M A Seelen

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. ncbi [The role of the complement system in the defence against infections and new ways of assessing the activation routes]
    M A Seelen
    Leids Universitair Medisch Centrum, afd Nierziekten, C3P 29, Albinusdreef 2, 2333 ZA Leiden
    Ned Tijdschr Geneeskd 148:2318-23. 2004
  2. ncbi Activation of the lectin pathway in murine lupus nephritis
    Leendert A Trouw
    Department of Nephrology, C3, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Mol Immunol 42:731-40. 2005
  3. ncbi Diagnostic and prognostic significance of anti-C1q antibodies in systemic lupus erythematosus
    Marc A Seelen
    Department of Nephrology, Leiden University Medical Center, The Netherlands
    Curr Opin Nephrol Hypertens 12:619-24. 2003
  4. pmc Autoantibodies against mannose-binding lectin in systemic lupus erythematosus
    M A Seelen
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Clin Exp Immunol 134:335-43. 2003
  5. ncbi A role for mannose-binding lectin dysfunction in generation of autoantibodies in systemic lupus erythematosus
    M A Seelen
    Department of Nephrology, C3P 29, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Rheumatology (Oxford) 44:111-9. 2005
  6. pmc Anti-C1q autoantibodies in murine lupus nephritis
    L A Trouw
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Clin Exp Immunol 135:41-8. 2004
  7. ncbi Functional analysis of the classical, alternative, and MBL pathways of the complement system: standardization and validation of a simple ELISA
    M A Seelen
    Department of Nephrology, C3P 29, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    J Immunol Methods 296:187-98. 2005
  8. pmc Glomerular deposition of C1q and anti-C1q antibodies in mice following injection of antimouse C1q antibodies
    L A Trouw
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Clin Exp Immunol 132:32-9. 2003
  9. ncbi Complement and renal disease
    L A Trouw
    Department of Nephrology, D3 P 39, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Mol Immunol 40:125-34. 2003
  10. ncbi Renal transplantation in patients with atypical haemolytic uraemic syndrome: a tailor made approach is necessary
    J van der Wijk
    Department of Nephrology, Academic Medical Centre, Groningen, The Netherlands
    Neth J Med 69:279-80. 2011

Detail Information

Publications13

  1. ncbi [The role of the complement system in the defence against infections and new ways of assessing the activation routes]
    M A Seelen
    Leids Universitair Medisch Centrum, afd Nierziekten, C3P 29, Albinusdreef 2, 2333 ZA Leiden
    Ned Tijdschr Geneeskd 148:2318-23. 2004
    ..A new ELISA assay has been developed to enable the assessment of the functional activity of the whole lectin pathway and to determine the classical and the alternative pathway functional activity in a simple uniform design...
  2. ncbi Activation of the lectin pathway in murine lupus nephritis
    Leendert A Trouw
    Department of Nephrology, C3, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Mol Immunol 42:731-40. 2005
    ..In conclusion, these data suggest that in addition to the classical pathway and the alternative pathway also the lectin pathway of complement activation is involved in murine lupus nephritis...
  3. ncbi Diagnostic and prognostic significance of anti-C1q antibodies in systemic lupus erythematosus
    Marc A Seelen
    Department of Nephrology, Leiden University Medical Center, The Netherlands
    Curr Opin Nephrol Hypertens 12:619-24. 2003
    ..Anti-C1q autoantibodies are strongly associated with renal involvement in systemic lupus erythematosus. This study will review recent findings on the pathogenic role and clinical importance of anti-C1q antibodies in lupus nephritis...
  4. pmc Autoantibodies against mannose-binding lectin in systemic lupus erythematosus
    M A Seelen
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Clin Exp Immunol 134:335-43. 2003
    ..We conclude that anti-MBL are present in sera from SLE patients and influence the functional activity of MBL...
  5. ncbi A role for mannose-binding lectin dysfunction in generation of autoantibodies in systemic lupus erythematosus
    M A Seelen
    Department of Nephrology, C3P 29, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Rheumatology (Oxford) 44:111-9. 2005
    ..To investigate the possible association of the mannose binding lectin (MBL) pathway of complement activation with different disease parameters and disease activity in patients with systemic lupus erythematosus (SLE)...
  6. pmc Anti-C1q autoantibodies in murine lupus nephritis
    L A Trouw
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Clin Exp Immunol 135:41-8. 2004
    ..In conclusion, anti-C1q antibodies are already present in serum and immune deposits of the kidney early in life and therefore can play a role in nephritis during experimental SLE-like disease in mice...
  7. ncbi Functional analysis of the classical, alternative, and MBL pathways of the complement system: standardization and validation of a simple ELISA
    M A Seelen
    Department of Nephrology, C3P 29, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    J Immunol Methods 296:187-98. 2005
    ..The results demonstrate the value of these ELISA-based procedures for the functional assessment of complement deficiencies in clinical practice. The assay is now available commercially in kit form...
  8. pmc Glomerular deposition of C1q and anti-C1q antibodies in mice following injection of antimouse C1q antibodies
    L A Trouw
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Clin Exp Immunol 132:32-9. 2003
    ..This deposition is stable for at least 2 weeks, causes complement activation, leucocyte influx and can lead to mild albuminuria...
  9. ncbi Complement and renal disease
    L A Trouw
    Department of Nephrology, D3 P 39, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Mol Immunol 40:125-34. 2003
    ..Current research provides clues on the role of individual complement components and activation pathways as well as possible modes of complement regulation in the management of renal disease...
  10. ncbi Renal transplantation in patients with atypical haemolytic uraemic syndrome: a tailor made approach is necessary
    J van der Wijk
    Department of Nephrology, Academic Medical Centre, Groningen, The Netherlands
    Neth J Med 69:279-80. 2011
    ..Extensive genetic investigation of the complement system was executed to rule out known mutations prone to development of HUS. This case illustrates the importance of genetic screening in patients with recurrent HUS...
  11. pmc Anti-C1q autoantibodies deposit in glomeruli but are only pathogenic in combination with glomerular C1q-containing immune complexes
    Leendert A Trouw
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    J Clin Invest 114:679-88. 2004
    ..This provides an explanation why anti-C1q antibodies are especially pathogenic in patients with SLE...
  12. pmc Deficiency of functional mannose-binding lectin is not associated with infections in patients with systemic lupus erythematosus
    Irene E M Bultink
    Department of Rheumatology, VU University Medical Center, Postbox 7057, Amsterdam 1007 MB, The Netherlands
    Arthritis Res Ther 8:R183. 2006
    ..In conclusion, SLE patients frequently suffer from infections, but deficiency of functional MBL does not confer additional risk...
  13. ncbi Maturation of dendritic cells abrogates C1q production in vivo and in vitro
    Giuseppe Castellano
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Blood 103:3813-20. 2004
    ..Therefore, immDCs may be considered an additional source of C1q in humans...