Eric Spierings

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. pmc A uniform genomic minor histocompatibility antigen typing methodology and database designed to facilitate clinical applications
    Eric Spierings
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center Leiden, The Netherlands
    PLoS ONE 1:e42. 2006
  2. ncbi request reprint Identification of HLA class II-restricted H-Y-specific T-helper epitope evoking CD4+ T-helper cells in H-Y-mismatched transplantation
    Eric Spierings
    Department of Immunohaematology and Blood Transfusion, Leiden University Medical Centre, Post Box 9600, 2300 RC, Leiden, Netherlands
    Lancet 362:610-5. 2003
  3. pmc Phenotype frequencies of autosomal minor histocompatibility antigens display significant differences among populations
    Eric Spierings
    Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    PLoS Genet 3:e103. 2007
  4. doi request reprint In situ detection of HY-specific T cells in acute graft-versus-host disease-affected male skin after sex-mismatched stem cell transplantation
    Yeung Hyen Kim
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Biol Blood Marrow Transplant 18:381-7. 2012
  5. ncbi request reprint Minor histocompatibility antigens--big in tumour therapy
    Eric Spierings
    Department of Immunohaematology and Blood Transfusion, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Trends Immunol 25:56-60. 2004
  6. doi request reprint Exogenous Addition of Minor H Antigen HA-1+ Dendritic Cells to Skin Tissues Ex Vivo Causes Infiltration and Activation of HA-1-Specific Cytotoxic T Cells
    Yeung Hyen Kim
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Biol Blood Marrow Transplant 17:69-77. 2011
  7. ncbi request reprint Risk assessment in haematopoietic stem cell transplantation: minor histocompatibility antigens
    Lothar Hambach
    Department of Immunohaematology and Blood Transfusion, Leiden University Medical Centre, Post Box 9600, 2300 RC Leiden, The Netherlands
    Best Pract Res Clin Haematol 20:171-87. 2007
  8. doi request reprint Gene therapy with IgG-HY fusion proteins to reduce male-specific T-cell reactivity in vitro
    Miranda P Dierselhuis
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Hum Gene Ther 22:44-54. 2011
  9. doi request reprint Multicenter analyses demonstrate significant clinical effects of minor histocompatibility antigens on GvHD and GvL after HLA-matched related and unrelated hematopoietic stem cell transplantation
    Eric Spierings
    Laboratory for Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Biol Blood Marrow Transplant 19:1244-53. 2013
  10. ncbi request reprint A possible role for CCL27/CTACK-CCR10 interaction in recruiting CD4 T cells to skin in human graft-versus-host disease
    Claudia M J M Faaij
    Department of Paediatrics, Division of Immunology, Haematology, Oncology, Bone Marrow Transplantation and Autoimmune Diseases, Leiden University Medical Centre, 2300 RC Leiden, The Netherlands
    Br J Haematol 133:538-49. 2006

Collaborators

Detail Information

Publications18

  1. pmc A uniform genomic minor histocompatibility antigen typing methodology and database designed to facilitate clinical applications
    Eric Spierings
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center Leiden, The Netherlands
    PLoS ONE 1:e42. 2006
    ..In parallel, clinical application of minor H antigen typing has gained interest. So far, relevant and simple tools to analyze the minor H antigens in a quick and reliable way are lacking...
  2. ncbi request reprint Identification of HLA class II-restricted H-Y-specific T-helper epitope evoking CD4+ T-helper cells in H-Y-mismatched transplantation
    Eric Spierings
    Department of Immunohaematology and Blood Transfusion, Leiden University Medical Centre, Post Box 9600, 2300 RC, Leiden, Netherlands
    Lancet 362:610-5. 2003
    ..We aimed to identify and clarify the role of MHC class II-restricted H-Y-specific T-helper cells in these transplant settings...
  3. pmc Phenotype frequencies of autosomal minor histocompatibility antigens display significant differences among populations
    Eric Spierings
    Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    PLoS Genet 3:e103. 2007
    ..Significant differences in minor H antigen frequencies were observed between the ethnic populations, some of which appeared to be geographically correlated...
  4. doi request reprint In situ detection of HY-specific T cells in acute graft-versus-host disease-affected male skin after sex-mismatched stem cell transplantation
    Yeung Hyen Kim
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Biol Blood Marrow Transplant 18:381-7. 2012
    ....
  5. ncbi request reprint Minor histocompatibility antigens--big in tumour therapy
    Eric Spierings
    Department of Immunohaematology and Blood Transfusion, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Trends Immunol 25:56-60. 2004
    ..This novel insight has important consequences in the search for, and the use of, minor H antigens as immunotherapeutics in stem-cell-based immunotherapy of haematological malignancies and solid tumours...
  6. doi request reprint Exogenous Addition of Minor H Antigen HA-1+ Dendritic Cells to Skin Tissues Ex Vivo Causes Infiltration and Activation of HA-1-Specific Cytotoxic T Cells
    Yeung Hyen Kim
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Biol Blood Marrow Transplant 17:69-77. 2011
    ..Although in our model the infiltrated and activated CTLs did not cause skin tissue destruction, our results provide a first step in understanding the reported association of HA-1 mismatching with clinical GVHD...
  7. ncbi request reprint Risk assessment in haematopoietic stem cell transplantation: minor histocompatibility antigens
    Lothar Hambach
    Department of Immunohaematology and Blood Transfusion, Leiden University Medical Centre, Post Box 9600, 2300 RC Leiden, The Netherlands
    Best Pract Res Clin Haematol 20:171-87. 2007
    ..Current research is elucidating the impact of e.g. donor immunization, immunodominance, or functional expression of minor H antigens on the extent of the GvH response...
  8. doi request reprint Gene therapy with IgG-HY fusion proteins to reduce male-specific T-cell reactivity in vitro
    Miranda P Dierselhuis
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Hum Gene Ther 22:44-54. 2011
    ..These first observations serve as a basis for further studying and understanding the tolerizing potential of IgG constructs with human T cells...
  9. doi request reprint Multicenter analyses demonstrate significant clinical effects of minor histocompatibility antigens on GvHD and GvL after HLA-matched related and unrelated hematopoietic stem cell transplantation
    Eric Spierings
    Laboratory for Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Biol Blood Marrow Transplant 19:1244-53. 2013
    ....
  10. ncbi request reprint A possible role for CCL27/CTACK-CCR10 interaction in recruiting CD4 T cells to skin in human graft-versus-host disease
    Claudia M J M Faaij
    Department of Paediatrics, Division of Immunology, Haematology, Oncology, Bone Marrow Transplantation and Autoimmune Diseases, Leiden University Medical Centre, 2300 RC Leiden, The Netherlands
    Br J Haematol 133:538-49. 2006
    ..These findings support the involvement of CCL27/CTACK-CCR10 interaction in recruiting CD4+ T cells to the skin, thus contributing to the pathogenesis of acute GvHD...
  11. pmc Expanding the immunotherapeutic potential of minor histocompatibility antigens
    Eric Spierings
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    J Clin Invest 115:3397-400. 2005
    ..This result represents another example of an mHAg-mediated graft-versus-leukemia response, thereby expanding the number of patients eligible for mHAg-based immunotherapy in the setting of HSCT...
  12. ncbi request reprint The DBY gene codes for an HLA-DQ5-restricted human male-specific minor histocompatibility antigen involved in graft-versus-host disease
    Mario H J Vogt
    Department of Hematology, Leiden University Medical Center, The Netherlands
    Blood 99:3027-32. 2002
    ..Although the epitope differed by 3 amino acids from its X-homolog DBX, only 2 polymorphisms were shown to be essential for recognition by the CTL clone...
  13. ncbi request reprint Molecular typing methods for minor histocompatibility antigens
    Eric Spierings
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Methods Mol Med 134:81-96. 2007
    ..It is therefore timely to type stem cell transplant recipients and their donors for minor H antigens. Here, we summarize all the currently known methodologies for minor H antigen typing on the genomic and on the RNA level...
  14. doi request reprint Steric hindrance and fast dissociation explain the lack of immunogenicity of the minor histocompatibility HA-1Arg Null allele
    Eric Spierings
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    J Immunol 182:4809-16. 2009
    ..These data provide a rationale for the lack of HA-1(Arg) peptide immunogenicity essential for the choice of tumor peptides for stem cell-based immunotherapeutic application...
  15. ncbi request reprint The minor histocompatibility antigen HA-3 arises from differential proteasome-mediated cleavage of the lymphoid blast crisis (Lbc) oncoprotein
    Eric Spierings
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Blood 102:621-9. 2003
    ..Thus, the immunogenicity of minor H antigens can result from proteasome-mediated destruction of the negative allelic peptide...
  16. ncbi request reprint Minor histocompatibility antigen DDX3Y induces HLA-DQ5-restricted T cell responses with limited TCR-Vbeta usage both in vivo and in vitro
    David Laurin
    Cell Therapy Department, Etablissement Français du Sang région Rhone Alpes, Rhone, France
    Biol Blood Marrow Transplant 12:1114-24. 2006
    ..The results also demonstrate that in vitro stimulation of T cells with allogeneic HLA-identical dendritic cells may facilitate the characterization of in vivo, potentially relevant HLA class II-restricted minor H epitopes...
  17. ncbi request reprint Matching of the minor histocompatibility antigen HLA-A1/H-Y may improve prognosis in corneal transplantation
    Daniel Böhringer
    Eye Hospital and LIONS Cornea Bank Regio Baden Württemberg, University Hospital Freiburg, Germany
    Transplantation 82:1037-41. 2006
    ..This investigation is to assess any benefit of matching the broadly expressed gender (H-Y) and HA-3 antigens in HLA-A1 donor positive human keratoplasty...
  18. ncbi request reprint In situ visualization of antigen-specific T cells in cryopreserved human tissues
    Florry A Vyth-Dreese
    Division of Immunology, The Netherlands Cancer Institute, Amsterdam
    J Immunol Methods 310:78-85. 2006
    ..The visualization of antigen-specific T cells, combined with detection of other membrane, cytoplasmic, or nuclear markers is now feasible...