J Schinkel

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint The potentiating effect of ribavirin on interferon in the treatment of hepatitis C: lack of evidence for ribavirin-induced viral mutagenesis
    Janke Schinkel
    Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands
    Antivir Ther 8:535-40. 2003
  2. ncbi request reprint Meta-analysis of mutations in the NS5A gene and hepatitis C virus resistance to interferon therapy: uniting discordant conclusions
    Janke Schinkel
    Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands
    Antivir Ther 9:275-86. 2004
  3. ncbi request reprint Monitoring response during a randomised controlled trial of escalating interferon dose for chronic hepatitis C infection: predictive value of quantitative and qualitative HCV RNA assays
    J Schinkel
    Department of Medical Microbiology, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands
    J Clin Virol 22:61-71. 2001
  4. ncbi request reprint Adenovirus infection in paediatric stem cell transplant recipients: increased risk in young children with a delayed immune recovery
    M J D van Tol
    The Department of Paediatrics, Section of Immunology, Haematology, Oncology, Bone Marrow Transplantation and Autoimmunity, Leiden University Medical Centre LUMC, Leiden, The Netherlands
    Bone Marrow Transplant 36:39-50. 2005
  5. doi request reprint Susceptibility of hepatitis B virus to lamivudine restored by resistance to adefovir
    H L Zaaijer
    Laboratory of Clinical Virology, Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Med Virol 81:413-6. 2009
  6. pmc Validation of clinical application of cytomegalovirus plasma DNA load measurement and definition of treatment criteria by analysis of correlation to antigen detection
    Jayant S Kalpoe
    Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands
    J Clin Microbiol 42:1498-504. 2004
  7. pmc Simultaneous detection of Entamoeba histolytica, Giardia lamblia, and Cryptosporidium parvum in fecal samples by using multiplex real-time PCR
    Jaco J Verweij
    Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
    J Clin Microbiol 42:1220-3. 2004
  8. ncbi request reprint Real-time PCR for the detection of Giardia lamblia
    Jaco J Verweij
    Department of Parasitology and Department of Medical Microbiology, Leiden University Medical Center, P O Box 9600, Leiden, The Netherlands
    Mol Cell Probes 17:223-5. 2003
  9. ncbi request reprint Simultaneous detection of five different DNA targets by real-time Taqman PCR using the Roche LightCycler480: Application in viral molecular diagnostics
    Richard Molenkamp
    Academic Medical Center, University of Amsterdam, Department of Medical Microbiology, Laboratory of Clinical Virology, Amsterdam, The Netherlands
    J Virol Methods 141:205-11. 2007
  10. ncbi request reprint Lack of value of routine analysis of cerebrospinal fluid for prediction and diagnosis of external drainage-related bacterial meningitis
    Rogier P Schade
    Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands
    J Neurosurg 104:101-8. 2006

Collaborators

Detail Information

Publications12

  1. ncbi request reprint The potentiating effect of ribavirin on interferon in the treatment of hepatitis C: lack of evidence for ribavirin-induced viral mutagenesis
    Janke Schinkel
    Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands
    Antivir Ther 8:535-40. 2003
    ....
  2. ncbi request reprint Meta-analysis of mutations in the NS5A gene and hepatitis C virus resistance to interferon therapy: uniting discordant conclusions
    Janke Schinkel
    Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands
    Antivir Ther 9:275-86. 2004
    ..The present study approached this issue by carrying out a meta-analysis of ISDR sequences and response to interferon treatment...
  3. ncbi request reprint Monitoring response during a randomised controlled trial of escalating interferon dose for chronic hepatitis C infection: predictive value of quantitative and qualitative HCV RNA assays
    J Schinkel
    Department of Medical Microbiology, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands
    J Clin Virol 22:61-71. 2001
    ....
  4. ncbi request reprint Adenovirus infection in paediatric stem cell transplant recipients: increased risk in young children with a delayed immune recovery
    M J D van Tol
    The Department of Paediatrics, Section of Immunology, Haematology, Oncology, Bone Marrow Transplantation and Autoimmunity, Leiden University Medical Centre LUMC, Leiden, The Netherlands
    Bone Marrow Transplant 36:39-50. 2005
    ..Manipulation of cellular immunity either by tapering of immunosuppression, infusion of donor lymphocytes or immunotherapy using HAdV-specific T cells should be considered in graft recipients at risk for a severe HAdV infection...
  5. doi request reprint Susceptibility of hepatitis B virus to lamivudine restored by resistance to adefovir
    H L Zaaijer
    Laboratory of Clinical Virology, Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Med Virol 81:413-6. 2009
    ..Although clinically insufficient, this effect indicates that HBV polymerase resistance mutations may be antagonistic, which is relevant if chronic HBV infection is to be treated by a combination of polymerase inhibitors...
  6. pmc Validation of clinical application of cytomegalovirus plasma DNA load measurement and definition of treatment criteria by analysis of correlation to antigen detection
    Jayant S Kalpoe
    Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands
    J Clin Microbiol 42:1498-504. 2004
    ..This approach may have important advantages, which include a superior reproducibility and sensitivity, allowing the inclusion of kinetic criteria in clinical guidelines...
  7. pmc Simultaneous detection of Entamoeba histolytica, Giardia lamblia, and Cryptosporidium parvum in fecal samples by using multiplex real-time PCR
    Jaco J Verweij
    Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
    J Clin Microbiol 42:1220-3. 2004
    ..The use of this assay in a diagnostic laboratory would provide sensitive and specific diagnosis of the main parasitic diarrheal infections and could improve patient management and infection control...
  8. ncbi request reprint Real-time PCR for the detection of Giardia lamblia
    Jaco J Verweij
    Department of Parasitology and Department of Medical Microbiology, Leiden University Medical Center, P O Box 9600, Leiden, The Netherlands
    Mol Cell Probes 17:223-5. 2003
    ..The real-time PCR is as specific and sensitive as antigen detection and is more sensitive than microscopy. Moreover, in two patients we were able to detect G. lamblia earlier in the course of infection than with any of the other methods...
  9. ncbi request reprint Simultaneous detection of five different DNA targets by real-time Taqman PCR using the Roche LightCycler480: Application in viral molecular diagnostics
    Richard Molenkamp
    Academic Medical Center, University of Amsterdam, Department of Medical Microbiology, Laboratory of Clinical Virology, Amsterdam, The Netherlands
    J Virol Methods 141:205-11. 2007
    ..The application of multiplex PCR for the detection of multiple pathogens within the same sample will provide a major contribution to the efficiency, logistics and cost-effectiveness of molecular diagnostics...
  10. ncbi request reprint Lack of value of routine analysis of cerebrospinal fluid for prediction and diagnosis of external drainage-related bacterial meningitis
    Rogier P Schade
    Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands
    J Neurosurg 104:101-8. 2006
    ..A cohort study was performed to investigate the value of several commonly used CSF parameters for the prediction and diagnosis of ED-BM...
  11. pmc Fourth human parechovirus serotype
    Kimberley S M Benschop
    Academic Medical Center, Amsterdam, The Netherlands
    Emerg Infect Dis 12:1572-5. 2006
    ..Analysis of the complete genome showed K251176-02 to be a new HPeV genotype. Since K251176-02 could not be neutralized with antibodies against known HPeV serotypes 1-3, it should be classified as a fourth HPeV serotype...
  12. doi request reprint Human parechoviruses as an important viral cause of sepsislike illness and meningitis in young children
    Katja C Wolthers
    Department of Medical Microbiology, Laboratory of Clinical Virology, Emma Children s Hospital, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Clin Infect Dis 47:358-63. 2008
    ..Six HPeV genotypes are currently known, of which HPeV3 is associated with neonatal sepsis and meningitis...