Research Topics
| Yvo W SijpkensSummaryAffiliation: Leiden University Medical Center Country: The Netherlands Publications
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Detail Information
Publications
Early versus late acute rejection episodes in renal transplantationYvo W J Sijpkens
Department of Nephrology, Leiden University Medical Center, The Netherlands
Transplantation 75:204-8. 2003..We investigated whether the timing of the last treated acute rejection episode (ARE) influences long-term outcome and compared the risk profiles of early versus late ARE...- Chronic rejection with or without transplant vasculopathyYvo W J Sijpkens
Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
Clin Transplant 17:163-70. 2003..We observed several patients who developed CAN without vascular changes or signs of cyclosporine toxicity. Therefore, we assessed the risk factor profiles of CAN with and without transplant vasculopathy... - Immunologic risk factors and glomerular C4d deposits in chronic transplant glomerulopathyYvo W Sijpkens
Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
Kidney Int 65:2409-18. 2004..We evaluated the epidemiologic, clinical, and histologic features of chronic transplant glomerulopathy. To determine the possible contribution of humoral immune responses, we assessed glomerular deposition of C4d... - Early interstitial accumulation of collagen type I discriminates chronic rejection from chronic cyclosporine nephrotoxicityRene C Bakker
Departments of Nephrology and Pathology, Leiden University Medical Center, Leiden, The Netherlands
J Am Soc Nephrol 14:2142-9. 2003..Early increases in the deposition of collagen I, with collagen III and IV, were more specific for CR. CR seems to elicit a more pronounced fibrotic response than does chronic CsAT... - High plasma phosphate as a risk factor for decline in renal function and mortality in pre-dialysis patientsNora Voormolen
Department of Clinical Radiology, Leiden University Medical Center, Albinusdreef 2, 2300 RC Leiden, The Netherlands
Nephrol Dial Transplant 22:2909-16. 2007..The aim of this study was to determine the association of plasma phosphate with renal function loss and mortality in CKD stage IV-V pre-dialysis patients with GFR <20 ml/min/1.73 m(2)... - Similar reduction of cytomegalovirus DNA load by oral valganciclovir and intravenous ganciclovir on pre-emptive therapy after renal and renal-pancreas transplantationJoyant S Kalpoe
Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands
Antivir Ther 10:119-23. 2005..In this observational study, the efficacy of the new oral prodrug valganciclovir was compared with iv ganciclovir... - MASTERPLAN: study of the role of nurse practitioners in a multifactorial intervention to reduce cardiovascular risk in chronic kidney disease patientsArjan D Van Zuilen
Department of Nephrology, University Medical Center Utrecht, Utrecht, The Netherlands
J Nephrol 21:261-7. 2008..Moreover, in only 1 patient were all risk factors within the limits as defined in various guidelines, which underscores the relevance of our initiative... - Expression of surfactant protein-C, S100A8, S100A9, and B cell markers in renal allografts: investigation of the prognostic valueMichael Eikmans
Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands
J Am Soc Nephrol 16:3771-86. 2005..Messenger RNA transcripts complement the biopsy in the prediction of graft function deterioration... - Endothelial cell chimerism occurs more often and earlier in female than in male recipients of kidney transplantsEveline P van Poelgeest
Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands
Kidney Int 68:847-53. 2005..We hypothesize that hormonal factors may influence the development of endothelial chimerism, in parallel with differences in endothelial function between males and females in cardiovascular disease... - Chronic renal allograft rejection: pathophysiologic considerationsSimone A Joosten
Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
Kidney Int 68:1-13. 2005..The most effective option to prevent renal failure from chronic rejection is to avoid graft injury from both immune and nonimmune mechanism together with nonnephrotoxic maintenance immunosuppression... - Antibody response against the glomerular basement membrane protein agrin in patients with transplant glomerulopathySimone A Joosten
Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
Am J Transplant 5:383-93. 2005..In conclusion, we have identified a humoral response against the GBM-HSPG agrin in patients with TGP, which may play a role in the pathogenesis of TGP... - The pathobiology of chronic allograft nephropathy: immune-mediated damage and accelerated agingSimone A Joosten
Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
Kidney Int 65:1556-9. 2004..Furthermore, at the tissue level, markers of senescence are found in the tubular epithelium contributing to the lesions of tubular atrophy and interstitial fibrosis... - High transforming growth factor-beta and extracellular matrix mRNA response in renal allografts during early acute rejection is associated with absence of chronic rejectionMichael Eikmans
Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands
Transplantation 73:573-9. 2002.... - Predicting kidney graft failure using time-dependent renal function covariatesMattheus H J de Bruijne
Department of Medical Statistics, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands
J Clin Epidemiol 56:448-55. 2003..This study illustrates that the prediction of late graft failure could be improved significantly by using time-dependent renal function covariates...