Amber B Ouweneel
Affiliation: Leiden University
Country: The Netherlands
Ouweneel A, Verwilligen R, Van Eck M. Vulnerable plaque and vulnerable blood: Two critical factors for spontaneous atherothrombosis in mouse models. Atherosclerosis. 2019;284:160-164 pubmed publisher
..In this review, we summarize the recent developments on mouse models for the investigation of atherothrombosis. ..
Ouweneel A, Hoekstra M, van der Wel E, Schaftenaar F, Snip O, Hassan J, et al
. Hypercholesterolemia impairs megakaryopoiesis and platelet production in scavenger receptor BI knockout mice. Atherosclerosis. 2019;282:176-182 pubmed publisher
..Our findings suggest that, in addition to an increased platelet clearance, a decrease in platelet production may also, in part, explain the thrombocytopenic phenotype associated with SR-BI deficiency in mice. ..
Ouweneel A, Van Eck M. Lipoproteins as modulators of atherothrombosis: From endothelial function to primary and secondary coagulation. Vascul Pharmacol. 2016;82:1-10 pubmed publisher
..We will conclude with future perspectives for lipid modulation in the prevention of atherothrombosis. ..
van der Geest R, Ouweneel A, van der Sluis R, Groen A, Van Eck M, Hoekstra M. Endogenous glucocorticoids exacerbate cholestasis-associated liver injury and hypercholesterolemia in mice. Toxicol Appl Pharmacol. 2016;306:1-7 pubmed publisher
..In conclusion, we have shown that endogenous glucocorticoids exacerbate the liver injury and hypercholesterolemia associated with acute cholestasis in mice. ..