Dave Roelen

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint Permissible and immunogenic HLA-A mismatches: cytotoxic T-cell precursor frequencies reflect graft survival data
    D L Roelen
    Deparment of Immunohaematology and Bloodbank, Leiden University Medical Centre, Leiden, The Netherlands
    Hum Immunol 62:661-7. 2001
  2. pmc Relevance of cytotoxic alloreactivity under different immunosuppressive regimens in clinical islet cell transplantation
    D L Roelen
    Department of Immunohaematology and Blood Transfusion, Leiden University Medical Centre, Leiden, The Netherlands
    Clin Exp Immunol 156:141-8. 2009
  3. doi request reprint Differential immunomodulatory effects of fetal versus maternal multipotent stromal cells
    Dave L Roelen
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, The Netherlands
    Hum Immunol 70:16-23. 2009
  4. ncbi request reprint Regulatory functions of human CD4(+) T cells recognizing allopeptides in the context of self-HLA class II
    Dave L Roelen
    Department of Immunohaematology and Blood Transfusion, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, The Netherlands
    Hum Immunol 63:902-11. 2002
  5. doi request reprint Differentially modulated dendritic cells induce regulatory T cells with different characteristics
    Dave L Roelen
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands
    Transpl Immunol 19:220-8. 2008
  6. ncbi request reprint Pretransplant blood transfusions revisited: a role for CD(4+) regulatory T cells?
    Dave Roelen
    Department of Immunohematology and Bloodtransfusion, Leiden University Medical Center, Leiden, The Netherlands
    Transplantation 77:S26-8. 2004
  7. ncbi request reprint Prolongation of skin graft survival by modulation of the alloimmune response with alternatively activated dendritic cells
    Dave L Roelen
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Transplantation 76:1608-15. 2003
  8. doi request reprint Impact of photodynamic treatment with meso-substituted porphyrin on the immunomodulatory capacity of white blood cell-containing red blood cell products
    Laurence Trannoy
    Department of Research and Education, Sanquin Blood Bank South west, Leiden, The Netherlands
    Photochem Photobiol 86:223-30. 2010
  9. ncbi request reprint Differential distribution of NK cells in decidua basalis compared with decidua parietalis after uncomplicated human term pregnancy
    Aliana P Sindram-Trujillo
    Department of Obstetrics A P S T, S A S, H H H K, Leiden University Medical Center, Leiden, The Netherlands
    Hum Immunol 64:921-9. 2003
  10. ncbi request reprint No in vitro evidence for a decreased alloreactivity toward noninherited maternal HLA antigens in healthy individuals
    Daniëlle E M van den Boogaardt
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Hum Immunol 66:1203-12. 2005

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Permissible and immunogenic HLA-A mismatches: cytotoxic T-cell precursor frequencies reflect graft survival data
    D L Roelen
    Deparment of Immunohaematology and Bloodbank, Leiden University Medical Centre, Leiden, The Netherlands
    Hum Immunol 62:661-7. 2001
    ..However, due to the big overlap of the CTLp frequencies in these populations, the permissible or immunogenic nature of a mismatch for a particular patient should be determined on an individual basis...
  2. pmc Relevance of cytotoxic alloreactivity under different immunosuppressive regimens in clinical islet cell transplantation
    D L Roelen
    Department of Immunohaematology and Blood Transfusion, Leiden University Medical Centre, Leiden, The Netherlands
    Clin Exp Immunol 156:141-8. 2009
    ..This observational study demonstrates the usefulness of monitoring T cell reactivity against islet allografts to correlate immune function with graft survival...
  3. doi request reprint Differential immunomodulatory effects of fetal versus maternal multipotent stromal cells
    Dave L Roelen
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, The Netherlands
    Hum Immunol 70:16-23. 2009
    ..Fetal MSC derived from the fetomaternal interface have a stronger inhibitory effect on naive and antigen-experienced T cells compared with maternal MSC, which is probably related to their higher IL-10 production...
  4. ncbi request reprint Regulatory functions of human CD4(+) T cells recognizing allopeptides in the context of self-HLA class II
    Dave L Roelen
    Department of Immunohaematology and Blood Transfusion, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, The Netherlands
    Hum Immunol 63:902-11. 2002
    ....
  5. doi request reprint Differentially modulated dendritic cells induce regulatory T cells with different characteristics
    Dave L Roelen
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands
    Transpl Immunol 19:220-8. 2008
    ..In summary, we show that differential modulation of DC results in the induction of different populations of regulatory T cells...
  6. ncbi request reprint Pretransplant blood transfusions revisited: a role for CD(4+) regulatory T cells?
    Dave Roelen
    Department of Immunohematology and Bloodtransfusion, Leiden University Medical Center, Leiden, The Netherlands
    Transplantation 77:S26-8. 2004
    ....
  7. ncbi request reprint Prolongation of skin graft survival by modulation of the alloimmune response with alternatively activated dendritic cells
    Dave L Roelen
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Transplantation 76:1608-15. 2003
    ..The authors explored the possibility of using these DC for the induction of transplantation tolerance in a fully allogeneic setting in mice...
  8. doi request reprint Impact of photodynamic treatment with meso-substituted porphyrin on the immunomodulatory capacity of white blood cell-containing red blood cell products
    Laurence Trannoy
    Department of Research and Education, Sanquin Blood Bank South west, Leiden, The Netherlands
    Photochem Photobiol 86:223-30. 2010
    ..It seems worthwhile to further explore PDT-induced immunomodulation to optimize conditions which may result in allo-tolerance by AAM phi...
  9. ncbi request reprint Differential distribution of NK cells in decidua basalis compared with decidua parietalis after uncomplicated human term pregnancy
    Aliana P Sindram-Trujillo
    Department of Obstetrics A P S T, S A S, H H H K, Leiden University Medical Center, Leiden, The Netherlands
    Hum Immunol 64:921-9. 2003
    ..We conclude that significant differences exist with respect to the distribution of NK cells in term decidua basalis and parietalis. Future functional studies may improve our understanding of their role at the maternal-fetal interface...
  10. ncbi request reprint No in vitro evidence for a decreased alloreactivity toward noninherited maternal HLA antigens in healthy individuals
    Daniëlle E M van den Boogaardt
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Hum Immunol 66:1203-12. 2005
    ..In conclusion, no evidence of an influence of a NIMA effect on the cellular level was found in healthy individuals with "standard" immunological techniques...
  11. ncbi request reprint Differential immunogenicity of HLA class I alloantigens for the humoral versus the cellular immune response: "towards tailor-made HLA mismatching"
    Frans H J Claas
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, The Netherlands
    Hum Immunol 67:424-9. 2006
    ..Depending on the clinical situation, one should select a donor with HLA mismatches according to the humoral or cellular mismatch algorithm...
  12. ncbi request reprint The ratio of interferon-gamma and interleukin-10 producing donor-specific cells as an in vitro monitoring tool for renal transplant patients
    Daniëlle E M van den Boogaardt
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, Leiden, The Netherlands
    Transplantation 82:844-8. 2006
    ..The ratio of IFN-gamma/IL-10 producing cells showed to be the best tool to discriminate between nonrejecting patients and rejecting patients...
  13. ncbi request reprint Enhanced expression and activation of pro-inflammatory transcription factors distinguish aneurysmal from atherosclerotic aorta: IL-6- and IL-8-dominated inflammatory responses prevail in the human aneurysm
    Jan H N Lindeman
    Department of Vascular and Transplantation Surgery, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Clin Sci (Lond) 114:687-97. 2008
    ....
  14. ncbi request reprint Evidence for a selective migration of fetus-specific CD4+CD25bright regulatory T cells from the peripheral blood to the decidua in human pregnancy
    Tamara Tilburgs
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, Leiden, The Netherlands
    J Immunol 180:5737-45. 2008
    ..These data suggest a preferential recruitment of fetus-specific regulatory T cells from maternal peripheral blood to the fetal-maternal interface, where they may contribute to the local regulation of fetus-specific responses...
  15. doi request reprint Protocolled blood transfusions in recipients of a simultaneous pancreas-kidney transplant reduce severe acute graft rejection
    Marloes M Waanders
    Transplantation 85:1668-70. 2008
  16. ncbi request reprint Activated HLA class I-reactive cytotoxic T lymphocytes associated with a positive historical crossmatch predict early graft failure
    Corine A van Kampen
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Building 1 E3 Q, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Transplantation 74:1114-9. 2002
    ..We wondered whether the persistence of activated CTLs might explain the poor results in a proportion of patients with a historical positive crossmatch...
  17. ncbi request reprint Kinetics of the pregnancy-induced humoral and cellular immune response against the paternal HLA class I antigens of the child
    Corine A van Kampen
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, The Netherlands
    Hum Immunol 63:452-8. 2002
    ..These data may be relevant for transplantation of female recipients with historical, pregnancy-induced HLA alloantibodies...
  18. ncbi request reprint Primed CTLs specific for HLA class I may still be present in sensitized patients when anti-HLA antibodies have disappeared: relevance for donor selection
    Corine A van Kampen
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, 2300 RC, Leiden, The Netherlands
    Transplantation 73:1286-90. 2002
    ..The presence of these CTLs is considered to be a reflection of an activated immune system and a contraindication for transplantation with a donor sharing these particular HLA antigens...
  19. ncbi request reprint The influence of inherited and noninherited parental antigens on outcome after transplantation
    Daniëlle E M van den Boogaardt
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Transpl Int 19:360-71. 2006
    ..This review provides an overview of the current knowledge on the impact of this fetal-maternal interaction on the alloimmune response and clinical transplantation...
  20. ncbi request reprint Allogeneic MHC class I molecules with numerous sequence differences do not elicit a CTL response
    Martin B A Heemskerk
    Department of Immunohaematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Hum Immunol 66:969-76. 2005
    ..These findings are important for donor and patient MHC matching strategies and our understanding of T cell-MHC interaction after haematopoietic stem cell transplantation...
  21. ncbi request reprint The putative mechanism of the immunomodulating effect of HLA-DR shared allogeneic blood transfusions on the alloimmune response
    Marloes M Waanders
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, RC Leiden, The Netherlands
    Transfus Med Rev 19:281-7. 2005
    ....
  22. ncbi request reprint The HLA-DR phenotype of the responder is predictive of humoral response against HLA class I antigens
    Marlies K A Dankers
    Department of Immunohematology and Blood Transfusion, Leiden University, Leiden, The Netherlands
    Hum Immunol 65:13-9. 2004
    ....
  23. ncbi request reprint Differential immunogenicity of paternal HLA Class I antigens in pregnant women
    Marlies K A Dankers
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Hum Immunol 64:600-6. 2003
    ..Information on the differential immunogenicity of HLA mismatches may be of benefit for the determination of acceptable and taboo mismatches in the case of donor selection for (highly sensitized) patients...
  24. ncbi request reprint Differential immunogenicity of HLA mismatches: HLA-A2 versus HLA-A28
    Marlies K A Dankers
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Transplantation 75:418-20. 2003
    ....
  25. ncbi request reprint The number of amino acid triplet differences between patient and donor is predictive for the antibody reactivity against mismatched human leukocyte antigens
    Marlies K A Dankers
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Transplantation 77:1236-9. 2004
    ..The correlation between antibody production against mismatched donor human leukocyte antigens (HLA) and the number of amino acid sequence mismatches was analyzed in patients who rejected a kidney transplant (n=146)...
  26. ncbi request reprint HLAMatchmaker algorithm is not a suitable tool to predict the alloreactive cytotoxic T-lymphocyte response in vitro
    Marlies K A Dankers
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, The Netherlands
    Transplantation 78:165-7. 2004
    ..This lack of correlation is probably caused by the fact that HLAMatchmaker considers only triplets on antibody-accessible positions, whereas CTLs also recognize other epitopes on the HLA molecule, including the bound peptides...
  27. ncbi request reprint The immunologic profile of infants born after maternal immunoglobulin treatment and intrauterine platelet transfusions for fetal/neonatal alloimmune thrombocytopenia
    Celine M Radder
    Department of Obstetrics, Leiden University Medical Center, Leiden, The Netherlands
    Am J Obstet Gynecol 191:815-20. 2004
    ....
  28. ncbi request reprint Future HLA matching strategies in clinical transplantation
    Frans H J Claas
    Department of Immunohaematology and Blood Transfusion, Leiden University Medical Center and Europdonor, Leiden, The Netherlands
    Dev Ophthalmol 36:62-73. 2003
    ..In order to select the optimal donor for this category of patients, it is important to take advantage of the differential immunogenicity and thus differential importance of mismatched HLA antigens...
  29. ncbi request reprint Alloreactivity against repeated HLA mismatches of sequential islet grafts transplanted in non-uremic type 1 diabetes patients
    Corine A van Kampen
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Transplantation 80:118-26. 2005
    ....
  30. ncbi request reprint Differential immunogenicity of HLA mismatches in clinical transplantation
    Frans H J Claas
    Leiden University Medical Center, Leiden, The Netherlands
    Transpl Immunol 14:187-91. 2005
    ..The theoretical background and practical implications of this acceptable mismatch approach are discussed...
  31. ncbi request reprint Comparison of decidual leukocytes following spontaneous vaginal delivery and elective cesarean section in uncomplicated human term pregnancy
    Aliana P Sindram-Trujillo
    Department of Obstetrics, Leiden University Medical Center, Albinusdreef 2 K6 27, 2333 ZA, Leiden, The Netherlands
    J Reprod Immunol 62:125-37. 2004
    ..Further investigation into factors affecting decidual leukocytes may expand our understanding of the immunological events at the maternal-fetal interface...
  32. pmc Cellular islet autoimmunity associates with clinical outcome of islet cell transplantation
    Volkert A L Huurman
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 3:e2435. 2008
    ..We tested the hypothesis that allograft rejection and recurrent autoimmunity contribute to this progressive loss of islet allograft function...