leukemia 24:491-9. 2010
  5. ncbi request reprint Human thymus contains multipotent progenitors with T/B lymphoid, myeloid, and erythroid lineage potential
    Floor Weerkamp
    Department of Immunology, Erasmus MC, University Medical Center Rotterdam, The Netherlands
    Blood 107:3131-7. 2006
  6. doi request reprint Wnt3a deficiency irreversibly impairs hematopoietic stem cell self-renewal and leads to defects in progenitor cell differentiation
    Tiago C Luis
    Department of Immunology, ErasmusMC, Erasmus University Medical Center, Rotterdam, The Netherlands
    Blood 113:546-54. 2009
  7. doi request reprint Combined TCRG and TCRA TREC analysis reveals increased peripheral T-lymphocyte but constant intra-thymic proliferative history upon ageing
    Kim van der Weerd
    Department of Immunology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Mol Immunol 53:302-12. 2013
  8. pmc Wnt signaling in the thymus is regulated by differential expression of intracellular signaling molecules
    Floor Weerkamp
    Department of Immunology, Erasmus MC, University Medical Center Rotterdam, The Netherlands
    Proc Natl Acad Sci U S A 103:3322-6. 2006
  9. ncbi request reprint Gene therapy: is IL2RG oncogenic in T-cell development?
    Karin Pike-Overzet
    Department of Immunology, Erasmus University Medical Center, 3015 GE Rotterdam, The Netherlands
    Nature 443:E5; discussion E6-7. 2006
  10. doi request reprint Canonical wnt signaling regulates hematopoiesis in a dosage-dependent fashion
    Tiago C Luis
    Department of Immunology, Erasmus University Medical Center, The Netherlands
    Cell Stem Cell 9:345-56. 2011

Collaborators

Detail Information

Publications41

  1. doi request reprint Tales of the unexpected: tcf1 functions as a tumor suppressor for leukemias
    Frank J T Staal
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands Electronic address
    Immunity 37:761-3. 2012
    ..In this issue of Immunity, Yu et al. (2012) report that Tcf1-deficient mice develop aggressive T cell lymphomas that are characterized by high Lef1 expression...
  2. doi request reprint Stem cell self-renewal: lessons from bone marrow, gut and iPS toward clinical applications
    F J T Staal
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Leukemia 25:1095-102. 2011
    ..Here, we review the basic principles of different SC systems, and on the basis of the experience with HSC-based SC therapy, provide recommendations for clinical application of emerging SC technologies...
  3. ncbi request reprint Wnt signaling in hematopoiesis: crucial factors for self-renewal, proliferation, and cell fate decisions
    Frank J T Staal
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    J Cell Biochem 109:844-9. 2010
    ....
  4. doi request reprint Genome-wide expression analysis of paired diagnosis-relapse samples in ALL indicates involvement of pathways related to DNA replication, cell cycle and DNA repair, independent of immune phenotype
    F J T Staal
    Department of Immunology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Leukemia 24:491-9. 2010
    ..Thus, about half of the relapses are due to the selection or emergence of a clone with deregulated expression of genes involved in pathways that regulate B-cell signaling, development, cell cycle, cellular division and replication...
  5. ncbi request reprint Human thymus contains multipotent progenitors with T/B lymphoid, myeloid, and erythroid lineage potential
    Floor Weerkamp
    Department of Immunology, Erasmus MC, University Medical Center Rotterdam, The Netherlands
    Blood 107:3131-7. 2006
    ..These cells resemble hematopoietic stem cells but, by analogy with murine thymocytes, apparently lack sufficient self-renewal capacity...
  6. doi request reprint Wnt3a deficiency irreversibly impairs hematopoietic stem cell self-renewal and leads to defects in progenitor cell differentiation
    Tiago C Luis
    Department of Immunology, ErasmusMC, Erasmus University Medical Center, Rotterdam, The Netherlands
    Blood 113:546-54. 2009
    ..Our results show that Wnt3a signaling not only provides proliferative stimuli, such as for immature thymocytes, but also regulates cell fate decisions of HSC during hematopoiesis...
  7. doi request reprint Combined TCRG and TCRA TREC analysis reveals increased peripheral T-lymphocyte but constant intra-thymic proliferative history upon ageing
    Kim van der Weerd
    Department of Immunology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Mol Immunol 53:302-12. 2013
    ..This novel TREC assay approach could prove valuable in immune status monitoring in a variety of conditions...
  8. pmc Wnt signaling in the thymus is regulated by differential expression of intracellular signaling molecules
    Floor Weerkamp
    Department of Immunology, Erasmus MC, University Medical Center Rotterdam, The Netherlands
    Proc Natl Acad Sci U S A 103:3322-6. 2006
    ..Thus, responsiveness to developmental signals can be regulated by differential expression of intracellular mediators rather than by abundance of receptors or ligands...
  9. ncbi request reprint Gene therapy: is IL2RG oncogenic in T-cell development?
    Karin Pike-Overzet
    Department of Immunology, Erasmus University Medical Center, 3015 GE Rotterdam, The Netherlands
    Nature 443:E5; discussion E6-7. 2006
    ....
  10. doi request reprint Canonical wnt signaling regulates hematopoiesis in a dosage-dependent fashion
    Tiago C Luis
    Department of Immunology, Erasmus University Medical Center, The Netherlands
    Cell Stem Cell 9:345-56. 2011
    ..Differential, lineage-specific optimal Wnt dosages provide a unifying concept that explains the differences reported among inducible gain-of-function approaches, leading to either HSC expansion or depletion of the HSC pool...
  11. ncbi request reprint T-sing progenitors to commit
    Floor Weerkamp
    Department of Immunology, Erasmus Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Trends Immunol 27:125-31. 2006
    ..Here we review the perspectives of different researchers working both on murine and human T-cell development and argue that a true T-cell commitment factor might not be required because of the unique properties of the thymus...
  12. pmc The nuclear effector of Wnt-signaling, Tcf1, functions as a T-cell-specific tumor suppressor for development of lymphomas
    Machteld M Tiemessen
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    PLoS Biol 10:e1001430. 2012
    ..Thus, Tcf1 acts as a molecular switch between proliferative and repressive signals during T-lymphocyte development in the thymus...
  13. pmc Distinct monocyte gene-expression profiles in autoimmune diabetes
    Roos C Padmos
    Department of Immunology, Erasmus MC, Rotterdam, The Netherlands
    Diabetes 57:2768-73. 2008
    ..Our hypothesis is that monocytes are distinctly activated/disturbed in different subforms of autoimmune diabetes...
  14. ncbi request reprint Ig gene rearrangement steps are initiated in early human precursor B cell subsets and correlate with specific transcription factor expression
    Menno C van Zelm
    Department of Immunology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    J Immunol 175:5912-22. 2005
    ....
  15. ncbi request reprint Differential requirements for Wnt and Notch signaling in hematopoietic versus thymic niches
    Paul P C Roozen
    Department of Immunohematology and Blood Transfusion IHB, Leiden University Medical Center, Leiden, The Netherlands
    Ann N Y Acad Sci 1266:78-93. 2012
    ..Here, we review the differences and similarities between the thymic and hematopoietic niches, with particular focus on Wnt and Notch signals, as well as the latest insights into regulation of these developmentally important pathways...
  16. ncbi request reprint New insights and unresolved issues regarding insertional mutagenesis in X-linked SCID gene therapy
    Karin Pike-Overzet
    Department of Immunology, Erasmus MC, Erasmus University Medical Center, Rotterdam, The Netherlands
    Mol Ther 15:1910-6. 2007
    ..Finally, we review some newly developed murine models that may have added value for gene therapy safety studies...
  17. doi request reprint Isolation of human and mouse hematopoietic stem cells
    Yuk Yin Ng
    Department of Immunology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Methods Mol Biol 506:13-21. 2009
    ..Here we described the most often used protocols and methods to isolate human and mouse HSC to high purity...
  18. pmc New insights on human T cell development by quantitative T cell receptor gene rearrangement studies and gene expression profiling
    Willem A Dik
    Department of Immunology, Erasmus MC, 3015 GE Rotterdam, Netherlands
    J Exp Med 201:1715-23. 2005
    ..Our data demonstrate that a number of key events occur earlier than assumed previously; therefore, human T cell development is much more similar to murine T cell development than reported before...
  19. doi request reprint Novel insights into the development of T-cell acute lymphoblastic leukemia
    Frank J T Staal
    Department of Immunology, Erasmus MC, Dr Molewaterplein 50, Rotterdam, The Netherlands
    Curr Hematol Malig Rep 2:176-82. 2007
    ..In particular, the activating mutations in the Notch pathways are believed to occur in a large proportion of human T-ALL. These findings on genetic events open up new therapeutic possibilities...
  20. doi request reprint DNA microarray studies of hematopoietic subpopulations
    Karin Pike-Overzet
    Department of Immunology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Methods Mol Biol 506:403-21. 2009
    ..Over the last decade, the combination of these purification techniques with microarray analysis has resulted in an enormous gain of knowledge of blood lineages and their development...
  21. ncbi request reprint Thyrotropin acts as a T-cell developmental factor in mice and humans
    Kim van der Weerd
    1 Department of Immunology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Thyroid 24:1051-61. 2014
    ..The direct effects of TSH on thymocytes may also explain the thus far enigmatic thymic hyperplasia in Graves' disease. ..
  22. ncbi request reprint Wnt target genes identified by DNA microarrays in immature CD34+ thymocytes regulate proliferation and cell adhesion
    Frank J T Staal
    Department of Immunology, Erasmus MC, University Medical Center Rotterdam, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    J Immunol 172:1099-108. 2004
    ..In conclusion, Wnt signals mediate proliferation and cell adhesion, but not differentiation of the immature thymic progenitor pool...
  23. doi request reprint Signaling pathways involved in the development of T-cell acute lymphoblastic leukemia
    Frank J T Staal
    Department of Immunology, ErasmusMC, Rotterdam, The Netherlands
    Haematologica 93:493-7. 2008
  24. pmc The canonical Wnt signaling pathway plays an important role in lymphopoiesis and hematopoiesis
    Frank J T Staal
    Department of Immunology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Eur J Immunol 38:1788-94. 2008
    ..In this perspective, we provide a broad background to the field with a discussion of the available data and create a framework within which the available and future studies may be evaluated...
  25. doi request reprint WNT proteins: environmental factors regulating HSC fate in the niche
    Tiago C Luis
    Department of Immunology, Erasmus MC, Erasmus University Medical Center, Rotterdam, The Netherlands
    Ann N Y Acad Sci 1176:70-6. 2009
    ..Our results show that while in the thymus Wnt3a provides cytokine-like, proliferative stimuli to developing thymocyte Wnt3a regulates cell fate decisions of FL HSC in a nonredundant way...
  26. pmc The effect of oligonucleotide microarray data pre-processing on the analysis of patient-cohort studies
    Roel G W Verhaak
    Department of Hematology, Erasmus Medical Center, Rotterdam, The Netherlands
    BMC Bioinformatics 7:105. 2006
    ..By focusing on practical applications of microarray-based research, this study provides insight into the relevance of pre-processing procedures to biology-oriented researchers...
  27. ncbi request reprint Alternative splicing and differential expression of the islet autoantigen IGRP between pancreas and thymus contributes to immunogenicity of pancreatic islets but not diabetogenicity in humans
    V Martijn de Jong
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, E3 Q, P O Box 9600, NL2300RC, Leiden, The Netherlands
    Diabetologia 56:2651-8. 2013
    ..We tested whether specific splice variation in islets vs thymus correlates with loss of tolerance to IGRP in type 1 diabetes...
  28. doi request reprint Induced pluripotent stem cells and severe combined immunodeficiency: merely disease modeling or potentially a novel cure?
    Harald Mikkers
    Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
    Pediatr Res 71:427-32. 2012
    ..Here, we review these recent advances in the field from an efficacy and safety point of view...
  29. pmc Morbidly obese human subjects have increased peripheral blood CD4+ T cells with skewing toward a Treg- and Th2-dominated phenotype
    Kim van der Weerd
    1Department of Immunology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Diabetes 61:401-8. 2012
    ..This is associated with increased CD4+ T cells, with skewing toward a Treg- and Th2-dominated phenotype, suggesting a more anti-inflammatory set point...
  30. ncbi request reprint Age-related changes in the cellular composition of the thymus in children
    Floor Weerkamp
    Department of Immunology, Erasmus MC, University Medical Center Rotterdam, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    J Allergy Clin Immunol 115:834-40. 2005
    ..T-cell development in the thymus is an extensively studied subject, mainly in mice. Nevertheless, the normal composition and cell numbers of the noninvoluted human thymus are largely unknown...
  31. doi request reprint Integrated transcript and genome analyses reveal NKX2-1 and MEF2C as potential oncogenes in T cell acute lymphoblastic leukemia
    Irene Homminga
    Department of Pediatric Oncology Hematology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Cancer Cell 19:484-97. 2011
    ..We propose NKX2-1, NKX2-2, and MEF2C as T-ALL oncogenes that are activated by various rearrangements...
  32. ncbi request reprint WNT signalling and haematopoiesis: a WNT-WNT situation
    Frank J T Staal
    Department of Immunology, Room Ee 838, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands
    Nat Rev Immunol 5:21-30. 2005
    ....
  33. ncbi request reprint Wnt signaling in leukemias and myeloma: T-cell factors are in control
    Machteld M Tiemessen
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Future Oncol 9:1757-72. 2013
    ..During the past decade it also became clear that in hematological malignancies abnormal regulation of the Wnt pathway can either be causative or enhance disease progression, which will be discussed in detail in this review. ..
  34. doi request reprint WNT signalling in the immune system: WNT is spreading its wings
    Frank J T Staal
    Department of Immunology, Erasmus University Medical Center, 3015 GE, Rotterdam, The Netherlands
    Nat Rev Immunol 8:581-93. 2008
    ..WNT signalling is therefore subject to strict molecular control, and dysregulated WNT signalling is implicated in the development of haematological malignancies...
  35. doi request reprint Canonical Wnt signaling negatively modulates regulatory T cell function
    Jorg van Loosdregt
    Department of Immunology, University Medical Center Utrecht, Utrecht 3584EA, The Netherlands
    Immunity 39:298-310. 2013
    ..We propose a model in which Wnt produced under inflammatory conditions represses Treg cell function, allowing a productive immune response, but, if uncontrolled, could lead to the development of autoimmunity. ..
  36. ncbi request reprint Gene expression profiling in acute lymphoblastic leukemia (ALL)
    Frank J T Staal
    Department of Immunology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Lab Hematol 10:178-81. 2004
  37. ncbi request reprint Selective in vitro expansion and efficient retroviral transduction of human CD34+ CD38- haematopoietic stem cells
    Yuk Yin Ng
    Departments of Hematology and Immunology, University Medical Center, Utrecht, The Netherlands
    Br J Haematol 117:226-37. 2002
    ....
  38. ncbi request reprint Wnt signaling in the thymus
    Frank J T Staal
    Department of Immunology, Erasmus MC, Erasmus University Rotterdam, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Curr Opin Immunol 15:204-8. 2003
    ..Active Wnt signaling is an absolute requirement for T-cell development, as demonstrated by the complete block in thymocyte development observed in the absence of Tcf1 and Lef1, or in the presence of extracellular Wnt inhibitors...
  39. doi request reprint Profiling of antibody production against xenograft-released proteins by protein microarrays discovers prostate cancer markers
    Flip H Jansen
    Department of Urology, Erasmus MC, 3000 CA Rotterdam, The Netherlands
    J Proteome Res 11:728-35. 2012
    ..In conclusion, this novel method allows for the identification of low abundant cancer-derived serum proteins, circumventing dynamic range and host-response issues in standard patient cohort proteomics comparisons...
  40. ncbi request reprint Endothelial progenitor cell dysfunction in type 1 diabetes: another consequence of oxidative stress?
    Cindy J M Loomans
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Antioxid Redox Signal 7:1468-75. 2005
    ..Finally, we discuss the potential implication of our findings for EPC-based therapies and the potential impact of pharmacological interventions on the vascular regenerative capacity of EPC...
  41. doi request reprint A discriminating messenger RNA signature for bipolar disorder formed by an aberrant expression of inflammatory genes in monocytes
    Roos C Padmos
    Department of Immunology, Erasmus Medical Center, 3000 DR Rotterdam, The Netherlands
    Arch Gen Psychiatry 65:395-407. 2008
    ..Mood disturbances are associated with an activated inflammatory response system...