Meta Roestenberg

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. pmc Comparison of clinical and parasitological data from controlled human malaria infection trials
    Meta Roestenberg
    Department of Medical Microbiology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    PLoS ONE 7:e38434. 2012
  2. doi request reprint Efficacy of preerythrocytic and blood-stage malaria vaccines can be assessed in small sporozoite challenge trials in human volunteers
    Meta Roestenberg
    Department of Medical Microbiology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Infect Dis 206:319-23. 2012
  3. pmc Cardiac complication after experimental human malaria infection: a case report
    An Emmie Nieman
    Department of Medical Microbiology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Malar J 8:277. 2009
  4. doi request reprint Mild increases in serum hepcidin and interleukin-6 concentrations impair iron incorporation in haemoglobin during an experimental human malaria infection
    Quirijn de Mast
    Departments of General Internal Medicine, of the Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Br J Haematol 145:657-64. 2009
  5. doi request reprint Long-term protection against malaria after experimental sporozoite inoculation: an open-label follow-up study
    Meta Roestenberg
    Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
    Lancet 377:1770-6. 2011
  6. pmc Longevity and composition of cellular immune responses following experimental Plasmodium falciparum malaria infection in humans
    Anne C Teirlinck
    Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    PLoS Pathog 7:e1002389. 2011
  7. pmc NF135.C10: a new Plasmodium falciparum clone for controlled human malaria infections
    Anne C Teirlinck
    Department of Medical Microbiology, Radboud University Nijmegen Medical Center, The Netherlands
    J Infect Dis 207:656-60. 2013
  8. doi request reprint Protection against a malaria challenge by sporozoite inoculation
    Meta Roestenberg
    Department of Medical Microbiology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    N Engl J Med 361:468-77. 2009
  9. pmc Controlled human malaria infections by intradermal injection of cryopreserved Plasmodium falciparum sporozoites
    Meta Roestenberg
    Radboud University Nijmegen Medical Center, Department of Medical Microbiology, Nijmegen, The Netherlands
    Am J Trop Med Hyg 88:5-13. 2013
  10. doi request reprint Memory-like IFN-γ response by NK cells following malaria infection reveals the crucial role of T cells in NK cell activation by P. falciparum
    Matthew B B McCall
    Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur J Immunol 40:3472-7. 2010

Collaborators

Detail Information

Publications13

  1. pmc Comparison of clinical and parasitological data from controlled human malaria infection trials
    Meta Roestenberg
    Department of Medical Microbiology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    PLoS ONE 7:e38434. 2012
    ..To accommodate the demand of the malaria vaccine pipeline, controlled infections are carried out in an increasing number of centers worldwide. We assessed their safety and reproducibility...
  2. doi request reprint Efficacy of preerythrocytic and blood-stage malaria vaccines can be assessed in small sporozoite challenge trials in human volunteers
    Meta Roestenberg
    Department of Medical Microbiology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Infect Dis 206:319-23. 2012
    ..Sporozoite challenge trials are thus a powerful tool for early selection of candidates that warrant efficacy of trials in the field...
  3. pmc Cardiac complication after experimental human malaria infection: a case report
    An Emmie Nieman
    Department of Medical Microbiology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Malar J 8:277. 2009
    ..Apart from acute coronary syndrome, myocarditis can be considered as a final diagnosis, but the true nature and patho-physiological explanation of the event remain unclear...
  4. doi request reprint Mild increases in serum hepcidin and interleukin-6 concentrations impair iron incorporation in haemoglobin during an experimental human malaria infection
    Quirijn de Mast
    Departments of General Internal Medicine, of the Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Br J Haematol 145:657-64. 2009
    ....
  5. doi request reprint Long-term protection against malaria after experimental sporozoite inoculation: an open-label follow-up study
    Meta Roestenberg
    Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
    Lancet 377:1770-6. 2011
    ..This immunity was associated with parasite-specific production of interferon γ and interleukin 2 by pluripotent effector memory cells in vitro. We aim to explore the persistence of protection and immune responses in the same volunteers...
  6. pmc Longevity and composition of cellular immune responses following experimental Plasmodium falciparum malaria infection in humans
    Anne C Teirlinck
    Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    PLoS Pathog 7:e1002389. 2011
    ..The implications hereof are positive for malaria vaccine development, but focus attention on those factors potentially inhibiting such responses in the field...
  7. pmc NF135.C10: a new Plasmodium falciparum clone for controlled human malaria infections
    Anne C Teirlinck
    Department of Medical Microbiology, Radboud University Nijmegen Medical Center, The Netherlands
    J Infect Dis 207:656-60. 2013
    ..C10 and 4 of 5 challenged with NF54 developed parasitemia as detected with microscopy. The 2 strains induced similar clinical signs and symptoms as well as cellular immunological responses...
  8. doi request reprint Protection against a malaria challenge by sporozoite inoculation
    Meta Roestenberg
    Department of Medical Microbiology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    N Engl J Med 361:468-77. 2009
    ..Naturally acquired immunity to malaria develops slowly, and induction of protection in humans can be achieved artificially by the inoculation of radiation-attenuated sporozoites by means of more than 1000 infective mosquito bites...
  9. pmc Controlled human malaria infections by intradermal injection of cryopreserved Plasmodium falciparum sporozoites
    Meta Roestenberg
    Radboud University Nijmegen Medical Center, Department of Medical Microbiology, Nijmegen, The Netherlands
    Am J Trop Med Hyg 88:5-13. 2013
    ..After further optimization, the use of such PfSPZ may facilitate and accelerate clinical development of novel malaria drugs and vaccines...
  10. doi request reprint Memory-like IFN-γ response by NK cells following malaria infection reveals the crucial role of T cells in NK cell activation by P. falciparum
    Matthew B B McCall
    Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur J Immunol 40:3472-7. 2010
    ..Thus, NK cells make a significant contribution to total IFN-γ production in response to PfRBC as a consequence of their dependency on (memory) T-cell help, with likely positive implications for malaria vaccine development...
  11. doi request reprint Thrombocytopenia in early malaria is associated with GP1b shedding in absence of systemic platelet activation and consumptive coagulopathy
    Quirijn de Mast
    Department of General Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Br J Haematol 151:495-503. 2010
    ..We hypothesize that the increase in sGP1b concentrations results from VWF-mediated GP1b shedding; a process that may prevent excessive adhesion of platelets and parasitized erythrocytes...
  12. pmc Safety and immunogenicity of a recombinant Plasmodium falciparum AMA1 malaria vaccine adjuvanted with Alhydrogel, Montanide ISA 720 or AS02
    Meta Roestenberg
    Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 3:e3960. 2008
    ..Plasmodium falciparum Apical Membrane Antigen 1 (PfAMA1) is a candidate vaccine antigen expressed by merozoites and sporozoites. It plays a key role in red blood cell and hepatocyte invasion that can be blocked by antibodies...
  13. ncbi request reprint Complement activation in experimental human malaria infection
    Meta Roestenberg
    Radboud University Nijmegen Medical Center, Postbus 9101, 6500 HB Nijmegen, The Netherlands
    Trans R Soc Trop Med Hyg 101:643-9. 2007
    ..Treatment with artemether/lumefantrine was followed by classical and alternative pathway complement activation, without evidence for mannan-binding-lectin-mediated complement activation...