Hermelijn H Smits

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. ncbi ICOS expression by activated human Th cells is enhanced by IL-12 and IL-23: increased ICOS expression enhances the effector function of both Th1 and Th2 cells
    Lianne Wassink
    Academic Medical Center, Department of Cell Biology and Histology, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 173:1779-86. 2004
  2. ncbi Dendritic cell-mediated T cell polarization
    Esther C de Jong
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1100 AZ, Amsterdam, The Netherlands
    Springer Semin Immunopathol 26:289-307. 2005
  3. pmc Alterations in peripheral blood B cell subsets and dynamics of B cell responses during human schistosomiasis
    Lucja A Labuda
    Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
    PLoS Negl Trop Dis 7:e2094. 2013
  4. pmc Potential of immunoglobulin A to prevent allergic asthma
    Anouk K Gloudemans
    Department of Pulmonology, Erasmus Medical Center, Rotterdam, The Netherlands
    Clin Dev Immunol 2013:542091. 2013
  5. pmc The mucosal adjuvant cholera toxin B instructs non-mucosal dendritic cells to promote IgA production via retinoic acid and TGF-β
    Anouk K Gloudemans
    Department of Pulmonary Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    PLoS ONE 8:e59822. 2013
  6. doi B cells in allergic diseases: bad or better?
    Hermelijn H Smits
    Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
    Autoimmunity 45:415-26. 2012
  7. ncbi Chronic helminth infections modulate allergen-specific immune responses: Protection against development of allergic disorders?
    Hermelijn H Smits
    Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
    Ann Med 39:428-39. 2007
  8. ncbi Helminth infections: protection from atopic disorders
    Hermelijn H Smits
    Department of Parasitology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Curr Allergy Asthma Rep 5:42-50. 2005
  9. ncbi Protective effect of Schistosoma mansoni infection on allergic airway inflammation depends on the intensity and chronicity of infection
    Hermelijn H Smits
    Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
    J Allergy Clin Immunol 120:932-40. 2007
  10. pmc Chronic helminth infections protect against allergic diseases by active regulatory processes
    Hermelijn H Smits
    Department of Parasitology, Leiden University Medical Center, Albinusdreef 2, Leiden, The Netherlands
    Curr Allergy Asthma Rep 10:3-12. 2010

Collaborators

Detail Information

Publications31

  1. ncbi ICOS expression by activated human Th cells is enhanced by IL-12 and IL-23: increased ICOS expression enhances the effector function of both Th1 and Th2 cells
    Lianne Wassink
    Academic Medical Center, Department of Cell Biology and Histology, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 173:1779-86. 2004
    ....
  2. ncbi Dendritic cell-mediated T cell polarization
    Esther C de Jong
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1100 AZ, Amsterdam, The Netherlands
    Springer Semin Immunopathol 26:289-307. 2005
    ..This review discusses the way DC adapt the T cell response to the type of pathogen, focusing on the tools that DC use in this management of the T cell response...
  3. pmc Alterations in peripheral blood B cell subsets and dynamics of B cell responses during human schistosomiasis
    Lucja A Labuda
    Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
    PLoS Negl Trop Dis 7:e2094. 2013
    ..These data show that S. haematobium infection leads to significant changes in the B cell compartment, both at the phenotypic and functional level...
  4. pmc Potential of immunoglobulin A to prevent allergic asthma
    Anouk K Gloudemans
    Department of Pulmonology, Erasmus Medical Center, Rotterdam, The Netherlands
    Clin Dev Immunol 2013:542091. 2013
    ..Finally, we discuss how this information can be used to translate into the development of new therapies for allergic diseases based on, or supplemented with, IgA boosting strategies...
  5. pmc The mucosal adjuvant cholera toxin B instructs non-mucosal dendritic cells to promote IgA production via retinoic acid and TGF-β
    Anouk K Gloudemans
    Department of Pulmonary Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    PLoS ONE 8:e59822. 2013
    ..This study highlights that synergism between CTB and MyD88-dependent TLR signals selectively imprints a TI IgA-inducing capacity in non-mucosal DCs, explaining how CTB acts as an IgA promoting adjuvant...
  6. doi B cells in allergic diseases: bad or better?
    Hermelijn H Smits
    Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
    Autoimmunity 45:415-26. 2012
    ..This review will highlight the current knowledge on disease-promoting or disease-protecting activities of B cells and discuss its potential for therapeutic applications in allergies...
  7. ncbi Chronic helminth infections modulate allergen-specific immune responses: Protection against development of allergic disorders?
    Hermelijn H Smits
    Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
    Ann Med 39:428-39. 2007
    ..Advantage should be taken from this knowledge to identify and select individual helminth-derived molecules that may harbor therapeutic potential against inflammatory diseases...
  8. ncbi Helminth infections: protection from atopic disorders
    Hermelijn H Smits
    Department of Parasitology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Curr Allergy Asthma Rep 5:42-50. 2005
    ..It would be interesting to define and characterize particular helminth molecules that have profound immunomodulatory capacities as a target for therapeutic application in the treatment or prophylaxis of allergic manifestations...
  9. ncbi Protective effect of Schistosoma mansoni infection on allergic airway inflammation depends on the intensity and chronicity of infection
    Hermelijn H Smits
    Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
    J Allergy Clin Immunol 120:932-40. 2007
    ..Population studies have suggested that chronic and intense helminth infections, in contrast to acute and mild helminth infections, might suppress allergic airway inflammation...
  10. pmc Chronic helminth infections protect against allergic diseases by active regulatory processes
    Hermelijn H Smits
    Department of Parasitology, Leiden University Medical Center, Albinusdreef 2, Leiden, The Netherlands
    Curr Allergy Asthma Rep 10:3-12. 2010
    ..It is of great interest to define and characterize specific helminth molecules that have profound immunomodulatory capacities as targets for therapeutic application in the treatment or prophylaxis of allergic manifestations...
  11. ncbi Specific glycan elements determine differential binding of individual egg glycoproteins of the human parasite Schistosoma mansoni by host C-type lectin receptors
    Moniek H J Meevissen
    Department of Parasitology, Leiden University Medical Centre, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Int J Parasitol 42:269-77. 2012
    ..This study provides a molecular and structural basis for future studies of the interaction between C-type lectin receptors and other soluble egg antigen glycoproteins and their effects on the host immune response...
  12. ncbi Rapamycin and omega-1: mTOR-dependent and -independent Th2 skewing by human dendritic cells
    Leonie Hussaarts
    Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
    Immunol Cell Biol 91:486-9. 2013
    ..We conclude that conditioning human moDCs to skew immune responses towards Th2 can be achieved via an mTOR-dependent and -independent pathway triggered by rapamycin and helminth antigens, respectively. ..
  13. pmc Schistosomes induce regulatory features in human and mouse CD1d(hi) B cells: inhibition of allergic inflammation by IL-10 and regulatory T cells
    Luciën E P M van der Vlugt
    Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 7:e30883. 2012
    ....
  14. pmc Functional impairment of human myeloid dendritic cells during Schistosoma haematobium infection
    Bart Everts
    Department of Parasitology, Leiden University Medical Centre, Leiden, The Netherlands
    PLoS Negl Trop Dis 4:e667. 2010
    ..haematobium infection is associated with functional impairment of human DC function in vivo and provide new insights into the underlying mechanisms of T cell hyporesponsiveness during chronic schistosomiasis...
  15. doi Regulatory B-cell induction by helminths: implications for allergic disease
    Leonie Hussaarts
    Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
    J Allergy Clin Immunol 128:733-9. 2011
    ....
  16. pmc Schistosome-derived omega-1 drives Th2 polarization by suppressing protein synthesis following internalization by the mannose receptor
    Bart Everts
    Department of Parasitology, Leiden University Medical Center, 2333 ZA Leiden, Netherlands
    J Exp Med 209:1753-67, S1. 2012
    ..These experiments reveal an unrecognized pathway involving MR and interference with protein synthesis that conditions DCs for Th2 priming...
  17. ncbi Helminths and dendritic cells: sensing and regulating via pattern recognition receptors, Th2 and Treg responses
    Bart Everts
    Department of Parasitology, Leiden University Medical Centre, ZA Leiden, The Netherlands
    Eur J Immunol 40:1525-37. 2010
    ..Here, we will discuss these new insights and will link them to the origin and importance of Th2 and regulatory immune responses with respect to the survival of both parasite and host...
  18. doi Asymptomatic plasmodial infection is associated with increased tumor necrosis factor receptor II-expressing regulatory T cells and suppressed type 2 immune responses
    Linda J Wammes
    Department of Parasitology, Leiden University Medical Center, The Netherlands
    J Infect Dis 207:1590-9. 2013
    ..In malaria-endemic areas, a proportion of individuals becomes chronic carriers of parasites with few or no clinical signs. There is little information on cellular immune responses in asymptomatic parasite carriers...
  19. ncbi Innate, adaptive and regulatory responses in schistosomiasis: relationship to allergy
    Franca C Hartgers
    Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
    Chem Immunol Allergy 90:157-75. 2006
    ..Furthermore, the different mechanisms of immune hyporesponsiveness are depicted with emphasis on regulatory T cells. Finally, the relationship between downregulatory responses and allergy is discussed...
  20. pmc Omega-1, a glycoprotein secreted by Schistosoma mansoni eggs, drives Th2 responses
    Bart Everts
    Department of Parasitology, Leiden University Medical Centre, Leiden 2333 ZA, The Netherlands
    J Exp Med 206:1673-80. 2009
    ..Collectively, we identify omega-1, a single component of SEA, as a potent inducer of Th2 responses...
  21. pmc Regulatory T cells in human lymphatic filariasis: stronger functional activity in microfilaremics
    Linda J Wammes
    Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
    PLoS Negl Trop Dis 6:e1655. 2012
    ..These suppressive effects were only observed in the MF group and not in EN or CP. These findings may be important when considering strategies for filarial treatment and the targeted prevention of filaria-induced lymphedema...
  22. ncbi Toll-like receptor ligation for the induction of regulatory B cells
    Luciën E P M van der Vlugt
    Department of Parasitology, Cellular Immunology of Helminths, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands
    Methods Mol Biol 1190:127-41. 2014
    ..Furthermore, we describe an assay to investigate the suppressive properties of TLR-induced B cells to confirm their regulatory B cell status. ..
  23. doi Regulatory T cells in human geohelminth infection suppress immune responses to BCG and Plasmodium falciparum
    Linda J Wammes
    Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Immunol 40:437-42. 2010
    ..Geohelminth-induced immune modulation may have important consequences for co-endemic infections and vaccine trials...
  24. ncbi Intercellular adhesion molecule-1/LFA-1 ligation favors human Th1 development
    Hermelijn H Smits
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, and Department of Molecular Cell Biology, Free University Medical Center, Amsterdam, The Netherlands
    J Immunol 168:1710-6. 2002
    ..This mechanism may be operational during viral infections...
  25. ncbi Different faces of regulatory DCs in homeostasis and immunity
    Hermelijn H Smits
    Departments of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1100 AZ Amsterdam, The Netherlands
    Trends Immunol 26:123-9. 2005
  26. pmc Helicobacter pylori modulates the T helper cell 1/T helper cell 2 balance through phase-variable interaction between lipopolysaccharide and DC-SIGN
    Mathijs P Bergman
    Department of Medical Microbiology and Infection Control, Vrije Universiteit Medical Center, 1081 BT Amsterdam, The Netherlands
    J Exp Med 200:979-90. 2004
    ..Our data indicate a role for LPS phase variation and Le antigen expression by H. pylori in suppressing immune responses through DC-SIGN...
  27. ncbi Selective probiotic bacteria induce IL-10-producing regulatory T cells in vitro by modulating dendritic cell function through dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin
    Hermelijn H Smits
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    J Allergy Clin Immunol 115:1260-7. 2005
    ..On the basis of pathogenic or tissue-specific priming, dendritic cells (DC) acquire different T cell-instructive signals and drive the differentiation of naive T H cells into either T H 1, T H 2, or regulatory effector T cells...
  28. ncbi Commensal Gram-negative bacteria prime human dendritic cells for enhanced IL-23 and IL-27 expression and enhanced Th1 development
    Hermelijn H Smits
    Academic Medical Center, Department of Cell Biology and Histology, University of Amsterdam, Amsterdam, The Netherlands
    Eur J Immunol 34:1371-80. 2004
    ..Importantly, this study gives indications that the expression of the different IL-12 family members is dictated by different priming conditions of immature DC...
  29. ncbi Monocyte-derived dendritic cells exposed to Der p 1 allergen enhance the recruitment of Th2 cells: major involvement of the chemokines TARC/CCL17 and MDC/CCL22
    Hamida Hammad
    INSERM U416, IFR 17, Institut Pasteur de Lille, France
    Eur Cytokine Netw 14:219-28. 2003
    ..These results suggest that in allergic patients exposed to house dust mites, DC may favour the exacerbation of the Th2 response via the increase in type 2 chemokine production...
  30. ncbi Sustained IL-12 signaling is required for Th1 development
    Veronica Athie-Morales
    Lymphocyte Activation Laboratory and Biochemical Regulatory Mechanisms Laboratory, Cancer Research UK London Research Institute, Lincoln s Inn Fields Laboratories, London, United Kingdom
    J Immunol 172:61-9. 2004
    ..Collectively these data show that the duration of cytokine signaling is important for determining the biological response...
  31. ncbi CD26/DPPIV signal transduction function, but not proteolytic activity, is directly related to its expression level on human Th1 and Th2 cell lines as detected with living cell cytochemistry
    Emil P Boonacker
    Academic Medical Center, University of Amsterdam, Department of Cell Biology and Histology, Amsterdam, The Netherlands
    J Histochem Cytochem 50:1169-77. 2002
    ..Western blotting and zymography of Th1 and Th2 whole-cell lysates demonstrated similar patterns. This study shows that two functions of one molecule can be controlled differentially...