Research Topics
Species | Hermelijn H SmitsSummaryAffiliation: Leiden University Medical Center Country: The Netherlands Publications
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Detail Information
Publications
ICOS expression by activated human Th cells is enhanced by IL-12 and IL-23: increased ICOS expression enhances the effector function of both Th1 and Th2 cellsLianne Wassink
Academic Medical Center, Department of Cell Biology and Histology, University of Amsterdam, Amsterdam, The Netherlands
J Immunol 173:1779-86. 2004....- Dendritic cell-mediated T cell polarizationEsther C de Jong
Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1100 AZ, Amsterdam, The Netherlands
Springer Semin Immunopathol 26:289-307. 2005..This review discusses the way DC adapt the T cell response to the type of pathogen, focusing on the tools that DC use in this management of the T cell response... 
B cells in allergic diseases: bad or better?Hermelijn H Smits
Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
Autoimmunity 45:415-26. 2012..This review will highlight the current knowledge on disease-promoting or disease-protecting activities of B cells and discuss its potential for therapeutic applications in allergies...- Protective effect of Schistosoma mansoni infection on allergic airway inflammation depends on the intensity and chronicity of infectionHermelijn H Smits
Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
J Allergy Clin Immunol 120:932-40. 2007..Population studies have suggested that chronic and intense helminth infections, in contrast to acute and mild helminth infections, might suppress allergic airway inflammation... 
Chronic helminth infections protect against allergic diseases by active regulatory processesHermelijn H Smits
Department of Parasitology, Leiden University Medical Center, Albinusdreef 2, Leiden, The Netherlands
Curr Allergy Asthma Rep 10:3-12. 2010..It is of great interest to define and characterize specific helminth molecules that have profound immunomodulatory capacities as targets for therapeutic application in the treatment or prophylaxis of allergic manifestations...- Chronic helminth infections modulate allergen-specific immune responses: Protection against development of allergic disorders?Hermelijn H Smits
Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
Ann Med 39:428-39. 2007..Advantage should be taken from this knowledge to identify and select individual helminth-derived molecules that may harbor therapeutic potential against inflammatory diseases... - Helminth infections: protection from atopic disordersHermelijn H Smits
Department of Parasitology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
Curr Allergy Asthma Rep 5:42-50. 2005..It would be interesting to define and characterize particular helminth molecules that have profound immunomodulatory capacities as a target for therapeutic application in the treatment or prophylaxis of allergic manifestations... - Specific glycan elements determine differential binding of individual egg glycoproteins of the human parasite Schistosoma mansoni by host C-type lectin receptorsMoniek H J Meevissen
Department of Parasitology, Leiden University Medical Centre, P O Box 9600, 2300 RC, Leiden, The Netherlands
Int J Parasitol 42:269-77. 2012..This study provides a molecular and structural basis for future studies of the interaction between C-type lectin receptors and other soluble egg antigen glycoproteins and their effects on the host immune response... - Helminths and dendritic cells: sensing and regulating via pattern recognition receptors, Th2 and Treg responsesBart Everts
Department of Parasitology, Leiden University Medical Centre, ZA Leiden, The Netherlands
Eur J Immunol 40:1525-37. 2010..Here, we will discuss these new insights and will link them to the origin and importance of Th2 and regulatory immune responses with respect to the survival of both parasite and host... - Schistosome-derived omega-1 drives Th2 polarization by suppressing protein synthesis following internalization by the mannose receptorBart Everts
Department of Parasitology, Leiden University Medical Center, 2333 ZA Leiden, Netherlands
J Exp Med 209:1753-67, S1. 2012..These experiments reveal an unrecognized pathway involving MR and interference with protein synthesis that conditions DCs for Th2 priming... - Regulatory B-cell induction by helminths: implications for allergic diseaseLeonie Hussaarts
Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
J Allergy Clin Immunol 128:733-9. 2011.... - Schistosomes induce regulatory features in human and mouse CD1d(hi) B cells: inhibition of allergic inflammation by IL-10 and regulatory T cellsLuciën E P M van der Vlugt
Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
PLoS ONE 7:e30883. 2012.... - Functional impairment of human myeloid dendritic cells during Schistosoma haematobium infectionBart Everts
Department of Parasitology, Leiden University Medical Centre, Leiden, The Netherlands
PLoS Negl Trop Dis 4:e667. 2010..haematobium infection is associated with functional impairment of human DC function in vivo and provide new insights into the underlying mechanisms of T cell hyporesponsiveness during chronic schistosomiasis... - Innate, adaptive and regulatory responses in schistosomiasis: relationship to allergyFranca C Hartgers
Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
Chem Immunol Allergy 90:157-75. 2006..Furthermore, the different mechanisms of immune hyporesponsiveness are depicted with emphasis on regulatory T cells. Finally, the relationship between downregulatory responses and allergy is discussed... - Omega-1, a glycoprotein secreted by Schistosoma mansoni eggs, drives Th2 responsesBart Everts
Department of Parasitology, Leiden University Medical Centre, Leiden 2333 ZA, The Netherlands
J Exp Med 206:1673-80. 2009..Collectively, we identify omega-1, a single component of SEA, as a potent inducer of Th2 responses... - Regulatory T cells in human lymphatic filariasis: stronger functional activity in microfilaremicsLinda J Wammes
Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
PLoS Negl Trop Dis 6:e1655. 2012..These suppressive effects were only observed in the MF group and not in EN or CP. These findings may be important when considering strategies for filarial treatment and the targeted prevention of filaria-induced lymphedema... - Regulatory T cells in human geohelminth infection suppress immune responses to BCG and Plasmodium falciparumLinda J Wammes
Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
Eur J Immunol 40:437-42. 2010..Geohelminth-induced immune modulation may have important consequences for co-endemic infections and vaccine trials... - Intercellular adhesion molecule-1/LFA-1 ligation favors human Th1 developmentHermelijn H Smits
Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, and Department of Molecular Cell Biology, Free University Medical Center, Amsterdam, The Netherlands
J Immunol 168:1710-6. 2002..This mechanism may be operational during viral infections... - Monocyte-derived dendritic cells exposed to Der p 1 allergen enhance the recruitment of Th2 cells: major involvement of the chemokines TARC/CCL17 and MDC/CCL22Hamida Hammad
INSERM U416, IFR 17, Institut Pasteur de Lille, France
Eur Cytokine Netw 14:219-28. 2003..These results suggest that in allergic patients exposed to house dust mites, DC may favour the exacerbation of the Th2 response via the increase in type 2 chemokine production... - Helicobacter pylori modulates the T helper cell 1/T helper cell 2 balance through phase-variable interaction between lipopolysaccharide and DC-SIGNMathijs P Bergman
Department of Medical Microbiology and Infection Control, Vrije Universiteit Medical Center, 1081 BT Amsterdam, The Netherlands
J Exp Med 200:979-90. 2004..Our data indicate a role for LPS phase variation and Le antigen expression by H. pylori in suppressing immune responses through DC-SIGN... - Selective probiotic bacteria induce IL-10-producing regulatory T cells in vitro by modulating dendritic cell function through dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrinHermelijn H Smits
Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
J Allergy Clin Immunol 115:1260-7. 2005..CONCLUSIONS: The targeting of DC-SIGN by certain probiotic bacteria might explain their beneficial effect in the treatment of a number of inflammatory diseases, including atopic dermatitis and Crohn's disease... - Sustained IL-12 signaling is required for Th1 developmentVeronica Athie-Morales
Lymphocyte Activation Laboratory and Biochemical Regulatory Mechanisms Laboratory, Cancer Research UK London Research Institute, Lincoln's Inn Fields Laboratories, London, United Kingdom
J Immunol 172:61-9. 2004..Collectively these data show that the duration of cytokine signaling is important for determining the biological response... - Different faces of regulatory DCs in homeostasis and immunityHermelijn H Smits
Departments of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1100 AZ Amsterdam, The Netherlands
Trends Immunol 26:123-9. 2005 - CD26/DPPIV signal transduction function, but not proteolytic activity, is directly related to its expression level on human Th1 and Th2 cell lines as detected with living cell cytochemistryEmil P Boonacker
Academic Medical Center, University of Amsterdam, Department of Cell Biology and Histology, Amsterdam, The Netherlands
J Histochem Cytochem 50:1169-77. 2002..Western blotting and zymography of Th1 and Th2 whole-cell lysates demonstrated similar patterns. This study shows that two functions of one molecule can be controlled differentially... - Commensal Gram-negative bacteria prime human dendritic cells for enhanced IL-23 and IL-27 expression and enhanced Th1 developmentHermelijn H Smits
Academic Medical Center, Department of Cell Biology and Histology, University of Amsterdam, Amsterdam, The Netherlands
Eur J Immunol 34:1371-80. 2004..Importantly, this study gives indications that the expression of the different IL-12 family members is dictated by different priming conditions of immature DC...