Bart O Roep

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint Are insights gained from NOD mice sufficient to guide clinical translation? Another inconvenient truth
    Bart O Roep
    Department of Immunohaematology and Blood Transfusion, E3 Q, LUMC, P O Box 9600, NL 2300 RC Leiden, The Netherlands
    Ann N Y Acad Sci 1103:1-10. 2007
  2. ncbi request reprint Islet autoreactive CD8 T-cells in type 1 diabetes: licensed to kill?
    Bart O Roep
    Department of Immunohaematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Diabetes 57:1156. 2008
  3. pmc Type 1 diabetes-associated HLA-DQ8 transdimer accommodates a unique peptide repertoire
    Menno van Lummel
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    J Biol Chem 287:9514-24. 2012
  4. pmc Regulatory multitasking of tolerogenic dendritic cells - lessons taken from vitamin d3-treated tolerogenic dendritic cells
    Tatjana Nikolic
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center Leiden, Netherlands
    Front Immunol 4:113. 2013
  5. ncbi request reprint Satisfaction (not) guaranteed: re-evaluating the use of animal models of type 1 diabetes
    Bart O Roep
    Bart O Roep is at the Leiden University Medical Center, Department of Immunohematology and Blood Transfusion, Leiden NL 2300 RC, The Netherlands
    Nat Rev Immunol 4:989-97. 2004
  6. ncbi request reprint [Indications for a favourable effect of intensive insulin therapy for newly-diagnosed type 2 diabetes]
    B O Roep
    Leids Universitair Medisch Centrum, Postbus 9600, 2300 RC Leiden
    Ned Tijdschr Geneeskd 152:2378-80. 2008
  7. doi request reprint Transfer of regulatory properties from tolerogenic to proinflammatory dendritic cells via induced autoreactive regulatory T cells
    Fleur S Kleijwegt
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands
    J Immunol 187:6357-64. 2011
  8. doi request reprint Discovery of low-affinity preproinsulin epitopes and detection of autoreactive CD8 T-cells using combinatorial MHC multimers
    Wendy W Unger
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    J Autoimmun 37:151-9. 2011
  9. doi request reprint Tolerogenic dendritic cells impede priming of naïve CD8⁺ T cells and deplete memory CD8⁺ T cells
    Fleur S Kleijwegt
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Immunol 43:85-92. 2013
  10. ncbi request reprint 1alpha,25-dihydroxyvitamin D3 or analogue treated dendritic cells modulate human autoreactive T cells via the selective induction of apoptosis
    Astrid G S van Halteren
    Department of Immunohematology and Blood Transfusion, E3Q, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Autoimmun 23:233-9. 2004

Detail Information

Publications68

  1. ncbi request reprint Are insights gained from NOD mice sufficient to guide clinical translation? Another inconvenient truth
    Bart O Roep
    Department of Immunohaematology and Blood Transfusion, E3 Q, LUMC, P O Box 9600, NL 2300 RC Leiden, The Netherlands
    Ann N Y Acad Sci 1103:1-10. 2007
    ..I will argue that animal models have limited but evident value when it comes to teaching us about type 1 diabetes in humans, and we can take advantage of this value more efficiently...
  2. ncbi request reprint Islet autoreactive CD8 T-cells in type 1 diabetes: licensed to kill?
    Bart O Roep
    Department of Immunohaematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Diabetes 57:1156. 2008
  3. pmc Type 1 diabetes-associated HLA-DQ8 transdimer accommodates a unique peptide repertoire
    Menno van Lummel
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    J Biol Chem 287:9514-24. 2012
    ..Our findings provide a molecular basis for the association between HLA-DQ transdimers and T1D and set the stage for rational testing of potential diabetogenic peptide epitopes...
  4. pmc Regulatory multitasking of tolerogenic dendritic cells - lessons taken from vitamin d3-treated tolerogenic dendritic cells
    Tatjana Nikolic
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center Leiden, Netherlands
    Front Immunol 4:113. 2013
    ....
  5. ncbi request reprint Satisfaction (not) guaranteed: re-evaluating the use of animal models of type 1 diabetes
    Bart O Roep
    Bart O Roep is at the Leiden University Medical Center, Department of Immunohematology and Blood Transfusion, Leiden NL 2300 RC, The Netherlands
    Nat Rev Immunol 4:989-97. 2004
    ....
  6. ncbi request reprint [Indications for a favourable effect of intensive insulin therapy for newly-diagnosed type 2 diabetes]
    B O Roep
    Leids Universitair Medisch Centrum, Postbus 9600, 2300 RC Leiden
    Ned Tijdschr Geneeskd 152:2378-80. 2008
    ..These interesting findings need confirmation, notably in caucasoid populations, before guidelines for treatment of patients with type 2 diabetes can be changed...
  7. doi request reprint Transfer of regulatory properties from tolerogenic to proinflammatory dendritic cells via induced autoreactive regulatory T cells
    Fleur S Kleijwegt
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands
    J Immunol 187:6357-64. 2011
    ..Our data indicated that human tolerogenic DCs confer infectious tolerance by inducing Ag-specific Tregs, which, in turn, re-educate proinflammatory mature DCs into DCs with regulatory properties...
  8. doi request reprint Discovery of low-affinity preproinsulin epitopes and detection of autoreactive CD8 T-cells using combinatorial MHC multimers
    Wendy W Unger
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    J Autoimmun 37:151-9. 2011
    ....
  9. doi request reprint Tolerogenic dendritic cells impede priming of naïve CD8⁺ T cells and deplete memory CD8⁺ T cells
    Fleur S Kleijwegt
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Immunol 43:85-92. 2013
    ..Yet, Combi-DCs pulsed with CD8(+) T-cell epitopes also act as targets of cytotoxicity, which is undesirable for survival of Combi-DCs infused into patients in therapeutic immune intervention strategies...
  10. ncbi request reprint 1alpha,25-dihydroxyvitamin D3 or analogue treated dendritic cells modulate human autoreactive T cells via the selective induction of apoptosis
    Astrid G S van Halteren
    Department of Immunohematology and Blood Transfusion, E3Q, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Autoimmun 23:233-9. 2004
    ..Thus, in vitro preconditioning of DC with 1,25(OH)2D3 or analogue yields regulatory DC that may interfere with ongoing autoimmunity in vivo without affecting T cells with other specificities...
  11. pmc Simultaneous detection of circulating autoreactive CD8+ T-cells specific for different islet cell-associated epitopes using combinatorial MHC multimers
    Jurjen H Velthuis
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Diabetes 59:1721-30. 2010
    ..Yet, conventional detection techniques (ELISPOT and HLA tetramers) require many cells and are relatively insensitive...
  12. doi request reprint Critical role for TNF in the induction of human antigen-specific regulatory T cells by tolerogenic dendritic cells
    Fleur S Kleijwegt
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    J Immunol 185:1412-8. 2010
    ..Interaction between mTNF and TNFRII instructs the induction of suppressive Tregs by VD3-DCs. Anti-TNF therapy may therefore act adversely in different patients or disease pathways...
  13. ncbi request reprint Therapy with the hsp60 peptide DiaPep277 in C-peptide positive type 1 diabetes patients
    Volkert A L Huurman
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Diabetes Metab Res Rev 23:269-75. 2007
    ..A randomized, double-blind, phase Ib/II study of peptide treatment was undertaken in recent onset type 1 diabetes patients with remaining insulin production...
  14. pmc Cellular islet autoimmunity associates with clinical outcome of islet cell transplantation
    Volkert A L Huurman
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 3:e2435. 2008
    ..We tested the hypothesis that allograft rejection and recurrent autoimmunity contribute to this progressive loss of islet allograft function...
  15. doi request reprint Induction of Treg by monocyte-derived DC modulated by vitamin D3 or dexamethasone: differential role for PD-L1
    Wendy W J Unger
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Immunol 39:3147-59. 2009
    ..Both are potentially useful to specifically down-regulate unwanted immune responses and induce immune tolerance. These modulated DC appear suitable as adjuvant in antigen-specific clinical vaccination intervention strategies...
  16. doi request reprint Posttranslational modification of HLA-DQ binding islet autoantigens in type 1 diabetes
    Menno van Lummel
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Diabetes 63:237-47. 2014
    ..Most patients responded by interferon-γ, whereas most healthy donors produced interleukin-10 only. Thus, T-cell autoreactivity exists to modified islet epitopes that differs in quality and quantity between patients and healthy donors. ..
  17. pmc Islet-specific CTL cloned from a type 1 diabetes patient cause beta-cell destruction after engraftment into HLA-A2 transgenic NOD/scid/IL2RG null mice
    Wendy W J Unger
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 7:e49213. 2012
    ....
  18. doi request reprint Gluten-specific T cells cross-react between HLA-DQ8 and the HLA-DQ2α/DQ8β transdimer
    Yvonne Kooy-Winkelaar
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands
    J Immunol 187:5123-9. 2011
    ..Because type 1 diabetes is strongly associated with the presence of HLA-DQ8trans, our findings may bear relevance to this disease as well...
  19. ncbi request reprint HLA class I epitope discovery in type 1 diabetes: independent and reproducible identification of proinsulin epitopes of CD8 T cells--report of the IDS T Cell Workshop Committee
    Gabrielle G M Pinkse
    Department of Immunohematology and Blood Transfusion, E3Q, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Ann N Y Acad Sci 1079:19-23. 2006
    ..These studies imply that CD8 T cell-based HLA tetramers and ELISPOT analyses can be useful to monitor T1DM as well as islet transplantation, and may provide useful tools to assess immunological efficacy of immune intervention trials...
  20. pmc Autoreactive CD8 T cells associated with beta cell destruction in type 1 diabetes
    Gabrielle G M Pinkse
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, 2300 RC, Leiden, The Netherlands
    Proc Natl Acad Sci U S A 102:18425-30. 2005
    ..We demonstrate that CD8 T cell autoreactivity is associated with beta cell destruction in type 1 diabetes in humans...
  21. ncbi request reprint [Immunotherapy for type 1 diabetes mellitus (DM1)]
    Cornelis R van der Torren
    Leids Universitair Medisch Centrum, afd Immunohaematologie and Bloedtransfusie, Leiden, The Netherlands
    Ned Tijdschr Geneeskd 156:A4268. 2012
    ..Discussion on the acceptability of the side effects of immunotherapy is desirable...
  22. pmc Antigen targets of type 1 diabetes autoimmunity
    Bart O Roep
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, 2333 Leiden, The Netherlands
    Cold Spring Harb Perspect Med 2:a007781. 2012
    ..Here we will discuss recently gained insights into the identity, biology, structure, and presentation of islet antigens in relation to disease heterogeneity and β-cell destruction...
  23. ncbi request reprint The role of T-cells in the pathogenesis of Type 1 diabetes: from cause to cure
    Bart O Roep
    Dept Immunohaematology and Blood Transfusion, E3 Q, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Diabetologia 46:305-21. 2003
    ....
  24. ncbi request reprint Alloreactivity against repeated HLA mismatches of sequential islet grafts transplanted in non-uremic type 1 diabetes patients
    Corine A van Kampen
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Transplantation 80:118-26. 2005
    ....
  25. ncbi request reprint Molecular mimicry in autoimmune neurological disease after viral infection
    Bart O Roep
    Department Immunoheamtology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Curr Med Chem 10:1939-43. 2003
    ..Subsequent microarray studies unequivocally demonstrated functional mimicry of seemingly disparate amino acid sequences. This review summarises the present evidence for molecular mimicry in neurological autoimmune diseases and virus..
  26. ncbi request reprint Mannose binding lectin gene polymorphisms confer a major risk for severe infections after liver transplantation
    Lee H Bouwman
    Department of Surgery, Leiden University Medical Center, The Netherlands
    Gastroenterology 129:408-14. 2005
    ..The aims of our study were to establish the role of the liver in production of serum MBL and to evaluate the effect of MBL variant alleles on the susceptibility to infection after liver transplantation...
  27. doi request reprint Clinical Dutch-English Lambert-Eaton Myasthenic syndrome (LEMS) tumor association prediction score accurately predicts small-cell lung cancer in the LEMS
    Maarten J Titulaer
    Leiden University Medical Center, Leiden, The Netherlands
    J Clin Oncol 29:902-8. 2011
    ..In view of its profound impact on therapy and survival, we developed and validated a score to identify the presence of SCLC early in the course of LEMS...
  28. ncbi request reprint HLA-B8 in patients with the Lambert-Eaton myasthenic syndrome reduces likelihood of associated small cell lung carcinoma
    Paul W Wirtz
    Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands
    Ann N Y Acad Sci 998:200-1. 2003
  29. doi request reprint Surrogate end points in the design of immunotherapy trials: emerging lessons from type 1 diabetes
    Bart O Roep
    Leiden University Medical Center, National Diabetes Expert Center, Leiden, The Netherlands
    Nat Rev Immunol 10:145-52. 2010
    ..In this Opinion article we offer a perspective on the future of clinical trial design in which the process is significantly shortened by making greater use of laboratory measures to determine therapeutic outcome...
  30. doi request reprint Alternative splicing and differential expression of the islet autoantigen IGRP between pancreas and thymus contributes to immunogenicity of pancreatic islets but not diabetogenicity in humans
    V Martijn de Jong
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, E3 Q, P O Box 9600, NL2300RC, Leiden, The Netherlands
    Diabetologia 56:2651-8. 2013
    ..We tested whether specific splice variation in islets vs thymus correlates with loss of tolerance to IGRP in type 1 diabetes...
  31. doi request reprint Changing faces, unmasking the beta-cell: post-translational modification of antigens in type 1 diabetes
    Menno van Lummel
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Curr Opin Endocrinol Diabetes Obes 20:299-306. 2013
    ..Description on post-translational modification of islet-autoantigens in type 1 diabetes (T1D)...
  32. ncbi request reprint Autoreactive T cells in endocrine/organ-specific autoimmunity: why has progress been so slow?
    Bart O Roep
    Department of Immunohaematology and Blood Transfusion, E3 Q, Leiden University Medical Center, Albinusdreef 2, P O Box 9600, 2300 RC Leiden, The Netherlands
    Springer Semin Immunopathol 24:261-71. 2002
    ....
  33. ncbi request reprint Redirection of human autoreactive T-cells Upon interaction with dendritic cells modulated by TX527, an analog of 1,25 dihydroxyvitamin D(3)
    Astrid G S van Halteren
    Department of Immunohematology and Blood Transfusion, Leids Universitair Medisch Centrum, 2300 RC Leiden, The Netherlands
    Diabetes 51:2119-25. 2002
    ..Collectively, we provide evidence that nonhypercalcemic TX527 is a potent in vitro DC modulator, yielding DCs with the potential to change cytokine responses of committed autoreactive T-cells...
  34. ncbi request reprint HLA and smoking in prediction and prognosis of small cell lung cancer in autoimmune Lambert-Eaton myasthenic syndrome
    Paul W Wirtz
    Department of Neurology, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    J Neuroimmunol 159:230-7. 2005
    ..Moreover, negativity for HLA-B8 combined with smoking behavior points more strongly to an underlying SCLC and predicts a worse prognosis in SCLC-LEMS patients...
  35. ncbi request reprint Infectious tolerance as candidate therapy for type 1 diabetes: transfer of immunoregulatory properties from human regulatory T cells to other T cells and proinflammatory dendritic cells
    Fleur S Kleijwegt
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Crit Rev Immunol 33:415-34. 2013
    ....
  36. doi request reprint Diabetogenic T lymphocytes in human Type 1 diabetes
    Bart O Roep
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, Leiden, The Netherlands
    Curr Opin Immunol 23:746-53. 2011
    ..For these reasons, this review will focus on the role of diabetogenic T lymphocytes in this disease-defining event...
  37. ncbi request reprint Cross-reactive mycobacterial and self hsp60 epitope recognition in I-A(g7) expressing NOD, NOD-asp and Biozzi AB/H mice
    Astrid G S van Halteren
    Department of Immunohematology and Blood Transfusion, Leids Universitair Medisch Centrum, The Netherlands
    J Autoimmun 18:139-47. 2002
    ..Yet, proliferation of hsp60 autoreactive T cells is solely measured in combination with insulitis and as such serves as a surrogate marker for islet inflammation...
  38. ncbi request reprint Mannose-binding lectin: clinical implications for infection, transplantation, and autoimmunity
    Lee H Bouwman
    Department of Surgery, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Hum Immunol 67:247-56. 2006
    ..This review provides a general outline of the genetic and molecular characteristics of MBL and discusses MBL-disease association and its consequence in infection, transplantation, and autoimmunity...
  39. ncbi request reprint Elevated levels of mannose-binding lectin at clinical manifestation of type 1 diabetes in juveniles
    Lee H Bouwman
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Diabetes 54:3002-6. 2005
    ....
  40. ncbi request reprint Detection of autoreactive T cells in type 1 diabetes using coded autoantigens and an immunoglobulin-free cytokine ELISPOT assay: report from the fourth immunology of diabetes society T cell workshop
    Masao Nagata
    Department of Immunobiology, Guy s, King s and St Thomas School of Medicine, 2nd Floor, New Guy s House, Guy s Hospital, London SE1 9RT, UK
    Ann N Y Acad Sci 1037:10-5. 2004
    ..These results confirm the utility of the blinded performance of T cell assays as the most robust platform for assessing technologies to T cell autoreactivity...
  41. ncbi request reprint T-cell assays to determine disease activity and clinical efficacy of immune therapy in type 1 diabetes
    Pieter van de Linde
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Am J Ther 12:573-9. 2005
    ....
  42. ncbi request reprint Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes
    Shelley Lindley
    Department of Immunobiology, Guy s, King s and St Thomas School of Medicine, 2nd Floor, New Guy s House, Guy s Hospital London SE1 9RT, UK
    Diabetes 54:92-9. 2005
    ..007) and intracellular CTLA-4 (P = 0.01). These data demonstrate deficiency in function of the CD4(+)CD25(+) Treg population that may influence the pathogenesis of type 1 diabetes...
  43. ncbi request reprint Analysis of a functional BTNL2 polymorphism in type 1 diabetes, rheumatoid arthritis, and systemic lupus erythematosus
    Gisela Orozco
    Instituto de Biomedicina, CSIC, Granada, Spain
    Hum Immunol 66:1235-41. 2005
    ..The BTNL2 rs2076530 polymorphism is associated with T1D, RA, and SLE because of its strong linkage disequalibrium with predisposing HLA DQB1-DRB1 haplotypes in Caucasian populations...
  44. ncbi request reprint A mini meta-analysis of studies on CD4+CD25+ T cells in human type 1 diabetes: report of the Immunology of Diabetes Society T Cell Workshop
    Timothy I M Tree
    Department of Immunobiology, King s College London, Guy s Hospital, London SE1 9RT, UK
    Ann N Y Acad Sci 1079:9-18. 2006
    ..We therefore performed a mini meta-analysis to compare the results in the four published studies, account for differences in their findings, and draw a consensus view on the role of this important cell subset in human T1DM...
  45. ncbi request reprint Enhancing the sensitivity of assays to detect T cell reactivity: the effect of cell separation and cryopreservation media
    Timothy I M Tree
    Department of Immunobiology, Guy s, King s and St Thomas School of Medicine, 2nd Floor, New Guy s House, Guy s Hospital London SE1 9RT, UK
    Ann N Y Acad Sci 1037:26-32. 2004
    ....
  46. ncbi request reprint HLA-DQ-regulated T-cell responses to islet cell autoantigens insulin and GAD65
    Timothy I M Tree
    Department of Immunology, Guy s, King s, and St Thomas School of Medicine, Denmark Hill Campus, Rayne Institute, London, UK
    Diabetes 53:1692-9. 2004
    ..These results indicate that HLA-DQ acts as a restriction element for both proliferative and suppressor cells, with the relative balance of these cells dependent on the nature of the autoantigen...
  47. pmc Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health
    Sefina Arif
    Department of Immunobiology, Guy s, King s and St Thomas School of Medicine, King s College London, Guy s Campus, London, United Kingdom
    J Clin Invest 113:451-63. 2004
    ..We conclude that development of T1DM depends on the balance of autoreactive Th1 and Treg cells, which may be open to favorable manipulation by immune intervention...
  48. ncbi request reprint Comparison of cytokine ELISpot assay formats for the detection of islet antigen autoreactive T cells. Report of the third immunology of diabetes society T-cell workshop
    Nanette C Schloot
    German Diabetes Research Institute at the Heinrich Heine University, Dusseldorf, Germany
    J Autoimmun 21:365-76. 2003
    ..The results demonstrate the potential for detection of low-level autoreactive T cell responses and identify assay characteristics that will be useful for studies in type 1 diabetes...
  49. pmc Coxsackie B4 virus infection of beta cells and natural killer cell insulitis in recent-onset type 1 diabetic patients
    Francesco Dotta
    Department of Internal Medicine, Endocrine and Metabolic Sciences, and Biochemistry, University of Siena, 53100 Siena, Italy
    Proc Natl Acad Sci U S A 104:5115-20. 2007
    ..These studies provide direct evidence that enterovirus can infect beta cells in patients with type 1 diabetes and that infection is associated with inflammation and functional impairment...
  50. ncbi request reprint Processing and presentation of the islet autoantigen GAD by vascular endothelial cells promotes transmigration of autoreactive T-cells
    James E Greening
    Department of Immunology, Guy s, King s and St Thomas School of Medicine, Rayne Institute, 123 Coldharbour Lane, London SE5 9NU, U K
    Diabetes 52:717-25. 2003
    ..These results support the hypothesis that presentation of autoantigens by islet endothelium in vivo could promote transmigration of circulating islet autoantigen-specific T-cells primed in regional lymph nodes against islet autoantigens...
  51. ncbi request reprint Enhanced concentrations of interleukin 16 are associated with joint destruction in patients with rheumatoid arthritis
    Leroy R Lard
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    J Rheumatol 31:35-9. 2004
    ..To investigate the role of interleukin 16 (IL-16) in the development of rheumatoid arthritis (RA) and joint destruction...
  52. ncbi request reprint KIR in type 1 diabetes: disparate distribution of activating and inhibitory natural killer cell receptors in patients versus HLA-matched control subjects
    Arno R van der Slik
    Department of Immunohaematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Diabetes 52:2639-42. 2003
    ..035). We propose that the genetic imbalance between KIR and their HLA class 1 ligands may enhance the activation of T-cells with a low affinity for pancreatic self-antigens, thereby contributing to the pathogenesis of type 1 diabetes...
  53. ncbi request reprint Susceptibility loci for complex regional pain syndrome
    Willem Johan T van de Beek
    Department of Neurology, Leiden University Medical Center, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Pain 103:93-7. 2003
    ..Additionally, an association with the D6S1014 locus was found, supporting the previous finding of an association with HLA-DR13...
  54. ncbi request reprint Precursor frequencies of T-cells reactive to insulin in recent onset type 1 diabetes mellitus
    Ramachandra G Naik
    Department of Medicine, Division of Metabolism, Endocrinology, and Nutrition, University of Washington and Department of Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA
    J Autoimmun 23:55-61. 2004
    ..Consequently the precursor frequency of insulin autoreactive cells in patients and their siblings is probably much higher than calculated...
  55. ncbi request reprint HLA incompatibility and immunogenicity of human pancreatic islet preparations cocultured with blood cells of healthy donors
    Lee H Bouwman
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Hum Immunol 66:494-500. 2005
    ..Our results identify the potential immunogenicity of islet preparations transplanted between HLA-DR incompatible subjects regardless of an autoimmune background of the recipient...
  56. ncbi request reprint CTLA4 is differentially associated with autoimmune diseases in the Dutch population
    Alexandra Zhernakova
    Department of Medical Genetics, University Medical Centre, Wilhelmina Children s Hospital, PO Box 85090, 3508, AB, Utrecht, The Netherlands
    Hum Genet 118:58-66. 2005
    ..The association of the CTLA4 haplotype 2 with the high-risk HLA genotype in T1D and CD, which share DQ2 as the one of high-risk alleles, might provide a clue to understanding the common genetic background of AID...
  57. ncbi request reprint MICA marks additional risk factors for Type 1 diabetes on extended HLA haplotypes: an association and meta-analysis
    Behrooz Z Alizadeh
    Complex Genetic Section, Department of Medical Genetics, University Medical Center Utrecht, P O Box 85060, 3508 AB Utrecht, The Netherlands
    Mol Immunol 44:2806-12. 2007
    ..Co-inheritance of MICA*A6 with the HLA DQ2DR17 haplotype in T1D indicates this haplotype may carry the additional genetic factors for T1D, but our study does not support an independent association between MICA variants and T1D...
  58. ncbi request reprint Association analysis of functional variants of the FcgRIIa and FcgRIIIa genes with type 1 diabetes, celiac disease and rheumatoid arthritis
    Behrooz Z Alizadeh
    Complex Genetics Section, Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands
    Hum Mol Genet 16:2552-9. 2007
    ..If replicated, our findings would suggest FcgRIIa*519G as a common risk factor for auto-immune diseases. This may have clinical implications with regard to efficacy or safety of antibody-based immuno-modulator therapies...
  59. pmc Novel association in chromosome 4q27 region with rheumatoid arthritis and confirmation of type 1 diabetes point to a general risk locus for autoimmune diseases
    Alexandra Zhernakova
    Complex Genetics Section, Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands
    Am J Hum Genet 81:1284-8. 2007
    ..72 [95% CI 0.61-0.86]). Our results replicate and extend the association found in the KIAA1109/Tenr/IL2/IL21 gene region with autoimmune diseases, implying that this locus is a general risk factor for multiple autoimmune diseases...
  60. ncbi request reprint Diabetes: missing links
    Bart O Roep
    Nature 450:799-800. 2007
  61. doi request reprint Association of IL-1ra and adiponectin with C-peptide and remission in patients with type 1 diabetes
    Christian Pfleger
    Institute for Clinical Diabetes Research at German Diabetes Centre, Leibniz Institute at Heinrich Heine University Düsseldorf, Auf m Hennekamp 65, 40225 Dusseldorf, Germany
    Diabetes 57:929-37. 2008
    ....
  62. doi request reprint Islet antigen specific IL-10+ immune responses but not CD4+CD25+FoxP3+ cells at diagnosis predict glycemic control in type 1 diabetes
    Srinath Sanda
    Benaroya Research Institute and the University of Washington School of Medicine, 1201 9th Avenue, Seattle, WA 98101, USA
    Clin Immunol 127:138-43. 2008
    ..These data provide an immune phenotype of the honeymoon phase and suggest that analyzing IL-10 and FoxP3 at diagnosis may identify patients that will experience better glucose control...
  63. pmc DRB1*0401-restricted human T cell clone specific for the major proinsulin73-90 epitope expresses a down-regulatory T helper 2 phenotype
    Ivana Durinovic-Bello
    Department of Internal Medicine I, Division of Endocrinology, University of Ulm, D 89081 Ulm, Germany
    Proc Natl Acad Sci U S A 103:11683-8. 2006
    ....
  64. pmc CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope
    Ania Skowera
    Department of Immunobiology, King s College London, London, United Kingdom
    J Clin Invest 118:3390-402. 2008
    ..Our findings suggest that autoreactive CTLs are important targets for immune-based interventions in type 1 diabetes and argue for early, aggressive insulin therapy to preserve remaining beta cells...
  65. ncbi request reprint Choice of antibody immunotherapy influences cytomegalovirus viremia in simultaneous pancreas-kidney transplant recipients
    Volkert A L Huurman
    Department of Surgery, Leiden University Medical Center, P O Box 9600, NL 2300 RC Leiden, Netherlands
    Diabetes Care 29:842-7. 2006
    ..In this study, we assessed the pattern of CMV viremia in SPK transplant recipients receiving either antithymocyte globulin (ATG) or anti-CD25 (daclizumab) immunosuppressive induction therapy...
  66. ncbi request reprint The association between autoimmune thyroiditis, autoimmune gastritis and type 1 diabetes
    Wai Kwan Lam-Tse
    Dept of Immunology, Erasmus MC, Rotterdam, The Netherlands
    Pediatr Endocrinol Rev 1:22-37. 2003
    ..If positive, excess iodine should be avoided and thyroxin treatment considered. Whether autoimmune thyroiditis and autoimmune gastritis patients should be screened for islet Ab is not clarified...
  67. ncbi request reprint The vitamin D receptor gene FokI polymorphism: functional impact on the immune system
    Evelyne van Etten
    Laboratory for Experimental Medicine and Endocrinology LEGENDO, Katholieke Universiteit Leuven, Leuven, Belgium
    Eur J Immunol 37:395-405. 2007
    ..Together, these data provide the first evidence that the VDR FokI polymorphism affects immune cell behavior, with a more active immune system for the short F-VDR, thus possibly playing a role in immune-mediated diseases...
  68. ncbi request reprint Seasonality of birth in patients with type 1 diabetes
    Bobby P C Koeleman
    Lancet 359:1246-7; author reply 1247-8. 2002