A Roos

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. ncbi Detection of three single nucleotide polymorphisms in the gene encoding mannose-binding lectin in a single pyrosequencing reaction
    Anja Roos
    Department of Nephrology, Leiden University Medical Center, Postbox 9600, 2300 RC Leiden, The Netherlands
    J Immunol Methods 309:108-14. 2006
  2. ncbi Antibody-mediated activation of the classical pathway of complement may compensate for mannose-binding lectin deficiency
    Anja Roos
    Leiden University Medical Center, Department of Nephrology, Leiden, The Netherlands
    Eur J Immunol 34:2589-98. 2004
  3. ncbi Underglycosylation of IgA in IgA nephropathy: more than a diagnostic marker?
    A Roos
    Department of Clinical Chemistry, Leiden University Medical Center, Leiden, The Netherlands
    Kidney Int 71:1089-91. 2007
  4. ncbi Glomerular activation of the lectin pathway of complement in IgA nephropathy is associated with more severe renal disease
    Anja Roos
    Department of Clinical Chemistry, Leiden University Medical Center, The Netherlands, and Fonazione D Amico per la Ricerca sulle Malattie Renali, Associazione Nuova Nefrologia, San Carlo Borromeo Hospital, Milano, Italy
    J Am Soc Nephrol 17:1724-34. 2006
  5. ncbi IgM-enriched human introvenous immunoglobulin strongly inhibits complement-dependent porcine cell cytotoxicity mediated by human xenoreactive antibodies
    Anja Roos
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Xenotransplantation 10:596-605. 2003
  6. ncbi Mini-review: A pivotal role for innate immunity in the clearance of apoptotic cells
    Anja Roos
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Immunol 34:921-9. 2004
  7. ncbi Therapeutic inhibition of the early phase of complement activation
    Anja Roos
    Department of Nephrology, Leiden University Medical Center, The Netherlands
    Immunobiology 205:595-609. 2002
  8. ncbi Antibody-mediated activation of the classical complement pathway in xenograft rejection
    Anja Roos
    Department of Nephrology, Leiden University Medical Center, The Netherlands
    Transpl Immunol 9:257-70. 2002
  9. ncbi Induction of renal cell apoptosis by antibodies and complement
    A Roos
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Exp Nephrol 9:65-70. 2001
  10. ncbi Both IgG and IgM anti-pig antibodies induce complement activation and cytotoxicity
    A Roos
    Department of Nephrology, Leiden University Medical Center, The Netherlands
    Xenotransplantation 8:3-14. 2001

Collaborators

Detail Information

Publications70

  1. ncbi Detection of three single nucleotide polymorphisms in the gene encoding mannose-binding lectin in a single pyrosequencing reaction
    Anja Roos
    Department of Nephrology, Leiden University Medical Center, Postbox 9600, 2300 RC Leiden, The Netherlands
    J Immunol Methods 309:108-14. 2006
    ..This method can be used for the easy and reliable detection of MBL SNPs to identify the basis of functional MBL deficiency in clinical diagnostics and research...
  2. ncbi Antibody-mediated activation of the classical pathway of complement may compensate for mannose-binding lectin deficiency
    Anja Roos
    Leiden University Medical Center, Department of Nephrology, Leiden, The Netherlands
    Eur J Immunol 34:2589-98. 2004
    ....
  3. ncbi Underglycosylation of IgA in IgA nephropathy: more than a diagnostic marker?
    A Roos
    Department of Clinical Chemistry, Leiden University Medical Center, Leiden, The Netherlands
    Kidney Int 71:1089-91. 2007
    ..Further studies on the nature, production, regulation, and cellular and molecular interactions of this undergalactosylated IgA may facilitate disease diagnosis and provide further insight into the pathogenesis of this important disease...
  4. ncbi Glomerular activation of the lectin pathway of complement in IgA nephropathy is associated with more severe renal disease
    Anja Roos
    Department of Clinical Chemistry, Leiden University Medical Center, The Netherlands, and Fonazione D Amico per la Ricerca sulle Malattie Renali, Associazione Nuova Nefrologia, San Carlo Borromeo Hospital, Milano, Italy
    J Am Soc Nephrol 17:1724-34. 2006
    ..Together, these findings strongly point to a role for the lectin pathway of complement in glomerular complement activation in IgAN and suggest a contribution for both MBL and L-ficolin in the progression of the disease...
  5. ncbi IgM-enriched human introvenous immunoglobulin strongly inhibits complement-dependent porcine cell cytotoxicity mediated by human xenoreactive antibodies
    Anja Roos
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Xenotransplantation 10:596-605. 2003
    ..Therefore, IVIgM has a promising therapeutic significance for the treatment of (hyper)acute xenograft rejection...
  6. ncbi Mini-review: A pivotal role for innate immunity in the clearance of apoptotic cells
    Anja Roos
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Immunol 34:921-9. 2004
    ..It is proposed that C1q and other opsonins prevent autoimmunity and maintain self-tolerance by supporting the efficient clearance of apoptotic material, as well as by actively modulating phagocyte function...
  7. ncbi Therapeutic inhibition of the early phase of complement activation
    Anja Roos
    Department of Nephrology, Leiden University Medical Center, The Netherlands
    Immunobiology 205:595-609. 2002
    ..The potential value of these molecules for the development of therapeutically active complement inhibitors is discussed...
  8. ncbi Antibody-mediated activation of the classical complement pathway in xenograft rejection
    Anja Roos
    Department of Nephrology, Leiden University Medical Center, The Netherlands
    Transpl Immunol 9:257-70. 2002
    ..Finally, various options that are currently under development for complement inhibition are discussed, with special reference to the specific inhibition of the classical complement pathway by soluble complement inhibitors...
  9. ncbi Induction of renal cell apoptosis by antibodies and complement
    A Roos
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Exp Nephrol 9:65-70. 2001
    ....
  10. ncbi Both IgG and IgM anti-pig antibodies induce complement activation and cytotoxicity
    A Roos
    Department of Nephrology, Leiden University Medical Center, The Netherlands
    Xenotransplantation 8:3-14. 2001
    ....
  11. ncbi Specific inhibition of the classical complement pathway by C1q-binding peptides
    A Roos
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    J Immunol 167:7052-9. 2001
    ..We conclude that peptide 2J is a promising reagent for the development of a therapeutic inhibitor of the earliest step of the classical complement pathway, i.e., the binding of C1q to its target...
  12. ncbi Functional characterization of the lectin pathway of complement in human serum
    Anja Roos
    Department of Nephrology, C3P, Leiden University Medical Center, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Mol Immunol 39:655-68. 2003
    ..This assay offers novel possibilities for patient diagnostics as well as for the study of disease association with the LP...
  13. ncbi Human IgA activates the complement system via the mannan-binding lectin pathway
    A Roos
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    J Immunol 167:2861-8. 2001
    ..Furthermore, our results may explain glomerular complement deposition in IgA nephropathy...
  14. ncbi A role for mannose-binding lectin dysfunction in generation of autoantibodies in systemic lupus erythematosus
    M A Seelen
    Department of Nephrology, C3P 29, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Rheumatology (Oxford) 44:111-9. 2005
    ..To investigate the possible association of the mannose binding lectin (MBL) pathway of complement activation with different disease parameters and disease activity in patients with systemic lupus erythematosus (SLE)...
  15. pmc Anti-C1q autoantibodies in murine lupus nephritis
    L A Trouw
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Clin Exp Immunol 135:41-8. 2004
    ..In conclusion, anti-C1q antibodies are already present in serum and immune deposits of the kidney early in life and therefore can play a role in nephritis during experimental SLE-like disease in mice...
  16. ncbi Functional analysis of the classical, alternative, and MBL pathways of the complement system: standardization and validation of a simple ELISA
    M A Seelen
    Department of Nephrology, C3P 29, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    J Immunol Methods 296:187-98. 2005
    ..The results demonstrate the value of these ELISA-based procedures for the functional assessment of complement deficiencies in clinical practice. The assay is now available commercially in kit form...
  17. doi Mannan-binding lectin mediates renal ischemia/reperfusion injury independent of complement activation
    P van der Pol
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Transplant 12:877-87. 2012
    ..Taken together, these data reveal a crucial role for MBL in the early pathophysiology of renal IRI and identify MBL as a novel therapeutic target in kidney transplantation...
  18. ncbi A pathogenic role for secretory IgA in IgA nephropathy
    B D Oortwijn
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Kidney Int 69:1131-8. 2006
    ..Furthermore, we showed that SIgA is accumulated in the glomeruli of an IgAN patient. These data suggest an important role for SIgA in the pathogenesis of IgAN...
  19. doi Early renal ischemia-reperfusion injury in humans is dominated by IL-6 release from the allograft
    D K de Vries
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Am J Transplant 9:1574-84. 2009
    ..In conclusion, this study shows that renal I/R in humans is dominated by local IL-6 release. Neutralization of IL-6 in mice resulted in a significant aggravation of renal I/R injury...
  20. ncbi Autoantibodies to complement components
    L A Trouw
    Department of Nephrology, D3 P, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Mol Immunol 38:199-206. 2001
    ..In the present review, we describe autoantibodies against complement components and their subsequent effects...
  21. ncbi [The role of the complement system in the defence against infections and new ways of assessing the activation routes]
    M A Seelen
    Leids Universitair Medisch Centrum, afd Nierziekten, C3P 29, Albinusdreef 2, 2333 ZA Leiden
    Ned Tijdschr Geneeskd 148:2318-23. 2004
    ..A new ELISA assay has been developed to enable the assessment of the functional activity of the whole lectin pathway and to determine the classical and the alternative pathway functional activity in a simple uniform design...
  22. pmc Autoantibodies against mannose-binding lectin in systemic lupus erythematosus
    M A Seelen
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Clin Exp Immunol 134:335-43. 2003
    ..We conclude that anti-MBL are present in sera from SLE patients and influence the functional activity of MBL...
  23. doi Mannose-binding lectin levels and infections in children after allogeneic hematopoietic SCT
    S H Chaudhry
    Department of Pediatrics, Leiden University Medical Center, Albinusdreef 2, RC Leiden, The Netherlands
    Bone Marrow Transplant 45:289-93. 2010
    ..In addition, low serum MBL concentrations were not associated with increased susceptibility to any type of infections post-HSCT in this cohort of pediatric HSCT recipients...
  24. pmc Genetic variants in the region of the C1q genes are associated with rheumatoid arthritis
    L A Trouw
    Department of Rheumatology, Leiden University Medical Center, The Netherlands
    Clin Exp Immunol 173:76-83. 2013
    ..Combined analysis, including integrated data from six GWAS studies, provides support for the genetic association. Genetic variants in C1q are correlated with C1q levels and may be a risk for the development of RA...
  25. ncbi MBL and C1q compete for interaction with human endothelial cells
    Melinda Oroszlan
    3rd Department of Internal Medicine, Semmelweis University, Kutvolgyi ut 4, 1125 Budapest, Hungary
    Mol Immunol 44:1150-8. 2007
    ..Interaction of MBL and C1q with receptors on endothelial cells may be involved in inflammatory processes, and in clearance of pathogens and apoptotic cells...
  26. ncbi Dendritic cell and macrophage subsets in the handling of dying cells
    Wei Xu
    Department of Nephrology, C3 P, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Immunobiology 211:567-75. 2006
    ..We hypothesize that under steady-state conditions, the clearance of apoptotic cells is mostly confined to a specialized subset of phagocytes with anti-inflammatory properties...
  27. ncbi Monomeric and polymeric IgA show a similar association with the myeloid FcalphaRI/CD89
    Beatrijs D Oortwijn
    Department of Nephrology, C3 P, Albinusdreef 2, 2333 ZA, Leiden University Medical Center, Leiden, The Netherlands
    Mol Immunol 44:966-73. 2007
    ....
  28. ncbi IL-10-producing macrophages preferentially clear early apoptotic cells
    Wei Xu
    Department of Nephrology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands
    Blood 107:4930-7. 2006
    ..Our studies suggest that, under steady-state conditions, IL-10-producing Mø2s are prominently involved in the clearance of early apoptotic cells...
  29. ncbi Evidence that complement protein C1q interacts with C-reactive protein through its globular head region
    Fabian D G McGrath
    Department of Immunopathology, Sanquin Research, Amsterdam, The Netherlands
    J Immunol 176:2950-7. 2006
    ..These results provide the first evidence that the interaction of C1q with CRP or IgG involves sites located in the C1qGR, whereas sites in the CLR do not seem to be involved in the physiological interaction of C1q with CRP...
  30. ncbi Mannose-binding lectin contributes to the severity of Guillain-Barré syndrome
    Karin Geleijns
    Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Immunol 177:4211-7. 2006
    ..These results support the hypothesis that complement activation mediated by MBL contributes to the extent of nerve damage in GBS, which is codetermined by the MBL2 haplotype...
  31. ncbi Mannose-binding lectin: clinical implications for infection, transplantation, and autoimmunity
    Lee H Bouwman
    Department of Surgery, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Hum Immunol 67:247-56. 2006
    ..This review provides a general outline of the genetic and molecular characteristics of MBL and discusses MBL-disease association and its consequence in infection, transplantation, and autoimmunity...
  32. ncbi Structure and function of the long pentraxin PTX3 glycosidic moiety: fine-tuning of the interaction with C1q and complement activation
    Antonio Inforzato
    Department of Biology, University Tor Vergata, Rome, Italy
    Biochemistry 45:11540-51. 2006
    ..In conclusion, our results provided evidence of an involvement of the PTX3 sugar moiety in C1q recognition and complement activation...
  33. ncbi Differential glycosylation of polymeric and monomeric IgA: a possible role in glomerular inflammation in IgA nephropathy
    Beatrijs D Oortwijn
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    J Am Soc Nephrol 17:3529-39. 2006
    ..Furthermore, pIgA has different N-glycans, which may recruit lectins of the inflammatory pathway. These results underscore the role of pIgA in glomerular inflammation in IgAN...
  34. doi The role of secretory IgA and complement in IgA nephropathy
    Beatrijs D Oortwijn
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Semin Nephrol 28:58-65. 2008
    ..In the present review we discuss recent developments in this area and provide a model of how mucosal immunity and renal inflammation may be interconnected...
  35. doi Infectious complications after simultaneous pancreas-kidney transplantation: a role for the lectin pathway of complement activation
    Jeffrey J W Verschuren
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Transplantation 85:75-80. 2008
    ..We questioned whether MBL deficiency influences infectious complications in patients after simultaneous pancreas-kidney transplantation (SPKT)...
  36. ncbi Mannose-binding lectin and the kidney
    Anja Roos
    Nephrol Dial Transplant 22:3370-7. 2007
  37. ncbi Low pretransplantation mannose-binding lectin levels predict superior patient and graft survival after simultaneous pancreas-kidney transplantation
    Stefan P Berger
    Department of Nephrology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, Netherlands
    J Am Soc Nephrol 18:2416-22. 2007
    ..It is hypothesized that MBL contributes to the pathogenesis of inflammation-induced vascular damage both in the transplanted organs and in the recipient's native blood vessels...
  38. ncbi Demonstration of secretory IgA in kidneys of patients with IgA nephropathy
    Beatrijs D Oortwijn
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Nephrol Dial Transplant 22:3191-5. 2007
    ..Therefore, we attempted to find support for these findings by analysis of the presence of SIgA in biopsies of IgAN patients...
  39. ncbi Human peritoneal macrophages show functional characteristics of M-CSF-driven anti-inflammatory type 2 macrophages
    Wei Xu
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Immunol 37:1594-9. 2007
    ..We propose that pMPhi have the potential to maintain an anti-inflammatory condition in the peritoneal cavity...
  40. ncbi Human neutrophil peptide-1 inhibits both the classical and the lectin pathway of complement activation
    Tom W L Groeneveld
    Department of Nephrology, C3 P, Leiden University Medical Center, Postbox 9600, 2300 RC Leiden, The Netherlands
    Mol Immunol 44:3608-14. 2007
    ..We conclude that HNP-1 may play a role in protection against tissue injury during inflammatory conditions by inhibiting the early phase of complement activation...
  41. ncbi Compliments from complement: A fourth pathway of complement activation?
    Mohamed R Daha
    LUMC, Department of Nephrology, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Nephrol Dial Transplant 21:3374-6. 2006
  42. ncbi Role of complement in innate and autoimmunity
    Marc A J Seelen
    Department of Nephrology, Leiden University Medical Center, Leiden The Netherlands
    J Nephrol 18:642-53. 2005
    ..This review describes the many faces of complement in the field of innate and acquired immunity and takes the reader on a journey of the role of complement in health and disease...
  43. ncbi Opsonization with C1q and mannose-binding lectin targets apoptotic cells to dendritic cells
    Alma J Nauta
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    J Immunol 173:3044-50. 2004
    ..Therefore, we propose that early complement components support safe clearance of cellular debris by facilitating phagocytosis and possibly by immunomodulatory mechanisms, thus preventing autoimmunity...
  44. ncbi A regulatory role for complement in innate immunity and autoimmunity
    Alma J Nauta
    Leiden University Medical Center, Nephrology Department, Leiden, The Netherlands
    Int Arch Allergy Immunol 134:310-23. 2004
    ..The present review summarizes these different contributions of complement to the shaping of the immune balance...
  45. ncbi Maturation of dendritic cells abrogates C1q production in vivo and in vitro
    Giuseppe Castellano
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Blood 103:3813-20. 2004
    ..Therefore, immDCs may be considered an additional source of C1q in humans...
  46. ncbi T-cell-specific immunosuppression results in more than 53 days survival of porcine islets of langerhans in the monkey
    Josephine K R A Rijkelijkhuizen
    Department of Surgery, Leiden University Medical Centre, Leiden, The Netherlands
    Transplantation 76:1359-68. 2003
    ..The present study was aimed at the characterization of rejection mechanisms of porcine islets transplanted into eight nondiabetic monkeys under the kidney capsule...
  47. ncbi Mannose-binding lectin engagement with late apoptotic and necrotic cells
    Alma J Nauta
    Department of Nephrology, Leiden University Medical Center, The Netherlands
    Eur J Immunol 33:2853-63. 2003
    ..These results demonstrate that MBL interacts with structures exposed on cells rendered late apoptotic or necrotic and facilitates uptake by macrophages. Thus, MBL may promote non-inflammatory sequestration of dying host cells...
  48. ncbi Biochemical and functional characterization of the interaction between pentraxin 3 and C1q
    Alma J Nauta
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Immunol 33:465-73. 2003
    ..These results indicate that PTX3 can both inhibit and activate the classical complement pathway by binding C1q, depending on the way it is presented. PTX3 may therefore be involved in the regulation of the innate immune response...
  49. ncbi Secretory IgA N- and O-glycans provide a link between the innate and adaptive immune systems
    Louise Royle
    Glycobiology Institute, Department of Biochemistry, Oxford University, United Kingdom
    J Biol Chem 278:20140-53. 2003
    ....
  50. ncbi Recognition and clearance of apoptotic cells: a role for complement and pentraxins
    Alma J Nauta
    Dept of Nephrology, Leiden University Medical Center, Postbox 9600, 2300 RC Leiden, The Netherlands
    Trends Immunol 24:148-54. 2003
  51. ncbi Activation of complement pathways in xenotransplantation: an in vitro study
    Alexander J Walpen
    Heart Transplantation Laboratory, Swiss Cardiovascular Center Bern, University Hospital
    Transpl Immunol 9:271-80. 2002
    ....
  52. ncbi Direct binding of C1q to apoptotic cells and cell blebs induces complement activation
    Alma J Nauta
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Immunol 32:1726-36. 2002
    ....
  53. ncbi The membrane attack complex of complement induces caspase activation and apoptosis
    Alma J Nauta
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Immunol 32:783-92. 2002
    ..Apoptosis as a consequence of complement-mediated cell damage may provide an explanation for the presence of apoptosis in inflammatory processes, for instance in hyperacute xenograft rejection...
  54. ncbi Proinflammatory changes in human umbilical cord vein endothelial cells can be induced neither by native nor by modified CRP
    Melinda Oroszlan
    3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary
    Int Immunol 18:871-8. 2006
    ....
  55. ncbi Complement and the kidney: what the nephrologist needs to know in 2006?
    Stefan P Berger
    Nephrol Dial Transplant 20:2613-9. 2005
  56. ncbi Evidence for Galalpha(1-3)Gal expression on primary porcine hepatocytes: implications for bioartificial liver systems
    Maarten Paul van de Kerkhove
    Dept of Surgery Surgical Laboratory, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    J Hepatol 42:541-7. 2005
    ..Conflicting data have been published concerning Galalpha(1-3)Gal expression on hepatocytes in intact porcine liver. We investigated whether isolated porcine hepatocytes express Galalpha(1-3)Gal...
  57. ncbi Elevated levels of mannose-binding lectin at clinical manifestation of type 1 diabetes in juveniles
    Lee H Bouwman
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Diabetes 54:3002-6. 2005
    ....
  58. ncbi Structures of complement component C3 provide insights into the function and evolution of immunity
    Bert J C Janssen
    Crystal and Structural Chemistry, Bijvoet Center for Biomolecular Research, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
    Nature 437:505-11. 2005
    ....
  59. ncbi Association between mannose-binding lectin levels and graft survival in kidney transplantation
    Stefan P Berger
    Department of Nephrology, Leiden University Medical Center, The Netherlands
    Am J Transplant 5:1361-6. 2005
    ..If these data can be confirmed, pre-transplant MBL levels may provide additional information for risk stratification prior to kidney transplantation...
  60. ncbi Mannose binding lectin gene polymorphisms confer a major risk for severe infections after liver transplantation
    Lee H Bouwman
    Department of Surgery, Leiden University Medical Center, The Netherlands
    Gastroenterology 129:408-14. 2005
    ..The aims of our study were to establish the role of the liver in production of serum MBL and to evaluate the effect of MBL variant alleles on the susceptibility to infection after liver transplantation...
  61. ncbi A missense mutation in factor I (IF) predisposes to atypical haemolytic uraemic syndrome
    Joyce Geelen
    Department of Paediatric Nephrology, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    Pediatr Nephrol 22:371-5. 2007
    ..One additional transplant was lost due to arterial thrombosis of the renal artery. This report confirms the gloomy outcome of renal transplants in patients with an IF deficiency. New therapies should be evaluated in these patients...
  62. ncbi Human renal epithelial cells produce the long pentraxin PTX3
    Alma J Nauta
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Kidney Int 67:543-53. 2005
    ..Unlike the classic pentraxins, PTX3 is mainly expressed extrahepatically. The present study was designed to investigate the expression of PTX3 by human proximal renal tubular epithelial cells (PTECs)...
  63. doi Mannose-binding lectin is involved in multiple organ dysfunction syndrome after cardiac surgery: effects of blood transfusions
    Yavuz M Bilgin
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Transfusion 48:601-8. 2008
    ..Preoperative transfusions of allogeneic white blood cells (WBCs) contribute to infectious and inflammatory complications. This study investigates the role of MBL in relation to blood transfusions and complications after cardiac surgery...
  64. ncbi Interactions of the extracellular matrix proteoglycans decorin and biglycan with C1q and collectins
    Tom W L Groeneveld
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    J Immunol 175:4715-23. 2005
    ..These two proteoglycans are likely to down-regulate proinflammatory effects mediated by C1q, and possibly also the collectins, at the tissue level...
  65. ncbi Immune evasion by a staphylococcal complement inhibitor that acts on C3 convertases
    Suzan H M Rooijakkers
    Eijkman Winkler Institute, University Medical Center Utrecht, G04 614, 3584 CX Utrecht, The Netherlands
    Nat Immunol 6:920-7. 2005
    ..As a highly active and small soluble protein that acts exclusively on surfaces, staphylococcal complement inhibitor may represent a promising anti-inflammatory molecule...
  66. ncbi Dendritic cells and complement: at the cross road of innate and adaptive immunity
    Giuseppe Castellano
    Department of Nephrology, Leiden University Medical Center, C3 P, Albinusdreef 2, P O Box 9600, 2333 ZA Leiden, The Netherlands
    Mol Immunol 41:133-40. 2004
    ..This review focuses on novel findings, which have started to shed light on these intriguing components of the innate immune system...
  67. ncbi Activation of the lectin pathway in murine lupus nephritis
    Leendert A Trouw
    Department of Nephrology, C3, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Mol Immunol 42:731-40. 2005
    ..In conclusion, these data suggest that in addition to the classical pathway and the alternative pathway also the lectin pathway of complement activation is involved in murine lupus nephritis...
  68. ncbi Factor B structure provides insights into activation of the central protease of the complement system
    Fin J Milder
    Crystal and Structural Chemistry, Bijvoet Center for Biomolecular Research, Faculty of Sciences, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
    Nat Struct Mol Biol 14:224-8. 2007
    ..This allosteric mechanism is crucial for tight regulation of the complement-amplification step in the immune response...
  69. ncbi Structure of complement component C2A: implications for convertase formation and substrate binding
    Fin J Milder
    Crystal and Structural Chemistry, Bijvoet Center for Biomolecular Research, Faculty of Science, Utrecht University, 3584 CH Utrecht, The Netherlands
    Structure 14:1587-97. 2006
    ..Together with a putative substrate-induced completion of the oxyanion hole, this may contribute to the high substrate specificity of the convertases...
  70. pmc A prospective study of anti-chromatin and anti-C1q autoantibodies in patients with proliferative lupus nephritis treated with cyclophosphamide pulses or azathioprine/methylprednisolone
    Cecile Grootscholten
    Division of Nephrology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Ann Rheum Dis 66:693-6. 2007
    ....