T J Rabelink

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint Peritubular endothelium: the Achilles heel of the kidney?
    T J Rabelink
    Department of Nephrology, Einthoven Centre of Experimental Vascular Medicine and Diabetes, Leiden University Medical Center, Leiden, The Netherlands
    Kidney Int 72:926-30. 2007
  2. ncbi request reprint Endothelial nitric oxide synthase: host defense enzyme of the endothelium?
    Ton J Rabelink
    Department of Nephrology and Hypertension, Leiden University Medical Center, The Netherlands
    Arterioscler Thromb Vasc Biol 26:267-71. 2006
  3. doi request reprint Hypertension and rarefaction during treatment with telatinib, a small molecule angiogenesis inhibitor
    Neeltje Steeghs
    Department of Clinical Oncology, Leiden University Medical Center, Leiden, The Netherlands
    Clin Cancer Res 14:3470-6. 2008
  4. ncbi request reprint Impact of thiazolidinedione therapy on atherogenesis
    Jeroen P H van Wijk
    University Medical Center Leiden, Department of Nephrology and Hypertension, Room C3 P, PO Box 9600, 2300 RC Leiden, The Netherlands
    Curr Atheroscler Rep 7:369-74. 2005
  5. doi request reprint Endothelial activation and circulating markers of endothelial activation in kidney disease
    Ton J Rabelink
    Department of Nephrology and Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands
    Nat Rev Nephrol 6:404-14. 2010
  6. doi request reprint Endothelin receptor blockade in patients with diabetic nephropathy
    Ton J Rabelink
    LUMC Department of Nephrology, Leiden, The Netherlands
    Contrib Nephrol 172:235-42. 2011
  7. ncbi request reprint Endothelial progenitor cells: more than an inflammatory response?
    Ton J Rabelink
    Department of Nephrology, Leiden University Medical Center, The Netherlands
    Arterioscler Thromb Vasc Biol 24:834-8. 2004
  8. pmc Enhanced complement activation is part of the unfavourable cardiovascular risk profile in South Asians
    M A Siezenga
    Leiden University Medical Center, Department of Nephrology, Leiden, The Netherlands
    Clin Exp Immunol 157:98-103. 2009
  9. doi request reprint Inflammation, vascular injury and repair in rheumatoid arthritis
    A J van Zonneveld
    Department of Nephrology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Ann Rheum Dis 69:i57-60. 2010
  10. ncbi request reprint Multipotent mesenchymal stromal cell therapy in renal disease and kidney transplantation
    Marlies E J Reinders
    Correspondence and offprint requests to Dr Marlies E J Reinders E mail
    Nephrol Dial Transplant 25:17-24. 2010

Detail Information

Publications87

  1. ncbi request reprint Peritubular endothelium: the Achilles heel of the kidney?
    T J Rabelink
    Department of Nephrology, Einthoven Centre of Experimental Vascular Medicine and Diabetes, Leiden University Medical Center, Leiden, The Netherlands
    Kidney Int 72:926-30. 2007
    ..In this mini review, the evidence for this pathophysiological concept as well as the possibility to detect such endothelial activation in the clinical arena is summarized...
  2. ncbi request reprint Endothelial nitric oxide synthase: host defense enzyme of the endothelium?
    Ton J Rabelink
    Department of Nephrology and Hypertension, Leiden University Medical Center, The Netherlands
    Arterioscler Thromb Vasc Biol 26:267-71. 2006
    ..The central role of uncoupled eNOS in redox signaling in the endothelium may open up new avenues for therapy to prevent atherosclerosis...
  3. doi request reprint Hypertension and rarefaction during treatment with telatinib, a small molecule angiogenesis inhibitor
    Neeltje Steeghs
    Department of Clinical Oncology, Leiden University Medical Center, Leiden, The Netherlands
    Clin Cancer Res 14:3470-6. 2008
    ..Hypertension is a commonly reported side effect in antiangiogenic therapy. We investigated the hypothesis that telatinib, a small molecule angiogenesis inhibitor, impairs vascular function, induces rarefaction, and causes hypertension...
  4. ncbi request reprint Impact of thiazolidinedione therapy on atherogenesis
    Jeroen P H van Wijk
    University Medical Center Leiden, Department of Nephrology and Hypertension, Room C3 P, PO Box 9600, 2300 RC Leiden, The Netherlands
    Curr Atheroscler Rep 7:369-74. 2005
    ..TZDs interfere with key processes in atherogenesis and may, therefore, offer additional opportunities to improve cardiovascular risk beyond treatment of glycemic control in patients with type 2 diabetes...
  5. doi request reprint Endothelial activation and circulating markers of endothelial activation in kidney disease
    Ton J Rabelink
    Department of Nephrology and Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands
    Nat Rev Nephrol 6:404-14. 2010
    ..This Review describes the biology of these circulating markers of vessel wall injury, the methodologies used to measure them, and their possible relevance to patients with kidney disease...
  6. doi request reprint Endothelin receptor blockade in patients with diabetic nephropathy
    Ton J Rabelink
    LUMC Department of Nephrology, Leiden, The Netherlands
    Contrib Nephrol 172:235-42. 2011
    ..Of particular concern is the edema formation during ET receptor blockade...
  7. ncbi request reprint Endothelial progenitor cells: more than an inflammatory response?
    Ton J Rabelink
    Department of Nephrology, Leiden University Medical Center, The Netherlands
    Arterioscler Thromb Vasc Biol 24:834-8. 2004
    ..Particularly when therapeutically mobilizing CEPs, a further understanding of this issue is essential to assess the risk of potentially harmful side effects of altered CEP function...
  8. pmc Enhanced complement activation is part of the unfavourable cardiovascular risk profile in South Asians
    M A Siezenga
    Leiden University Medical Center, Department of Nephrology, Leiden, The Netherlands
    Clin Exp Immunol 157:98-103. 2009
    ..4, 95% confidence interval 1.8-15.8). These results suggest that enhanced complement activation is part of the unfavourable cardiovascular risk profile in South Asians...
  9. doi request reprint Inflammation, vascular injury and repair in rheumatoid arthritis
    A J van Zonneveld
    Department of Nephrology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Ann Rheum Dis 69:i57-60. 2010
    ..Taken together, in patients with RA, the impaired capacity of circulating cells to support vascular regeneration may comprise a novel pathway in the development of premature atherosclerosis...
  10. ncbi request reprint Multipotent mesenchymal stromal cell therapy in renal disease and kidney transplantation
    Marlies E J Reinders
    Correspondence and offprint requests to Dr Marlies E J Reinders E mail
    Nephrol Dial Transplant 25:17-24. 2010
    ..In this review, evidence for the renoprotective mechanisms of MSCs as well as their therapeutic possibilities and potential hazards in acute and chronic renal disease and allograft rejection is summarized...
  11. doi request reprint Recombinant human GH replacement increases CD34+ cells and improves endothelial function in adults with GH deficiency
    Agatha A van der Klaauw
    Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Eur J Endocrinol 159:105-11. 2008
    ..The aim of this study was to assess vascular structure and function in relation to circulating CD34+ cells in adults with GHD before and during 1 year of recombinant human GH (rhGH) replacement...
  12. doi request reprint Preservation of beta-cell function by targeting beta-cell mass
    Eelco J P de Koning
    Department of Nephrology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Trends Pharmacol Sci 29:218-27. 2008
    ..In this review, we address the mechanisms involved in beta-cell dysfunction and beta-cell loss, and provide a rationale for pharmacological intervention for the preservation and/or expansion of beta-cell mass in type 2 diabetes...
  13. ncbi request reprint Opportunities and challenges for mesenchymal stem cell-mediated heart repair
    Douwe E Atsma
    Department of Cardiology, and Einthoven Laboratory, Leiden University Medical Center, Leiden, The Netherlands
    Curr Opin Lipidol 18:645-9. 2007
    ..This review describes the potential of cardiac mesenchymal stem cell therapy, but also highlights some recently discovered less favorable mesenchymal stem cell characteristics...
  14. doi request reprint Urinary properdin excretion is associated with intrarenal complement activation and poor renal function
    Machiel A Siezenga
    Leiden University Medical Center, Department of Nephrology, Leiden, The Netherlands
    Nephrol Dial Transplant 25:1157-61. 2010
    ..We measured properdin in proteinuric urine and assessed its relation with urinary SC5b-9 levels, the soluble form of the effector phase of complement activation...
  15. doi request reprint Elevated CRP levels are associated with increased carotid atherosclerosis independent of visceral obesity
    Reza Alizadeh Dehnavi
    Department of General Internal Medicine and Endocrinology, Leiden University Medical Centre, Leiden, The Netherlands
    Atherosclerosis 200:417-23. 2008
    ..Elevated C-reactive protein (CRP) levels are associated with VO and cardiovascular disease. After exploring the relation between CRP and VO, we aimed to evaluate the VO independent relation between CRP and carotid atherosclerosis...
  16. doi request reprint Lower frequency of the 5/5 homozygous CNDP1 genotype in South Asian Surinamese
    A L Mooyaart
    Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands
    Diabetes Res Clin Pract 85:272-8. 2009
    ..Our study provides an indication that South Asian Surinamese are genetically at risk for developing diabetic nephropathy...
  17. doi request reprint Activated platelets correlate with mobilization of naïve CD34(+) cells and generation of CD34(+) /KDR(+) cells in the circulation. A meta-regression analysis
    H C de Boer
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands The Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
    J Thromb Haemost 11:1583-92. 2013
    ..Recently, we provided evidence that the major fraction of circulating CD34(+) /KDR(+) cells is not mobilized from bone marrow, but is generated at sites of vascular injury through interaction with platelets...
  18. doi request reprint Microvascular damage in type 1 diabetic patients is reversed in the first year after simultaneous pancreas-kidney transplantation
    M Khairoun
    Department of Nephrology, Leiden University Medical Center, The Netherlands
    Am J Transplant 13:1272-81. 2013
    ..SPK is effective in reversing the systemic microvascular structural abnormalities in DN patients in the first year after transplantation...
  19. doi request reprint Reversibility of capillary density after discontinuation of bevacizumab treatment
    N Steeghs
    Department of Clinical Oncology, Leiden University Medical Center, Leiden, The Netherlands
    Ann Oncol 21:1100-5. 2010
    ..Decreased capillary density may be the basis for VEGF inhibitor-related side-effects. We investigated whether the effects of bevacizumab on capillary density are reversible...
  20. ncbi request reprint Early mechanisms of renal injury in hypercholesterolemic or hypertriglyceridemic rats
    J A Joles
    Department of Nephrology and Hypertension, University Medical Center, Utrecht, The Netherlands
    J Am Soc Nephrol 11:669-83. 2000
    ..Such podocyte injury is accompanied by tubulointerstitial cell activation and injury...
  21. ncbi request reprint The renin-angiotensin system in diabetic nephropathy: the endothelial connection
    T J Rabelink
    Department of Nephrology and Hypertension, University Medical Center Utrecht, The Netherlands
    Miner Electrolyte Metab 24:381-8. 1998
    ..In addition, the potentially beneficial effects of blockade of the renin-angiotensin system on this endothelial dysbalance is discussed...
  22. pmc Non-invasive cardiac imaging techniques and vascular tools for the assessment of cardiovascular disease in type 2 diabetes mellitus
    R Djaberi
    Department of Cardiology, C5 P33, Leiden University Medical Center, Postbus 9600, 2300 RC, Leiden, The Netherlands
    Diabetologia 51:1581-93. 2008
    ..Therefore, we propose an algorithm for the screening of asymptomatic diabetic patients, the first step of which consists of coronary artery calcium score assessment and exercise ECG...
  23. ncbi request reprint Cyclosporine is associated with endothelial dysfunction but not with platelet activation in renal transplantation
    Y C Schrama
    Department of Nephrology, University Medical Centre Utrecht, Utrecht, The Netherlands
    Neth J Med 59:6-15. 2001
    ..CONCLUSIONS: The use of CsA is not accompanied by platelet activation. However endothelial dysfunction induced by CsA does occur as reflected by increased vWF and sP-selectin. (See Editorial p. 1)...
  24. doi request reprint Donor brain death predisposes human kidney grafts to a proinflammatory reaction after transplantation
    D K de Vries
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Am J Transplant 11:1064-70. 2011
    ..These observations suggest that brain dead donors require a novel approach for donor pretreatment aimed at preventing this inflammatory response to increase graft survival...
  25. doi request reprint Randomized trial of short-course high-dose erythropoietin in donation after cardiac death kidney transplant recipients
    Z Aydin
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Transplant 12:1793-800. 2012
    ..8 vs. placebo 78.7%, p = 1.00). Epoetin treatment significantly increased the risk of thrombotic events at 1 month and 1 year (Epoetin 24.4% vs. placebo 6.4%, p = 0.02)...
  26. ncbi request reprint Fibrin and activated platelets cooperatively guide stem cells to a vascular injury and promote differentiation towards an endothelial cell phenotype
    H C de Boer
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 26:1653-9. 2006
    ..One of the earliest responses to an injury is the activation of coagulation and platelets. In this study we assessed the role of hemostatic components in the recruitment of CD34+ cells to sites of injury...
  27. ncbi request reprint Proportionate increase of fibrinogen and albumin synthesis in nephrotic patients: measurements with stable isotopes
    M G de Sain-van der Velden
    Department of Nephrology, University Hospital Utrecht, The Netherlands
    Kidney Int 53:181-8. 1998
    ..These data suggest that in nephrotic patients the increased albumin synthesis is associated with an increase in synthesis of a specific and coordinated group of proteins, among which is fibrinogen...
  28. ncbi request reprint Endothelin-A receptor antagonist-mediated vasodilatation is attenuated by inhibition of nitric oxide synthesis and by endothelin-B receptor blockade
    M C Verhaar
    Department of Nephrology and Hypertension, University Hospital Utrecht, The Netherlands
    Circulation 97:752-6. 1998
    ....
  29. ncbi request reprint Central obesity is an independent risk factor for albuminuria in nondiabetic South Asian subjects
    Prataap K Chandie Shaw
    Department of Nephrology, Medical Center Haaglanden, Lijnbaan 32, P O Box 432, The Hague 2501 CK, The Netherlands
    Diabetes Care 30:1840-4. 2007
    ..In the current study, we explored the hypothesis that central obesity is associated with the development of renal injury, before the manifestation of diabetes...
  30. ncbi request reprint The role of nitric oxide in renal transplantation
    Ingrid H C Vos
    Department of Pathobiology, Division of Physiology, Leiden University Medical Center, The Netherlands
    Semin Nephrol 24:379-88. 2004
    ..This review focuses on the role of NO in the inflammatory endothelial-leukocyte interactions, which are implicated in acute and chronic rejection of the transplanted kidney...
  31. doi request reprint Glucagon-like peptide-1 receptor agonist treatment reduces beta cell mass in normoglycaemic mice
    J H Ellenbroek
    Department of Nephrology, Leiden University Medical Center, Postal Zone C7 P, PO Box 9600, 2300 RC, Leiden, The Netherlands
    Diabetologia 56:1980-6. 2013
    ..However, their effect on beta cell mass in normoglycaemic conditions is not clear. Here, we investigate the effects of the GLP-1RA liraglutide on beta cell mass and function in normoglycaemic mice...
  32. ncbi request reprint Reduction of VEGF-A and CTGF expression in diabetic nephropathy is associated with podocyte loss
    H J Baelde
    Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands
    Kidney Int 71:637-45. 2007
    ..This downregulation was related to a reduction of podocytes in DN. The results may suggest that downregulation of VEGF-A and CTGF in DN is a result of podocyte loss...
  33. pmc Increased carotid intima-media thickness as a predictor of the presence and extent of abnormal myocardial perfusion in type 2 diabetes
    Roxana Djaberi
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Diabetes Care 33:372-4. 2010
    ..We evaluated the potential of carotid intima-media thickness (CIMT) for prediction of abnormal myocardial perfusion in this population...
  34. ncbi request reprint Tetrahydrobiopterin, but not L-arginine, decreases NO synthase uncoupling in cells expressing high levels of endothelial NO synthase
    Lonneke M Bevers
    Department of Nephrology and Hypertension, Institute and Graduate School of Biomembranes, University Medical Centre, Utrecht, The Netherlands
    Hypertension 47:87-94. 2006
    ..Therefore, sustained increases of eNOS or VEGF activity should be accompanied by concomitant supplementation of BH4...
  35. pmc Differentiation of bone marrow-derived endothelial progenitor cells is shifted into a proinflammatory phenotype by hyperglycemia
    Cindy Jm Loomans
    Department of Nephrology and the Einthoven Laboratory for Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
    Mol Med 15:152-9. 2009
    ..Our study results show that hyperglycemia alters the differentiation fate of BM precursor cells, reducing the potential to generate vascular regenerative cells and favoring the development of proinflammatory cells...
  36. ncbi request reprint Endothelial progenitor cells: biology and therapeutic potential in hypertension
    Anton Jan van Zonneveld
    Department of Nephrology and Hypertension, Leiden University Medical Center, Leiden, The Netherlands
    Curr Opin Nephrol Hypertens 15:167-72. 2006
    ....
  37. ncbi request reprint An integrated evaluation of endothelial constitutive nitric oxide synthase polymorphisms and coronary artery disease in men
    Willem R P Agema
    Department of Cardiology, Leiden University Medical Center, The Netherlands
    Clin Sci (Lond) 107:255-61. 2004
    ..We conclude that the E/D298 polymorphism is most consistently associated with CAD, but not with progression of atherosclerosis. The E allele is associated with CAD and MI, whereas the D allele is associated with ischaemia...
  38. doi request reprint Complement activation by tubular cells is mediated by properdin binding
    Hilde Gaarkeuken
    Department of Nephrology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands
    Am J Physiol Renal Physiol 295:F1397-403. 2008
    ..We propose that this contribution of properdin is pivotal in tubular complement activation and subsequent damage. Interference with properdin binding to tubular cells may provide an option for the treatment of proteinuric renal disease...
  39. ncbi request reprint Disparate systemic and renal blocking properties of angiotensin II antagonists during exogenous angiotensin II administration: implications for treatment
    J M Willemsen
    Department of Nephrology, University Medical Center, Utrecht, The Netherlands
    J Hum Hypertens 18:857-63. 2004
    ..This sustained renal effect of candesartan may be of importance, especially in pathophysiological circumstances in which (high renal levels of) Ang II contributes to cardiovascular damage...
  40. doi request reprint Usefulness of carotid intima-media thickness in patients with diabetes mellitus as a predictor of coronary artery disease
    Roxana Djaberi
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Cardiol 104:1041-6. 2009
    ..01). In conclusion, a significant relation was shown between CIMT and the presence and severity of CAD in asymptomatic patients with DM. Assessment of CIMT may be useful to identify diabetic patients at higher risk for CAD...
  41. doi request reprint Improved viscosity modeling in patients with type 2 diabetes mellitus by accounting for enhanced red blood cell aggregation tendency
    Henri J M M Mutsaerts
    Division of Image Processing, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
    Clin Hemorheol Microcirc 44:303-13. 2010
    ..The present study evaluates viscosity modeling by implementation of hematocrit and RAT in patients with and without T2DM (non-T2DM)...
  42. ncbi request reprint Endothelial progenitor cell dysfunction in type 1 diabetes: another consequence of oxidative stress?
    Cindy J M Loomans
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Antioxid Redox Signal 7:1468-75. 2005
    ..Finally, we discuss the potential implication of our findings for EPC-based therapies and the potential impact of pharmacological interventions on the vascular regenerative capacity of EPC...
  43. doi request reprint Endothelial dysfunction in diabetic patients with abnormal myocardial perfusion in the absence of epicardial obstructive coronary artery disease
    Roxana Djaberi
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    J Nucl Med 50:1980-6. 2009
    ..We hypothesized that these perfusion abnormalities may be explained by endothelial dysfunction or occult coronary atherosclerosis...
  44. ncbi request reprint Angiotensin II type 1 receptor blockade improves hyperglycemia-induced endothelial dysfunction and reduces proinflammatory cytokine release from leukocytes
    Judith M Willemsen
    Department of Nephrology, Academic Medical Center, Amsterdam, The Netherlands
    J Cardiovasc Pharmacol 49:6-12. 2007
    ....
  45. ncbi request reprint Inducible nitric oxide synthase in renal transplantation
    Jaap A Joles
    Department of Nephrology and Hypertension, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Kidney Int 61:872-5. 2002
    ..This brief review discusses these aspects in relation to renal transplantation...
  46. doi request reprint Antagomir-mediated silencing of endothelial cell specific microRNA-126 impairs ischemia-induced angiogenesis
    Coen van Solingen
    Department of Nephrology and the Einthoven Laboratory for Experimental Vascular Medicine, LUMC, Leiden, The Netherlands
    J Cell Mol Med 13:1577-85. 2009
    ..Our data demonstrate a facilitary function for miR-126 in ischemia-induced angiogenesis and show the efficacy and specificity of antagomir-induced silencing of EC-specific microRNAs in vivo...
  47. ncbi request reprint Involvement of the proteasome in activation of endothelial nitric oxide synthase
    Roland Govers
    Department of Vascular Medicine, UMC Utrecht, Utrecht, The Netherlands
    Life Sci 73:2225-36. 2003
    ..Taken together, these data may indicate that eNOS is regulated by an interacting protein, different from caveolin-1, that inhibits its activity and is rapidly degraded by the proteasome in the presence of eNOS agonists...
  48. ncbi request reprint Is endothelial progenitor cell dysfunction involved in altered angiogenic processes in patients with hypertension?
    Cindy J M Loomans
    Department of Vascular Medicine, University Medical Center of Utrecht, G02 228, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Curr Hypertens Rep 6:51-4. 2004
    ....
  49. ncbi request reprint Endothelial progenitor cells: mainly derived from the monocyte/macrophage-containing CD34- mononuclear cell population and only in part from the hematopoietic stem cell-containing CD34+ mononuclear cell population
    Maarten B Rookmaaker
    Circulation 108:e150; author reply e150. 2003
  50. ncbi request reprint Thiazolidinediones and blood lipids in type 2 diabetes
    Jeroen P H van Wijk
    Department of Vascular Medicine, University Medical Center, University of Utrecht, Utrecht, The Netherlands
    Arterioscler Thromb Vasc Biol 23:1744-9. 2003
    ..Differences in both pharmacologic properties between agents and study population characteristics are likely to have influenced the results...
  51. ncbi request reprint Bone-marrow-derived cells contribute to endothelial repair after thrombotic microangiopathy
    Maarten B Rookmaaker
    Blood 99:1095. 2002
  52. ncbi request reprint Metabolic and additional vascular effects of thiazolidinediones
    Fabrice M A C Martens
    Department of Internal Medicine, Section of Vascular Medicine and Diabetology, University Medical Center Utrecht, Room F 02 126, Heidelberglaan 100, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Drugs 62:1463-80. 2002
    ..Furthermore, thiazolidinediones could have specific, direct effects on processes involved in the development of vascular abnormalities...
  53. ncbi request reprint Intensive lipid lowering by statin therapy does not improve vasoreactivity in patients with type 2 diabetes
    Ronald W van Etten
    Department of Vascular Medicine and Diabetes, University Medical Center, Utrecht, The Netherlands
    Arterioscler Thromb Vasc Biol 22:799-804. 2002
    ..Other factors, such as hyperglycemia, may be a more important contributing factor regarding impaired vasoreactivity in this patient group...
  54. ncbi request reprint Sympathetic activation markedly reduces endothelium-dependent, flow-mediated vasodilation
    Michel L Hijmering
    Department of Internal Medicine, Eemland Hospital, Amersfoort, The Netherlands
    J Am Coll Cardiol 39:683-8. 2002
    ..We sought to evaluate whether increased sympathetic outflow may interfere with flow-mediated dilation (FMD)...
  55. ncbi request reprint Wine polyphenols and ethanol do not significantly scavenge superoxide nor affect endothelial nitric oxide production
    Albert Huisman
    Department of Clinical Chemistry and Laboratory Medicine, University Medical Center, Utrecht, The Netherlands
    J Nutr Biochem 15:426-32. 2004
    ..The observed antiatherogenic effects must be caused by a mechanism other than direct scavenging of superoxide or influence on maximal endothelial NO production...
  56. ncbi request reprint Endothelial function and dysfunction: testing and clinical relevance
    John E Deanfield
    Vascular Physiology Unit, UCL Institute of Child Health, London, UK
    Circulation 115:1285-95. 2007
  57. ncbi request reprint Rosiglitazone improves postprandial triglyceride and free fatty acid metabolism in type 2 diabetes
    Jeroen P H van Wijk
    Department of Internal Medicine, University Medical Center Utrecht, Room G02 402, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Diabetes Care 28:844-9. 2005
    ..We investigated the effects of the peroxisome proliferator-activated receptor-gamma agonist rosiglitazone on postprandial lipemia in patients with type 2 diabetes...
  58. ncbi request reprint Comparison of rosiglitazone and metformin for treating HIV lipodystrophy: a randomized trial
    Jeroen P H van Wijk
    Department of Infectious Disease, University Medical Center, Utrecht, The Netherlands
    Ann Intern Med 143:337-46. 2005
    ..The use of antiretroviral combination therapy in HIV has been associated with lipodystrophy and cardiovascular risk factors...
  59. doi request reprint Nifedipine improves endothelial function: role of endothelial progenitor cells
    Tomonori Sugiura
    Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Hypertension 52:491-8. 2008
    ..These results demonstrate that nifedipine preserves endothelial integrity in patients with hypertension, at least partly, by enhancing EPC numbers and activity...
  60. ncbi request reprint CD34+ cells home, proliferate, and participate in capillary formation, and in combination with CD34- cells enhance tube formation in a 3-dimensional matrix
    Maarten B Rookmaaker
    Department of Vascular Medicine, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Arterioscler Thromb Vasc Biol 25:1843-50. 2005
    ..Most studies, however, used crude cell populations. Identifying the role of different cell populations is important for developing improved cellular therapies...
  61. ncbi request reprint TNF-alpha induces endothelial dysfunction in diabetic adults, an effect reversible by the PPAR-gamma agonist pioglitazone
    Fabrice M A C Martens
    Department of Internal Medicine, Section of Vascular Medicine, University Medical Center Utrecht, F02 126, Heidelberglaan 100, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Eur Heart J 27:1605-9. 2006
    ....
  62. ncbi request reprint FGFR1 and the bloodline of the vasculature
    Victor W M van Hinsbergh
    Arterioscler Thromb Vasc Biol 25:883-6. 2005
  63. ncbi request reprint Short-term pioglitazone treatment improves vascular function irrespective of metabolic changes in patients with type 2 diabetes
    Fabrice M A C Martens
    Department of Internal Medicine, Section of Vascular Medicine and Diabetology, University Medical Center, Utrecht, The Netherlands
    J Cardiovasc Pharmacol 46:773-8. 2005
    ..Short-term pioglitazone treatment ameliorates endothelial dysfunction in conduit arteries irrespective of changes in insulin, FFA, adiponectin, or CRP in type 2 patients with diabetes...
  64. ncbi request reprint Progenitor cells in the kidney: biology and therapeutic perspectives
    Maarten B Rookmaaker
    Department of Vascular Medicine, University Medical Center, Utrecht, The Netherlands
    Kidney Int 66:518-22. 2004
    ..Specifically, it will discuss the role of progenitor cells and transdifferentiation in renal repair and maintenance. Finally, the potential clinical implications of these findings will be discussed...
  65. ncbi request reprint Endothelial function in the post-prandial state
    Eelco J P de Koning
    Department of Vascular Medicine and Diabetes F02 126, University Medical Centre Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands
    Atheroscler Suppl 3:11-6. 2002
    ..This review will focus on post-prandial endothelial function characterised by endothelium-dependent changes in vasomotion...
  66. ncbi request reprint Anti-inflammatory effects of tetrahydrobiopterin on early rejection in renal allografts: modulation of inducible nitric oxide synthase
    Albert Huisman
    Department of Vascular Medicine, University Medical Center, Utrecht, The Netherlands
    FASEB J 16:1135-7. 2002
    ..Our findings support the hypothesis that BH4 can be used to modulate the function of the inflammatory iNOS isoform and suggest a potential therapeutic role for sepiapterin in early allograft rejection...
  67. ncbi request reprint Endothelial nitric oxide synthase and its negative regulator caveolin-1 localize to distinct perinuclear organelles
    Roland Govers
    Department of Vascular Medicine, UMC Utrecht, Utrecht, The Netherlands
    J Histochem Cytochem 50:779-88. 2002
    ..The localization of eNOS and caveolin-1 at distinct perinuclear compartments that behave differently in the presence of nocodazole indicates that eNOS activity is not regulated by caveolin-1 in the Golgi complex...
  68. ncbi request reprint Angiogenesis and endothelial cell repair in renal disease and allograft rejection
    Marlies E J Reinders
    Division of Nephrology, Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
    J Am Soc Nephrol 17:932-42. 2006
    ..Manipulation of the response may have therapeutic implications to protect against injury and chronic disease processes...
  69. ncbi request reprint Difference in the relation between urinary albumin excretion and carotid intima-media thickness in nondiabetic and type 2 diabetic subjects
    Gilles F H Diercks
    Diabetes Care 25:936-7. 2002
  70. ncbi request reprint A study of neovascularization in the rat ischemic hindlimb using Araldite casting and Spalteholtz tissue clearing
    Peter E Westerweel
    Department of Vascular Medicine, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands
    Cardiovasc Pathol 14:294-7. 2005
    ..We explored an alternative strategy to corrosion casting for visualizing neovascularization in a rat hindlimb ischemia model...
  71. pmc Endothelial nitric oxide synthase activity is linked to its presence at cell-cell contacts
    Roland Govers
    Department of Vascular Medicine, UMC Utrecht, Utrecht, The Netherlands
    Biochem J 361:193-201. 2002
    ..These data imply that cell-cell contact induces the localization of eNOS at intercellular junctions, which is required for agonist-induced eNOS activation...
  72. ncbi request reprint Assessment of flow-mediated vasodilatation (FMD) of the brachial artery: effects of technical aspects of the FMD measurement on the FMD response
    Michiel L Bots
    Julius Center for Health Sciences and Primary Care, HP Str 6 131 University Medical Center, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands
    Eur Heart J 26:363-8. 2005
    ..However, the absolute values obtained using this approach vary considerably across studies. We studied whether technical aspects of the methodology can explain the wide variety in absolute values across studies...
  73. pmc Bone-marrow-derived cells contribute to glomerular endothelial repair in experimental glomerulonephritis
    Maarten B Rookmaaker
    Department of Vascular Medicine, University Medical Center, Utrecht, The Netherlands
    Am J Pathol 163:553-62. 2003
    ..These findings provide novel insights into the pathogenesis of renal disease and suggest a potential role for stem cell therapy...
  74. ncbi request reprint Coupling eNOS uncoupling to the innate immune response
    Ton J Rabelink
    Arterioscler Thromb Vasc Biol 26:2585-7. 2006
  75. ncbi request reprint PPAR-gamma agonists: shifting attention from the belly to the heart?
    Jeroen P H van Wijk
    Arterioscler Thromb Vasc Biol 24:798-800. 2004
  76. ncbi request reprint Pharmacogenetics of the CD14 endotoxin receptor polymorphism and progression of coronary atherosclerosis
    Willem R P Agema
    Leiden University Medical Center, Department of Cardiology, C5 P, Albinusdreef 2, PO Box 9600, 2300 RC Leiden, The Netherlands
    Thromb Haemost 91:986-90. 2004
    ....
  77. ncbi request reprint Addition of glucose to an oral fat load reduces postprandial free fatty acids and prevents the postprandial increase in complement component 3
    Antonie J van Oostrom
    Department of Vascular Medicine, University Medical Center Utrecht, Utrecht, Netherlands
    Am J Clin Nutr 79:510-5. 2004
    ..C3 is the central component of the complement system and the precursor of acylation-stimulating protein (ASP). Insulin and ASP are principal determinants of free fatty acid (FFA) trapping by adipose tissue...
  78. ncbi request reprint Endothelin-A receptor antagonism reduces blood pressure and increases renal blood flow in hypertensive patients with chronic renal failure: a comparison of selective and combined endothelin receptor blockade
    Jane Goddard
    Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom
    Circulation 109:1186-93. 2004
    ..We therefore studied the systemic and renal hemodynamic effects of ET receptor antagonists in CRF and examined differences between selective ETA, selective ETB, and combined ETA/B receptor blockade...
  79. doi request reprint RANTES is required for ischaemia-induced angiogenesis, which may hamper RANTES-targeted anti-atherosclerotic therapy
    Peter E Westerweel
    Thromb Haemost 99:794-5. 2008
  80. ncbi request reprint Effects of rosiglitazone and metformin on postprandial paraoxonase-1 and monocyte chemoattractant protein-1 in human immunodeficiency virus-infected patients with lipodystrophy
    Blai Coll
    Servei de Medicina Interna and Centre de Recerca Biomèdica, Hospital Universitari, de Sant Joan, Reus, Spain
    Eur J Pharmacol 544:104-10. 2006
    ..To decrease insulin resistance results in a higher anti-oxidant and consequent lower pro-inflammatory action of HDL. This may confer protection against accelerated atherosclerosis in these patients...
  81. ncbi request reprint Endothelial progenitor cell dysfunction: a novel concept in the pathogenesis of vascular complications of type 1 diabetes
    Cindy J M Loomans
    Department of Vascular Medicine and Diabetology, University Medical Center Utrecht, Utrecht, The Netherlands
    Diabetes 53:195-9. 2004
    ..We hypothesize that EPC dysfunction contributes to the pathogenesis of vascular complications in type 1 diabetes...
  82. ncbi request reprint Cardiovascular risk in patients with renal disease: treating the risk or treating the risk factor?
    Ton J Rabelink
    University Medical Center Utrecht, Internal Medicine, Room G 02 228, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Nephrol Dial Transplant 19:23-6. 2004
  83. ncbi request reprint Microvessel haemodynamics: interesting news which is not NO news?
    Eelco J P de Koning
    Eur Heart J 24:2081-2. 2003
  84. ncbi request reprint Stem cell therapy for glomerular disease
    Ton J Rabelink
    J Am Soc Nephrol 17:2086-8. 2006
  85. ncbi request reprint Met-RANTES reduces endothelial progenitor cell homing to activated (glomerular) endothelium in vitro and in vivo
    Maarten B Rookmaaker
    Dept of Vascular Medicine, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Am J Physiol Renal Physiol 293:F624-30. 2007
    ..In conclusion, our data suggest that RANTES is involved in the homing and participation of BM-derived endothelial cells in glomerular repair...
  86. ncbi request reprint South-Asian type 2 diabetic patients have higher incidence and faster progression of renal disease compared with Dutch-European diabetic patients
    Prataap K Chandie Shaw
    Department of Internal Medicine and Nephrology, Medical Center Haaglanden, Lijnbaan 32, P O Box 432, 2501 CK The Hague, Netherlands
    Diabetes Care 29:1383-5. 2006
  87. ncbi request reprint Urinary albumin excretion is related to cardiovascular risk indicators, not to flow-mediated vasodilation, in apparently healthy subjects
    Gilles F H Diercks
    Department of Clinical Pharmacology, University of Groningen, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Atherosclerosis 163:121-6. 2002
    ..These data suggest that the presence of atherogenic risk factors precedes the development of endothelial dysfunction in microalbuminuric, but otherwise healthy subjects...