H Putter

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint Tutorial in biostatistics: competing risks and multi-state models
    H Putter
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands
    Stat Med 26:2389-430. 2007
  2. pmc NKG2D ligand tumor expression and association with clinical outcome in early breast cancer patients: an observational study
    Esther M de Kruijf
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    BMC Cancer 12:24. 2012
  3. pmc Dynamic predicting by landmarking as an alternative for multi-state modeling: an application to acute lymphoid leukemia data
    Hans C van Houwelingen
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Post Zone S5 P, P O Box 9600, Leiden, 2300 RC, The Netherlands
    Lifetime Data Anal 14:447-63. 2008
  4. pmc Impact of established prognostic factors and molecular subtype in very young breast cancer patients: pooled analysis of four EORTC randomized controlled trials
    Jos A van der Hage
    Division of Surgical Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Breast Cancer Res 13:R68. 2011
  5. pmc The influence of micrometastases on prognosis and survival in stage I-II colon cancer patients: the Enroute⊕ Study
    Daniel J Lips
    Department of Surgery, Jeroen Bosch Hospital, Nieuwstraat 34, 5211 NL s Hertogenbosch, The Netherlands
    BMC Surg 11:11. 2011
  6. pmc Model selection based on logistic regression in a highly correlated candidate gene region
    Hae Won Uh
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands
    BMC Proc 1:S114. 2007
  7. pmc How to quantify information loss due to phase ambiguity in haplotype case-control studies
    Hae Won Uh
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands
    BMC Genet 6:S108. 2005
  8. pmc Modeling the effect of an associated single-nucleotide polymorphism in linkage studies
    Jeanine J Houwing-Duistermaat
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands
    BMC Genet 6:S46. 2005
  9. pmc Influence of genotyping error in linkage mapping for complex traits--an analytic study
    Jeremie J P Lebrec
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Postzone S 05 P, PO Box 9600 2300 RC Leiden, The Netherlands
    BMC Genet 9:57. 2008
  10. pmc Assessment of global phase uncertainty in case-control studies
    Hae Won Uh
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands
    BMC Genet 10:54. 2009

Detail Information

Publications145 found, 100 shown here

  1. ncbi request reprint Tutorial in biostatistics: competing risks and multi-state models
    H Putter
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands
    Stat Med 26:2389-430. 2007
    ..Examples of analysis with standard software are shown...
  2. pmc NKG2D ligand tumor expression and association with clinical outcome in early breast cancer patients: an observational study
    Esther M de Kruijf
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    BMC Cancer 12:24. 2012
    ..We examined tumor expression and prognostic effect of NKG2DL in breast cancer patients...
  3. pmc Dynamic predicting by landmarking as an alternative for multi-state modeling: an application to acute lymphoid leukemia data
    Hans C van Houwelingen
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Post Zone S5 P, P O Box 9600, Leiden, 2300 RC, The Netherlands
    Lifetime Data Anal 14:447-63. 2008
    ..The landmark methodology does not need complex modeling and leads to easy prediction rules. On the other hand, it does not give the insight in the biological processes as obtained for the multi-state model...
  4. pmc Impact of established prognostic factors and molecular subtype in very young breast cancer patients: pooled analysis of four EORTC randomized controlled trials
    Jos A van der Hage
    Division of Surgical Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Breast Cancer Res 13:R68. 2011
    ..The purpose of this study was to determine the prognostic value of established clinical and pathological prognostic factors in young breast cancer patients...
  5. pmc The influence of micrometastases on prognosis and survival in stage I-II colon cancer patients: the Enroute⊕ Study
    Daniel J Lips
    Department of Surgery, Jeroen Bosch Hospital, Nieuwstraat 34, 5211 NL s Hertogenbosch, The Netherlands
    BMC Surg 11:11. 2011
    ..The purpose of the present study is to delineate the subset of pN0 patients with micrometastases (pN0(micro+)) and evaluate the benefits from adjuvant chemotherapy in pN0(micro+) CC patients...
  6. pmc Model selection based on logistic regression in a highly correlated candidate gene region
    Hae Won Uh
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands
    BMC Proc 1:S114. 2007
    ..We also evaluate model selection in terms of average prediction error across nine replicates. We conclude that for the Genetic Analysis Workshop 15 (GAW15) data, the newly developed Bayesian selection method performs well...
  7. pmc How to quantify information loss due to phase ambiguity in haplotype case-control studies
    Hae Won Uh
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands
    BMC Genet 6:S108. 2005
    ..We determined which individuals were responsible for the information loss, and calculated how much information could be gained when the ambiguous individuals could be resolved by adding additional parental information...
  8. pmc Modeling the effect of an associated single-nucleotide polymorphism in linkage studies
    Jeanine J Houwing-Duistermaat
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands
    BMC Genet 6:S46. 2005
    ..The question to be answered was whether one of the single-nucleotide polymorphisms partly explains these high LOD scores. We did not have the answers when we analyzed the data...
  9. pmc Influence of genotyping error in linkage mapping for complex traits--an analytic study
    Jeremie J P Lebrec
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Postzone S 05 P, PO Box 9600 2300 RC Leiden, The Netherlands
    BMC Genet 9:57. 2008
    ..The influence of genotyping error on selective designs for continuous traits has not been assessed yet...
  10. pmc Assessment of global phase uncertainty in case-control studies
    Hae Won Uh
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands
    BMC Genet 10:54. 2009
    ..All three methods are designed for single populations; they can be applied in cases only, controls only or the whole data. Therefore they are not necessarily optimal for haplotype testing in case-control studies...
  11. pmc Neo-adjuvant chemotherapy followed by surgery and chemotherapy or by surgery and chemoradiotherapy for patients with resectable gastric cancer (CRITICS)
    Johan L Dikken
    Department of Surgery, K6 R, Leiden University Medical Center, P O Box9600, 2300 RC Leiden, The Netherlands
    BMC Cancer 11:329. 2011
    ..This study aims to obtain an improved overall survival for patients treated with preoperative chemotherapy and surgery by incorporating radiotherapy concurrently with chemotherapy postoperatively...
  12. ncbi request reprint Estimation and prediction in a multi-state model for breast cancer
    Hein Putter
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, The Netherlands
    Biom J 48:366-80. 2006
    ..The estimated transition rates between the states in the model are used to obtain predictions for patients with a given history. Formulas are developed and illustrated for these prediction probabilities for the clock reset approach...
  13. pmc Combining evidence for association from transmission disequilibrium and case-control studies using single-nucleotide polymorphisms
    Hein Putter
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, University of Leiden, PO Box 9604, 2300 RC, Leiden, The Netherlands
    BMC Genet 6:S106. 2005
    ..Combining the evidence from the case-control and TDT designs yielded a 5-10% reduction in the standard errors of the relative risk estimates. The authors did not know the results before the analyses were conducted...
  14. ncbi request reprint Long-term survival with non-proportional hazards: results from the Dutch Gastric Cancer Trial
    H Putter
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Centre, University of Leiden, The Netherlands
    Stat Med 24:2807-21. 2005
    ..We illustrate a number of ways of dealing with survival data that do not obey the proportional hazards assumption, each of which can be easily implemented in standard statistical packages...
  15. ncbi request reprint Relative efficiency of haplotype frequency estimation in sibships and nuclear families compared to unrelated individuals
    H Putter
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands
    Hum Hered 64:52-62. 2007
    ..We argue that the relative efficiencies can also be used to correct for dependence in the calculation of standard errors after initially ignoring the dependence in the estimation phase...
  16. ncbi request reprint Score test for detecting linkage to quantitative traits
    H Putter
    Department of Medical Statistics, Leiden University Medical Center, Leiden, The Netherlands
    Genet Epidemiol 22:345-55. 2002
    ..Perhaps more importantly for practical purposes, the score test can also be extended in a natural way to support the simultaneous analysis of more than two subjects and multivariate phenotypes...
  17. ncbi request reprint Missing forms and dropout in the TME quality of life substudy
    H Putter
    Department of Medical Statistics, Leiden University Medical Centre, Leiden, The Netherlands
    Qual Life Res 14:857-65. 2005
    ..We study patterns of dropout and evaluate the impact of missing forms in the TME QOL substudy...
  18. ncbi request reprint Selection strategies for linkage studies using twins
    Hein Putter
    Department of Medical Statistics, Leiden University Medical Center, University of Leiden, Leiden, The Netherlands
    Twin Res 6:377-82. 2003
    ..We present tables with required sample sizes for height, insulin levels and migraine, three of the traits studied in the GenomEUtwin project...
  19. doi request reprint Joint analysis of multiple longitudinal outcomes: application of a latent class model
    Hein Putter
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, RC, Leiden, The Netherlands
    Stat Med 27:6228-49. 2008
    ....
  20. doi request reprint Meta-analysis of diagnostic test accuracy studies with multiple thresholds using survival methods
    H Putter
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands
    Biom J 52:95-110. 2010
    ....
  21. ncbi request reprint A Bayesian approach to parameter estimation in HIV dynamical models
    H Putter
    Department of Medical Statistics, Leiden University Medical Center, University of Leiden, P O Box 9604, 2300 RC Leiden, The Netherlands
    Stat Med 21:2199-214. 2002
    ....
  22. doi request reprint Patterns of care in Dutch postmenopausal patients with hormone-sensitive early breast cancer participating in the Tamoxifen Exemestane Adjuvant Multinational (TEAM) trial
    J G H van Nes
    Department of Surgery, Leiden University Medical Centre, Leiden, The Netherlands
    Ann Oncol 21:974-82. 2010
    ..As there was a nationwide participation in The Netherlands, we studied the variations in patterns of care in the Comprehensive Cancer Centre Regions (CCCRs) and compliance with national guidelines...
  23. doi request reprint Differences in outcomes of oesophageal and gastric cancer surgery across Europe
    J L Dikken
    Departments of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Br J Surg 100:83-94. 2013
    ..The present study was designed to evaluate differences in resection rates, outcomes and annual hospital volumes between these countries, and to analyse the relationship between hospital volume and outcomes...
  24. pmc Quality of life in relation to tamoxifen or exemestane treatment in postmenopausal breast cancer patients: a Tamoxifen Exemestane Adjuvant Multinational (TEAM) Trial side study
    J G H van Nes
    Department of Surgery, K6 R, Leiden University Medical Centre, P O Box 9600, 2300, RC, Leiden, The Netherlands
    Breast Cancer Res Treat 134:267-76. 2012
    ..Certain QoL issues are treatment- and/or time-specific and deserve attention by health care providers. There is a need for careful inquiry into QoL issues by those prescribing endocrine treatment to optimize QoL and treatment adherence...
  25. doi request reprint Risk factors for sexual dysfunction after rectal cancer treatment
    M M Lange
    Department of Surgery, Leiden University Medical Center, K6 R, P O Box 9600, 2300 RC Leiden, The Netherlands
    Eur J Cancer 45:1578-88. 2009
    ..Patients should be informed preoperatively, and education of surgeons in neuroanatomy may provide the key to the improvement of functional outcome...
  26. doi request reprint Tailored follow-up for early breast cancer patients: a prognostic index that predicts locoregional recurrence
    J G H van Nes
    Department of Surgery, Leiden University Medical Centre, K6 R, P O Box 9600, 2300 RC Leiden, The Netherlands
    Eur J Surg Oncol 36:617-24. 2010
    ..After the first year, the main goal is particularly to detect locoregional recurrences (LRR). Our aim was to develop a simple prognostic index to predict LRR to tailor the follow-up programme...
  27. doi request reprint Quality assurance in rectal cancer treatment in the Netherlands: a catch up compared to colon cancer treatment
    W van Gijn
    Department of Surgery, Leiden University Medical Center, K6 R, P O Box 9600, 2300 RC Leiden, The Netherlands
    Eur J Surg Oncol 36:340-4. 2010
    ..The aim of this study is to examine the effects of the structural changes in rectal cancer care on survival compared to colon cancer for patients treated before, during and after the TME trial...
  28. ncbi request reprint Neo-adjuvant chemotherapy for operable gastric cancer: long term results of the Dutch randomised FAMTX trial
    H H Hartgrink
    Department of Surgery, Leiden University Medical Centre, P O Box 9600, 2300 RC Leiden, The Netherlands
    Eur J Surg Oncol 30:643-9. 2004
    ..We performed a randomised trial with pre-operative FAMTX vs. surgery alone in order to evaluate the effect of pre-operative chemotherapy on resectability and survival...
  29. doi request reprint Metastatic lymph node ratio in stage III rectal cancer; prognostic significance in addition to the 7th edition of the TNM classification
    J W T Dekker
    Department of Surgery, Leiden University Medical Center, Albinushof 2a, 2300 RC Leiden, The Netherlands
    Eur J Surg Oncol 36:1180-6. 2010
    ..This study assesses the prognostic capacity of the metastatic lymph node ratio (LNR) in addition to the new TNM classification...
  30. ncbi request reprint Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer
    E Kapiteijn
    Department of Surgery, Leiden University Medical Center, The Netherlands
    N Engl J Med 345:638-46. 2001
    ..2 percent in the surgery-only group (P<0.001). CONCLUSIONS: Short-term preoperative radiotherapy reduces the risk of local recurrence in patients with rectal cancer who undergo a standardized total mesorectal excision...
  31. ncbi request reprint Extended lymph node dissection for gastric cancer: who may benefit? Final results of the randomized Dutch gastric cancer group trial
    H H Hartgrink
    Department of Surgery, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Clin Oncol 22:2069-77. 2004
    ..We have reviewed the results of our trial after follow-up of more than 10 years...
  32. doi request reprint Meta-analysis of pairs of survival curves under heterogeneity: a Poisson correlated gamma-frailty approach
    M Fiocco
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands
    Stat Med 28:3782-97. 2009
    ..The methodology is illustrated with an observational study on breast cancer...
  33. doi request reprint Use of different comorbidity scores for risk-adjustment in the evaluation of quality of colorectal cancer surgery: does it matter?
    J W T Dekker
    Department of Surgery, Leiden University Medical Centre, Albinusdreef 2, PO Box 9600, 2300 RC Leiden, The Netherlands
    Eur J Surg Oncol 38:1071-8. 2012
    ..Comorbidity affects outcomes after colorectal cancer surgery. However, it's importance in risk adjustment is unclear and different measures are being used. This study aims to assess its impact on post-operative outcomes...
  34. doi request reprint High non-compliance in the use of letrozole after 2.5 years of extended adjuvant endocrine therapy. Results from the IDEAL randomized trial
    D B Y Fontein
    Department of Surgical Oncology, Leiden University Medical Centre, Albinusdreef 2, 2333ZA Leiden, The Netherlands
    Eur J Surg Oncol 38:110-7. 2012
    ..The aim of this study was to investigate non-compliance to aromatase inhibitors and factors associated with early treatment discontinuation in the extended adjuvant setting...
  35. doi request reprint Relationship between specific adverse events and efficacy of exemestane therapy in early postmenopausal breast cancer patients
    D B Y Fontein
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Ann Oncol 23:3091-7. 2012
    ..Additionally, the relationship between hormone receptor expression and AEs was assessed...
  36. ncbi request reprint Dynamic pseudo-observations: a robust approach to dynamic prediction in competing risks
    M A Nicolaie
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Biometrics 69:1043-52. 2013
    ..We illustrate our approach on a real data set of chronic myeloid leukemia patients after bone marrow transplantation. ..
  37. doi request reprint Multicentre analysis of oncological and survival outcomes following anastomotic leakage after rectal cancer surgery
    M den Dulk
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Br J Surg 96:1066-75. 2009
    ....
  38. ncbi request reprint Reduced rank proportional hazards model for competing risks
    M Fiocco
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, P O Box 9604, 2300 RC Leiden, The Netherlands
    Biostatistics 6:465-78. 2005
    ....
  39. doi request reprint Expression of cell adhesion molecules and prognosis in breast cancer
    S Saadatmand
    Department of Surgery, Leiden University Medical Centre, Leiden, The Netherlands
    Br J Surg 100:252-60. 2013
    ..The prognostic value of tumour expression of N-cadherin, E-cadherin, carcinoembryonic antigen (CEA) and epithelial CAM (Ep-CAM) was evaluated in patients with breast cancer...
  40. doi request reprint Vertical modeling: a pattern mixture approach for competing risks modeling
    M A Nicolaie
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Stat Med 29:1190-205. 2010
    ..We illustrate our methods using data of 8966 leukemia patients from the European Group for Blood and Marrow Transplantation...
  41. ncbi request reprint Impact of locoregional treatment on the early-stage breast cancer patients: a retrospective analysis
    J A van der Hage
    Department of Surgery, D6 43, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Eur J Cancer 39:2192-9. 2003
    ..Adjuvant radiotherapy in mastectomised patients was associated with both a significantly superior locoregional control and overall survival. The effect of adjuvant radiotherapy was most profound in patients who had 1-3 positive nodes...
  42. ncbi request reprint Combined expression of the non-receptor protein tyrosine kinases FAK and Src in primary colorectal cancer is associated with tumor recurrence and metastasis formation
    P de Heer
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Surg Oncol 34:1253-61. 2008
    ..The aim of the current study was to examine the expression of FAK, Src, and paxillin using immunohistochemistry in the context of disease progression and to evaluate its clinical significance as a prognostic factor...
  43. ncbi request reprint The impact of the implementation of a rehabilitation tool on the contents of the communication during multidisciplinary team conferences in rheumatology
    J Verhoef
    Clinical Informatics, Leiden University Medical Center, The Netherlands
    Int J Med Inform 76:856-63. 2007
    ..The aim of this study was to investigate the effect of the implementation of a rehabilitation tool on the contents of communication during multidisciplinary team conferences in a rheumatology setting...
  44. doi request reprint CYP2D6 genotype in relation to tamoxifen efficacy in a Dutch cohort of the tamoxifen exemestane adjuvant multinational (TEAM) trial
    V O Dezentje
    Department of Clinical Oncology, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands
    Breast Cancer Res Treat 140:363-73. 2013
    ..Polymorphisms in the estrogen receptor-1 and UGT2B15 may be associated with tamoxifen efficacy, but these findings need replication. ..
  45. doi request reprint Dynamic prediction by landmarking in competing risks
    M A Nicolaie
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands
    Stat Med 32:2031-47. 2013
    ..Fitting this model is possible within the standard statistical software. We illustrate the features of the landmark modelling on a real data set on bone marrow transplantation...
  46. ncbi request reprint A new serially correlated gamma-frailty process for longitudinal count data
    M Fiocco
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Postzone S 05 P, PO Box 9600, 2300 RC Leiden, The Netherlands
    Biostatistics 10:245-57. 2009
    ..A 2-stage composite-likelihood procedure is developed for estimating the model parameters. The suggested method is applied to a meta-analysis study for survival curves...
  47. ncbi request reprint Validity and responsiveness of the Rehabilitation Activities Profile (RAP) in patients with rheumatoid arthritis
    J Verhoef
    Department of Physical Therapy, Leiden University Medical Center, Leiden, The Netherlands
    Clin Rehabil 22:788-800. 2008
    ..To investigate the internal consistency, validity and responsiveness of the Rehabilitation Activities Profile (RAP; a rehabilitation tool structuring the multidisciplinary team care process) in patients with rheumatoid arthritis...
  48. doi request reprint Impact of the extent of surgery and postoperative chemoradiotherapy on recurrence patterns in gastric cancer
    Johan L Dikken
    Leiden University Medical Center, Leiden, The Netherlands
    J Clin Oncol 28:2430-6. 2010
    ....
  49. doi request reprint Effect of concomitant CYP2D6 inhibitor use and tamoxifen adherence on breast cancer recurrence in early-stage breast cancer
    Vincent O Dezentjé
    Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, The Netherlands
    J Clin Oncol 28:2423-9. 2010
    ..The objectives of this study were to relate concomitant CYP2D6 inhibitor use and tamoxifen adherence to breast cancer event-free time (EFT)...
  50. ncbi request reprint Down-regulation of HLA-A expression correlates with a better prognosis in colorectal cancer patients
    Anand G Menon
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Lab Invest 82:1725-33. 2002
    ..The better prognosis may be caused by elimination of HLA-negative cells by natural killer cells or by an attenuated tumor aggressiveness, as is seen in tumors with a MSI-high phenotype...
  51. doi request reprint Discussing sexual function in the cardiology practice
    M P J Nicolai
    Department of Urology, Leiden University Medical Center, J3P, PO Box 9600, 2300 WB Leiden, The Netherlands
    Clin Res Cardiol 102:329-36. 2013
    ..To optimise healthcare, knowledge of cardiologists' attitude and practice patterns regarding the discussion about sexual function is essential...
  52. doi request reprint The prognostic role of TGF-β signaling pathway in breast cancer patients
    E M de Kruijf
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Ann Oncol 24:384-90. 2013
    ..Improved prognostic information for breast cancer patients might be obtained by assessing interactions among TGF-β signaling biomarkers...
  53. doi request reprint Vaginal brachytherapy versus pelvic external beam radiotherapy for patients with endometrial cancer of high-intermediate risk (PORTEC-2): an open-label, non-inferiority, randomised trial
    R A Nout
    Department of Clinical Oncology, Leiden University Medical Center, Leiden, Netherlands
    Lancet 375:816-23. 2010
    ..This study established whether vaginal brachytherapy (VBT) is as effective as pelvic external beam radiotherapy (EBRT) in prevention of vaginal recurrence, with fewer adverse effects and improved quality of life...
  54. doi request reprint Variations in locoregional therapy in postmenopausal patients with early breast cancer treated in different countries
    J G H van Nes
    Department of Surgery, Leiden University Medical Centre, Leiden, The Netherlands
    Br J Surg 97:671-9. 2010
    ..The large number of patients already recruited offered the opportunity to explore locoregional treatment practices between countries...
  55. doi request reprint The abdominoperineal resection itself is associated with an adverse outcome: the European experience based on a pooled analysis of five European randomised clinical trials on rectal cancer
    Marcel den Dulk
    Department of Surgery, Leiden University Medical Center, K6 R, P O Box 9600, 2300 RC Leiden, The Netherlands
    Eur J Cancer 45:1175-83. 2009
    ....
  56. doi request reprint Influence of hospital type on outcomes after oesophageal and gastric cancer surgery
    J L Dikken
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Br J Surg 99:954-63. 2012
    ..The present study examined the distribution of oesophagectomies and gastrectomies between hospital types in the Netherlands, and the relationship between hospital type and outcome...
  57. ncbi request reprint Potential bias in Generalized Estimating Equations linkage methods under incomplete information
    J Lebrec
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, The Netherlands
    Genet Epidemiol 30:94-100. 2006
    ..We show that properly standardized statistics based on IBD sharing provide a valid alternative...
  58. ncbi request reprint Value of palliative resection in gastric cancer
    H H Hartgrink
    Department of Surgery, Leiden University Medical Centre, The Netherlands
    Br J Surg 89:1438-43. 2002
    ..The role of palliative surgical resection is still debatable. Non-curatively treated patients from the Dutch Gastric Cancer Trial were studied to define more accurately which patients might benefit from palliative resection...
  59. ncbi request reprint Impact of the introduction and training of total mesorectal excision on recurrence and survival in rectal cancer in The Netherlands
    E Kapiteijn
    Department of Surgery, Leiden University Medical Centre, Leiden, The Netherlands
    Br J Surg 89:1142-9. 2002
    ..The aim of this study was to determine the nationwide impact of the introduction and training of TME on recurrence and survival in rectal cancer...
  60. pmc The in- or exclusion of non-breast cancer related death and contralateral breast cancer significantly affects estimated outcome probability in early breast cancer
    R A Nout
    Department of Clinical Oncology, Leiden University Medical Center, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Breast Cancer Res Treat 109:567-72. 2008
    ..Knowledge of the contribution of non-disease related death or contralateral breast cancer to estimated recurrent disease rate and overall death rate is indispensable for a correct interpretation and comparison of outcome analyses...
  61. ncbi request reprint The impact of introducing an ICF-based rehabilitation tool on staff satisfaction with multidisciplinary team care in rheumatology: an exploratory study
    J Verhoef
    Department of Clinical Informatics, Leiden University Medical Center LUMC, The Netherlands
    Clin Rehabil 22:23-37. 2008
    ..To investigate the impact of introducing a rehabilitation tool on multidisciplinary team members' satisfaction with team functioning, team conferences and written information exchange...
  62. doi request reprint Assessment of regional progression of pulmonary emphysema with CT densitometry
    M Els Bakker
    Division of Image Processing, Department of Radiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Chest 134:931-7. 2008
    ..To test this hypothesis, a method was developed to assess emphysema severity at different levels in the lungs in order to estimate regional changes...
  63. doi request reprint Hypertension and rarefaction during treatment with telatinib, a small molecule angiogenesis inhibitor
    Neeltje Steeghs
    Department of Clinical Oncology, Leiden University Medical Center, Leiden, The Netherlands
    Clin Cancer Res 14:3470-6. 2008
    ..Hypertension is a commonly reported side effect in antiangiogenic therapy. We investigated the hypothesis that telatinib, a small molecule angiogenesis inhibitor, impairs vascular function, induces rarefaction, and causes hypertension...
  64. doi request reprint Preoperative chemotherapy is safe in early breast cancer, even after 10 years of follow-up; clinical and translational results from the EORTC trial 10902
    Johanna G H van Nes
    Department of Surgery, K6 R, Leiden University Medical Centre, Leiden, The Netherlands
    Breast Cancer Res Treat 115:101-13. 2009
    ....
  65. doi request reprint Quality of life after pelvic radiotherapy or vaginal brachytherapy for endometrial cancer: first results of the randomized PORTEC-2 trial
    Remi A Nout
    Department of Clinical Oncology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Clin Oncol 27:3547-56. 2009
    ..Vaginal brachytherapy provides a better QOL, and should be the preferred treatment from a QOL perspective...
  66. doi request reprint The place of female sexual dysfunction in the urological practice: results of a Dutch survey
    Milou Bekker
    Department of Urology, Leiden University Medical Center, Albinusdreef, Leiden 2333 ZA, The Netherlands
    J Sex Med 6:2979-87. 2009
    ..Female sexual dysfunction (FSD) is a highly prevalent and often underestimated problem. There is a strong association between urological complaints and FSD...
  67. ncbi request reprint Validity and responsiveness of the World Health Organization Disability Assessment Schedule II to assess disability in rheumatoid arthritis patients
    Jorit J L Meesters
    Department of Rheumatology, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands
    Rheumatology (Oxford) 49:326-33. 2010
    ..To investigate the validity and responsiveness of the World Health Organization Disability Schedule II (WHODAS II) in patients with established RA...
  68. doi request reprint Predicting the risk of anastomotic leakage in left-sided colorectal surgery using a colon leakage score
    Jan Willem T Dekker
    Department of Surgery, Leiden University Medical Center, The Netherlands
    J Surg Res 166:e27-34. 2011
    ..More accurate assessments of the risk of anastomotic leakage would be very helpful in tailoring treatment in colorectal surgery. Therefore, a Colon Leakage Score (CLS) was developed and tested...
  69. pmc Plasma apolipoprotein CI and CIII levels are associated with increased plasma triglyceride levels and decreased fat mass in men with the metabolic syndrome
    Rachel L M van der Ham
    Section of Vascular Medicine, Department of Endocrinology and Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands
    Diabetes Care 32:184-6. 2009
    ....
  70. doi request reprint Sexual function improvement following surgery for stress incontinence: the relevance of coital incontinence
    Milou Bekker
    Department of Urology, Leiden University Medical Center, PO Box 9600, Leiden 2300 RC, The Netherlands
    J Sex Med 6:3208-13. 2009
    ..Little is known about the impact of surgery for stress urinary incontinence (SUI) on female sexual function, and results are conflicting...
  71. pmc Persistent epigenetic differences associated with prenatal exposure to famine in humans
    Bastiaan T Heijmans
    Departments of Molecular Epidemiology, Medical Statistics, and Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    Proc Natl Acad Sci U S A 105:17046-9. 2008
    ..These data are the first to contribute empirical support for the hypothesis that early-life environmental conditions can cause epigenetic changes in humans that persist throughout life...
  72. ncbi request reprint Volume correction in computed tomography densitometry for follow-up studies on pulmonary emphysema
    Berend C Stoel
    Leiden University Medical Center, Albinusdreef 2, 2333 AA Leiden, The Netherlands
    Proc Am Thorac Soc 5:919-24. 2008
    ..Sensitivity was improved using repeated CT scans by applying volume correction to individual patient data. Volume correction reduces the variability in progression estimation by a factor of two, and is therefore recommended...
  73. doi request reprint The mstate package for estimation and prediction in non- and semi-parametric multi-state and competing risks models
    Liesbeth C de Wreede
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Comput Methods Programs Biomed 99:261-74. 2010
    ....
  74. ncbi request reprint The epidemiology of myasthenia gravis, Lambert-Eaton myasthenic syndrome and their associated tumours in the northern part of the province of South Holland
    Paul W Wirtz
    Department of Neurology, J3R 166, Leiden University Medical Centre, P O Box 9600, The Netherlands
    J Neurol 250:698-701. 2003
    ..The frequency of LEMS in our patients with SCLC was lower than reported in previous studies. In patients with a SCLC or thymoma, the tumour was diagnosed at younger age in those who had the associated myasthenic syndrome...
  75. ncbi request reprint Sexual experiences of men with incontinent partners
    Milou D Bekker
    Department of Urology, University of Groningen, Groningen, The Netherlands corrected
    J Sex Med 7:1877-82. 2010
    ..Several studies show that urinary incontinence (UI) impairs women's sexual functioning and sexual satisfaction. However, there is no scientific knowledge about the effects of UI on sexual functioning of the male partners...
  76. doi request reprint Efficacy of a hypofractionated schedule in electron beam radiotherapy for epithelial skin cancer: Analysis of 434 cases
    Marjan van Hezewijk
    Department of Radiation Oncology, Leiden University Medical Center, Leiden, The Netherlands
    Radiother Oncol 95:245-9. 2010
    ..Efficacy of radiotherapy for epithelial skin cancer was evaluated and treatment outcomes of two electron beam fractionation schedules were compared...
  77. ncbi request reprint Meta-analysis of four new genome scans for lipid parameters and analysis of positional candidates in positive linkage regions
    Bastiaan T Heijmans
    Molecular Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands
    Eur J Hum Genet 13:1143-53. 2005
    ..In conclusion, application of a new meta-analysis approach maximised the power to detect QTLs for lipid levels and improved the precision of their location estimate...
  78. doi request reprint Adjuvant tamoxifen and exemestane in early breast cancer (TEAM): a randomised phase 3 trial
    Cornelis J H Van De Velde
    Leiden University Medical Centre, Leiden, Netherlands
    Lancet 377:321-31. 2011
    ..We therefore compared the long-term effects of exemestane monotherapy with sequential treatment (tamoxifen followed by exemestane)...
  79. ncbi request reprint Effectiveness of the introduction of an International Classification of Functioning, Disability and Health-based rehabilitation tool in multidisciplinary team care in patients with rheumatoid arthritis
    John Verhoef
    Department of Physical Therapy, Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 57:240-8. 2007
    ....
  80. doi request reprint The PreventCD Study design: towards new strategies for the prevention of coeliac disease
    Caroline Elisabeth Hogen Esch
    Department of Pediatric Gastroenterology, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Gastroenterol Hepatol 22:1424-30. 2010
    ....
  81. ncbi request reprint Two-year statin therapy does not alter the progression of intima-media thickness in patients with type 2 diabetes without manifest cardiovascular disease
    Edith D Beishuizen
    Department of General Internal Medicine, C1 R41, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, Netherlands
    Diabetes Care 27:2887-92. 2004
    ..We aimed to determine the effect of statin therapy versus placebo on the progression of carotid intima-media thickness (IMT) in type 2 diabetic patients without manifest CVD...
  82. ncbi request reprint Hemodynamic effects of long-term cardiac resynchronization therapy: analysis by pressure-volume loops
    Paul Steendijk
    Department of Cardiology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Circulation 113:1295-304. 2006
    ..Acute hemodynamic effects of cardiac resynchronization therapy (CRT) were reported previously, but detailed invasive studies showing hemodynamic consequences of long-term CRT are not available...
  83. ncbi request reprint Impact of short-term preoperative radiotherapy on health-related quality of life and sexual functioning in primary rectal cancer: report of a multicenter randomized trial
    Corrie A M Marijnen
    Department of Clinical Oncology, Leiden University Medical Center, K1 P, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Clin Oncol 23:1847-58. 2005
    ..This report describes the HRQL and sexual functioning of 990 patients who underwent TME and were randomly assigned to short-term PRT (5 x 5 Gy)...
  84. ncbi request reprint Variability in densitometric assessment of pulmonary emphysema with computed tomography
    M Els Bakker
    Division of Image Processing, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands, and the Department of Respiratory Medicine, Gentofte Hospital, Hellerup, Denmark
    Invest Radiol 40:777-83. 2005
    ....
  85. ncbi request reprint The impact of diagnosis and treatment of rectal cancer on paid and unpaid labor
    Mandy Van Den Brink
    Department of Medical Decision Making, Leiden University Medical Center, Leiden, The Netherlands
    Dis Colon Rectum 48:1875-82. 2005
    ....
  86. ncbi request reprint No effect of statin therapy on silent myocardial ischemia in patients with type 2 diabetes without manifest cardiovascular disease
    Edith D Beishuizen
    Department of General Internal Medicine, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, Netherlands
    Diabetes Care 28:1675-9. 2005
    ..We aimed to determine the prevalence of silent myocardial ischemia (SMI) and the effect of statin therapy on SMI in type 2 diabetic patients without manifest cardiovascular disease...
  87. ncbi request reprint Assessment of the carotid artery by MRI at 3T: a study on reproducibility
    Reza Alizadeh Dehnavi
    Vascular Medicine, Department of General Internal Medicine and Endocrinology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    J Magn Reson Imaging 25:1035-43. 2007
    ..To examine the reproducibility of carotid artery dimension measurements using 3T MRI...
  88. ncbi request reprint Factors influencing the local failure rate of radiofrequency ablation of colorectal liver metastases
    Fredericke H van Duijnhoven
    Department of Surgery, Leiden University Medical Center, Albinusdreef 2, Leiden, RC, 2300, The Netherlands
    Ann Surg Oncol 13:651-8. 2006
    ..The objectives of this study were to identify risk factors for local RFA failure and to define exclusion criteria for RFA treatment of colorectal liver metastases...
  89. doi request reprint "Diagnostic investigation of the pelvic floor": a helpful tool in the approach in patients with complaints of micturition, defecation, and/or sexual dysfunction
    Petra J Voorham-van der Zalm
    University Medical Center Leiden Urology, Leiden, The Netherlands
    J Sex Med 5:864-71. 2008
    ..In our hospital, this diagnostic consultation is indicated as Diagnostic Investigation of Pelvic Floor Function (DIPFF)...
  90. ncbi request reprint Female sexual function after surgery for stress urinary incontinence: transobturator suburethral tape vs. tension-free vaginal tape obturator
    Henk Willem Elzevier
    Leiden University Medical Center Urology, Leiden, The Netherlands
    J Sex Med 5:400-6. 2008
    ..Studies on the influence on sexual function as a result of these procedures are limited...
  91. doi request reprint Tumor-stroma ratio in the primary tumor is a prognostic factor in early breast cancer patients, especially in triple-negative carcinoma patients
    Esther M de Kruijf
    Departments of Surgery, Leiden University Medical Center, P O Box 9600, Albinusdreef 2, 2300 RC, Leiden, The Netherlands
    Breast Cancer Res Treat 125:687-96. 2011
    ..Tumor-stroma ratio could be easily implemented in routine daily pathology diagnostics, as it is simple to determine, reproducible, and performed in quick time...
  92. ncbi request reprint The TME trial after a median follow-up of 6 years: increased local control but no survival benefit in irradiated patients with resectable rectal carcinoma
    Koen C M J Peeters
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Ann Surg 246:693-701. 2007
    ..To investigate the efficacy of preoperative short-term radiotherapy in patients with mobile rectal cancer undergoing total mesorectal excision (TME) surgery...
  93. pmc Clinical impact of HLA class I expression in rectal cancer
    Frank M Speetjens
    Department of Surgery, Leiden University Medical Center, 2300 RC, Leiden, The Netherlands
    Cancer Immunol Immunother 57:601-9. 2008
    ..To determine the clinical impact of human leukocyte antigen (HLA) class I expression in irradiated and non-irradiated rectal carcinomas...
  94. ncbi request reprint Progression parameters for emphysema: a clinical investigation
    Jan Stolk
    Department of Pulmonology, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Respir Med 101:1924-30. 2007
    ..5-fold more sensitive using lung densitometry than by using currently recommended lung function parameters. Our results support CT scan as an efficacious test for novel drugs for emphysema...
  95. pmc Risk factors for adverse outcome in patients with rectal cancer treated with an abdominoperineal resection in the total mesorectal excision trial
    Marcel den Dulk
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Ann Surg 246:83-90. 2007
    ....
  96. ncbi request reprint Reduced-rank proportional hazards regression and simulation-based prediction for multi-state models
    Marta Fiocco
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, P O Box 9604, 2300 RC, Leiden, The Netherlands
    Stat Med 27:4340-58. 2008
    ..We use data from the European Group for Blood and Marrow Transplantation to illustrate our techniques...
  97. pmc Epigenetic status of LINE-1 predicts clinical outcome in early-stage rectal cancer
    A Benard
    1 Department of Molecular Oncology, John Wayne Cancer Institute, Santa Monica, CA 90404, USA 2 Department of Surgery, Leiden University Medical Center, Leiden 2300RC, The Netherlands
    Br J Cancer 109:3073-83. 2013
    ..In addition to DNA methylation, expression of histone modifications H3K27me3 and H3K9Ac was studied in this patient cohort...
  98. doi request reprint Isolated hepatic melphalan perfusion of colorectal liver metastases: outcome and prognostic factors in 154 patients
    L B J van Iersel
    Department of Clinical Oncology, Leiden University Medical Center, Leiden, The Netherlands
    Ann Oncol 19:1127-34. 2008
    ..The aim of this study was to identify prognostic factors for local and systemic failure after isolated hepatic perfusion (IHP) with 200 mg melphalan in patients with colorectal liver metastases...
  99. doi request reprint Prevalence of vertebral fractures independent of BMD and anticancer treatment in patients with testicular germ cell tumors
    P M Willemse
    Department of Clinical Oncology, Leiden University Medical Center, Leiden, The Netherlands
    J Clin Endocrinol Metab 95:4933-42. 2010
    ..However, skeletal morbidity may potentially be increased in these patients due to chemotherapy-associated hypogonadism...
  100. ncbi request reprint Score test for detecting linkage to complex traits in selected samples
    J Lebrec
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, University of Leiden, PO Box 9604, Leiden, The Netherlands
    Genet Epidemiol 27:97-108. 2004
    ..For dichotomous traits, pairs of pedigree members of different phenotypic nature (e.g., affected sib pairs and discordant sib pairs) can easily be combined as well as populations with different trait prevalences...
  101. doi request reprint Leucocyte depletion of perioperative blood transfusion does not affect long-term survival and recurrence in patients with gastrointestinal cancer
    M M Lange
    Department of Surgery, Leiden University Medical Centre, Leiden, The Netherlands
    Br J Surg 96:734-40. 2009
    ..Allogeneic leucocytes are assumed to play a causal role. This study evaluated the long-term effect of transfusion with leucocyte-depleted (LD) blood in patients with gastrointestinal cancer...