Vered Raz

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint Changes in lamina structure are followed by spatial reorganization of heterochromatic regions in caspase-8-activated human mesenchymal stem cells
    Vered Raz
    Department of Molecular Cell Biology, Leiden University Medical Center, Einsteinweg 20, 2300RC Leiden, The Netherlands
    J Cell Sci 119:4247-56. 2006
  2. ncbi request reprint Segmentation and analysis of the three-dimensional redistribution of nuclear components in human mesenchymal stem cells
    Bart J Vermolen
    Department of Imaging Science and Technology, Delft University of Technology, Delft, The Netherlands
    Cytometry A 73:816-24. 2008
  3. pmc Reversible aggregation of PABPN1 pre-inclusion structures
    Vered Raz
    Department of Human Genetics, Leiden University Medical Centre, The Netherlands
    Nucleus 2:208-18. 2011
  4. pmc Poly(A) binding protein nuclear 1 levels affect alternative polyadenylation
    Eleonora de Klerk
    Center for Human and Clinical Genetics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Nucleic Acids Res 40:9089-101. 2012
  5. pmc Robust nuclear lamina-based cell classification of aging and senescent cells
    Christiaan H Righolt
    Department of Human Genetics, Leiden University Medical Center, The Netherlands
    Aging (Albany NY) 3:1192-201. 2011
  6. doi request reprint A novel feed-forward loop between ARIH2 E3-ligase and PABPN1 regulates aging-associated muscle degeneration
    Vered Raz
    Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands Electronic address
    Am J Pathol 184:1119-31. 2014
  7. pmc Major aging-associated RNA expressions change at two distinct age-positions
    Marius Gheorghe
    Department of Human and Clinical Genetics, Leiden University Medical Centre, Leiden, The Netherlands
    BMC Genomics 15:132. 2014
  8. pmc Nuclear entrapment and extracellular depletion of PCOLCE is associated with muscle degeneration in oculopharyngeal muscular dystrophy
    Vered Raz
    Center for Human and Clinical Genetics, Leiden University Medical Center, Einthovenweg 20, Leiden, The Netherlands
    BMC Neurol 13:70. 2013
  9. pmc Modeling oculopharyngeal muscular dystrophy in myotube cultures reveals reduced accumulation of soluble mutant PABPN1 protein
    Vered Raz
    Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Am J Pathol 179:1988-2000. 2011
  10. pmc Deregulation of the ubiquitin-proteasome system is the predominant molecular pathology in OPMD animal models and patients
    Seyed Yahya Anvar
    Center for Human and Clinical Genetics, Leiden University Medical Center, P, O, Box 9600, 2300 RC Leiden, The Netherlands
    Skelet Muscle 1:15. 2011

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Changes in lamina structure are followed by spatial reorganization of heterochromatic regions in caspase-8-activated human mesenchymal stem cells
    Vered Raz
    Department of Molecular Cell Biology, Leiden University Medical Center, Einsteinweg 20, 2300RC Leiden, The Netherlands
    J Cell Sci 119:4247-56. 2006
    ..We suggest that during activation of the caspase-8 pathway changes in the lamina structure precede changes in heterochromatin spatial organization, and the subsequent breakdown of lamina and PML-NB...
  2. ncbi request reprint Segmentation and analysis of the three-dimensional redistribution of nuclear components in human mesenchymal stem cells
    Bart J Vermolen
    Department of Imaging Science and Technology, Delft University of Technology, Delft, The Netherlands
    Cytometry A 73:816-24. 2008
    ..We propose that the use of this new image segmentation method will contribute to a better understanding of the 3D spatial organization of the cell nucleus...
  3. pmc Reversible aggregation of PABPN1 pre-inclusion structures
    Vered Raz
    Department of Human Genetics, Leiden University Medical Centre, The Netherlands
    Nucleus 2:208-18. 2011
    ..Together our results demonstrate that the aggregation process of WT- and expPABPN1 differs in steps preceding inclusion formation, suggesting that pre-aggregated protein species could represent the cytotoxic structures...
  4. pmc Poly(A) binding protein nuclear 1 levels affect alternative polyadenylation
    Eleonora de Klerk
    Center for Human and Clinical Genetics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Nucleic Acids Res 40:9089-101. 2012
    ....
  5. pmc Robust nuclear lamina-based cell classification of aging and senescent cells
    Christiaan H Righolt
    Department of Human Genetics, Leiden University Medical Center, The Netherlands
    Aging (Albany NY) 3:1192-201. 2011
    ..We suggest that this method can be applied to identify abnormal cells during aging, in in vitro propagation, and in lamina disorders...
  6. doi request reprint A novel feed-forward loop between ARIH2 E3-ligase and PABPN1 regulates aging-associated muscle degeneration
    Vered Raz
    Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands Electronic address
    Am J Pathol 184:1119-31. 2014
    ..We suggest that the expression of both genes is maintained by a feed-forward loop between mRNA stability regulated by PABPN1 and protein turnover regulated by ARIH2. ..
  7. pmc Major aging-associated RNA expressions change at two distinct age-positions
    Marius Gheorghe
    Department of Human and Clinical Genetics, Leiden University Medical Centre, Leiden, The Netherlands
    BMC Genomics 15:132. 2014
    ..Age-regulated mRNA expression trends from cross-sectional studies could describe how aging progresses. We developed a novel statistical methodology to identify age-regulated expression trends in cross-sectional datasets...
  8. pmc Nuclear entrapment and extracellular depletion of PCOLCE is associated with muscle degeneration in oculopharyngeal muscular dystrophy
    Vered Raz
    Center for Human and Clinical Genetics, Leiden University Medical Center, Einthovenweg 20, Leiden, The Netherlands
    BMC Neurol 13:70. 2013
    ..OPMD is characterized by fibrosis in skeletal muscles but the causative molecular mechanisms are not fully understood...
  9. pmc Modeling oculopharyngeal muscular dystrophy in myotube cultures reveals reduced accumulation of soluble mutant PABPN1 protein
    Vered Raz
    Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Am J Pathol 179:1988-2000. 2011
    ..We suggest that this difference can contribute to muscle weakness in OPMD...
  10. pmc Deregulation of the ubiquitin-proteasome system is the predominant molecular pathology in OPMD animal models and patients
    Seyed Yahya Anvar
    Center for Human and Clinical Genetics, Leiden University Medical Center, P, O, Box 9600, 2300 RC Leiden, The Netherlands
    Skelet Muscle 1:15. 2011
    ..We suggest that the natural decrease in proteasome expression and its activity during muscle aging contributes to the onset of the disease...
  11. ncbi request reprint The nuclear lamina promotes telomere aggregation and centromere peripheral localization during senescence of human mesenchymal stem cells
    Vered Raz
    Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
    J Cell Sci 121:4018-28. 2008
    ....
  12. pmc A decline in PABPN1 induces progressive muscle weakness in oculopharyngeal muscle dystrophy and in muscle aging
    Seyed Yahya Anvar
    Center for Human and Clinical Genetics, Leiden University Medical Center, The Netherlands
    Aging (Albany NY) 5:412-26. 2013
    ..We suggest that PABPN1 levels regulate muscle cell aging and OPMD represents an accelerated muscle aging disorder. ..
  13. pmc Interspecies translation of disease networks increases robustness and predictive accuracy
    Seyed Yahya Anvar
    Center for Human and Clinical Genetics, Leiden University Medical Center, The Netherlands
    PLoS Comput Biol 7:e1002258. 2011
    ..This study presents a state-of-the-art strategy in constructing interspecies disease networks that provide crucial information on regulatory relationships among genes, leading to better understanding of the disease molecular mechanisms...
  14. pmc Regenerative potential of human muscle stem cells in chronic inflammation
    Bouke J Duijnisveld
    Department of Orthopaedics, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Arthritis Res Ther 13:R207. 2011
    ..The aim of this study was to define the role of chronic inflammation on the regenerative potential of satellite cells in human muscle...
  15. pmc Differential temporal and spatial progerin expression during closure of the ductus arteriosus in neonates
    Regina Bokenkamp
    Department of Pediatric Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 6:e23975. 2011
    ..We suggest that activation of LMNA alternative splicing is involved in vascular remodeling in the circulatory system during normal neonatal DA closure...