Frits R Rosendaal

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. pmc Statins and venous thrombosis: a story too good to be true?
    Frits R Rosendaal
    Department of Clinical Epidemiology and Department of Thrombosis and Haemostasis, Leiden University Medical Center, Leiden, The Netherlands
    PLoS Med 9:e1001311. 2012
  2. pmc Experience with multiple control groups in a large population-based case-control study on genetic and environmental risk factors
    E R Pomp
    Department of Clinical Epidemiology, C7 P, Leiden University Medical Center, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Eur J Epidemiol 25:459-66. 2010
  3. ncbi request reprint Female hormones and thrombosis
    F R Rosendaal
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 22:201-10. 2002
  4. ncbi request reprint [Errors in methodology (conclusion). XXXIX. The ultimate truth]
    F R Rosendaal
    Leids Universitair Medisch Centrum, afd Klinische Epidemiologie, Postbus 9600, 2300 RC Leiden
    Ned Tijdschr Geneeskd 146:304-9. 2002
  5. ncbi request reprint Hormonal replacement therapy, prothrombotic mutations and the risk of venous thrombosis
    F R Rosendaal
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Br J Haematol 116:851-4. 2002
  6. doi request reprint Hormone replacement therapy and thrombotic risk: beauty is only skin deep
    Frits R Rosendaal
    Department of Clinical Epidemiology at Leiden University Medical Center, Leiden, The Netherlands
    Nat Clin Pract Cardiovasc Med 5:684-5. 2008
  7. ncbi request reprint Estrogens, progestogens and thrombosis
    F R Rosendaal
    Department of Clinical Epidemiology, Leiden University Medical Center, The Netherlands
    J Thromb Haemost 1:1371-80. 2003
  8. ncbi request reprint Clotting and myocardial infarction: a cycle of insights
    F R Rosendaal
    Clinical Epidemiology and Haematology, Leiden University Medical Center, Leiden, The Netherlands
    J Thromb Haemost 1:640-2. 2003
  9. ncbi request reprint Genetic studies in complex disease: the case pro association studies
    F R Rosendaal
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    J Thromb Haemost 1:1679-80. 2003
  10. ncbi request reprint Air travel and thrombosis
    F R Rosendaal
    Department of Clinical Epidemiology and Hematology, Leiden University Medical Center, Leiden, The Netherlands
    Pathophysiol Haemost Thromb 32:341-2. 2002

Detail Information

Publications173 found, 100 shown here

  1. pmc Statins and venous thrombosis: a story too good to be true?
    Frits R Rosendaal
    Department of Clinical Epidemiology and Department of Thrombosis and Haemostasis, Leiden University Medical Center, Leiden, The Netherlands
    PLoS Med 9:e1001311. 2012
    ..Frits Rosendaal comments on new findings from a meta-analysis conducted by Kazem Rahimi and colleagues, evaluating whether statins can prevent venous thromboembolism...
  2. pmc Experience with multiple control groups in a large population-based case-control study on genetic and environmental risk factors
    E R Pomp
    Department of Clinical Epidemiology, C7 P, Leiden University Medical Center, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Eur J Epidemiol 25:459-66. 2010
    ..Our experience with the intricacies of dealing with two control groups may be useful to others when thinking about an optimal research design or the best statistical approach...
  3. ncbi request reprint Female hormones and thrombosis
    F R Rosendaal
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 22:201-10. 2002
    ..The risk becomes very high in women with a previous venous thrombosis. Randomized trials have not confirmed a beneficial effect of postmenopausal hormones on the occurrence of myocardial infarction...
  4. ncbi request reprint [Errors in methodology (conclusion). XXXIX. The ultimate truth]
    F R Rosendaal
    Leids Universitair Medisch Centrum, afd Klinische Epidemiologie, Postbus 9600, 2300 RC Leiden
    Ned Tijdschr Geneeskd 146:304-9. 2002
    ..For example, chance circumstances might lead to the incomparability of groups. Bayes' theorem clarifies why different experts may come to opposite conclusions based on the same studies. The ultimate truth remains elusive...
  5. ncbi request reprint Hormonal replacement therapy, prothrombotic mutations and the risk of venous thrombosis
    F R Rosendaal
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Br J Haematol 116:851-4. 2002
    ..1 (under an additive model). We conclude that the thrombotic risk of HRT may particularly affect women with prothrombotic mutations. Efforts to avoid HRT in women with increased risk of thrombosis are advisable...
  6. doi request reprint Hormone replacement therapy and thrombotic risk: beauty is only skin deep
    Frits R Rosendaal
    Department of Clinical Epidemiology at Leiden University Medical Center, Leiden, The Netherlands
    Nat Clin Pract Cardiovasc Med 5:684-5. 2008
    ....
  7. ncbi request reprint Estrogens, progestogens and thrombosis
    F R Rosendaal
    Department of Clinical Epidemiology, Leiden University Medical Center, The Netherlands
    J Thromb Haemost 1:1371-80. 2003
    ..The risk of arterial disease in oral contraceptive users and users of hormone replacement therapy is at most weakly affected by the presence of prothrombotic abnormalities...
  8. ncbi request reprint Clotting and myocardial infarction: a cycle of insights
    F R Rosendaal
    Clinical Epidemiology and Haematology, Leiden University Medical Center, Leiden, The Netherlands
    J Thromb Haemost 1:640-2. 2003
  9. ncbi request reprint Genetic studies in complex disease: the case pro association studies
    F R Rosendaal
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    J Thromb Haemost 1:1679-80. 2003
  10. ncbi request reprint Air travel and thrombosis
    F R Rosendaal
    Department of Clinical Epidemiology and Hematology, Leiden University Medical Center, Leiden, The Netherlands
    Pathophysiol Haemost Thromb 32:341-2. 2002
  11. ncbi request reprint Genetic studies in complex disease
    F R Rosendaal
    Departments of Clinical Epidemiology and Hematology, Leiden University Medical Center, Leiden, The Netherlands
    J Thromb Haemost 2:342. 2004
  12. ncbi request reprint Venous thrombosis in the elderly
    F R Rosendaal
    Department of Clinical Epidemiology and Hematology, Leiden University Medical Center, Leiden, The Netherlands
    J Thromb Haemost 5:310-7. 2007
    ..In addition to a review of the literature, new data are presented from the MEGA-study. Thrombosis in the elderly should be a focus of future studies...
  13. ncbi request reprint Interventions to prevent venous thrombosis after air travel: are they necessary? No
    F R Rosendaal
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    J Thromb Haemost 4:2306-7. 2006
  14. doi request reprint Genetics of venous thrombosis
    F R Rosendaal
    Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    J Thromb Haemost 7:301-4. 2009
    ..There are many weak genetic risk factors, including fibrinogen, factor XIII and factor XI variants. Even for moderately strong risk factors (relative risks 2-5), the majority of carriers will never develop thrombosis...
  15. ncbi request reprint Heritability of clotting factors and the revival of the prothrombotic state
    F R Rosendaal
    Department of Clinical Epidemiology and Haematology, Leiden University Medical Center, 2300 RC Leiden, Netherlands
    Lancet 359:638-9. 2002
  16. ncbi request reprint Oral contraceptives, hormone replacement therapy and thrombosis
    F R Rosendaal
    Department of Hematology, Leiden University Medical Center, The Netherlands
    Thromb Haemost 86:112-23. 2001
    ..First results are emerging that specific subgroups of women, with prothrombotic or other abnormalities, may be at risk, especially during the first years of use of hormone substitution...
  17. ncbi request reprint The contribution of factor V Leiden and prothrombin G20210A mutation to the risk of central venous catheter-related thrombosis
    Cornelis J van Rooden
    Department of General Internal Medicine Leiden University Medical Center LUMC, Leiden, The Netherlands
    Haematologica 89:201-6. 2004
    ....
  18. ncbi request reprint Polymorphisms in the protein C gene as risk factor for venous thrombosis
    Elisabeth R Pomp
    Department of Clinical Epidemiology, C9 P, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Thromb Haemost 101:62-7. 2009
    ..There is no clear synergistic effect of the CC/GG genotype with factor V Leiden or oral contraceptive use on thrombotic risk...
  19. pmc F9 Malmö, factor IX and deep vein thrombosis
    Irene D Bezemer
    Department of Clinical Epidemiology, C7 P Leiden University Medical Center, Leiden, The Netherlands
    Haematologica 94:693-9. 2009
    ..We recently reported the association between the Malmö sequence variant in F9 (rs6048) and deep vein thrombosis...
  20. ncbi request reprint Haplotypes of IL1B, IL1RN, IL1R1, and IL1R2 and the risk of venous thrombosis
    Rick van Minkelen
    Hemostasis and Thrombosis Research Center, Department of Hematology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 27:1486-91. 2007
    ..The aim of this study was to investigate whether common variations in IL1B, IL1RN, IL1R1, and IL1R2 influence the risk of venous thrombosis...
  21. ncbi request reprint The influence of established genetic variation in the haemostatic system on clinical restenosis after percutaneous coronary interventions
    Douwe Pons
    Leiden University Medical Center, Department of Cardiology, C5 P, Albinusdreef 2, P O Box 9600, 2300 RC Leiden, The Netherlands
    Thromb Haemost 98:1323-8. 2007
    ..41, 95% CI: 0.19-0.86). Our findings indicate that polymorphisms in the factorV and PAI-1 genes may play a role in the process of restenosis...
  22. doi request reprint Optimal level of oral anticoagulant therapy for the prevention of arterial thrombosis in patients with mechanical heart valve prostheses, atrial fibrillation, or myocardial infarction: a prospective study of 4202 patients
    Marieke Torn
    Department of Clinical Epidemiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Arch Intern Med 169:1203-9. 2009
    ..Finding the optimal intensity at which the overall incidence rate of both bleeding and thromboembolic events is minimized represents a way to improve the safety of oral anticoagulant treatment...
  23. doi request reprint Haplotypes of the interleukin-1 receptor antagonist gene, interleukin-1 receptor antagonist mRNA levels and the risk of myocardial infarction
    Rick van Minkelen
    Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
    Atherosclerosis 203:201-5. 2009
    ..It is unclear whether variations in IL1RN affect the risk of myocardial infarction...
  24. ncbi request reprint Social participation of patients with hemophilia in the Netherlands
    Iris Plug
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Blood 111:1811-5. 2008
    ..After the introduction of prophylactic treatment, the number of patients who are occupationally disabled is reduced...
  25. ncbi request reprint Risks of oral anticoagulant therapy with increasing age
    Marieke Torn
    Department of Hematology, Leiden University Medical Center, Leiden, Netherlands
    Arch Intern Med 165:1527-32. 2005
    ..We investigated the risk of hemorrhage and thromboembolism according to age in patients who were treated with oral anticoagulants in the routine setting of an anticoagulation clinic...
  26. ncbi request reprint Risk of venous thrombosis: obesity and its joint effect with oral contraceptive use and prothrombotic mutations
    Elisabeth R Pomp
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Br J Haematol 139:289-96. 2007
    ..70-13.15); for prothrombin 20210A this was a 6.6-fold increased risk (OR(adj) 6.58, 95% CI 2.31-18.69). Body height, weight and obesity increase the risk of venous thrombosis, especially obesity in women using oral contraceptives...
  27. ncbi request reprint No association between the common MTHFR 677C->T polymorphism and venous thrombosis: results from the MEGA study
    Irene D Bezemer
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Arch Intern Med 167:497-501. 2007
    ..The aim of the present study was to evaluate the effect of the MTHFR genotype on the risk of venous thrombosis, overall and in subgroups of known risk factors, in a single large study...
  28. doi request reprint The effect of flight-related behaviour on the risk of venous thrombosis after air travel
    Anja J M Schreijer
    Department of Clinical Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands
    Br J Haematol 144:425-9. 2009
    ..The effect of behavioural factors during flying on the risk of venous thrombosis after air travel is limited. Current advice on prevention of travel-related thrombosis may have to be reconsidered...
  29. pmc Low thrombin activatable fibrinolysis inhibitor activity levels are associated with an increased risk of a first myocardial infarction in men
    Mirjam E Meltzer
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Haematologica 94:811-8. 2009
    ..TAFI regulates fibrinolysis, but other roles of this inhibitor, including anti-inflammatory properties, have also been demonstrated...
  30. doi request reprint Myocardial infarction occurs with a similar 24 h pattern in the 4G/5G versions of plasminogen activator inhibitor-1
    Sandrin C Bergheanu
    Department of Cardiology, Leiden University Medical Center, The Netherlands
    Chronobiol Int 26:637-52. 2009
    ..Our findings show that 24 h variation of cardiac risk is not more pronounced among the 4G4G genotype of PAI-1...
  31. doi request reprint Alcohol consumption is associated with a decreased risk of venous thrombosis
    Elisabeth R Pomp
    Department of Clinical Epidemiology, C9 P, Leiden University Medical Center, Leiden, The Netherlands
    Thromb Haemost 99:59-63. 2008
    ..In conclusion, alcohol consumption is associated with a reduced risk of venous thrombosis, which may be in part mediated by decreased fibrinogen levels...
  32. doi request reprint Family history differs between young women with myocardial infarction and ischemic stroke: results from the RATIO case-control study
    Bob Siegerink
    Department of Clinical Epidemiology, Leiden University Medical Center, The Netherlands
    Atherosclerosis 223:235-8. 2012
    ..Family history may help in risk stratification, especially in the young. This study assesses the predictive value of a positive family history of cardiovascular disease for myocardial infarction (MI) and ischemic stroke (IS)...
  33. doi request reprint Multiple SNP testing improves risk prediction of first venous thrombosis
    Hugoline G de Haan
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Blood 120:656-63. 2012
    ..82 (95% CI, 0.81-0.83), indicating good diagnostic accuracy. To become clinically useful, subgroups of high-risk persons must be identified in whom genetic profiling will also be cost-effective...
  34. ncbi request reprint Bleeding in carriers of hemophilia
    Iris Plug
    Leinden Unversity Medical Center, Clinical Epidemiology, Leiden, Netherlands
    Blood 108:52-6. 2006
    ..Our findings suggest that not only clotting factor levels at the extreme of the distribution, resembling mild hemophilia, but also mildly reduced clotting factor levels between 0.41 and 0.60 IU/mL are associated with bleeding...
  35. ncbi request reprint Sensitivity to activated protein C during the menstrual cycle in women with and without factor VLeiden
    Huib A A M van Vliet
    Department of Gynaecology, Division of Reproductive Medicine, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Thromb Res 121:757-61. 2008
    ..The aim of the study was to evaluate whether varying levels of estradiol and progesterone during the menstrual cycle are associated with differences in sensitivity to APC...
  36. ncbi request reprint Haplotypes encoding the factor VIII 1241 Glu variation, factor VIII levels and the risk of venous thrombosis
    A Yaël Nossent
    Department of Haematology, C2 R, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Thromb Haemost 95:942-8. 2006
    ..However, FVIII gene variations do contribute to both levels of FVIII and the risk of thrombosis...
  37. ncbi request reprint Characterization of an immunologic polymorphism (D79H) in the heavy chain of factor V
    M van der Neut Kolfschoten
    Hemostasis and Thrombosis Research Center, Department of Hematology, LUMC, Leiden, The Netherlands
    J Thromb Haemost 2:910-7. 2004
    ....
  38. doi request reprint Role of hemostatic factors on the risk of venous thrombosis in people with impaired kidney function
    Gürbey Ocak
    Departments of Clinical Epidemiology G O, C Y V, W M L, M V, F W D, F R R, S C C and Thrombosis and Haemostasis F R R, Leiden University Medical Center, Leiden, The Netherlands and Division of Biomedical Genetics, Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands C Y V
    Circulation 129:683-91. 2014
    ..The aim of our study was to determine whether the association between impaired kidney function and venous thrombosis can be explained by the concurrent presence of genetic or acquired venous thrombosis risk factors...
  39. doi request reprint Sex difference in risk of second but not of first venous thrombosis: paradox explained
    Rachel E J Roach
    Department of Clinical Epidemiology R E J R, W M L, F R R, S C C, S L C, Einthoven Laboratory for Experimental Vascular Medicine W M L, F R R, S C C, Thrombosis and Hemostasis Research Center F R R, and Department of Medical Statistics and Bioinformatics S l C, Leiden University Medical Center, Leiden, The Netherlands
    Circulation 129:51-6. 2014
    ..We hypothesized that, for a first event, a risk difference between the sexes is masked by female exposure to reproductive factors (oral contraception, pregnancy/puerperium, and postmenopausal hormone therapy)...
  40. doi request reprint Pregnancy, the postpartum period and prothrombotic defects: risk of venous thrombosis in the MEGA study
    E R Pomp
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    J Thromb Haemost 6:632-7. 2008
    ..Objective: In the MEGA study, we evaluated pregnancy and the postpartum period as risk factors for venous thrombosis in 285 patients and 857 control subjects...
  41. doi request reprint Broadening the factor V Leiden paradox: pulmonary embolism and deep-vein thrombosis as 2 sides of the spectrum
    Kirsten van Langevelde
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Blood 120:933-46. 2012
    ..These findings suggest that pulmonary embolism and DVT may not always have the same etiology, and encourage unraveling this phenomenon in further studies...
  42. ncbi request reprint The effect of the levonorgestrel-releasing intrauterine system on the resistance to activated protein C (APC)
    Huib A A M van Vliet
    Department of Gynaecology and Reproductive Medicine, Leiden University Medical Center, Leiden, The Netherlands
    Thromb Haemost 101:691-5. 2009
    ..48; 95% CI -0.85 to -2.11). In this study we observed that the levonorgestrel-intrauterine system decreases the resistance to APC which indicates that the levonorgestrel-intrauterine system does not have a prothrombotic effect...
  43. ncbi request reprint Candidate gene approach in association studies: would the factor V Leiden mutation have been found by this approach?
    Astrid van Hylckama Vlieg
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Hum Genet 12:478-82. 2004
    ....
  44. ncbi request reprint Infectious complications of central venous catheters increase the risk of catheter-related thrombosis in hematology patients: a prospective study
    Cornelis J van Rooden
    Department of General Internal Medicine, Room C1 R 43, Leiden University Medical Center, 2300 RC Leiden, Netherlands
    J Clin Oncol 23:2655-60. 2005
    ..Secondly, we determined whether thrombosis can be predicted or excluded by CVC lock fluid surveillance cultures...
  45. doi request reprint Prevention of coagulase-negative staphylococcal central venous catheter-related infection using urokinase rinses: a randomized double-blind controlled trial in patients with hematologic malignancies
    Cornelis J van Rooden
    Department of General Internal Medicine Endocrinology, Leiden University Medical Center, Albinusdreef 2, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Clin Oncol 26:428-33. 2008
    ....
  46. ncbi request reprint ABO blood group genotypes, plasma von Willebrand factor levels and loading of von Willebrand factor with A and B antigens
    Vania M Morelli
    Hemostasis and Thrombosis Research Center, Dept of Hematology, Leiden University Medical Center, C2 R, Leiden, The Netherlands
    Thromb Haemost 97:534-41. 2007
    ..All had a reduced nA-ratio compared to A(1)O carriers with one repeat in their A(1) allele. The amount of A- and B-antigens expressed onVWF (nA-ratio and nB-ratio) explained about 18% (R(2)) of the variation in VWF levels...
  47. doi request reprint Mortality risk score in primary prevention implantable cardioverter defibrillator recipients with non-ischaemic or ischaemic heart disease
    C Jan Willem Borleffs
    Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, Leiden 2333 ZA, The Netherlands
    Eur Heart J 31:712-8. 2010
    ..To assess survival and to construct a baseline mortality risk score in primary prevention implantable cardioverter defibrillator (ICD) patients with non-ischaemic or ischaemic heart disease...
  48. ncbi request reprint Post-intervention IVUS is not predictive for very late in-stent thrombosis in drug-eluting stents
    Sandrin C Bergheanu
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Acta Cardiol 64:611-6. 2009
    ..Our aim was to investigate if late stent malapposition in DES could be predicted by immediate postintervention intra-vascular ultrasonography (IVUS)...
  49. ncbi request reprint Interaction of coagulation defects and cardiovascular risk factors: increased risk of myocardial infarction associated with factor V Leiden or prothrombin 20210A
    C J Doggen
    Department of Clinical Epidemiology, Leiden University Hospital, Netherlands
    Circulation 97:1037-41. 1998
    ..Furthermore, we studied the risk of myocardial infarction associated with the simultaneous presence of a coagulation defect (ie, the 20210 AG genotype of prothrombin or the factor V Leiden mutation) and Major cardiovascular risk factors...
  50. doi request reprint Mechanisms of the factor V Leiden paradox
    K J van Stralen
    Department of Clinical Epidemiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 28:1872-7. 2008
    ..So far few studies have investigated possible mechanisms for this so-called FVL paradox...
  51. doi request reprint Suspected survivor bias in case-control studies: stratify on survival time and use a negative control
    Nienke van Rein
    Department of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, The Netherlands Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands Electronic address
    J Clin Epidemiol 67:232-5. 2014
    ..However, selection bias due to improper case sampling is less well recognized. We describe how to recognize survivor bias (i.e., selection on exposed cases) and illustrate this with an example study...
  52. doi request reprint Role of obesity in the etiology of deep vein thrombosis and pulmonary embolism: current epidemiological insights
    Sigrid K Braekkan
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Semin Thromb Hemost 39:533-40. 2013
    ....
  53. pmc Type of arteriovenous vascular access and association with patency and mortality
    Gürbey Ocak
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    BMC Nephrol 14:79. 2013
    ..The aim of this study was to investigate risk factors for patency loss and to investigate the association between graft versus fistula use and outcomes (patency loss and mortality)...
  54. doi request reprint Heart rate variability and first cardiovascular event in populations without known cardiovascular disease: meta-analysis and dose-response meta-regression
    Stefanie Hillebrand
    Department of Clinical Epidemiology, Leiden University Medical Centre, Albinusdreef 2, Leiden, The Netherlands
    Europace 15:742-9. 2013
    ..It is less clear whether HRV is associated with a first cardiovascular event. Therefore, we performed a meta-analysis to study the association between HRV and incident cardiovascular events in populations without known CVD...
  55. pmc Long-term survival in a large cohort of patients with venous thrombosis: incidence and predictors
    Linda E Flinterman
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    PLoS Med 9:e1001155. 2012
    ..However, details on long-term mortality in these patients are lacking. The aim of this study was to determine long-term mortality in a large cohort of patients with venous thrombosis...
  56. ncbi request reprint Subtherapeutic oral anticoagulant therapy: frequency and risk factors
    Eva K Rombouts
    Department of Thrombosis and Haemostasis, C2 R Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands
    Thromb Haemost 101:552-6. 2009
    ..In 30% of cases the subtherapeutic INR was preceded by an event necessitating vitamin K or discontinuation of the anticoagulant drug...
  57. doi request reprint Combining matched and unmatched control groups in case-control studies
    Saskia le Cessie
    Department of Medical Statistics and Bioinformatics, S5 P, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Am J Epidemiol 168:1204-10. 2008
    ....
  58. doi request reprint Changes in outcome measures for impairment, activity limitation, and participation restriction over two years in osteoarthritis of the lower extremities
    Stella Botha-Scheepers
    Leiden University Medical Center, Department of Rheumatology, Leiden, The Netherlands
    Arthritis Rheum 59:1750-5. 2008
    ....
  59. doi request reprint Influence of dietary vitamin K intake on subtherapeutic oral anticoagulant therapy
    Eva K Rombouts
    Department of Thrombosis and Haemostasis, Leiden University Medical Centre, Leiden, The Netherlands
    Br J Haematol 149:598-605. 2010
    ..These findings support the recommendation for patients on vitamin K antagonists to eat a sufficient amount of vitamin-K containing foods...
  60. doi request reprint Effect of elevated levels of coagulation factors on the risk of venous thrombosis in long-distance travelers
    Saskia Kuipers
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Blood 113:2064-9. 2009
    ..7; 95% CI, 5.4-498). We conclude that increased levels of FII and FVIII increase the risk of venous thrombosis in travelers. Furthermore, the risk is greatly increased if other risk factors are present as well...
  61. doi request reprint Minor injuries as a risk factor for venous thrombosis
    Karlijn J van Stralen
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Arch Intern Med 168:21-6. 2008
    ..We studied the association of venous thrombosis with common minor injuries, such as minor sural muscle ruptures and ankle sprains...
  62. ncbi request reprint Malignancies, prothrombotic mutations, and the risk of venous thrombosis
    Jeanet W Blom
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    JAMA 293:715-22. 2005
    ..Venous thrombosis is a common complication in patients with cancer, leading to additional morbidity and compromising quality of life...
  63. ncbi request reprint Lowering the intensity of oral anticoagulant therapy: effects on the risk of hemorrhage and thromboembolism
    Marieke Torn
    Department of Hematology, Leiden University Medical Center, The Netherlands
    Arch Intern Med 164:668-73. 2004
    ....
  64. ncbi request reprint Mutation in blood coagulation factor V associated with resistance to activated protein C
    R M Bertina
    Hemostasis and Thrombosis Research Center, University Hospital, Leiden, The Netherlands
    Nature 369:64-7. 1994
    ..8), protein S (ref. 9), antithrombin10 deficiency) together...
  65. ncbi request reprint Old and new risk factors for upper extremity deep venous thrombosis
    J W Blom
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    J Thromb Haemost 3:2471-8. 2005
    ....
  66. ncbi request reprint Elevated endogenous thrombin potential is associated with an increased risk of a first deep venous thrombosis but not with the risk of recurrence
    A Van Hylckama Vlieg
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Br J Haematol 138:769-74. 2007
    ..5-2.2). Thus, a high ETP was not associated with an increased relative risk of recurrent venous thrombosis. At present, the clinical relevance of the thrombin generation assay in predicting recurrent venous thrombosis remains uncertain...
  67. ncbi request reprint The HR2 haplotype of factor V is not associated with the risk of myocardial infarction
    C J Doggen
    Department of Clinical Epidemiology, Leiden University Medical Center, The Netherlands
    Thromb Haemost 84:815-8. 2000
    ..We conclude that the risk of myocardial infarction for men in the presence of the R2 allele of the His1299Arg polymorphism is neither increased nor decreased...
  68. ncbi request reprint von Willebrand factor and its propeptide: the influence of secretion and clearance on protein levels and the risk of venous thrombosis
    A Y Nossent
    Hematology, Hemostasis and Thrombosis Research Center, Leiden University Medical Center, Leiden, The Netherlands
    J Thromb Haemost 4:2556-62. 2006
    ..VWF is secreted in equimolar amounts with its propeptide, which has a shorter half-life. VWF propeptide can be used as a measure of VWF secretion and allows estimation of the VWF half-life...
  69. ncbi request reprint Risk of a first venous thrombotic event in carriers of a familial thrombophilic defect. The European Prospective Cohort on Thrombophilia (EPCOT)
    C Y Vossen
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    J Thromb Haemost 3:459-64. 2005
    ..Reliable risk estimates for venous thrombosis in families with inherited thrombophilia are scarce but necessary for determining optimal screening and treatment policies...
  70. ncbi request reprint A mutation in the thrombomodulin gene, 127G to A coding for Ala25Thr, and the risk of myocardial infarction in men
    C J Doggen
    Department of Clinical Epidemiology, Leiden University Medical Center, The Netherlands
    Thromb Haemost 80:743-8. 1998
    ..4, CI 0.9-21.3), respectively. While not conclusive, these results strongly suggest that the Ala25Thr substitution is a risk factor for myocardial infarction, especially in young men, and when in the presence of additional risk factors...
  71. doi request reprint Patients with early arthritis consume less alcohol than controls, regardless of the type of arthritis
    Annekoos L Huidekoper
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Rheumatology (Oxford) 52:1701-7. 2013
    ..To assess whether alcohol consumption affects long-term disease outcome, we also investigated its association with radiographic progression and sustained drug-free remission in RA...
  72. ncbi request reprint Recurrence rate after a first venous thrombosis in patients with familial thrombophilia
    Carla Y Vossen
    Department of Clinical Epidemiology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 25:1992-7. 2005
    ..We prospectively determined the recurrence rate after a first venous thrombotic event in patients with familial thrombophilia attributable to factor V Leiden or deficiencies of protein C, S, or antithrombin...
  73. doi request reprint Quantification of bias in direct effects estimates due to different types of measurement error in the mediator
    Saskia le Cessie
    Departments of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Epidemiology 23:551-60. 2012
    ....
  74. doi request reprint Venous and arterial thrombosis in dialysis patients
    Gürbey Ocak
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Thromb Haemost 106:1046-52. 2011
    ....
  75. pmc Travel-related venous thrombosis: results from a large population-based case control study (MEGA study)
    Suzanne C Cannegieter
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands
    PLoS Med 3:e307. 2006
    ..Recent studies have indicated an increased risk of venous thrombosis after air travel. Nevertheless, questions on the magnitude of risk, the underlying mechanism, and modifying factors remain unanswered...
  76. pmc Inflammatory cytokines as risk factors for a first venous thrombosis: a prospective population-based study
    Sverre C Christiansen
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands
    PLoS Med 3:e334. 2006
    ..In order to distinguish between the two, we set out to measure the levels of six inflammatory markers prior to thrombosis in a population-based cohort using a nested case-cohort design...
  77. ncbi request reprint Genetic variation in thrombin-activatable fibrinolysis inhibitor (TAFI) is associated with the risk of splanchnic vein thrombosis
    Emile L E de Bruijne
    Department of Hematology, Erasmus MC, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Thromb Haemost 97:181-5. 2007
    ..In conclusion, genetic variation in the TAFI gene is associated with risk of SVT, suggesting a role for TAFI in the pathogenetic mechanism of SVT...
  78. doi request reprint Increased risk of venous thrombosis in persons with clinically diagnosed superficial vein thrombosis: results from the MEGA study
    Kirsten van Langevelde
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Blood 118:4239-41. 2011
    ..In conclusion, clinically diagnosed SVT was a risk factor for venous thrombosis. Given that thrombophilia was only weakly associated with SVT, it is likely that other factors (varicosis, obesity, stasis) also play a role in its etiology...
  79. ncbi request reprint Smoking increases the risk of venous thrombosis and acts synergistically with oral contraceptive use
    Elisabeth R Pomp
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Hematol 83:97-102. 2008
    ..0-fold increased risk. In conclusion, smoking appears to be a risk factor for venous thrombosis with the greatest relative effect among young women using oral contraceptives...
  80. doi request reprint Fluid loss does not explain coagulation activation during air travel
    Anja J M Schreijer
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Thromb Haemost 99:1053-9. 2008
    ..These findings do not support the hypothesis that fluid loss contributes to thrombus formation during air travel...
  81. doi request reprint The value of family history as a risk indicator for venous thrombosis
    Irene D Bezemer
    Department of Clinical Epidemiology, Leiden University Medical Center, The Netherlands
    Arch Intern Med 169:610-5. 2009
    ..We studied the contribution of family history to the risk of venous thrombosis in relation to known risk factors...
  82. doi request reprint Venous thrombosis of the upper extremity: effect of blood group and coagulation factor levels on risk
    Linda E Flinterman
    Department of Clinical Epidemiology, Leiden University, The Netherlands
    Br J Haematol 149:118-23. 2010
    ..1, 95% CI, 1.3-3.6). The other factors were not associated with an increased risk. Elevated levels of several procoagulant factors are associated with a strongly increased risk of venous thrombosis of the upper extremity...
  83. ncbi request reprint Using the common-sense model to predict risk perception and disease-related worry in individuals at increased risk for venous thrombosis
    Ad A Kaptein
    Unit of Psychology, Leiden University Medical Center, Leiden, The Netherlands
    Health Psychol 26:807-12. 2007
    ..This study applied the Common-Sense Model (CSM) to predict risk perception and disease-related worry in 174 individuals with a genetic predisposition to venous thrombosis (thrombophilia)...
  84. ncbi request reprint The effect of genetic variants in the thrombin activatable fibrinolysis inhibitor (TAFI) gene on TAFI-antigen levels, clot lysis time and the risk of venous thrombosis
    C H Martini
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Br J Haematol 134:92-4. 2006
    ..This indicates that the relationship between TAFI and venous thrombosis is more complex than previously suggested...
  85. ncbi request reprint High factor VIII antigen levels increase the risk of venous thrombosis but are not associated with polymorphisms in the von Willebrand factor and factor VIII gene
    P W Kamphuisen
    Haemostasis and Thrombosis Research Centre, Leiden University Medical Centre, Leiden, The Netherlands
    Br J Haematol 115:156-8. 2001
    ..Our data do not support the hypothesis that a single functional sequence variation in the factor VIII or VWF gene explains the majority of high factor VIII levels and thrombotic risk...
  86. doi request reprint Selectin haplotypes and the risk of venous thrombosis: influence of linkage disequilibrium with the factor V Leiden mutation
    S Uitte de Willige
    Einthoven Laboratory for Experimental Vascular Medicine, Department of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, The Netherlands
    J Thromb Haemost 6:478-85. 2008
    ..Selectin polymorphisms/haplotypes have been associated with cardiovascular disease...
  87. doi request reprint Polymorphisms in coagulation factors and the risk of recurrent cardiovascular events in men after a first myocardial infarction
    M D van der Krabben
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    J Thromb Haemost 6:720-5. 2008
    ..The aim of this study was to examine whether genetic predisposition to high levels of coagulation factors influences the risk of developing fatal and non-fatal arterial cardiovascular events in men with a first myocardial infarction (MI)...
  88. ncbi request reprint Oral contraceptives and the risk of myocardial infarction
    B C Tanis
    Thrombosis and Hemostasis Research Center, Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands
    N Engl J Med 345:1787-93. 2001
    ..The risk of myocardial infarction was similar among women who used oral contraceptives whether or not they had a prothrombotic mutation...
  89. doi request reprint Genetic variation in fibrinogen; its relationship to fibrinogen levels and the risk of myocardial infarction and ischemic stroke
    B Siegerink
    Department of Clinical Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands
    J Thromb Haemost 7:385-90. 2009
    ..Genetic variants can alter fibrinogen characteristics and are not subject to these problems...
  90. pmc Association between several clinical and radiological determinants with long-term clinical progression and good prognosis of lower limb osteoarthritis
    Erlangga Yusuf
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 6:e25426. 2011
    ..To investigate the factors associated with clinical progression and good prognosis in patients with lower limb osteoarthritis (OA)...
  91. ncbi request reprint Association between sex hormone-binding globulin levels and activated protein C resistance in explaining the risk of thrombosis in users of oral contraceptives containing different progestogens
    Huib A A M van Vliet
    Department of Gynaecology and Reproductive Medicine, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Hum Reprod 20:563-8. 2005
    ..Our objective was to test the usefulness of sex hormone-binding globulin (SHBG) as a marker for the thrombotic risk of an oral contraceptive...
  92. ncbi request reprint Venous and arterial thrombosis during oral contraceptive use: risks and risk factors
    Bea C Tanis
    Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands
    Semin Vasc Med 3:69-84. 2003
    ..However, this is unlikely to counterbalance the adverse effect of third generation contraceptives on venous thrombosis...
  93. ncbi request reprint Incidence and risk factors of early venous thrombosis associated with permanent pacemaker leads
    Cornelis J van Rooden
    Department of General Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands
    J Cardiovasc Electrophysiol 15:1258-62. 2004
    ..Few reliable estimates of the incidence of thrombosis have been reported. The contribution of established risk factors to venous thrombosis in patients with implanted pacemaker leads is unknown...
  94. doi request reprint Gene variants associated with deep vein thrombosis
    Irene D Bezemer
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    JAMA 299:1306-14. 2008
    ..The genetic causes of deep vein thrombosis (DVT) are not fully understood...
  95. doi request reprint Offering a medical examination following disaster exposure does not result in long-lasting reassurance about health complaints
    Margot J Verschuur
    Department of Psychology, Leiden University, Leiden, The Netherlands
    Gen Hosp Psychiatry 30:200-7. 2008
    ....
  96. ncbi request reprint Decreased mortality of ischaemic heart disease among carriers of haemophilia
    A Sramek
    Department of Clinical Epidemiology, Leiden University Medical Center, Netherlands
    Lancet 362:351-4. 2003
    ..We have investigated overall mortality and death from cardiovascular causes in carriers of haemophilia, who in most cases have mildly decreased coagulability without clinical signs...
  97. ncbi request reprint Factor V Leiden mutation in relation to fecundity and miscarriage in women with venous thrombosis
    F M van Dunne
    Department of Obstetrics, Gynaecology and Reproductive Medicine, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Hum Reprod 20:802-6. 2005
    ..This may manifest itself as a reduced time to pregnancy (increased fecundity) and fewer miscarriages in the first trimester...
  98. ncbi request reprint Risk factors for catheter-related thrombosis in cancer patients
    M E T Tesselaar
    Department of Clinical Oncology, Leiden University Medical Center, P O Box, Albinusdreef 2, Leiden ZA 2333, The Netherlands
    Eur J Cancer 40:2253-9. 2004
    ..Prophylaxis with anticoagulants is recommended for chest, but not for arm ports. Determination of plasma homocysteine levels may identify patients at an increased risk for thrombosis...
  99. doi request reprint Intrinsic coagulation activation and the risk of arterial thrombosis in young women: results from the Risk of Arterial Thrombosis in relation to Oral contraceptives (RATIO) case-control study
    B Siegerink
    Department of Clinical Epidemiology, LUMC, Leiden, The Netherlands
    Circulation 122:1854-61. 2010
    ..This study aims to determine the risks of arterial thrombosis conferred by increased activation of intrinsic coagulation proteins in young women and the effect of oral contraceptive use on this association...
  100. ncbi request reprint Interaction between oral contraceptive use and coagulation factor levels in deep venous thrombosis
    A Van Hylckama Vlieg
    Department of Clinical Epidemiology and Hemostasis, Leiden University Medical Center, NL 2300 RC Leiden, The Netherlands
    J Thromb Haemost 1:2186-90. 2003
    ..The results of this study indicate that the risk for the joint effects of oral contraceptive use and coagulation factor levels are minor compared with the joint effect of oral contraceptive use and the FV Leiden mutation (RR > 30)...
  101. ncbi request reprint Incidence of venous thrombosis in a large cohort of 66,329 cancer patients: results of a record linkage study
    J W Blom
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    J Thromb Haemost 4:529-35. 2006
    ..Large registries offer an opportunity to study the risk of VT in large cohorts of cancer patients, which is essential in decisions on prophylactic anti-coagulant treatment...