Klaus F Rabe

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. ncbi Guidelines for chronic obstructive pulmonary disease treatment and issues of implementation
    Klaus F Rabe
    Department of Pulmonology, C3 P, Leiden University Medical Center, Albinusdreef 2 Postbus 9600, Leiden 2300 RC, The Netherlands
    Proc Am Thorac Soc 3:641-4. 2006
  2. doi An electronic nose in the discrimination of patients with non-small cell lung cancer and COPD
    Silvano Dragonieri
    Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
    Lung Cancer 64:166-70. 2009
  3. ncbi Improving dyspnea in chronic obstructive pulmonary disease: optimal treatment strategies
    Klaus F Rabe
    Leiden University Medical Center, Department of Pulmonology, The Netherlands
    Proc Am Thorac Soc 3:270-5. 2006
  4. ncbi Worldwide severity and control of asthma in children and adults: the global asthma insights and reality surveys
    Klaus F Rabe
    Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
    J Allergy Clin Immunol 114:40-7. 2004
  5. doi Roflumilast for the treatment of chronic obstructive pulmonary disease
    Klaus F Rabe
    Leiden University Medical Center, Department of Pulmonology, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Expert Rev Respir Med 4:543-55. 2010
  6. doi Comparison of a combination of tiotropium plus formoterol to salmeterol plus fluticasone in moderate COPD
    Klaus F Rabe
    Department of Pulmonology C3 P, Leiden University Medical Center, Albinus dreef 2 Postbus, NL 2300 Leiden, The Netherlands
    Chest 134:255-62. 2008
  7. ncbi Effect of budesonide in combination with formoterol for reliever therapy in asthma exacerbations: a randomised controlled, double-blind study
    Klaus F Rabe
    Department of Pulmonology, University of Leiden, Leiden, Netherlands
    Lancet 368:744-53. 2006
  8. ncbi Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary
    Klaus F Rabe
    Leiden University Medical Center, Pulmonology, P O Box 9600, NL 2300 RC, Leiden, The Netherlands
    Am J Respir Crit Care Med 176:532-55. 2007
  9. ncbi Budesonide/formoterol in a single inhaler for maintenance and relief in mild-to-moderate asthma: a randomized, double-blind trial
    Klaus F Rabe
    Department of Pulmonology, C3 P, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Chest 129:246-56. 2006
  10. ncbi Roflumilast--an oral anti-inflammatory treatment for chronic obstructive pulmonary disease: a randomised controlled trial
    Klaus F Rabe
    Leiden University Medical Centre, Leiden, Netherlands
    Lancet 366:563-71. 2005

Detail Information

Publications87

  1. ncbi Guidelines for chronic obstructive pulmonary disease treatment and issues of implementation
    Klaus F Rabe
    Department of Pulmonology, C3 P, Leiden University Medical Center, Albinusdreef 2 Postbus 9600, Leiden 2300 RC, The Netherlands
    Proc Am Thorac Soc 3:641-4. 2006
    ..Large ongoing outcome studies may also have an effect on defining best practice within future guideline recommendations...
  2. doi An electronic nose in the discrimination of patients with non-small cell lung cancer and COPD
    Silvano Dragonieri
    Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
    Lung Cancer 64:166-70. 2009
    ..We hypothesized that an electronic nose can discriminate patients with lung cancer from COPD patients and healthy controls by analyzing the VOC-profile in exhaled breath...
  3. ncbi Improving dyspnea in chronic obstructive pulmonary disease: optimal treatment strategies
    Klaus F Rabe
    Leiden University Medical Center, Department of Pulmonology, The Netherlands
    Proc Am Thorac Soc 3:270-5. 2006
    ..The following short review aims to give an overview of the available clinical information of clinical trials performed over the last couple of years...
  4. ncbi Worldwide severity and control of asthma in children and adults: the global asthma insights and reality surveys
    Klaus F Rabe
    Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
    J Allergy Clin Immunol 114:40-7. 2004
    ..In 1995, the Global Initiative for Asthma (GINA) guidelines recommended goals for the management of asthma, which were updated in 2002. However, there are no recent international surveys on the real management of asthma...
  5. doi Roflumilast for the treatment of chronic obstructive pulmonary disease
    Klaus F Rabe
    Leiden University Medical Center, Department of Pulmonology, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Expert Rev Respir Med 4:543-55. 2010
    ..This article reviews the pharmacology, pharmacokinetics and preclinical pharmacology of roflumilast, the clinical studies supporting its use in COPD and its side-effect profile...
  6. doi Comparison of a combination of tiotropium plus formoterol to salmeterol plus fluticasone in moderate COPD
    Klaus F Rabe
    Department of Pulmonology C3 P, Leiden University Medical Center, Albinus dreef 2 Postbus, NL 2300 Leiden, The Netherlands
    Chest 134:255-62. 2008
    ....
  7. ncbi Effect of budesonide in combination with formoterol for reliever therapy in asthma exacerbations: a randomised controlled, double-blind study
    Klaus F Rabe
    Department of Pulmonology, University of Leiden, Leiden, Netherlands
    Lancet 368:744-53. 2006
    ....
  8. ncbi Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary
    Klaus F Rabe
    Leiden University Medical Center, Pulmonology, P O Box 9600, NL 2300 RC, Leiden, The Netherlands
    Am J Respir Crit Care Med 176:532-55. 2007
    ..The GOLD initiative will continue to bring COPD to the attention of governments, public health officials, health care workers, and the general public, but a concerted effort by all involved in health care will be necessary...
  9. ncbi Budesonide/formoterol in a single inhaler for maintenance and relief in mild-to-moderate asthma: a randomized, double-blind trial
    Klaus F Rabe
    Department of Pulmonology, C3 P, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Chest 129:246-56. 2006
    ..To compare a novel asthma management strategy--budesonide/formoterol in a single inhaler for both maintenance therapy and symptom relief--with a higher dose of budesonide plus as-needed terbutaline...
  10. ncbi Roflumilast--an oral anti-inflammatory treatment for chronic obstructive pulmonary disease: a randomised controlled trial
    Klaus F Rabe
    Leiden University Medical Centre, Leiden, Netherlands
    Lancet 366:563-71. 2005
    ..There are few treatment options for the disease. This study assessed the efficacy and safety of roflumilast, a phosphodiesterase-4 inhibitor, in patients with moderate to severe COPD...
  11. pmc Reduction in sputum neutrophil and eosinophil numbers by the PDE4 inhibitor roflumilast in patients with COPD
    Diana C Grootendorst
    Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
    Thorax 62:1081-7. 2007
    ..Results from in vitro studies with roflumilast indicate that it has anti-inflammatory properties that may be applicable for the treatment of COPD...
  12. doi Expression of smooth muscle and extracellular matrix proteins in relation to airway function in asthma
    Annelies M Slats
    Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
    J Allergy Clin Immunol 121:1196-202. 2008
    ..However, smooth muscle cells express several contractile and structural proteins, and each of these proteins may influence airway function distinctly...
  13. pmc Weekly self-monitoring and treatment adjustment benefit patients with partly controlled and uncontrolled asthma: an analysis of the SMASHING study
    Victor van der Meer
    Department of Medical Decision Making, Leiden University Medical Center, Leiden, The Netherlands
    Respir Res 11:74. 2010
    ..We hypothesized that self-management guided by weekly monitoring of asthma control tailors pharmacological therapy to individual needs and improves asthma control for patients with partly controlled or uncontrolled asthma...
  14. ncbi Effect of fluticasone with and without salmeterol on pulmonary outcomes in chronic obstructive pulmonary disease: a randomized trial
    Thérèse S Lapperre
    Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
    Ann Intern Med 151:517-27. 2009
    ..Inhaled corticosteroids (ICSs) and long-acting beta(2)-agonists (LABAs) are used to treat moderate to severe chronic obstructive pulmonary disease (COPD)...
  15. doi CD8(+) T cells characterize early smoking-related airway pathology in patients with asthma
    A Janneke Ravensberg
    Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
    Respir Med 107:959-66. 2013
    ..Bronchial CD8(+) T cells are implicated in lung function decline in asthma and COPD. We hypothesized that smoking modifies airway inflammation in asthma by increasing the number of CD8(+) T cells at an early stage...
  16. pmc Smoking status and anti-inflammatory macrophages in bronchoalveolar lavage and induced sputum in COPD
    Lisette I Z Kunz
    Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
    Respir Res 12:34. 2011
    ..Our aim was to study macrophage heterogeneity using the M2-marker CD163 and selected pro- and anti-inflammatory mediators in bronchoalveolar lavage (BAL) fluid and induced sputum from current smokers and ex-smokers with COPD...
  17. pmc IL-4 and IL-13 exposure during mucociliary differentiation of bronchial epithelial cells increases antimicrobial activity and expression of antimicrobial peptides
    Suzanne Zuyderduyn
    Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
    Respir Res 12:59. 2011
    ..These data suggest that prolonged exposure to Th2 cytokines during mucociliary differentiation contributes to antimicrobial defence by increasing the expression and release of selected antimicrobial peptides and mucus...
  18. ncbi Epithelial differentiation is a determinant in the production of eotaxin-2 and -3 by bronchial epithelial cells in response to IL-4 and IL-13
    Sandra van Wetering
    Department of Pulmonology, Bldg 1, C3 P, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Mol Immunol 44:803-11. 2007
    ..These findings may provide new insights into the role of airway epithelial differentiation and Th2 cytokines in the pathogenesis of inflammatory lung disorders such as asthma...
  19. pmc A molecular signature of epithelial host defense: comparative gene expression analysis of cultured bronchial epithelial cells and keratinocytes
    Joost B Vos
    Dept of Pulmonology, Leiden University Medical Center, Leiden, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    BMC Genomics 7:9. 2006
    ..These data sets were used to elucidate a common denominator in epithelial host defense...
  20. ncbi Are rhinovirus-induced airway responses in asthma aggravated by chronic allergen exposure?
    Josephine de Kluijver
    Lung Function Laboratory, Department of Pulmonology, Leiden University Medical Center, P O Box 9600, NL 2300 RC Leiden, The Netherlands
    Am J Respir Crit Care Med 168:1174-80. 2003
    ..This suggests that preceding allergen exposure, at the used dose and duration, is not a determinant of the severity of RV-induced exacerbations in patients with mild to moderate asthma...
  21. ncbi Neutrophil defensins enhance lung epithelial wound closure and mucin gene expression in vitro
    Jamil Aarbiou
    Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Respir Cell Mol Biol 30:193-201. 2004
    ..Neutrophil defensin-enhanced wound repair appears to require epidermal growth factor receptor activation and downstream signaling pathways...
  22. pmc Cost-effectiveness of Internet-based self-management compared with usual care in asthma
    Victor van der Meer
    Department of Medical Decision Making, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 6:e27108. 2011
    ..Effectiveness of Internet-based self-management in patients with asthma has been shown, but its cost-effectiveness is unknown. We conducted a cost-effectiveness analysis of Internet-based asthma self-management compared with usual care...
  23. ncbi Asymptomatic worsening of airway inflammation during low-dose allergen exposure in asthma: protection by inhaled steroids
    Josephine de Kluijver
    Department of Pulmonology, Lung Function Laboratory, C2 P 62 Leiden University Medical Center, PO Box 9600, NL 2300 RC Leiden, The Netherlands
    Am J Respir Crit Care Med 166:294-300. 2002
    ..This suggests that antiinflammatory therapy is beneficial during allergen exposure, even during asymptomatic episodes...
  24. ncbi The antimicrobial peptide LL-37 enhances IL-8 release by human airway smooth muscle cells
    Suzanne Zuyderduyn
    Department of Pulmonology, Leiden University Medical Center, The Netherlands
    J Allergy Clin Immunol 117:1328-35. 2006
    ..Inflammatory cells contain antimicrobial peptides including the cathelicidin LL-37 and neutrophil defensins (HNP1-3)...
  25. pmc Comparison of exhaled breath condensate pH using two commercially available devices in healthy controls, asthma and COPD patients
    Rembert Koczulla
    Department of Pulmonology, Leiden University Medical Center, The Netherlands
    Respir Res 10:78. 2009
    ..Analysis of exhaled breath condensate (EBC) is a non-invasive method for studying the acidity (pH) of airway secretions in patients with inflammatory lung diseases...
  26. ncbi Human cathelicidin LL-37 is a chemoattractant for eosinophils and neutrophils that acts via formyl-peptide receptors
    G Sandra Tjabringa
    Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
    Int Arch Allergy Immunol 140:103-12. 2006
    ..Therefore, the aim of the present study was to investigate the chemotactic activity of LL-37 for eosinophils and to explore the mechanisms involved in LL-37-mediated attraction of neutrophils and eosinophils...
  27. ncbi Bronchial inflammation and airway responses to deep inspiration in asthma and chronic obstructive pulmonary disease
    Annelies M Slats
    Leiden University Medical Center, Department of Pulmonology C2 P 62, P O Box 9600, 2300 RC Leiden, and Department of Pediatrics, Erasmus University Medical Center Sophia Children s Hospital, Rotterdam, The Netherlands
    Am J Respir Crit Care Med 176:121-8. 2007
    ..Airway inflammation has been suggested to alter airway mechanics during deep inspiration...
  28. doi Transesophageal ultrasound-guided fine-needle aspiration for the mediastinal restaging of non-small cell lung cancer
    Martin B von Bartheld
    Divisions of Pulmonary Medicine, Leiden University Medical Center, Leiden, The Netherlands
    J Thorac Oncol 6:1510-5. 2011
    ..We assessed sensitivity and false-negative rate of EUS-FNA for the mediastinal restaging of patients with stage III NSCLC...
  29. ncbi Small airways dysfunction and neutrophilic inflammation in bronchial biopsies and BAL in COPD
    Thérèse S Lapperre
    Department of Pulmonology, Leiden University Medical Center, Albinusdreef 2, PO Box 9600, NL 2300 RC Leiden, The Netherlands
    Chest 131:53-9. 2007
    ..We investigated whether uneven ventilation and airway closure are associated with specific markers of airway inflammation as obtained by bronchial biopsies, BAL, and induced sputum in patients with manifest COPD...
  30. pmc Differential distribution of inflammatory cells in large and small airways in smokers
    Salvatore Battaglia
    Department of Pulmonology, Leiden University Medical Centre LUMC, Leiden, The Netherlands
    J Clin Pathol 60:907-11. 2007
    ..Hypothesis: The content of cells infiltrating the airway wall differs between LA and SA...
  31. doi Illness perceptions and COPD: an emerging field for COPD patient management
    Ad A Kaptein
    Unit of Psychology, Leiden University Medical Centre LUMC, Leiden, The Netherlands
    J Asthma 45:625-9. 2008
    ..This article reviews the empirical literature on illness perceptions in patients with COPD to provide clinicians with information regarding the potential utility of incorporating illness perceptions into clinical COPD care...
  32. doi 50 years of psychological research on patients with COPD--road to ruin or highway to heaven?
    Ad A Kaptein
    Unit of Psychology, Leiden University Medical Centre LUMC, Leiden, The Netherlands
    Respir Med 103:3-11. 2009
    ..To review the topic of behavioural research on patients with COPD over the past 50 years in order to help inform clinical management and future research on psychosocial aspects of COPD...
  33. ncbi Host defense effector molecules in mucosal secretions
    G Sandra Tjabringa
    Department of Pulmonology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    FEMS Immunol Med Microbiol 45:151-8. 2005
    ....
  34. ncbi Endoscopic ultrasound-guided fine-needle aspiration in the diagnosis and staging of lung cancer and its impact on surgical staging
    Jouke T Annema
    Department of Pulmonary Medicine, Leiden University Medical Center, Leiden, The Netherlands
    J Clin Oncol 23:8357-61. 2005
    ..The goal of this study was to assess to what extent EUS-FNA could prevent surgical interventions...
  35. ncbi Eotaxin-2 and eotaxin-3 expression is associated with persistent eosinophilic bronchial inflammation in patients with asthma after allergen challenge
    A Janneke Ravensberg
    Department of Pulmonology, Lung Function Laboratory C2 P 62, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Allergy Clin Immunol 115:779-85. 2005
    ..Eotaxin-2 and eotaxin-3 might play a role in the subsequent persistence of allergen-induced bronchial eosinophilia...
  36. ncbi The antimicrobial peptide LL-37 activates innate immunity at the airway epithelial surface by transactivation of the epidermal growth factor receptor
    G Sandra Tjabringa
    Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
    J Immunol 171:6690-6. 2003
    ..LL-37 may thus constitute one of the mediators by which neutrophils regulate epithelial cell activity in the lung...
  37. ncbi Internet-based self-management plus education compared with usual care in asthma: a randomized trial
    Victor van der Meer
    Leiden University Medical Center, Leiden, The Netherlands
    Ann Intern Med 151:110-20. 2009
    ..The Internet may support patient self-management of chronic conditions, such as asthma...
  38. doi Mediastinoscopy vs endosonography for mediastinal nodal staging of lung cancer: a randomized trial
    Jouke T Annema
    Department of Pulmonology, C3 P, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    JAMA 304:2245-52. 2010
    ..Current guidelines acknowledge minimally invasive endosonography followed by surgical staging (if no nodal metastases are found by endosonography) as an alternative to immediate surgical staging...
  39. doi Endosonography vs conventional bronchoscopy for the diagnosis of sarcoidosis: the GRANULOMA randomized clinical trial
    Martin B von Bartheld
    Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
    JAMA 309:2457-64. 2013
    ..Bronchoscopy with transbronchial lung biopsies, the current diagnostic standard, has moderate sensitivity in assessing granulomas. Endosonography with intrathoracic nodal aspiration appears to be a promising diagnostic technique...
  40. pmc Effects of cigarette smoke condensate on proliferation and wound closure of bronchial epithelial cells in vitro: role of glutathione
    Fabrizio Luppi
    Department of Pulmonology, Leiden University Medical Center, PO Box 9600, 2300RC, Leiden, The Netherlands
    Respir Res 6:140. 2005
    ..We also studied whether modulation of intracellular glutathione/thiol levels could attenuate CSC-induced cell proliferation...
  41. ncbi Antiinflammatory effects of the phosphodiesterase-4 inhibitor cilomilast (Ariflo) in chronic obstructive pulmonary disease
    Elizabeth Gamble
    Department of Pulmonology, Leiden University Medical Centre, Leiden, The Netherlands
    Am J Respir Crit Care Med 168:976-82. 2003
    ..Phosphodiesterase-4 inhibitors represent a promising new class of substances for use in antiinflammatory treatment of this disease...
  42. doi Patients cured from craniopharyngioma or nonfunctioning pituitary macroadenoma (NFMA) suffer similarly from increased daytime somnolence despite normal sleep patterns compared to healthy controls
    Agatha A van der Klaauw
    Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands
    Clin Endocrinol (Oxf) 69:769-74. 2008
    ..This could be related to disturbed sleep patterns. The aim of this study was to compare sleepiness and sleep patterns in those patients to healthy controls and to patients treated for nonfunctioning macroadenomas (NFMA) of the pituitary...
  43. doi Transaortic EUS-guided FNA in the diagnosis of lung tumors and lymph nodes
    Martin B von Bartheld
    Division of Pulmonary Medicine, Leiden University Medical Center, Leiden, The Netherlands
    Gastrointest Endosc 69:345-9. 2009
    ..Para-aortic lung tumors can be clearly visualized by EUS. Although the accessibility of lesions adjacent to the esophagus is well documented, the para-aortic region has never been systematically explored...
  44. pmc Concerns about exercise are related to walk test results in pulmonary rehabilitation for patients with COPD
    Maarten J Fischer
    Medical Psychology, Leiden University Medical Center LUMC, P O Box 9555, 2300, RB, Leiden, The Netherlands
    Int J Behav Med 19:39-47. 2012
    ....
  45. ncbi Expression of the anaphylatoxin receptors C3aR and C5aR is increased in fatal asthma
    Laura Fregonese
    Department of Pulmonology, Leiden University Medical Centre, Albinusdreef 2, 2233 ZA Leiden, The Netherlands
    J Allergy Clin Immunol 115:1148-54. 2005
    ..Recent studies suggest the involvement of the anaphylatoxins C3a and C5a, generated during complement activation, and their receptors C3aR and C5aR in the pathogenesis of asthma...
  46. ncbi An electronic nose in the discrimination of patients with asthma and controls
    Silvano Dragonieri
    Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
    J Allergy Clin Immunol 120:856-62. 2007
    ..Exhaled breath contains thousands of volatile organic compounds (VOCs) that could serve as biomarkers of lung disease. Electronic noses can distinguish VOC mixtures by pattern recognition...
  47. ncbi Exploring host-pathogen interactions at the epithelial surface: application of transcriptomics in lung biology
    Joost B Vos
    Department of Pulmonology, Leiden Amsterdam Center for Drug Research, Leiden University Medical Center, Leiden, The Netherlands
    Am J Physiol Lung Cell Mol Physiol 292:L367-77. 2007
    ..In particular, the interactions between epithelial cells in the human lungs and clinically relevant microorganisms are the central focus of this review...
  48. pmc Rapid KRAS, EGFR, BRAF and PIK3CA mutation analysis of fine needle aspirates from non-small-cell lung cancer using allele-specific qPCR
    Ronald van Eijk
    Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 6:e17791. 2011
    ..We conclude that molecular profiling can be reliably performed on fine needle cytology aspirates from NSCLC patients...
  49. ncbi Diaphragm plication in adult patients with diaphragm paralysis leads to long-term improvement of pulmonary function and level of dyspnea
    Michel I M Versteegh
    Department of Cardio Thoracic Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Cardiothorac Surg 32:449-56. 2007
    ..We analyzed the long-term effects on pulmonary function and level of dyspnea after unilateral or bilateral diaphragm plication...
  50. ncbi Mechanisms of bronchial hyperreactivity in asthma and chronic obstructive pulmonary disease
    Diana C Grootendorst
    Leiden University Medical Centre, Department of Pulmonology C3 P, P O Box 9600, 2300 RC Leiden, The Netherlands
    Proc Am Thorac Soc 1:77-87. 2004
    ..The aim of this review is to present an overview of current knowledge of the mechanisms of bronchial hyperreactivity in asthma and COPD...
  51. ncbi Update in chronic obstructive pulmonary disease 2006
    Klaus F Rabe
    Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Respir Crit Care Med 175:1222-32. 2007
  52. doi Implementation of endoscopic ultrasound for lung cancer staging
    Jouke T Annema
    Division of Pulmonary Medicine, Leiden University Medical Center, Leiden, The Netherlands
    Gastrointest Endosc 71:64-70, 70.e1. 2010
    ..To date, training requirements for chest physicians to obtain competency in EUS for lung cancer staging are unknown...
  53. ncbi The human cathelicidin LL-37: a multifunctional peptide involved in infection and inflammation in the lung
    G Sandra Tjabringa
    Department of Pulmonology, Leiden University Medical Center, Building 1, C3 P, P O Box 9600, NL 2300 RC Leiden, The Netherlands
    Pulm Pharmacol Ther 18:321-7. 2005
    ..In addition, the importance of the fact that antimicrobial peptides such as LL-37 display a range of activities for the design and development of antimicrobial peptides for therapeutic use is discussed...
  54. ncbi Illness perceptions and quality of life in patients with chronic obstructive pulmonary disease
    Margreet Scharloo
    Medical Psychology, Leiden University Medical Center, Leiden, The Netherlands
    J Asthma 44:575-81. 2007
    ..The results of this study are discussed in relation to the associations found in other illnesses...
  55. ncbi Transcriptional response of bronchial epithelial cells to Pseudomonas aeruginosa: identification of early mediators of host defense
    Joost B Vos
    Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
    Physiol Genomics 21:324-36. 2005
    ..aeruginosa is characterized by expression of genes involved in epithelial barrier formation and host defense...
  56. ncbi Selective phosphodiesterase inhibitors for the treatment of asthma and chronic obstructive pulmonary disease
    Diana C Grootendorst
    Department of Pulmonology C2 P, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Curr Opin Allergy Clin Immunol 2:61-7. 2002
    ..The aim of the present review is to discuss the results of recent clinical intervention studies with phosphodiesterase-4 inhibitors in patients with asthma or chronic obstructive pulmonary disease...
  57. doi Illness perceptions about asthma are determinants of outcome
    Ad A Kaptein
    Unit of Psychology, Leiden University Medical Centre, Leiden, The Netherlands
    J Asthma 45:459-64. 2008
    ....
  58. doi Drop-out and attendance in pulmonary rehabilitation: the role of clinical and psychosocial variables
    Maarten J Fischer
    Medical Psychology, Leiden University Medical Centre LUMC, Wassenaarseweg 52, 2333 AK Leiden, The Netherlands
    Respir Med 103:1564-71. 2009
    ....
  59. doi Somatostatin analog treatment is associated with an increased sleep latency in patients with long-term biochemical remission of acromegaly
    Agatha A van der Klaauw
    Department of Endocrinology and Metabolic Diseases C4 R, Leiden University Medical Center, PO Box 9600, RC Leiden, The Netherlands
    Growth Horm IGF Res 18:446-53. 2008
    ..Somatostatin analogs induce alterations in sleep in healthy adults. Presently, it is unknown whether somatostatin analog treatment affects sleep parameters in patients with acromegaly...
  60. ncbi Sexuality in patients with asthma and COPD
    Ad A Kaptein
    Psychology Unit, Leiden University Medical Centre LUMC, P O Box 9555, 2300 RB Leiden, The Netherlands
    Respir Med 102:198-204. 2008
    ..Sexuality needs to be discussed by the health care provider in the consultation in order to improve quality of life of patients with chronic respiratory disorders...
  61. ncbi Mediastinal restaging: EUS-FNA offers a new perspective
    Jouke T Annema
    Department of Pulmonology C3 P, Albinusdreef 2, P O Box 9600, 2300 RC Leiden University Medical Center, Leiden, The Netherlands
    Lung Cancer 42:311-8. 2003
    ..The current restaging modalities either have a low diagnostic accuracy (computed tomography (CT) scan of the thorax) or they are invasive, can be technically difficult and are therefore not commonly performed (remediastinoscopy)...
  62. ncbi TGF-beta differentially regulates TH2 cytokine-induced eotaxin and eotaxin-3 release by human airway smooth muscle cells
    Suzanne Zuyderduyn
    Department of Pulmonology, Leiden University Medical Center, The Netherlands
    J Allergy Clin Immunol 114:791-8. 2004
    ..TH2 cytokines and TGF-beta can be found in increased levels in patients with asthma, and these cytokines may be involved in the regulation of chemokine expression...
  63. ncbi Analysis of subcarinal lymph nodes in (suspected) non-small-cell lung cancer after a negative transbronchial needle aspiration -- what's next? A preliminary report
    Jouke T Annema
    Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
    Respiration 71:630-4. 2004
    ..Transbronchial needle aspiration (TBNA) of subcarinal lymph nodes (LN) has a variable yield. Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) has demonstrated a high accuracy in the analysis of enlarged subcarinal LN...
  64. ncbi EUS-guided FNA of centrally located lung tumours following a non-diagnostic bronchoscopy
    Jouke T Annema
    Division of Pulmonary Medicine, Leiden University Medical Center, Leiden, The Netherlands
    Lung Cancer 48:357-61; discussion 363-4. 2005
    ..To assess the feasibility and yield of endoscopic ultrasound (EUS) guided fine needle aspiration (FNA) in diagnosing centrally located lung tumours after a previously non-diagnostic bronchoscopy...
  65. ncbi Rounded mass in the middle lobe after Swan-Ganz catheterization
    Joey J Brahim
    Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
    Chest 121:261-3. 2002
  66. pmc Markers of exacerbation severity in chronic obstructive pulmonary disease
    Luigi G Franciosi
    Leiden Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands
    Respir Res 7:74. 2006
    ..In an attempt to find the best surrogates for exacerbations, we have reviewed the literature to identify which of these markers change in a consistent manner with the severity of the exacerbation event...
  67. ncbi Assessment of microvascular leakage via sputum induction: the role of substance P and neurokinin A in patients with asthma
    Elizabeth L J Van Rensen
    Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Respir Crit Care Med 165:1275-9. 2002
    ..This investigational model of "dual induction" (first leakage, then sputum) may therefore be useful to test the antiexudative effect of newly develop drugs, such as NK1 antagonists...
  68. ncbi Role of defensins in inflammatory lung disease
    Jamil Aarbiou
    Department of Pulmonology, Leiden University Medical Center, The Netherlands
    Ann Med 34:96-101. 2002
    ..Future studies are required to elucidate their role in the pathogenesis of these diseases...
  69. ncbi Human neutrophil defensins induce lung epithelial cell proliferation in vitro
    Jamil Aarbiou
    Departments of Pulmonology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    J Leukoc Biol 72:167-74. 2002
    ..These data suggest that neutrophil defensins may possibly be involved in epithelial repair in the airways by inducing lung epithelial cell proliferation...
  70. ncbi Endoscopic ultrasound added to mediastinoscopy for preoperative staging of patients with lung cancer
    Jouke T Annema
    Division of Pulmonary Medicine, Leiden University Medical Center, Leiden, The Netherlands
    JAMA 294:931-6. 2005
    ..In addition, EUS can identify tumor invasion in neighboring organs if tumors are located adjacent to the esophagus...
  71. doi EUS-FNA for the detection of left adrenal metastasis in patients with lung cancer
    Olga C J Schuurbiers
    Department of Pulmonology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Lung Cancer 73:310-5. 2011
    ..Therefore, EUS-FNA qualifies as the staging test of choice for patients with lung cancer with suspected left adrenal metastases...
  72. ncbi Bilateral cavitary pulmonary consolidations in a patient undergoing allogeneic bone marrow transplantation for acute leukemia
    Thyo J N Hiltermann
    Department of Pulmonology, Leiden University Medical Center, The Netherlands
    Chest 123:929-34. 2003
  73. doi Systemic manifestations of COPD
    Yvonne Nussbaumer-Ochsner
    Department of Pulmonology, Leiden University Medical Center, C3 P, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Chest 139:165-73. 2011
    ..The treatment of COPD is no longer focused exclusively on inhaled therapy but is taking on a multidimensional approach, especially because the treatment of the comorbidities might positively affect the course of COPD itself...
  74. ncbi Chronic sinusitis in severe asthma is related to sputum eosinophilia
    Anneke ten Brinke
    Department of Pulmonary Diseases, Leiden University Medical Center, Leiden, The Netherlands
    J Allergy Clin Immunol 109:621-6. 2002
    ..We hypothesized that the extent of inflammation in the nasal mucosa is related to lung function and inflammation in the bronchial mucosa in patients with severe asthma...
  75. ncbi A prospective clinical study of theophylline safety in 3810 elderly with asthma or COPD
    Ken Ohta
    Department of Medicine, School of Medicine, Teikyo University, 2 11 1 Kaga, Itabashi ku, Tokyo, Japan
    Respir Med 98:1016-24. 2004
    ..1%), and no correlation was noted between dose and theophylline-related adverse events. These results suggest that sustained-release theophylline can be used safely in elderly patients with asthma or COPD...
  76. ncbi Update in chronic obstructive pulmonary disease 2005
    Leonardo M Fabbri
    Department of Respiratory Diseases, University of Modena and Reggio Emilia, Via del Pozzo 71, 41100 Modena, Italy
    Am J Respir Crit Care Med 173:1056-65. 2006
  77. ncbi Novel concepts of neuropeptide-based drug therapy: vasoactive intestinal polypeptide and its receptors
    David A Groneberg
    Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany
    Eur J Pharmacol 533:182-94. 2006
    ....
  78. ncbi Formoterol for maintenance and as-needed treatment of chronic obstructive pulmonary disease
    Malcolm Campbell
    University of Glasgow, Glasgow, UK
    Respir Med 99:1511-20. 2005
    ..Both formoterol regimens were well tolerated with no differences in adverse events or electrocardiogram profiles...
  79. ncbi Markers of disease severity in chronic obstructive pulmonary disease
    Luigi G Franciosi
    Gorlaeus Laboratories, Leiden Amsterdam Center for Drug Research, Leiden University, The Netherlands
    Pulm Pharmacol Ther 19:189-99. 2006
    ....
  80. ncbi Predictors of poor asthma control in European adults
    Joan B Soriano
    Worldwide Epidemiology, GlaxoSmithKline Research and Development, Greenford, Middlesex, UK
    J Asthma 40:803-13. 2003
    ..Asthma management practices and the knowledge, attitudes, and behavior of adult asthmatics in the general population are associated with the degree of asthma control...
  81. ncbi Patient preferences for asthma therapy: a discrete choice experiment
    Andrew Lloyd
    Deputy Director Europe, United BioSource Corporation, 20 Bloomsbury Square, London, WC1A 2NS, UK
    Prim Care Respir J 16:241-8. 2007
    ..This study was designed to capture patient preferences for different aspects of asthma treatment from people with asthma in the UK, the Netherlands and Spain...
  82. doi Lung cancer staging with minimally invasive endoscopic techniques
    Jouke T Annema
    JAMA 299:2510; author reply 2510-1. 2008
  83. ncbi Obtaining optimal control in mild asthma: theory and practice
    Louise Watson
    Department of Worldwide Epidemiology, GlaxoSmithKline, Greenford, Middlesex, UK
    Fam Pract 22:305-10. 2005
    ..Studies have shown that asthma severity is easily under-estimated and as a result, patients may be under-treated with reduced asthma control...
  84. ncbi "Refractory" eosinophilic airway inflammation in severe asthma: effect of parenteral corticosteroids
    Anneke ten Brinke
    Department of Pulmonary Diseases, Leeuwarden Medical Center, The Netherlands
    Am J Respir Crit Care Med 170:601-5. 2004
    ..This implies that these patients with severe asthma need additional or alternative antiinflammatory treatment to combat the eosinophilia and associated poor prognosis...
  85. ncbi Treating COPD--the TORCH trial, P values, and the Dodo
    Klaus F Rabe
    N Engl J Med 356:851-4. 2007
  86. ncbi Why respiratory physicians should learn and implement EUS-FNA
    Jouke T Annema
    Am J Respir Crit Care Med 176:99; author reply 99. 2007
  87. ncbi [Guidelines for diagnosis and therapy of patients with asthma 2005. The most important aspects for adults]
    Gerhard Schultze-Werninghaus
    BG Kliniken Bergmannsheil Ruhr Universität Bochum, Medizinische Klinik III Pneumologie, Allergologie, Schlaf und Beatmungsmedizin, Burkle de la Camp Platz 1, 44789 Bochum
    Med Klin (Munich) 101:60-4. 2006