Marlies E J Reinders

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint Mesenchymal stromal cell therapy for cardio renal disorders
    Marlies E J Reinders
    Department of Nephrology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Curr Pharm Des 20:2412-29. 2014
  2. pmc Mesenchymal stromal cells in renal ischemia/reperfusion injury
    Dorottya K de Vries
    Department of Surgery, Leiden University Medical Center, Leiden, Netherlands
    Front Immunol 3:162. 2012
  3. doi request reprint Renal ischemia-reperfusion induces a dysbalance of angiopoietins, accompanied by proliferation of pericytes and fibrosis
    Meriem Khairoun
    Dept of Nephrology, Leiden Univ Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Am J Physiol Renal Physiol 305:F901-10. 2013
  4. doi request reprint Bone marrow-derived mesenchymal stromal cells from patients with end-stage renal disease are suitable for autologous therapy
    Marlies E J Reinders
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Cytotherapy 15:663-72. 2013
  5. ncbi request reprint Multipotent mesenchymal stromal cell therapy in renal disease and kidney transplantation
    Marlies E J Reinders
    Correspondence and offprint requests to Dr Marlies E J Reinders E mail
    Nephrol Dial Transplant 25:17-24. 2010
  6. pmc Autologous bone marrow-derived mesenchymal stromal cells for the treatment of allograft rejection after renal transplantation: results of a phase I study
    Marlies E J Reinders
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Stem Cells Transl Med 2:107-11. 2013
  7. doi request reprint The role of mesenchymal stromal cells in chronic transplant rejection after solid organ transplantation
    Marlies E J Reinders
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Curr Opin Organ Transplant 18:44-50. 2013
  8. doi request reprint Renal ischemia-reperfusion induces release of angiopoietin-2 from human grafts of living and deceased donors
    Dorottya K de Vries
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Transplantation 96:282-9. 2013
  9. doi request reprint Mesenchymal stromal cells to prevent fibrosis in kidney transplantation
    Marlies E J Reinders
    aDepartment of Nephrology bEinthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
    Curr Opin Organ Transplant 19:54-9. 2014
  10. doi request reprint Interleukin-9 release from human kidney grafts and its potential protective role in renal ischemia/reperfusion injury
    Kirsten A Kortekaas
    Department of Cardiothoracic Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Inflamm Res 62:53-9. 2013

Collaborators

  • Martin J Hoogduijn
  • Kirsten A Kortekaas
  • Meindert Palmen
  • Anne Christine W Vos
  • Philip G de Groot
  • Jeffrey Damman
  • Marjolijn Duijvestein
  • Dorottya K de Vries
  • Meriem Khairoun
  • Ton J Rabelink
  • Cees van Kooten
  • Martijn J C Dane
  • Anton Jan van Zonneveld
  • Alexander F Schaapherder
  • Ingeborg M Bajema
  • Pieter van der Pol
  • Jan H N Lindeman
  • Alexander F M Schaapherder
  • Marina D Kraaij
  • Bart J M Eskens
  • Hans Vink
  • Angelique L W M M Rops
  • Bernard M van den Berg
  • Dae Hyun Lee
  • Margien G S Boels
  • Jurgen W G E Van Teeffelen
  • Johan van der Vlag
  • Gerritje E van Anken
  • Ellen Lievers
  • Joris I Rotmans
  • Cees Van Kooten
  • Nicole Schlagwein
  • Mark Roest
  • Hetty C de Boer
  • DaniĆ«lle J van Gijlswijk
  • Jan H Lindeman
  • Anton J van Zonneveld
  • Leonie G M Wijermars
  • Emile De Heer
  • Sandra W van der Kooij
  • Kyra A Gelderman
  • Karin Koekkoek

Detail Information

Publications16

  1. ncbi request reprint Mesenchymal stromal cell therapy for cardio renal disorders
    Marlies E J Reinders
    Department of Nephrology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Curr Pharm Des 20:2412-29. 2014
    ....
  2. pmc Mesenchymal stromal cells in renal ischemia/reperfusion injury
    Dorottya K de Vries
    Department of Surgery, Leiden University Medical Center, Leiden, Netherlands
    Front Immunol 3:162. 2012
    ..In this review, preliminary results and opportunities of MSCs in human renal I/R injury are summarized. We might be heading towards a cell-based paradigm shift in the treatment of renal I/R injury...
  3. doi request reprint Renal ischemia-reperfusion induces a dysbalance of angiopoietins, accompanied by proliferation of pericytes and fibrosis
    Meriem Khairoun
    Dept of Nephrology, Leiden Univ Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Am J Physiol Renal Physiol 305:F901-10. 2013
    ..Our findings suggest that angiopoietins and pericytes play an important role in renal microvascular remodeling and development of fibrosis. ..
  4. doi request reprint Bone marrow-derived mesenchymal stromal cells from patients with end-stage renal disease are suitable for autologous therapy
    Marlies E J Reinders
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Cytotherapy 15:663-72. 2013
    ..We assessed whether renal failure affected the function and therapeutic potential of BM-MSCs...
  5. ncbi request reprint Multipotent mesenchymal stromal cell therapy in renal disease and kidney transplantation
    Marlies E J Reinders
    Correspondence and offprint requests to Dr Marlies E J Reinders E mail
    Nephrol Dial Transplant 25:17-24. 2010
    ..In this review, evidence for the renoprotective mechanisms of MSCs as well as their therapeutic possibilities and potential hazards in acute and chronic renal disease and allograft rejection is summarized...
  6. pmc Autologous bone marrow-derived mesenchymal stromal cells for the treatment of allograft rejection after renal transplantation: results of a phase I study
    Marlies E J Reinders
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Stem Cells Transl Med 2:107-11. 2013
    ..Autologous BM MSC treatment in transplant recipients with subclinical rejection and IF/TA is clinically feasible and safe, and the findings are suggestive of systemic immunosuppression...
  7. doi request reprint The role of mesenchymal stromal cells in chronic transplant rejection after solid organ transplantation
    Marlies E J Reinders
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Curr Opin Organ Transplant 18:44-50. 2013
    ....
  8. doi request reprint Renal ischemia-reperfusion induces release of angiopoietin-2 from human grafts of living and deceased donors
    Dorottya K de Vries
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Transplantation 96:282-9. 2013
    ..Experimental data have shown that enhancement of Angiopoietin (Ang)-1 signaling might be beneficial in renal I/R injury. However, little is known about the role of angiopoietins in human renal I/R injury...
  9. doi request reprint Mesenchymal stromal cells to prevent fibrosis in kidney transplantation
    Marlies E J Reinders
    aDepartment of Nephrology bEinthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
    Curr Opin Organ Transplant 19:54-9. 2014
    ..Mesenchymal stromal cells (MSCs) have potent anti-inflammatory and reparative properties, and could thus play a role in controlling these processes...
  10. doi request reprint Interleukin-9 release from human kidney grafts and its potential protective role in renal ischemia/reperfusion injury
    Kirsten A Kortekaas
    Department of Cardiothoracic Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Inflamm Res 62:53-9. 2013
    ..Interleukin (IL)-9 is a pleiotropic cytokine recently identified to be involved in various immune responses. In this study, the role of IL-9 in renal I/R injury was assessed...
  11. doi request reprint Acute but transient release of terminal complement complex after reperfusion in clinical kidney transplantation
    Dorottya K de Vries
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Transplantation 95:816-20. 2013
    ..Animal studies have suggested a role for complement activation in mediating I/R injury; however, results are not unambiguous. Whether complement activation is involved in clinical I/R injury in humans is still unclear...
  12. pmc Pre-existing endothelial cell activation predicts vasoplegia after mitral valve surgery
    Kirsten A Kortekaas
    Department of Cardiothoracic Surgery, Leiden University Medical Center, Leiden, Netherlands
    Interact Cardiovasc Thorac Surg 17:523-30. 2013
    ..The pathophysiological mechanisms underlying this syndrome remain unknown. We hypothesized that this vasoplegia reflects endothelial dysfunction, either as pre-existing condition or as a consequence of the surgical procedure...
  13. doi request reprint Donor pre-treatment in clinical kidney transplantation: a critical appraisal
    Dorottya K de Vries
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Clin Transplant 27:799-808. 2013
    ..This review provides an overview of promising therapeutical strategies for donor pre-treatment in kidney transplantation and discusses the clinical trials that have been conducted thus far. ..
  14. doi request reprint Mesenchymal stromal cell function is not affected by drugs used in the treatment of inflammatory bowel disease
    Marjolijn Duijvestein
    Department of Gastroenterology and Hepatology, Leiden University, Medical Center, Leiden, The Netherlands
    Cytotherapy 13:1066-73. 2011
    ..However, little is known about MSC interactions with these immunosuppressive drugs. To address this issue we studied the combined effect of MSC and IBD drugs in in vitro functionality assays...
  15. doi request reprint Dexamethasone increases ROS production and T cell suppressive capacity by anti-inflammatory macrophages
    Marina D Kraaij
    Leiden University Medical Center, Department of Nephrology, 2300 RC Leiden, The Netherlands
    Mol Immunol 49:549-57. 2011
    ..In conclusion, we show that the anti-inflammatory drug dexamethasone increases the ROS producing capacity of macrophages...
  16. ncbi request reprint Association of kidney function with changes in the endothelial surface layer
    Martijn J C Dane
    Department of Nephrology, Einthoven Laboratory for Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands, Department of Physiology, Maastricht University Medical Center, Maastricht, The Netherlands, Department of Nephrology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Clin J Am Soc Nephrol 9:698-704. 2014
    ....