Elisabeth H Slager

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint Identification of the angiogenic endothelial-cell growth factor-1/thymidine phosphorylase as a potential target for immunotherapy of cancer
    Elisabeth H Slager
    Department of Hematology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Blood 107:4954-60. 2006
  2. pmc Identification of phosphatidylinositol 4-kinase type II beta as HLA class II-restricted target in graft versus leukemia reactivity
    Marieke Griffioen
    Departments of Hematology and Immunohematology and Blood Transfusion, Leiden University Medical Center, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Proc Natl Acad Sci U S A 105:3837-42. 2008
  3. ncbi request reprint CD4+ Th2 cell recognition of HLA-DR-restricted epitopes derived from CAMEL: a tumor antigen translated in an alternative open reading frame
    Elisabeth H Slager
    Department of Clinical Oncology, Leiden University Medical Center, The Netherlands
    J Immunol 170:1490-7. 2003
  4. ncbi request reprint Induction of CAMEL/NY-ESO-ORF2-specific CD8+ T cells upon stimulation with dendritic cells infected with a modified Ad5 vector expressing a chimeric Ad5/35 fiber
    Elisabeth H Slager
    Department of Clinical Oncology, Leiden University Medical Center, Leiden, The Netherlands
    Cancer Gene Ther 11:227-36. 2004
  5. ncbi request reprint Identification of multiple HLA-DR-restricted epitopes of the tumor-associated antigen CAMEL by CD4+ Th1/Th2 lymphocytes
    Elisabeth H Slager
    Department of Clinical Oncology, Leiden University Medical Center, Leiden, The Netherlands
    J Immunol 172:5095-102. 2004
  6. ncbi request reprint UTY-specific TCR-transfer generates potential graft-versus-leukaemia effector T cells
    Roman Ivanov
    Jordan Laboratory for Haemato Oncology, Department of Haematology, University Medical Centre Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Br J Haematol 129:392-402. 2005

Detail Information

Publications6

  1. ncbi request reprint Identification of the angiogenic endothelial-cell growth factor-1/thymidine phosphorylase as a potential target for immunotherapy of cancer
    Elisabeth H Slager
    Department of Hematology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Blood 107:4954-60. 2006
    ..Because solid tumors expressing ECGF-1 could also be lysed by the CTL, ECGF-1 is an interesting target for immunotherapy of both hematologic and solid tumors...
  2. pmc Identification of phosphatidylinositol 4-kinase type II beta as HLA class II-restricted target in graft versus leukemia reactivity
    Marieke Griffioen
    Departments of Hematology and Immunohematology and Blood Transfusion, Leiden University Medical Center, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Proc Natl Acad Sci U S A 105:3837-42. 2008
    ..We hypothesize that LB-PI4K2B-1S-specific CD4(+) T cells contributed to the antitumor response by both directly eliminating malignant cells as effector cells and stimulating CD8(+) T cell immunity as helper cells...
  3. ncbi request reprint CD4+ Th2 cell recognition of HLA-DR-restricted epitopes derived from CAMEL: a tumor antigen translated in an alternative open reading frame
    Elisabeth H Slager
    Department of Clinical Oncology, Leiden University Medical Center, The Netherlands
    J Immunol 170:1490-7. 2003
    ..In conclusion, this study shows the presence of Th cells specific for the alternatively translated tumor Ag CAMEL in melanoma patients and is the first report that describes the isolation of tumor Ag-specific CD4(+) Th 2 clones...
  4. ncbi request reprint Induction of CAMEL/NY-ESO-ORF2-specific CD8+ T cells upon stimulation with dendritic cells infected with a modified Ad5 vector expressing a chimeric Ad5/35 fiber
    Elisabeth H Slager
    Department of Clinical Oncology, Leiden University Medical Center, Leiden, The Netherlands
    Cancer Gene Ther 11:227-36. 2004
    ....
  5. ncbi request reprint Identification of multiple HLA-DR-restricted epitopes of the tumor-associated antigen CAMEL by CD4+ Th1/Th2 lymphocytes
    Elisabeth H Slager
    Department of Clinical Oncology, Leiden University Medical Center, Leiden, The Netherlands
    J Immunol 172:5095-102. 2004
    ..Introduction of the TCRs into proper recipient cells should reveal whether the different complementarity-determining region 3 alpha loops are important for tumor cell recognition...
  6. ncbi request reprint UTY-specific TCR-transfer generates potential graft-versus-leukaemia effector T cells
    Roman Ivanov
    Jordan Laboratory for Haemato Oncology, Department of Haematology, University Medical Centre Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Br J Haematol 129:392-402. 2005
    ..These results indicate that it may be feasible to enhance the GVL effect of donor lymphocyte infusions in lymphoproliferative malignancies by the transfer of TCRs specific to epitopes that are differentially recognized on lymphoblasts...