F Roelfsema

Summary

Affiliation: Leiden University
Country: The Netherlands

Publications

  1. ncbi request reprint Growth hormone (GH) secretion in patients with an inactivating defect of the GH-releasing hormone (GHRH) receptor is pulsatile: evidence for a role for non-GHRH inputs into the generation of GH pulses
    F Roelfsema
    Department of Endocrinology and Metabolism, Leiden University Medical Center, 2333AA Leiden, The Netherlands
    J Clin Endocrinol Metab 86:2459-64. 2001
  2. doi request reprint The exon-3 deleted growth hormone receptor polymorphism predisposes to long-term complications of acromegaly
    M J E Wassenaar
    Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    J Clin Endocrinol Metab 94:4671-8. 2009
  3. ncbi request reprint GH deficiency in patients irradiated for acromegaly: significance of GH stimulatory tests in relation to the 24 h GH secretion
    A A van der Klaauw
    Department of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Endocrinol 154:851-8. 2006
  4. doi request reprint Acromegaly is associated with an increased prevalence of colonic diverticula: a case-control study
    M J E Wassenaar
    Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    J Clin Endocrinol Metab 95:2073-9. 2010
  5. ncbi request reprint Quality of life is decreased after treatment for nonfunctioning pituitary macroadenoma
    O M Dekkers
    Department of Endocrinology and Metabolic Diseases C4 R, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    J Clin Endocrinol Metab 91:3364-9. 2006
  6. ncbi request reprint Pulsatile LH release is diminished, whereas FSH secretion is normal, in hypocretin-deficient narcoleptic men
    S W Kok
    Leiden University Medical Center, Department of General Internal Medicine, 2300 RC, The Netherlands
    Am J Physiol Endocrinol Metab 287:E630-6. 2004
  7. doi request reprint Clinical osteoarthritis predicts physical and psychological QoL in acromegaly patients
    M J E Wassenaar
    Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands
    Growth Horm IGF Res 20:226-33. 2010
  8. ncbi request reprint Attenuated pulse size, disorderly growth hormone and prolactin secretion with preserved nyctohemeral rhythm distinguish irradiated from surgically treated acromegaly patients
    A A van der Klaauw
    Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands
    Clin Endocrinol (Oxf) 66:489-98. 2007
  9. doi request reprint Progression of acromegalic arthropathy despite long-term biochemical control: a prospective, radiological study
    K M J A Claessen
    Department of Endocrinology and Metabolic Diseases C4 R, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Eur J Endocrinol 167:235-44. 2012
  10. ncbi request reprint Mortality in patients treated for Cushing's disease is increased, compared with patients treated for nonfunctioning pituitary macroadenoma
    O M Dekkers
    Department of Endocrinology and Metabolic Diseases C4 R, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    J Clin Endocrinol Metab 92:976-81. 2007

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Growth hormone (GH) secretion in patients with an inactivating defect of the GH-releasing hormone (GHRH) receptor is pulsatile: evidence for a role for non-GHRH inputs into the generation of GH pulses
    F Roelfsema
    Department of Endocrinology and Metabolism, Leiden University Medical Center, 2333AA Leiden, The Netherlands
    J Clin Endocrinol Metab 86:2459-64. 2001
    ..In addition, we infer that effectual GHRH input controls the GH cell mass and the orderliness of the secretory process...
  2. doi request reprint The exon-3 deleted growth hormone receptor polymorphism predisposes to long-term complications of acromegaly
    M J E Wassenaar
    Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    J Clin Endocrinol Metab 94:4671-8. 2009
    ..The aim of the study was to evaluate the impact of the genomic deletion of exon 3 of the GH receptor (d3GHR) on long-term clinical outcome of acromegaly in a well-characterized cohort of patients with long-term remission of acromegaly...
  3. ncbi request reprint GH deficiency in patients irradiated for acromegaly: significance of GH stimulatory tests in relation to the 24 h GH secretion
    A A van der Klaauw
    Department of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Endocrinol 154:851-8. 2006
    ..Radiotherapy for pituitary adenomas frequently leads to GH deficiency (GHD). The characteristics of GH secretion in GHD induced by postoperative radiotherapy for acromegaly are not known...
  4. doi request reprint Acromegaly is associated with an increased prevalence of colonic diverticula: a case-control study
    M J E Wassenaar
    Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    J Clin Endocrinol Metab 95:2073-9. 2010
    ..Because the relation between acromegaly and colonic diverticula is unknown, the study aim was to assess the prevalence of colonic diverticula in patients with cured acromegaly...
  5. ncbi request reprint Quality of life is decreased after treatment for nonfunctioning pituitary macroadenoma
    O M Dekkers
    Department of Endocrinology and Metabolic Diseases C4 R, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    J Clin Endocrinol Metab 91:3364-9. 2006
    ..Therefore, we evaluated a broad spectrum of QoL parameters in patients successfully treated for NFMA in our center...
  6. ncbi request reprint Pulsatile LH release is diminished, whereas FSH secretion is normal, in hypocretin-deficient narcoleptic men
    S W Kok
    Leiden University Medical Center, Department of General Internal Medicine, 2300 RC, The Netherlands
    Am J Physiol Endocrinol Metab 287:E630-6. 2004
    ..In particular, reduced LH release in the face of normal pituitary responsivity to GnRH stimulation in narcoleptic men suggests that hypocretins promote endogenous GnRH secretion...
  7. doi request reprint Clinical osteoarthritis predicts physical and psychological QoL in acromegaly patients
    M J E Wassenaar
    Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands
    Growth Horm IGF Res 20:226-33. 2010
    ..The aim of this study was to assess the impact of joint-specific complaints, clinical and radiological signs of arthropathy on different aspects of quality of life (QoL) in patients with acromegaly after long-term disease control...
  8. ncbi request reprint Attenuated pulse size, disorderly growth hormone and prolactin secretion with preserved nyctohemeral rhythm distinguish irradiated from surgically treated acromegaly patients
    A A van der Klaauw
    Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands
    Clin Endocrinol (Oxf) 66:489-98. 2007
    ..The development of growth hormone deficiency (GHD) in irradiated acromegaly patients is not well defined...
  9. doi request reprint Progression of acromegalic arthropathy despite long-term biochemical control: a prospective, radiological study
    K M J A Claessen
    Department of Endocrinology and Metabolic Diseases C4 R, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Eur J Endocrinol 167:235-44. 2012
    ..Therefore, the objective of the present study was to investigate the radiographic progression of arthropathy over a mean follow-up period of 2.6 years and determinants of outcome in patients with long-term, well-controlled acromegaly...
  10. ncbi request reprint Mortality in patients treated for Cushing's disease is increased, compared with patients treated for nonfunctioning pituitary macroadenoma
    O M Dekkers
    Department of Endocrinology and Metabolic Diseases C4 R, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    J Clin Endocrinol Metab 92:976-81. 2007
    ..However, it is unknown to what extent excess mortality is caused by pituitary tumors and their treatment in general and to what extent by previous exposure to hormonal overproduction...
  11. ncbi request reprint Dynamics of the pituitary-adrenal ensemble in hypocretin-deficient narcoleptic humans: blunted basal adrenocorticotropin release and evidence for normal time-keeping by the master pacemaker
    S W Kok
    Department of General Internal Medicine C1 R38, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Clin Endocrinol Metab 87:5085-91. 2002
    ..The reduced (basal) ACTH secretion and the diminished secretory process regularity of the ACTH/cortisol ensemble conjointly suggest that hypocretin deficiency induces changes in the interplay between PA hormones...
  12. pmc Progressive improvement of impaired visual acuity during the first year after transsphenoidal surgery for non-functioning pituitary macroadenoma
    O M Dekkers
    Department of Endocrinology and Metabolic Diseases C4 R, Leiden University Medical Center, P O Box 9600, Leiden 2300 RC, The Netherlands
    Pituitary 10:61-5. 2007
    ....
  13. ncbi request reprint Uncontrolled acromegaly is associated with progressive mitral valvular regurgitation
    A A van der Klaauw
    Department of Endocrinology and Metabolic Diseases C4 R, Leiden University Medical Center, Albinusdreef 2, P O Box 9600, 2300 RC Leiden, The Netherlands
    Growth Horm IGF Res 16:101-7. 2006
    ..The aim of this study was to evaluate the change in prevalence of valvular heart disease in relation to the clinical activity, because the natural history of valvular changes in acromegaly is unknown...
  14. doi request reprint Pretreatment insulin-like growth factor-I concentrations predict radiographic osteoarthritis in acromegalic patients with long-term cured disease
    N R Biermasz
    Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    J Clin Endocrinol Metab 94:2374-9. 2009
    ....
  15. ncbi request reprint The natural course of non-functioning pituitary macroadenomas
    O M Dekkers
    Department of Endocrinology, Leiden University Medical Center, The Netherlands
    Eur J Endocrinol 156:217-24. 2007
    ..Therefore, we evaluated pituitary function, visual fields, and tumor size during long-term follow-up of non-operated patients with NFMA...
  16. ncbi request reprint Sustained effects of recombinant GH replacement after 7 years of treatment in adults with GH deficiency
    A A van der Klaauw
    Department of Endocrinology and Metabolic Diseases C4 R, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands
    Eur J Endocrinol 155:701-8. 2006
    ..To determine whether the observed short-term beneficial effects of rhGH treatment are sustained in the long term, we evaluated biochemical and anthropometric parameters after 7 years of rhGH replacement...
  17. pmc Irregular and frequent cortisol secretory episodes with preserved diurnal rhythmicity in primary adrenal Cushing's syndrome
    M O van Aken
    Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    J Clin Endocrinol Metab 90:1570-7. 2005
    ..We speculate that partial preservation of secretory regularity and diurnal rhythmicity point to incomplete autonomy of these tumors...
  18. ncbi request reprint Basal, pulsatile, entropic, and 24-hour rhythmic features of secondary hyperprolactinemia due to functional pituitary stalk disconnection mimic tumoral (primary) hyperprolactinemia
    R G Veldman
    Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, 2333AA Leiden, The Netherlands
    J Clin Endocrinol Metab 86:1562-7. 2001
    ..The latter may reflect abnormal secretory behavior associated with lactotrope neoplastic transformation and/or isolation of the tumor cell mass from normal hypothalamic controls...
  19. ncbi request reprint Pituitary magnetic resonance imaging is not required in the postoperative follow-up of acromegalic patients with long-term biochemical cure after transsphenoidal surgery
    E J M Zirkzee
    Department of Endocrinology and Metabolism, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    J Clin Endocrinol Metab 89:4320-4. 2004
    ..In conclusion, in patients with acromegaly, initially cured by transsphenoidal surgery, it appears safe to check for recurrent disease during long-term follow-up of these patients by biochemical markers only...
  20. ncbi request reprint Persistent diastolic dysfunction despite successful long-term octreotide treatment in acromegaly
    S W van Thiel
    Department of Endocrinology and Metabolism, Leiden University Medical Center, The Netherlands
    Eur J Endocrinol 153:231-8. 2005
    ..It is unknown whether the cardiac changes induced by acromegaly can be reversed completely by long-term strict control of growth hormone excess by octreotide...
  21. doi request reprint Arthropathy in long-term cured acromegaly is characterised by osteophytes without joint space narrowing: a comparison with generalised osteoarthritis
    M J E Wassenaar
    Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands
    Ann Rheum Dis 70:320-5. 2011
    ....
  22. doi request reprint Diurnal secretion profiles of growth hormone, thyrotrophin and prolactin in Parkinson's disease
    N A Aziz
    Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands
    J Neuroendocrinol 23:519-24. 2011
    ..050) levels correlated inversely with body fat content. Apart from a mild increase in free T(4) levels, we found no indications for altered somatotrophic, thyrotrophic and lactotrophic axes activity in early-stage PD patients...
  23. ncbi request reprint Observation alone after transsphenoidal surgery for nonfunctioning pituitary macroadenoma
    O M Dekkers
    Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    J Clin Endocrinol Metab 91:1796-801. 2006
    ..In this study we evaluated the long-term effects of a treatment strategy in which postoperative radiotherapy was not routinely applied to patients with NFMA...
  24. ncbi request reprint Quality of life in patients after long-term biochemical cure of Cushing's disease
    M O van Aken
    Department of Endocrinology, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    J Clin Endocrinol Metab 90:3279-86. 2005
    ..In conclusion, despite long-term cure of Cushing's disease, patients experience a considerable decrease in quality of life, with physical and psychosocial impairments, especially in the presence of hypopituitarism...
  25. ncbi request reprint Quality of life in treated adult craniopharyngioma patients
    O M Dekkers
    Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, The Netherlands
    Eur J Endocrinol 154:483-9. 2006
    ..In the present study, we assessed QoL in adult patients successfully treated for craniopharyngioma in our centre...
  26. doi request reprint Growth hormone and ghrelin secretion are associated with clinical severity in Huntington's disease
    N A Aziz
    Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Neurol 17:280-8. 2010
    ..Therefore, we aimed to perform a detailed analysis of GH and ghrelin secretion in HD patients in relation to clinical signs and symptoms...
  27. doi request reprint Low prevalence of hypopituitarism after traumatic brain injury: a multicenter study
    N E Kokshoorn
    Department of Endocrinology and Metabolic Diseases C4 R, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Eur J Endocrinol 165:225-31. 2011
    ..Aim To evaluate the prevalence of hypopituitarism in a large cohort of TBI patients after long-term follow-up using a standardized endocrine evaluation. Study design Cross-sectional study...
  28. doi request reprint Automated image analysis of hand radiographs reveals widened joint spaces in patients with long-term control of acromegaly: relation to disease activity and symptoms
    N R Biermasz
    Department of Endocrinology and Metabolism C4 R, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Eur J Endocrinol 166:407-13. 2012
    ..Therefore, the objective of the current study was to assess joint space widths (JSWs) of hand joints in patients with long-term control of acromegaly and to identify factors associated with JSW...
  29. doi request reprint High prevalence of vertebral fractures despite normal bone mineral density in patients with long-term controlled acromegaly
    M J E Wassenaar
    Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Eur J Endocrinol 164:475-83. 2011
    ..To establish the prevalence of osteoporosis, vertebral fractures (VFs), and non-VFs in acromegaly patients with long-term controlled disease and factors potentially influencing fracture risk...
  30. ncbi request reprint Impact of meal timing and frequency on the twenty-four-hour leptin rhythm
    A J Fogteloo
    Department of General Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands
    Horm Res 62:71-8. 2004
    ..To study the influence of changes in meal timing and frequency on the diurnal rhythm of leptin and on the 24-hour profile of insulin and glucose...
  31. ncbi request reprint Six months of recombinant human GH therapy in patients with ischemic cardiac failure does not influence left ventricular function and mass
    J W Smit
    Department of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands
    J Clin Endocrinol Metab 86:4638-43. 2001
    ..We conclude that 6 months of recombinant human GH treatment in patients with ischemic cardiac failure had no beneficial effect on left ventricular function and mass...
  32. ncbi request reprint Patients with Cushing's disease secrete adrenocorticotropin and cortisol jointly more asynchronously than healthy subjects
    F Roelfsema
    Department of Endocrinology, Leiden University Medical Center, The Netherlands
    J Clin Endocrinol Metab 83:688-92. 1998
    ..Moreover, Cushing's disease is marked further by deterioriation of bihormonal synchrony between ACTH and cortisol release, thus suggesting further erosion of within-axis feedback control...
  33. ncbi request reprint Additional beneficial effects of alendronate in growth hormone (GH)-deficient adults with osteoporosis receiving long-term recombinant human GH replacement therapy: a randomized controlled trial
    N R Biermasz
    Department of Endocrinology and Metabolism, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    J Clin Endocrinol Metab 86:3079-85. 2001
    ..Further investigation is required to assess whether rhGH replacement alone or combined treatment with rhGH and alendronate is able to reduce the increased fracture risk associated with GHD...
  34. ncbi request reprint Octreotide long-acting repeatable and lanreotide Autogel are equally effective in controlling growth hormone secretion in acromegalic patients
    S W van Thiel
    Department of Endocrinology and Metabolism, Leiden University Medical Centre, Leiden, The Netherlands
    Eur J Endocrinol 150:489-95. 2004
    ..We hypothesized that the ability to suppress growth hormone (GH) secretion in patients with acromegaly would be similar for these depot preparations...
  35. ncbi request reprint Reduction of plasma leptin levels and loss of its circadian rhythmicity in hypocretin (orexin)-deficient narcoleptic humans
    S W Kok
    Department of General Internal Medicine, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    J Clin Endocrinol Metab 87:805-9. 2002
    ..As leptin deficiency clearly leads to morbid obesity in experimental animals and humans, we infer that the observed reduction of plasma leptin levels may predispose narcoleptic humans to weight gain...