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Genomes and Genes | A RoosSummaryAffiliation: Leiden University Medical Center Country: The Netherlands Publications
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Publications
Induction of renal cell apoptosis by antibodies and complementA Roos
Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
Exp Nephrol 9:65-70. 2001....- Detection of three single nucleotide polymorphisms in the gene encoding mannose-binding lectin in a single pyrosequencing reactionAnja Roos
Department of Nephrology, Leiden University Medical Center, Postbox 9600, 2300 RC Leiden, The Netherlands
J Immunol Methods 309:108-14. 2006..This method can be used for the easy and reliable detection of MBL SNPs to identify the basis of functional MBL deficiency in clinical diagnostics and research... - Glomerular activation of the lectin pathway of complement in IgA nephropathy is associated with more severe renal diseaseAnja Roos
Department of Clinical Chemistry, Leiden University Medical Center, The Netherlands, and Fonazione D Amico per la Ricerca sulle Malattie Renali, Associazione Nuova Nefrologia, San Carlo Borromeo Hospital, Milano, Italy
J Am Soc Nephrol 17:1724-34. 2006..Together, these findings strongly point to a role for the lectin pathway of complement in glomerular complement activation in IgAN and suggest a contribution for both MBL and L-ficolin in the progression of the disease... - Antibody-mediated activation of the classical pathway of complement may compensate for mannose-binding lectin deficiencyAnja Roos
Leiden University Medical Center, Department of Nephrology, Leiden, The Netherlands
Eur J Immunol 34:2589-98. 2004.... - Mini-review: A pivotal role for innate immunity in the clearance of apoptotic cellsAnja Roos
Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
Eur J Immunol 34:921-9. 2004..It is proposed that C1q and other opsonins prevent autoimmunity and maintain self-tolerance by supporting the efficient clearance of apoptotic material, as well as by actively modulating phagocyte function... - IgM-enriched human introvenous immunoglobulin strongly inhibits complement-dependent porcine cell cytotoxicity mediated by human xenoreactive antibodiesAnja Roos
Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
Xenotransplantation 10:596-605. 2003..Therefore, IVIgM has a promising therapeutic significance for the treatment of (hyper)acute xenograft rejection... - Underglycosylation of IgA in IgA nephropathy: more than a diagnostic marker?A Roos
Department of Clinical Chemistry, Leiden University Medical Center, Leiden, The Netherlands
Kidney Int 71:1089-91. 2007..Further studies on the nature, production, regulation, and cellular and molecular interactions of this undergalactosylated IgA may facilitate disease diagnosis and provide further insight into the pathogenesis of this important disease... - Functional characterization of the lectin pathway of complement in human serumAnja Roos
Department of Nephrology, C3P, Leiden University Medical Center, P O Box 9600, 2300 RC, Leiden, The Netherlands
Mol Immunol 39:655-68. 2003..This assay offers novel possibilities for patient diagnostics as well as for the study of disease association with the LP... - Therapeutic inhibition of the early phase of complement activationAnja Roos
Department of Nephrology, Leiden University Medical Center, The Netherlands
Immunobiology 205:595-609. 2002..The potential value of these molecules for the development of therapeutically active complement inhibitors is discussed... - Antibody-mediated activation of the classical complement pathway in xenograft rejectionAnja Roos
Department of Nephrology, Leiden University Medical Center, The Netherlands
Transpl Immunol 9:257-70. 2002..Finally, various options that are currently under development for complement inhibition are discussed, with special reference to the specific inhibition of the classical complement pathway by soluble complement inhibitors... - Both IgG and IgM anti-pig antibodies induce complement activation and cytotoxicityA Roos
Department of Nephrology, Leiden University Medical Center, The Netherlands
Xenotransplantation 8:3-14. 2001.... - Human IgA activates the complement system via the mannan-binding lectin pathwayA Roos
Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
J Immunol 167:2861-8. 2001..Furthermore, our results may explain glomerular complement deposition in IgA nephropathy... - Specific inhibition of the classical complement pathway by C1q-binding peptidesA Roos
Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
J Immunol 167:7052-9. 2001..We conclude that peptide 2J is a promising reagent for the development of a therapeutic inhibitor of the earliest step of the classical complement pathway, i.e., the binding of C1q to its target... - A role for mannose-binding lectin dysfunction in generation of autoantibodies in systemic lupus erythematosusM A Seelen
Department of Nephrology, C3P 29, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
Rheumatology (Oxford) 44:111-9. 2005..To investigate the possible association of the mannose binding lectin (MBL) pathway of complement activation with different disease parameters and disease activity in patients with systemic lupus erythematosus (SLE)... 
Anti-C1q autoantibodies in murine lupus nephritisL A Trouw
Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
Clin Exp Immunol 135:41-8. 2004..In conclusion, anti-C1q antibodies are already present in serum and immune deposits of the kidney early in life and therefore can play a role in nephritis during experimental SLE-like disease in mice...- Functional analysis of the classical, alternative, and MBL pathways of the complement system: standardization and validation of a simple ELISAM A Seelen
Department of Nephrology, C3P-29, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
J Immunol Methods 296:187-98. 2005..The results demonstrate the value of these ELISA-based procedures for the functional assessment of complement deficiencies in clinical practice. The assay is now available commercially in kit form... 
Mannan-binding lectin mediates renal ischemia/reperfusion injury independent of complement activationP van der Pol
Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
Am J Transplant 12:877-87. 2012..Taken together, these data reveal a crucial role for MBL in the early pathophysiology of renal IRI and identify MBL as a novel therapeutic target in kidney transplantation...- A pathogenic role for secretory IgA in IgA nephropathyB D Oortwijn
Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
Kidney Int 69:1131-8. 2006..Furthermore, we showed that SIgA is accumulated in the glomeruli of an IgAN patient. These data suggest an important role for SIgA in the pathogenesis of IgAN... - Early renal ischemia-reperfusion injury in humans is dominated by IL-6 release from the allograftD K de Vries
Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
Am J Transplant 9:1574-84. 2009..In conclusion, this study shows that renal I/R in humans is dominated by local IL-6 release. Neutralization of IL-6 in mice resulted in a significant aggravation of renal I/R injury... - Autoantibodies to complement componentsL A Trouw
Department of Nephrology, D3 P, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
Mol Immunol 38:199-206. 2001..In the present review, we describe autoantibodies against complement components and their subsequent effects... - [The role of the complement system in the defence against infections and new ways of assessing the activation routes]M A Seelen
Leids Universitair Medisch Centrum, afd Nierziekten, C3P 29, Albinusdreef 2, 2333 ZA Leiden
Ned Tijdschr Geneeskd 148:2318-23. 2004..A new ELISA assay has been developed to enable the assessment of the functional activity of the whole lectin pathway and to determine the classical and the alternative pathway functional activity in a simple uniform design... - Autoantibodies against mannose-binding lectin in systemic lupus erythematosusM A Seelen
Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
Clin Exp Immunol 134:335-43. 2003..We conclude that anti-MBL are present in sera from SLE patients and influence the functional activity of MBL... - Mannose-binding lectin levels and infections in children after allogeneic hematopoietic SCTS H Chaudhry
Department of Pediatrics, Leiden University Medical Center, Albinusdreef 2, RC Leiden, The Netherlands
Bone Marrow Transplant 45:289-93. 2010..In addition, low serum MBL concentrations were not associated with increased susceptibility to any type of infections post-HSCT in this cohort of pediatric HSCT recipients... - Proinflammatory changes in human umbilical cord vein endothelial cells can be induced neither by native nor by modified CRPMelinda Oroszlan
3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary
Int Immunol 18:871-8. 2006.... - Evidence that complement protein C1q interacts with C-reactive protein through its globular head regionFabian D G McGrath
Department of Immunopathology, Sanquin Research, Amsterdam, The Netherlands
J Immunol 176:2950-7. 2006..These results provide the first evidence that the interaction of C1q with CRP or IgG involves sites located in the C1qGR, whereas sites in the CLR do not seem to be involved in the physiological interaction of C1q with CRP... - Monomeric and polymeric IgA show a similar association with the myeloid FcalphaRI/CD89Beatrijs D Oortwijn
Department of Nephrology, C3 P, Albinusdreef 2, 2333 ZA, Leiden University Medical Center, Leiden, The Netherlands
Mol Immunol 44:966-73. 2007.... - Infectious complications after simultaneous pancreas-kidney transplantation: a role for the lectin pathway of complement activationJeffrey J W Verschuren
Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
Transplantation 85:75-80. 2008..We questioned whether MBL deficiency influences infectious complications in patients after simultaneous pancreas-kidney transplantation (SPKT)... - Mannose-binding lectin and the kidneyAnja Roos
Nephrol Dial Transplant 22:3370-7. 2007 - Mannose-binding lectin: clinical implications for infection, transplantation, and autoimmunityLee H Bouwman
Department of Surgery, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
Hum Immunol 67:247-56. 2006..This review provides a general outline of the genetic and molecular characteristics of MBL and discusses MBL-disease association and its consequence in infection, transplantation, and autoimmunity... - MBL and C1q compete for interaction with human endothelial cellsMelinda Oroszlan
3rd Department of Internal Medicine, Semmelweis University, Kutvolgyi ut 4, 1125 Budapest, Hungary
Mol Immunol 44:1150-8. 2007..Interaction of MBL and C1q with receptors on endothelial cells may be involved in inflammatory processes, and in clearance of pathogens and apoptotic cells... - Dendritic cell and macrophage subsets in the handling of dying cellsWei Xu
Department of Nephrology, C3-P, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
Immunobiology 211:567-75. 2006..We hypothesize that under steady-state conditions, the clearance of apoptotic cells is mostly confined to a specialized subset of phagocytes with anti-inflammatory properties... - Mannose-binding lectin contributes to the severity of Guillain-Barré syndromeKarin Geleijns
Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands
J Immunol 177:4211-7. 2006..These results support the hypothesis that complement activation mediated by MBL contributes to the extent of nerve damage in GBS, which is codetermined by the MBL2 haplotype... - Compliments from complement: A fourth pathway of complement activation?Mohamed R Daha
LUMC, Department of Nephrology, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
Nephrol Dial Transplant 21:3374-6. 2006 - Low pretransplantation mannose-binding lectin levels predict superior patient and graft survival after simultaneous pancreas-kidney transplantationStefan P Berger
Department of Nephrology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, Netherlands
J Am Soc Nephrol 18:2416-22. 2007..It is hypothesized that MBL contributes to the pathogenesis of inflammation-induced vascular damage both in the transplanted organs and in the recipient's native blood vessels... - Structure and function of the long pentraxin PTX3 glycosidic moiety: fine-tuning of the interaction with C1q and complement activationAntonio Inforzato
Department of Biology, University Tor Vergata, Rome, Italy
Biochemistry 45:11540-51. 2006..In conclusion, our results provided evidence of an involvement of the PTX3 sugar moiety in C1q recognition and complement activation... - Demonstration of secretory IgA in kidneys of patients with IgA nephropathyBeatrijs D Oortwijn
Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
Nephrol Dial Transplant 22:3191-5. 2007..Therefore, we attempted to find support for these findings by analysis of the presence of SIgA in biopsies of IgAN patients... - Differential glycosylation of polymeric and monomeric IgA: a possible role in glomerular inflammation in IgA nephropathyBeatrijs D Oortwijn
Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
J Am Soc Nephrol 17:3529-39. 2006..Furthermore, pIgA has different N-glycans, which may recruit lectins of the inflammatory pathway. These results underscore the role of pIgA in glomerular inflammation in IgAN... - Human neutrophil peptide-1 inhibits both the classical and the lectin pathway of complement activationTom W L Groeneveld
Department of Nephrology, C3 P, Leiden University Medical Center, Postbox 9600, 2300 RC Leiden, The Netherlands
Mol Immunol 44:3608-14. 2007..We conclude that HNP-1 may play a role in protection against tissue injury during inflammatory conditions by inhibiting the early phase of complement activation... - Human peritoneal macrophages show functional characteristics of M-CSF-driven anti-inflammatory type 2 macrophagesWei Xu
Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
Eur J Immunol 37:1594-9. 2007..We propose that pMPhi have the potential to maintain an anti-inflammatory condition in the peritoneal cavity... - The role of secretory IgA and complement in IgA nephropathyBeatrijs D Oortwijn
Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
Semin Nephrol 28:58-65. 2008..In the present review we discuss recent developments in this area and provide a model of how mucosal immunity and renal inflammation may be interconnected... - Role of complement in innate and autoimmunityMarc A J Seelen
Department of Nephrology, Leiden University Medical Center, Leiden - The Netherlands
J Nephrol 18:642-53. 2005..This review describes the many faces of complement in the field of innate and acquired immunity and takes the reader on a journey of the role of complement in health and disease... - Maturation of dendritic cells abrogates C1q production in vivo and in vitroGiuseppe Castellano
Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
Blood 103:3813-20. 2004..Therefore, immDCs may be considered an additional source of C1q in humans... - Mannose-binding lectin engagement with late apoptotic and necrotic cellsAlma J Nauta
Department of Nephrology, Leiden University Medical Center, The Netherlands
Eur J Immunol 33:2853-63. 2003..These results demonstrate that MBL interacts with structures exposed on cells rendered late apoptotic or necrotic and facilitates uptake by macrophages. Thus, MBL may promote non-inflammatory sequestration of dying host cells... - Biochemical and functional characterization of the interaction between pentraxin 3 and C1qAlma J Nauta
Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
Eur J Immunol 33:465-73. 2003..These results indicate that PTX3 can both inhibit and activate the classical complement pathway by binding C1q, depending on the way it is presented. PTX3 may therefore be involved in the regulation of the innate immune response... - Secretory IgA N- and O-glycans provide a link between the innate and adaptive immune systemsLouise Royle
Glycobiology Institute, Department of Biochemistry, Oxford University, United Kingdom
J Biol Chem 278:20140-53. 2003.... - Recognition and clearance of apoptotic cells: a role for complement and pentraxinsAlma J Nauta
Dept of Nephrology, Leiden University Medical Center, Postbox 9600, 2300 RC Leiden, The Netherlands
Trends Immunol 24:148-54. 2003 - A regulatory role for complement in innate immunity and autoimmunityAlma J Nauta
Leiden University Medical Center, Nephrology Department, Leiden, The Netherlands
Int Arch Allergy Immunol 134:310-23. 2004..The present review summarizes these different contributions of complement to the shaping of the immune balance... - Opsonization with C1q and mannose-binding lectin targets apoptotic cells to dendritic cellsAlma J Nauta
Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
J Immunol 173:3044-50. 2004..Therefore, we propose that early complement components support safe clearance of cellular debris by facilitating phagocytosis and possibly by immunomodulatory mechanisms, thus preventing autoimmunity... - Evidence for Galalpha(1-3)Gal expression on primary porcine hepatocytes: implications for bioartificial liver systemsMaarten-Paul van de Kerkhove
Dept. of Surgery (Surgical Laboratory, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
J Hepatol 42:541-7. 2005..CONCLUSIONS: Isolation and culture of porcine hepatocytes induce Galalpha(1-3)Gal expression, which may elicit immunological responses potentially compromising BAL functionality... - Activation of complement pathways in xenotransplantation: an in vitro studyAlexander J Walpen
Heart Transplantation Laboratory, Swiss Cardiovascular Center Bern, University Hospital
Transpl Immunol 9:271-80. 2002.... - Association between mannose-binding lectin levels and graft survival in kidney transplantationStefan P Berger
Department of Nephrology, Leiden University Medical Center, The Netherlands
Am J Transplant 5:1361-6. 2005..If these data can be confirmed, pre-transplant MBL levels may provide additional information for risk stratification prior to kidney transplantation... - Complement and the kidney: what the nephrologist needs to know in 2006?Stefan P Berger
Nephrol Dial Transplant 20:2613-9. 2005 - The membrane attack complex of complement induces caspase activation and apoptosisAlma J Nauta
Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
Eur J Immunol 32:783-92. 2002..Apoptosis as a consequence of complement-mediated cell damage may provide an explanation for the presence of apoptosis in inflammatory processes, for instance in hyperacute xenograft rejection... - Elevated levels of mannose-binding lectin at clinical manifestation of type 1 diabetes in juvenilesLee H Bouwman
Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
Diabetes 54:3002-6. 2005.... - Structures of complement component C3 provide insights into the function and evolution of immunityBert J C Janssen
Crystal and Structural Chemistry, Bijvoet Center for Biomolecular Research, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
Nature 437:505-11. 2005.... - IL-10-producing macrophages preferentially clear early apoptotic cellsWei Xu
Department of Nephrology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands
Blood 107:4930-7. 2006..Our studies suggest that, under steady-state conditions, IL-10-producing Mø2s are prominently involved in the clearance of early apoptotic cells... - Direct binding of C1q to apoptotic cells and cell blebs induces complement activationAlma J Nauta
Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
Eur J Immunol 32:1726-36. 2002.... - Mannose binding lectin gene polymorphisms confer a major risk for severe infections after liver transplantationLee H Bouwman
Department of Surgery, Leiden University Medical Center, The Netherlands
Gastroenterology 129:408-14. 2005..The aims of our study were to establish the role of the liver in production of serum MBL and to evaluate the effect of MBL variant alleles on the susceptibility to infection after liver transplantation... - T-cell-specific immunosuppression results in more than 53 days survival of porcine islets of langerhans in the monkeyJosephine K R A Rijkelijkhuizen
Department of Surgery, Leiden University Medical Centre, Leiden, The Netherlands
Transplantation 76:1359-68. 2003..CONCLUSIONS: This study demonstrates that cultured adult pig islets can survive in the monkey for more than 53 days without signs of rejection under standard immunosuppression... - Mannose-binding lectin is involved in multiple organ dysfunction syndrome after cardiac surgery: effects of blood transfusionsYavuz M Bilgin
Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
Transfusion 48:601-8. 2008..Preoperative transfusions of allogeneic white blood cells (WBCs) contribute to infectious and inflammatory complications. This study investigates the role of MBL in relation to blood transfusions and complications after cardiac surgery... - Dendritic cells and complement: at the cross road of innate and adaptive immunityGiuseppe Castellano
Department of Nephrology, Leiden University Medical Center, C3-P, Albinusdreef 2, P.O. Box 9600, 2333 ZA Leiden, The Netherlands
Mol Immunol 41:133-40. 2004..This review focuses on novel findings, which have started to shed light on these intriguing components of the innate immune system... - Factor B structure provides insights into activation of the central protease of the complement systemFin J Milder
Crystal and Structural Chemistry, Bijvoet Center for Biomolecular Research, Faculty of Sciences, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
Nat Struct Mol Biol 14:224-8. 2007..This allosteric mechanism is crucial for tight regulation of the complement-amplification step in the immune response... - A prospective study of anti-chromatin and anti-C1q autoantibodies in patients with proliferative lupus nephritis treated with cyclophosphamide pulses or azathioprine/methylprednisoloneCecile Grootscholten
Division of Nephrology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Ann Rheum Dis 66:693-6. 2007.... - A missense mutation in factor I (IF) predisposes to atypical haemolytic uraemic syndromeJoyce Geelen
Department of Paediatric Nephrology, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
Pediatr Nephrol 22:371-5. 2007..One additional transplant was lost due to arterial thrombosis of the renal artery. This report confirms the gloomy outcome of renal transplants in patients with an IF deficiency. New therapies should be evaluated in these patients... - Human renal epithelial cells produce the long pentraxin PTX3Alma J Nauta
Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
Kidney Int 67:543-53. 2005..Local expression of PTX3 may play a role in the innate immune response and inflammatory reactions in the kidney... - Activation of the lectin pathway in murine lupus nephritisLeendert A Trouw
Department of Nephrology, C3, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
Mol Immunol 42:731-40. 2005..In conclusion, these data suggest that in addition to the classical pathway and the alternative pathway also the lectin pathway of complement activation is involved in murine lupus nephritis... - Immune evasion by a staphylococcal complement inhibitor that acts on C3 convertasesSuzan H M Rooijakkers
Eijkman Winkler Institute, University Medical Center Utrecht, G04 614, 3584 CX Utrecht, The Netherlands
Nat Immunol 6:920-7. 2005..As a highly active and small soluble protein that acts exclusively on surfaces, staphylococcal complement inhibitor may represent a promising anti-inflammatory molecule... - Interactions of the extracellular matrix proteoglycans decorin and biglycan with C1q and collectinsTom W L Groeneveld
Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
J Immunol 175:4715-23. 2005..These two proteoglycans are likely to down-regulate proinflammatory effects mediated by C1q, and possibly also the collectins, at the tissue level... - Structure of complement component C2A: implications for convertase formation and substrate bindingFin J Milder
Crystal and Structural Chemistry, Bijvoet Center for Biomolecular Research, Faculty of Science, Utrecht University, 3584 CH Utrecht, The Netherlands
Structure 14:1587-97. 2006..Together with a putative substrate-induced completion of the oxyanion hole, this may contribute to the high substrate specificity of the convertases...