P H Reitsma

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. doi request reprint Mechanistic view of risk factors for venous thromboembolism
    Pieter H Reitsma
    Department of Thrombosis and Hemostasis, Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Albinusdreef 2, 2300 RC, Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 32:563-8. 2012
  2. ncbi request reprint VKORC1 gene variation and venous thrombosis: 'another one bites the dust'?
    P H Reitsma
    Einthoven Laboratory for Experimental Vascular Medicine, and Department of Thrombosis and Haemostasis, Leiden University Medical Centre, Leiden, The Netherlands
    J Thromb Haemost 5:2017-9. 2007
  3. ncbi request reprint Past and future of genetic research in thrombosis
    P H Reitsma
    Einthoven Laboratory for Experimental Vascular Medicine, Department of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, The Netherlands
    J Thromb Haemost 5:264-9. 2007
  4. doi request reprint How to identify new genetic risk factors for VTE?
    Pieter H Reitsma
    Department of Thrombosis and Hemostasis, Leiden University Medical Center, The Netherlands
    Thromb Res 123:S22-4. 2009
  5. doi request reprint High levels of protein C are determined by PROCR haplotype 3
    M C Pintao
    Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
    J Thromb Haemost 9:969-76. 2011
  6. ncbi request reprint Twelve novel and two recurrent mutations in 14 Austrian families with hereditary protein C deficiency
    S R Poort
    Department of Hematology, University Hospital, Leiden, The Netherlands
    Blood Coagul Fibrinolysis 4:273-80. 1993
  7. ncbi request reprint Dominant type 1 von Willebrand disease caused by mutated cysteine residues in the D3 domain of von Willebrand factor
    J C Eikenboom
    Department of Hematology, University Hospital, Leiden, The Netherlands
    Blood 88:2433-41. 1996
  8. doi request reprint Formation of platelet-binding von Willebrand factor strings on non-endothelial cells
    J W Wang
    Einthoven Laboratory for Experimental Vascular Medicine, Department of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, The Netherlands
    J Thromb Haemost 10:2168-78. 2012
  9. doi request reprint Explanations for coagulation activation after air travel
    A J M Schreijer
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    J Thromb Haemost 8:971-8. 2010
  10. ncbi request reprint No praise for folly: genomics will never be useful in arterial thrombosis
    P H Reitsma
    Einthoven Laboratory for Experimental Vascular Medicine, Departments of Hematology and Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    J Thromb Haemost 5:454-7. 2007

Collaborators

Detail Information

Publications32

  1. doi request reprint Mechanistic view of risk factors for venous thromboembolism
    Pieter H Reitsma
    Department of Thrombosis and Hemostasis, Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Albinusdreef 2, 2300 RC, Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 32:563-8. 2012
    ..In this narrative review we will discuss the known common risk factors within this pathophysiological framework...
  2. ncbi request reprint VKORC1 gene variation and venous thrombosis: 'another one bites the dust'?
    P H Reitsma
    Einthoven Laboratory for Experimental Vascular Medicine, and Department of Thrombosis and Haemostasis, Leiden University Medical Centre, Leiden, The Netherlands
    J Thromb Haemost 5:2017-9. 2007
  3. ncbi request reprint Past and future of genetic research in thrombosis
    P H Reitsma
    Einthoven Laboratory for Experimental Vascular Medicine, Department of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, The Netherlands
    J Thromb Haemost 5:264-9. 2007
    ....
  4. doi request reprint How to identify new genetic risk factors for VTE?
    Pieter H Reitsma
    Department of Thrombosis and Hemostasis, Leiden University Medical Center, The Netherlands
    Thromb Res 123:S22-4. 2009
    ..This short narrative review discusses several of the approaches which can be taken to identify new risk factors that predispose to venous thrombosis...
  5. doi request reprint High levels of protein C are determined by PROCR haplotype 3
    M C Pintao
    Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
    J Thromb Haemost 9:969-76. 2011
    ..Recently, we identified a locus on chromosome 20 determining high PC levels in a large Dutch pedigree with unexplained thrombophilia. Candidate genes in the LOD-1 support interval included FOXA2, THBD and PROCR...
  6. ncbi request reprint Twelve novel and two recurrent mutations in 14 Austrian families with hereditary protein C deficiency
    S R Poort
    Department of Hematology, University Hospital, Leiden, The Netherlands
    Blood Coagul Fibrinolysis 4:273-80. 1993
    ..Only two of the genetic defects (157Arg-->Stop and 178Arg-->Gln) have been found previously in other geographic locations. These data confirm the large genetic heterogeneity of protein C deficiency...
  7. ncbi request reprint Dominant type 1 von Willebrand disease caused by mutated cysteine residues in the D3 domain of von Willebrand factor
    J C Eikenboom
    Department of Hematology, University Hospital, Leiden, The Netherlands
    Blood 88:2433-41. 1996
    ..We conclude that the loss of cysteine pairing in the D3 domain, leaving one free cysteine, can induce a purely quantitative deficiency of vWF by dominantly suppressing the secretion of normal vWF...
  8. doi request reprint Formation of platelet-binding von Willebrand factor strings on non-endothelial cells
    J W Wang
    Einthoven Laboratory for Experimental Vascular Medicine, Department of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, The Netherlands
    J Thromb Haemost 10:2168-78. 2012
    ..Alterations in VWF strings may disturb hemostasis. This study was aimed at developing a flexible model system for structure-function studies of VWF strings...
  9. doi request reprint Explanations for coagulation activation after air travel
    A J M Schreijer
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    J Thromb Haemost 8:971-8. 2010
    ..It is unknown whether venous thrombosis after long haul air travel is exclusively attributable to immobilization...
  10. ncbi request reprint No praise for folly: genomics will never be useful in arterial thrombosis
    P H Reitsma
    Einthoven Laboratory for Experimental Vascular Medicine, Departments of Hematology and Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    J Thromb Haemost 5:454-7. 2007
  11. doi request reprint TF:FVIIa-specific activation of CREB upregulates proapoptotic proteins via protease-activated receptor-2
    H H Versteeg
    Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
    J Thromb Haemost 6:1550-7. 2008
    ..Our previous findings indicated that the TF:FVIIa complex activates signal transducer and activator of transcription (STAT) signaling, leading to cell survival in TF-transfected baby hamster kidney (BHK) cells...
  12. doi request reprint Genetics of venous thrombosis
    F R Rosendaal
    Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    J Thromb Haemost 7:301-4. 2009
    ..There are many weak genetic risk factors, including fibrinogen, factor XIII and factor XI variants. Even for moderately strong risk factors (relative risks 2-5), the majority of carriers will never develop thrombosis...
  13. pmc Unique distance- and DNA-turn-dependent interactions in the human protein C gene promoter confer submaximal transcriptional activity
    C A Spek
    Hemostasis and Thrombosis Research Center, Department of Hematology, University Hospital, Leiden, The Netherlands
    Biochem J 340:513-8. 1999
    ....
  14. ncbi request reprint Genetic studies in complex disease
    F R Rosendaal
    Departments of Clinical Epidemiology and Hematology, Leiden University Medical Center, Leiden, The Netherlands
    J Thromb Haemost 2:342. 2004
  15. ncbi request reprint Geographic distribution of the 20210 G to A prothrombin variant
    F R Rosendaal
    Department of Clinical Epidemiology, Leiden University Medical Centre, The Netherlands
    Thromb Haemost 79:706-8. 1998
    ..Since this distribution within Europe is very different to that of another prothrombotic mutation (factor V Leiden or factor V R506Q), founder effects are the most likely explanation for the geographical distribution of both mutations...
  16. ncbi request reprint Protein C deficiency: a database of mutations. For the Protein C & S Subcommittee of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis
    P H Reitsma
    Hemostasis and Thrombosis Research Unit, University, Hospital, Leiden, The Netherlands
    Thromb Haemost 69:77-84. 1993
  17. pmc Alternatively spliced tissue factor induces angiogenesis through integrin ligation
    Y W van den Berg
    The Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Proc Natl Acad Sci U S A 106:19497-502. 2009
    ..We conclude that asTF, unlike flTF, does not affect angiogenesis via PAR-dependent pathways but relies on integrin ligation. These findings indicate that asTF may serve as a target to prevent pathological angiogenesis...
  18. doi request reprint 17α-Ethinylestradiol rapidly alters transcript levels of murine coagulation genes via estrogen receptor α
    A C A Cleuren
    Einthoven Laboratory for Experimental Vascular Medicine, Department of Thrombosis and Haemostasis, Leiden University Medical Center, Leiden, The Netherlands
    J Thromb Haemost 8:1838-46. 2010
    ..Oral estrogen use is associated with changes in plasma levels of many coagulation proteins...
  19. ncbi request reprint Mutation in blood coagulation factor V associated with resistance to activated protein C
    R M Bertina
    Hemostasis and Thrombosis Research Center, University Hospital, Leiden, The Netherlands
    Nature 369:64-7. 1994
    ..8), protein S (ref. 9), antithrombin10 deficiency) together...
  20. doi request reprint Not exclusively tissue factor: neutrophil extracellular traps provide another link between chemotherapy and thrombosis
    Y W van den Berg
    Einthoven Laboratory for Experimental Vascular Medicine, Department of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, The Netherlands
    J Thromb Haemost 9:2311-2. 2011
    ..See also Swystun LL, Mukherjee S, Liaw PC. Breast cancer chemotherapy induces the release of cell-free DNA, a novel procoagulant stimulus. This issue, pp 2313-21...
  21. ncbi request reprint Mutations in hemophilia Bm occur at the Arg180-Val activation site or in the catalytic domain of factor IX
    R M Bertina
    Haemostasis and Thrombosis Research Unit, University Hospital, Leiden, The Netherlands
    J Biol Chem 265:10876-83. 1990
    ..Pro368----Thr near the catalytic center) or indirectly (mutations at the Arg180-Val activation site) therefore lead to a combination of 1) the loss of coagulant activity and 2) an inhibitory effect in the ox brain prothrombin time assay...
  22. ncbi request reprint Intron-exon organization of the human gene coding for the lipoprotein-associated coagulation inhibitor: the factor Xa dependent inhibitor of the extrinsic pathway of coagulation
    C P van der Logt
    Haemostasis and Trombosis Research Unit, University Hospital, Leiden, The Netherlands
    Biochemistry 30:1571-7. 1991
    ..The putative promoter was examined and found to contain two consensus sequences for AP-1 binding and one for NF-1 binding, but no TATA consensus promoter element...
  23. ncbi request reprint Refined regional assignment of the human tissue factor pathway inhibitor (TFPI) gene to chromosome band 2q32 by non-isotopic in situ hybridization
    C P van der Logt
    Haemostasis and Thrombosis Research Unit, University Hospital, Leiden, The Netherlands
    Hum Genet 89:577-8. 1992
  24. ncbi request reprint Alternatively spliced tissue factor in mice: induction by Streptococcus pneumoniae
    L W Brüggemann
    J Thromb Haemost 4:918-20. 2006
  25. ncbi request reprint Factor XIII Val34Leu and the risk of venous thromboembolism in factor V Leiden carriers
    R F Franco
    Laboratory for Experimental Internal Medicine, Academic Medical Centre, Amsterdam, The Netherlands
    Br J Haematol 111:118-21. 2000
    ..5 (95% CI 0.06-4.5) in relatives older than 60 years. In conclusion, the impact of FXIII Val34Leu on the venous thromboembolic risk is modest, suggesting that screening for this mutation in factor V Leiden carriers is not justified...
  26. ncbi request reprint Identification of polymorphisms in the 5'-untranslated region of the TAFI gene: relationship with plasma TAFI levels and risk of venous thrombosis
    R F Franco
    Laboratory of Hematology, Department of Clinical Medicine, School of Medicine of Ribeirao Preto, University of Sao Paulo, 14048 900, Ribeirao Preto, SP, Brazil
    Haematologica 86:510-7. 2001
    ..Thrombin activatable fibrinolysis inhibitor (TAFI) plays an important role in hemostasis, functioning as a potent fibrinolysis inhibitor. TAFI gene variations may contribute to plasma TAFI levels and thrombotic risk...
  27. ncbi request reprint Apolipoprotein A-V: a novel apolipoprotein associated with an early phase of liver regeneration
    H N van der Vliet
    Department of Experimental Hepatology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Amsterdam 1105 AZ, The Netherlands
    J Biol Chem 276:44512-20. 2001
    ..The protein was present in plasma fractions containing high density lipoprotein particles. Therefore, we have identified a novel apolipoprotein, designated apolipoprotein A-V, that is associated with an early phase of liver regeneration...
  28. ncbi request reprint [From gene to disease; risk factors for venous thrombosis: factor V Leiden and prothrombin 20210A]
    P H Reitsma
    European School for Science Education, Eikenheuveldreef 16, 5263 EM Vught
    Ned Tijdschr Geneeskd 145:1843-5. 2001
    ..The APC-resistance assay is used to screen for the presence of factor V-Leiden. Both factor V-Leiden and prothrombin 20210A are diagnosed by DNA analysis...
  29. ncbi request reprint A functional single nucleotide polymorphism in the thrombin-activatable fibrinolysis inhibitor (TAFI) gene associates with outcome of meningococcal disease
    J A Kremer Hovinga
    Laboratory for Experimental Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
    J Thromb Haemost 2:54-7. 2004
    ..0-9.5) increased risk to die from the infection compared with all other genotypes. Survivors had a genotype frequency (4.0%) that was lower than in the general population. TAFI 325 variants affect the outcome of meningococcal disease...
  30. ncbi request reprint Homocysteine and markers of coagulation and endothelial cell activation
    V E A Gerdes
    Department of Internal Medicine Clinical Chemistry, Slotervaart Hospital, Amsterdam, The Netherlands
    J Thromb Haemost 2:445-51. 2004
    ..In vitro studies suggest an influence of hyperhomocysteinemia on the coagulation system, but the influence of mild hyperhomocysteinemia in vivo is unclear...
  31. ncbi request reprint Activation of innate immunity in patients with venous thrombosis: the Leiden Thrombophilia Study
    P H Reitsma
    Laboratory for Experimental Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
    J Thromb Haemost 2:619-22. 2004
    ..We have sought to confirm and extend these findings by measuring plasma tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6, IL-8, IL-10 and IL-12p70 levels in a case-control study for venous thrombotic disease...
  32. ncbi request reprint Is hypercoagulability an issue in arterial thrombosis? No
    P H Reitsma
    Laboratory for Experimental Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
    J Thromb Haemost 2:692-4. 2004