Research Topics
| Dave RoelenSummaryAffiliation: Leiden University Medical Center Country: The Netherlands Publications
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Detail Information
Publications
Permissible and immunogenic HLA-A mismatches: cytotoxic T-cell precursor frequencies reflect graft survival dataD L Roelen
Deparment of Immunohaematology and Bloodbank, Leiden University Medical Centre, Leiden, The Netherlands
Hum Immunol 62:661-7. 2001..However, due to the big overlap of the CTLp frequencies in these populations, the permissible or immunogenic nature of a mismatch for a particular patient should be determined on an individual basis...
Relevance of cytotoxic alloreactivity under different immunosuppressive regimens in clinical islet cell transplantationD L Roelen
Department of Immunohaematology and Blood Transfusion, Leiden University Medical Centre, Leiden, The Netherlands
Clin Exp Immunol 156:141-8. 2009..This observational study demonstrates the usefulness of monitoring T cell reactivity against islet allografts to correlate immune function with graft survival...
Differential immunomodulatory effects of fetal versus maternal multipotent stromal cellsDave L Roelen
Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, The Netherlands
Hum Immunol 70:16-23. 2009..Fetal MSC derived from the fetomaternal interface have a stronger inhibitory effect on naive and antigen-experienced T cells compared with maternal MSC, which is probably related to their higher IL-10 production...- Regulatory functions of human CD4(+) T cells recognizing allopeptides in the context of self-HLA class IIDave L Roelen
Department of Immunohaematology and Blood Transfusion, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, The Netherlands
Hum Immunol 63:902-11. 2002.... - Differentially modulated dendritic cells induce regulatory T cells with different characteristicsDave L Roelen
Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands
Transpl Immunol 19:220-8. 2008..In summary, we show that differential modulation of DC results in the induction of different populations of regulatory T cells... - Pretransplant blood transfusions revisited: a role for CD(4+) regulatory T cells?Dave Roelen
Department of Immunohematology and Bloodtransfusion, Leiden University Medical Center, Leiden, The Netherlands
Transplantation 77:S26-8. 2004.... - Prolongation of skin graft survival by modulation of the alloimmune response with alternatively activated dendritic cellsDave L Roelen
Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
Transplantation 76:1608-15. 2003..The authors explored the possibility of using these DC for the induction of transplantation tolerance in a fully allogeneic setting in mice... - Impact of photodynamic treatment with meso-substituted porphyrin on the immunomodulatory capacity of white blood cell-containing red blood cell productsLaurence Trannoy
Department of Research and Education, Sanquin Blood Bank South west, Leiden, The Netherlands
Photochem Photobiol 86:223-30. 2010..It seems worthwhile to further explore PDT-induced immunomodulation to optimize conditions which may result in allo-tolerance by AAM phi... - Differential distribution of NK cells in decidua basalis compared with decidua parietalis after uncomplicated human term pregnancyAliana P Sindram-Trujillo
Department of Obstetrics (A.P.S.-T, S.A.S, H.H.H.K, Leiden University Medical Center, Leiden, The Netherlands
Hum Immunol 64:921-9. 2003..We conclude that significant differences exist with respect to the distribution of NK cells in term decidua basalis and parietalis. Future functional studies may improve our understanding of their role at the maternal-fetal interface... - No in vitro evidence for a decreased alloreactivity toward noninherited maternal HLA antigens in healthy individualsDaniëlle E M van den Boogaardt
Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
Hum Immunol 66:1203-12. 2005..In conclusion, no evidence of an influence of a NIMA effect on the cellular level was found in healthy individuals with "standard" immunological techniques... - Differential immunogenicity of HLA class I alloantigens for the humoral versus the cellular immune response: "towards tailor-made HLA mismatching"Frans H J Claas
Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, The Netherlands
Hum Immunol 67:424-9. 2006..Depending on the clinical situation, one should select a donor with HLA mismatches according to the humoral or cellular mismatch algorithm... - The ratio of interferon-gamma and interleukin-10 producing donor-specific cells as an in vitro monitoring tool for renal transplant patientsDaniëlle E M van den Boogaardt
Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, Leiden, The Netherlands
Transplantation 82:844-8. 2006..The ratio of IFN-gamma/IL-10 producing cells showed to be the best tool to discriminate between nonrejecting patients and rejecting patients... - Enhanced expression and activation of pro-inflammatory transcription factors distinguish aneurysmal from atherosclerotic aorta: IL-6- and IL-8-dominated inflammatory responses prevail in the human aneurysmJan H N Lindeman
Department of Vascular and Transplantation Surgery, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
Clin Sci (Lond) 114:687-97. 2008.... - Evidence for a selective migration of fetus-specific CD4+CD25bright regulatory T cells from the peripheral blood to the decidua in human pregnancyTamara Tilburgs
Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, Leiden, The Netherlands
J Immunol 180:5737-45. 2008..These data suggest a preferential recruitment of fetus-specific regulatory T cells from maternal peripheral blood to the fetal-maternal interface, where they may contribute to the local regulation of fetus-specific responses... - Protocolled blood transfusions in recipients of a simultaneous pancreas-kidney transplant reduce severe acute graft rejectionMarloes M Waanders
Transplantation 85:1668-70. 2008 - Activated HLA class I-reactive cytotoxic T lymphocytes associated with a positive historical crossmatch predict early graft failureCorine A van Kampen
Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Building 1 E3 Q, P O Box 9600, 2300 RC, Leiden, The Netherlands
Transplantation 74:1114-9. 2002..We wondered whether the persistence of activated CTLs might explain the poor results in a proportion of patients with a historical positive crossmatch... - Kinetics of the pregnancy-induced humoral and cellular immune response against the paternal HLA class I antigens of the childCorine A van Kampen
Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, The Netherlands
Hum Immunol 63:452-8. 2002..These data may be relevant for transplantation of female recipients with historical, pregnancy-induced HLA alloantibodies... - Primed CTLs specific for HLA class I may still be present in sensitized patients when anti-HLA antibodies have disappeared: relevance for donor selectionCorine A van Kampen
Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, 2300 RC, Leiden, The Netherlands
Transplantation 73:1286-90. 2002..If the antibodies have disappeared and only naive CTLs are present, a successful transplantation should be feasible. A prospective study will reveal whether this is indeed the case... - The influence of inherited and noninherited parental antigens on outcome after transplantationDaniëlle E M van den Boogaardt
Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
Transpl Int 19:360-71. 2006..This review provides an overview of the current knowledge on the impact of this fetal-maternal interaction on the alloimmune response and clinical transplantation... - Allogeneic MHC class I molecules with numerous sequence differences do not elicit a CTL responseMartin B A Heemskerk
Department of Immunohaematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
Hum Immunol 66:969-76. 2005..These findings are important for donor and patient MHC matching strategies and our understanding of T cell-MHC interaction after haematopoietic stem cell transplantation... - The putative mechanism of the immunomodulating effect of HLA-DR shared allogeneic blood transfusions on the alloimmune responseMarloes M Waanders
Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, RC Leiden, The Netherlands
Transfus Med Rev 19:281-7. 2005.... - The HLA-DR phenotype of the responder is predictive of humoral response against HLA class I antigensMarlies K A Dankers
Department of Immunohematology and Blood Transfusion, Leiden University, Leiden, The Netherlands
Hum Immunol 65:13-9. 2004.... - Differential immunogenicity of paternal HLA Class I antigens in pregnant womenMarlies K A Dankers
Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
Hum Immunol 64:600-6. 2003..Information on the differential immunogenicity of HLA mismatches may be of benefit for the determination of acceptable and taboo mismatches in the case of donor selection for (highly sensitized) patients... - Differential immunogenicity of HLA mismatches: HLA-A2 versus HLA-A28Marlies K A Dankers
Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
Transplantation 75:418-20. 2003.... - The number of amino acid triplet differences between patient and donor is predictive for the antibody reactivity against mismatched human leukocyte antigensMarlies K A Dankers
Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
Transplantation 77:1236-9. 2004..The correlation between antibody production against mismatched donor human leukocyte antigens (HLA) and the number of amino acid sequence mismatches was analyzed in patients who rejected a kidney transplant (n=146)... - HLAMatchmaker algorithm is not a suitable tool to predict the alloreactive cytotoxic T-lymphocyte response in vitroMarlies K A Dankers
Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, The Netherlands
Transplantation 78:165-7. 2004..This lack of correlation is probably caused by the fact that HLAMatchmaker considers only triplets on antibody-accessible positions, whereas CTLs also recognize other epitopes on the HLA molecule, including the bound peptides... - The immunologic profile of infants born after maternal immunoglobulin treatment and intrauterine platelet transfusions for fetal/neonatal alloimmune thrombocytopeniaCeline M Radder
Department of Obstetrics, Leiden University Medical Center, Leiden, The Netherlands
Am J Obstet Gynecol 191:815-20. 2004.... - Future HLA matching strategies in clinical transplantationFrans H J Claas
Department of Immunohaematology and Blood Transfusion, Leiden University Medical Center and Europdonor, Leiden, The Netherlands
Dev Ophthalmol 36:62-73. 2003..In order to select the optimal donor for this category of patients, it is important to take advantage of the differential immunogenicity and thus differential importance of mismatched HLA antigens... - Alloreactivity against repeated HLA mismatches of sequential islet grafts transplanted in non-uremic type 1 diabetes patientsCorine A van Kampen
Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
Transplantation 80:118-26. 2005..They demonstrate the usefulness of monitoring T-cell reactivity against islet allografts to correlate immune function with graft survival and to identify conditions for preservation of beta-cell function... - Differential immunogenicity of HLA mismatches in clinical transplantationFrans H J Claas
Leiden University Medical Center, Leiden, The Netherlands
Transpl Immunol 14:187-91. 2005..The theoretical background and practical implications of this acceptable mismatch approach are discussed... - Comparison of decidual leukocytes following spontaneous vaginal delivery and elective cesarean section in uncomplicated human term pregnancyAliana P Sindram-Trujillo
Department of Obstetrics, Leiden University Medical Center, Albinusdreef 2 K6-27, 2333 ZA, Leiden, The Netherlands
J Reprod Immunol 62:125-37. 2004..Further investigation into factors affecting decidual leukocytes may expand our understanding of the immunological events at the maternal-fetal interface... - Cellular islet autoimmunity associates with clinical outcome of islet cell transplantationVolkert A L Huurman
Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
PLoS ONE 3:e2435. 2008..We tested the hypothesis that allograft rejection and recurrent autoimmunity contribute to this progressive loss of islet allograft function...