K Sankaranarayanan

Summary

Affiliation: Leiden University
Country: The Netherlands

Publications

  1. ncbi request reprint Ionizing radiation and genetic risks. VI. Chronic multifactorial diseases: a review of epidemiological and genetical aspects of coronary heart disease, essential hypertension and diabetes mellitus
    K Sankaranarayanan
    MGC, Department of Radiation Genetics and Chemical Mutagenesis, Sylvius Laboratories, Leiden University, Wassenaarseweg 72, 2333 AL, Leiden
    Mutat Res 436:21-57. 1999
  2. ncbi request reprint Ionizing radiation and genetic risks. X. The potential "disease phenotypes" of radiation-induced genetic damage in humans: perspectives from human molecular biology and radiation genetics
    K Sankaranarayanan
    MGC, Department of Radiation Genetics and Chemical Mutagenesis, Leiden University Medical Centre, Sylvius Laboratories, Wassenaarseweg 72, 2333 AL, Leiden, Netherlands
    Mutat Res 429:45-83. 1999
  3. ncbi request reprint Ionizing radiation and genetic risks. XII. The concept of "potential recoverability correction factor" (PRCF) and its use for predicting the risk of radiation-inducible genetic disease in human live births
    K Sankaranarayanan
    Department of Radiation Genetics and Chemical Mutagenesis, Leiden University Medical Centre, Sylvius Laboratories, Wassenaarseweg 72, 2333, AL Leiden, The Netherlands
    Mutat Res 453:129-81. 2000
  4. ncbi request reprint Ionizing radiation and genetic risks. XIII. Summary and synthesis of papers VI to XII and estimates of genetic risks in the year 2000
    K Sankaranarayanan
    Sylvius Laboratories, Department of Radiation Genetics and Chemical Mutagenesis, Leiden University Medical Center, Wassenaarseweg 72, 2333, AL Leiden, The Netherlands
    Mutat Res 453:183-97. 2000
  5. ncbi request reprint Ionizing radiation, genetic risk estimation and molecular biology: impact and inferences
    K Sankaranarayanan
    Department of Radiation Genetics and Chemical Mutagenesis, Sylvius Laboratories, University of Leiden, The Netherlands
    Trends Genet 9:79-84. 1993
  6. ncbi request reprint Ionizing radiation and genetic risks. XI. The doubling dose estimates from the mid-1950s to the present and the conceptual change to the use of human data on spontaneous mutation rates and mouse data on induced mutation rates for doubling dose calculation
    K Sankaranarayanan
    Department of Radiation Genetics and Chemical Mutagenesis, Leiden University Medical Centre, Sylvius Laboratories, Wassenaarseweg 72, 2333 AL, Leiden, The Netherlands
    Mutat Res 453:107-27. 2000
  7. ncbi request reprint Impact of cancer predisposition and radiosensitivity on the population risk of radiation-induced cancers
    K Sankaranarayanan
    Department of Radiation Genetics and Chemical Mutagenesis, Leiden University Medical Center, Sylvius Laboratories, Wassenaarseweg 72, 2333 AL Leiden, The Netherlands
    Radiat Res 156:648-56. 2001
  8. ncbi request reprint Ionizing radiation and genetic risks XIV. Potential research directions in the post-genome era based on knowledge of repair of radiation-induced DNA double-strand breaks in mammalian somatic cells and the origin of deletions associated with human genomic
    K Sankaranarayanan
    Department of Toxicogenetics, Leiden University Medical Centre, Sylvius Laboratories, Wassenaarseweg 72, 2333 AL Leiden, The Netherlands
    Mutat Res 578:333-70. 2005

Detail Information

Publications8

  1. ncbi request reprint Ionizing radiation and genetic risks. VI. Chronic multifactorial diseases: a review of epidemiological and genetical aspects of coronary heart disease, essential hypertension and diabetes mellitus
    K Sankaranarayanan
    MGC, Department of Radiation Genetics and Chemical Mutagenesis, Sylvius Laboratories, Leiden University, Wassenaarseweg 72, 2333 AL, Leiden
    Mutat Res 436:21-57. 1999
    ..The size of the gene correlates with the size of the Lp(a) protein. The smaller the size of the Lp(a) protein, the higher are the Lp(a) levels. (ABSTRACT TRUNCATED)..
  2. ncbi request reprint Ionizing radiation and genetic risks. X. The potential "disease phenotypes" of radiation-induced genetic damage in humans: perspectives from human molecular biology and radiation genetics
    K Sankaranarayanan
    MGC, Department of Radiation Genetics and Chemical Mutagenesis, Leiden University Medical Centre, Sylvius Laboratories, Wassenaarseweg 72, 2333 AL, Leiden, Netherlands
    Mutat Res 429:45-83. 1999
    ..abstract truncated)..
  3. ncbi request reprint Ionizing radiation and genetic risks. XII. The concept of "potential recoverability correction factor" (PRCF) and its use for predicting the risk of radiation-inducible genetic disease in human live births
    K Sankaranarayanan
    Department of Radiation Genetics and Chemical Mutagenesis, Leiden University Medical Centre, Sylvius Laboratories, Wassenaarseweg 72, 2333, AL Leiden, The Netherlands
    Mutat Res 453:129-81. 2000
    ..Since PRCF is a fraction, it is obvious that the estimate of risk obtained with the revised risk equation will be smaller than previously calculated values...
  4. ncbi request reprint Ionizing radiation and genetic risks. XIII. Summary and synthesis of papers VI to XII and estimates of genetic risks in the year 2000
    K Sankaranarayanan
    Sylvius Laboratories, Department of Radiation Genetics and Chemical Mutagenesis, Leiden University Medical Center, Wassenaarseweg 72, 2333, AL Leiden, The Netherlands
    Mutat Res 453:183-97. 2000
    ..The total risk per Gy is of the order of approximately 3000-4700 cases which represent approximately 0.4-0.6% of the baseline frequency of these diseases (738,000 per million) in the population...
  5. ncbi request reprint Ionizing radiation, genetic risk estimation and molecular biology: impact and inferences
    K Sankaranarayanan
    Department of Radiation Genetics and Chemical Mutagenesis, Sylvius Laboratories, University of Leiden, The Netherlands
    Trends Genet 9:79-84. 1993
    ....
  6. ncbi request reprint Ionizing radiation and genetic risks. XI. The doubling dose estimates from the mid-1950s to the present and the conceptual change to the use of human data on spontaneous mutation rates and mouse data on induced mutation rates for doubling dose calculation
    K Sankaranarayanan
    Department of Radiation Genetics and Chemical Mutagenesis, Leiden University Medical Centre, Sylvius Laboratories, Wassenaarseweg 72, 2333 AL, Leiden, The Netherlands
    Mutat Res 453:107-27. 2000
    ..Although this value is the same as that used previously, its conceptual basis is different and the present estimate is based on more extensive data than has so far been the case...
  7. ncbi request reprint Impact of cancer predisposition and radiosensitivity on the population risk of radiation-induced cancers
    K Sankaranarayanan
    Department of Radiation Genetics and Chemical Mutagenesis, Leiden University Medical Center, Sylvius Laboratories, Wassenaarseweg 72, 2333 AL Leiden, The Netherlands
    Radiat Res 156:648-56. 2001
    ....
  8. ncbi request reprint Ionizing radiation and genetic risks XIV. Potential research directions in the post-genome era based on knowledge of repair of radiation-induced DNA double-strand breaks in mammalian somatic cells and the origin of deletions associated with human genomic
    K Sankaranarayanan
    Department of Toxicogenetics, Leiden University Medical Centre, Sylvius Laboratories, Wassenaarseweg 72, 2333 AL Leiden, The Netherlands
    Mutat Res 578:333-70. 2005
    ..Such efforts may have particular significance in the context of the estimation of genetic risks of radiation exposure of human females, a problem that is still with us...