E Olofsen

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. ncbi The influence of remifentanil on the dynamic relationship between sevoflurane and surrogate anesthetic effect measures derived from the EEG
    Erik Olofsen
    Department of Anesthesiology, Leiden University Medical Center, Leiden, The Netherlands
    Anesthesiology 96:555-64. 2002
  2. ncbi Nonlinear mixed-effects modeling: individualization and prediction
    Erik Olofsen
    Department of Anesthesiology, Leiden University Medical Center, Leiden, The Netherlands
    Aviat Space Environ Med 75:A134-40. 2004
  3. ncbi Population pharmacokinetics/pharmacodynamics of anesthetics
    Erik Olofsen
    Department of Anesthesiology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    AAPS J 7:E383-9. 2005
  4. ncbi Response surface modeling of alfentanil-sevoflurane interaction on cardiorespiratory control and bispectral index
    A Dahan
    Department of Anesthesiology, Leiden University Medical Center, The Netherlands
    Anesthesiology 94:982-91. 2001
  5. ncbi Recirculatory and compartmental pharmacokinetic modeling of alfentanil in pigs: the influence of cardiac output
    J A Kuipers
    Department of Anesthesiology, Leiden University Medical Center, The Netherlands
    Anesthesiology 90:1146-57. 1999
  6. ncbi Propofol alters the pharmacokinetics of alfentanil in healthy male volunteers
    M J Mertens
    Department of Anesthesiology, Leiden University Medical Center, The Netherlands
    Anesthesiology 94:949-57. 2001
  7. ncbi Permutation entropy of the electroencephalogram: a measure of anaesthetic drug effect
    E Olofsen
    Department of Anesthesiology, Leiden University Medical Center, Leiden University, Leiden, The Netherlands
    Br J Anaesth 101:810-21. 2008
  8. ncbi Speed of onset and offset and mechanisms of ventilatory depression from sevoflurane: an experimental study in the cat
    A Dahan
    Department of Anesthesiology, Leiden University Medical Center, The Netherlands
    Anesthesiology 90:1119-28. 1999
  9. ncbi The dynamic relationship between end-tidal sevoflurane and isoflurane concentrations and bispectral index and spectral edge frequency of the electroencephalogram
    E Olofsen
    Department of Anesthesiology, Leiden University Medical Center, The Netherlands
    Anesthesiology 90:1345-53. 1999
  10. ncbi Mechanism-based PK/PD modeling of the respiratory depressant effect of buprenorphine and fentanyl in healthy volunteers
    A Yassen
    Department of Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden, The Netherlands
    Clin Pharmacol Ther 81:50-8. 2007

Collaborators

Detail Information

Publications33

  1. ncbi The influence of remifentanil on the dynamic relationship between sevoflurane and surrogate anesthetic effect measures derived from the EEG
    Erik Olofsen
    Department of Anesthesiology, Leiden University Medical Center, Leiden, The Netherlands
    Anesthesiology 96:555-64. 2002
    ....
  2. ncbi Nonlinear mixed-effects modeling: individualization and prediction
    Erik Olofsen
    Department of Anesthesiology, Leiden University Medical Center, Leiden, The Netherlands
    Aviat Space Environ Med 75:A134-40. 2004
    ..The results serve to demonstrate the usefulness of mixed-effects modeling for data-driven development of individualized predictive models of fatigue and performance...
  3. ncbi Population pharmacokinetics/pharmacodynamics of anesthetics
    Erik Olofsen
    Department of Anesthesiology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    AAPS J 7:E383-9. 2005
    ....
  4. ncbi Response surface modeling of alfentanil-sevoflurane interaction on cardiorespiratory control and bispectral index
    A Dahan
    Department of Anesthesiology, Leiden University Medical Center, The Netherlands
    Anesthesiology 94:982-91. 2001
    ..The authors examined the influence of the combined administration of sevoflurane and alfentanil on ventilatory control, heart rate (HR), and Bispectral Index (BIS) in healthy volunteers...
  5. ncbi Recirculatory and compartmental pharmacokinetic modeling of alfentanil in pigs: the influence of cardiac output
    J A Kuipers
    Department of Anesthesiology, Leiden University Medical Center, The Netherlands
    Anesthesiology 90:1146-57. 1999
    ..The influence of CO on the pharmacokinetic parameters of alfentanil in pigs was evaluated using compartmental and recirculatory models...
  6. ncbi Propofol alters the pharmacokinetics of alfentanil in healthy male volunteers
    M J Mertens
    Department of Anesthesiology, Leiden University Medical Center, The Netherlands
    Anesthesiology 94:949-57. 2001
    ..The influence of propofol on the pharmacokinetics of alfentanil is poorly understood. The authors therefore studied the effect of a pseudo-steady state concentration of propofol on the pharmacokinetics of alfentanil...
  7. ncbi Permutation entropy of the electroencephalogram: a measure of anaesthetic drug effect
    E Olofsen
    Department of Anesthesiology, Leiden University Medical Center, Leiden University, Leiden, The Netherlands
    Br J Anaesth 101:810-21. 2008
    ....
  8. ncbi Speed of onset and offset and mechanisms of ventilatory depression from sevoflurane: an experimental study in the cat
    A Dahan
    Department of Anesthesiology, Leiden University Medical Center, The Netherlands
    Anesthesiology 90:1119-28. 1999
    ..To learn more about the mechanisms of sevoflurane-induced respiratory depression, the authors also studied its influence on the dynamic ventilatory response to carbon dioxide...
  9. ncbi The dynamic relationship between end-tidal sevoflurane and isoflurane concentrations and bispectral index and spectral edge frequency of the electroencephalogram
    E Olofsen
    Department of Anesthesiology, Leiden University Medical Center, The Netherlands
    Anesthesiology 90:1345-53. 1999
    ..The authors analyzed the relationship between end-tidal sevoflurane and isoflurane concentrations (FET) and BIS and SEF and determined the speed of onset and offset of effect (t1/2k(e0))...
  10. ncbi Mechanism-based PK/PD modeling of the respiratory depressant effect of buprenorphine and fentanyl in healthy volunteers
    A Yassen
    Department of Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden, The Netherlands
    Clin Pharmacol Ther 81:50-8. 2007
    ..56, 95% confidence interval (CI): 0.50-0.62), whereas fentanyl displayed full respiratory depressant effect (alpha=0.91, 95% CI: 0.19-1.62)...
  11. ncbi Buprenorphine induces ceiling in respiratory depression but not in analgesia
    A Dahan
    Department of Anesthesiology, Leiden University Medical Center PO Box 9600, 2300 RC Leiden, The Netherlands
    Br J Anaesth 96:627-32. 2006
    ..The aim of the study was to compare buprenorphine's behaviour with respect to the occurrence of ceiling (or apparent maximum) in these typical micro-opioid protein-(MOP) receptor effects...
  12. ncbi Comparison of the respiratory effects of intravenous buprenorphine and fentanyl in humans and rats
    A Dahan
    Department of Anesthesiology, Leiden University Medical Center, Leiden, The Netherlands
    Br J Anaesth 94:825-34. 2005
    ..To study whether an apparent ceiling effect exists for respiratory depression induced by buprenorphine, we compared the respiratory effects of buprenorphine and fentanyl in humans and rats...
  13. ncbi Validation of a novel respiratory rate monitor based on exhaled humidity
    M Niesters
    Department of Anesthesiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Br J Anaesth 109:981-9. 2012
    ..measurement is inadequate when used with supplemental oxygen and ECG-derived RR is subject to artifacts. A new monitor measures RR by quantifying the humidity of exhaled air (respiR8(®))...
  14. ncbi Recirculatory pharmacokinetics and pharmacodynamics of rocuronium in patients: the influence of cardiac output
    J A Kuipers
    Department of Anesthesiology, Leiden University Medical Center, Leiden, The Netherlands
    Anesthesiology 94:47-55. 2001
    ..For drugs with a fast onset of effect, a recirculatory model, which includes CO, can give a good description of the relation between concentration and effect, in contrast to a conventional compartmental pharmacokinetic model...
  15. ncbi Modeling population pharmacokinetics of lidocaine: should cardiac output be included as a patient factor?
    J A Kuipers
    Department of Anesthesiology, Leiden University Medical Center, The Netherlands
    Anesthesiology 94:566-73. 2001
    ..Inclusion of cardiac output and other physiologic parameters, in addition to or instead of, demographic variables might improve the population pharmacokinetic modeling of lidocaine...
  16. ncbi Pharmacokinetic-pharmacodynamic modeling of morphine-6-glucuronide-induced analgesia in healthy volunteers: absence of sex differences
    Raymonda Romberg
    Department of Anesthesiology, Leiden University Medical Center, The Netherlands
    Anesthesiology 100:120-33. 2004
    ..The predictive pharmacokinetic-pharmacodynamic model was applied successfully and was used to estimate M6G analgesia after morphine in patients with normal and impaired renal function...
  17. ncbi Mechanism-based pharmacokinetic-pharmacodynamic modelling of the reversal of buprenorphine-induced respiratory depression by naloxone : a study in healthy volunteers
    Ashraf Yassen
    Division of Pharmacology, Leiden Amsterdam Centre for Drug Research, Leiden, The Netherlands
    Clin Pharmacokinet 46:965-80. 2007
    ..The aim of this study was to characterise the pharmacodynamic interaction between buprenorphine and naloxone in healthy volunteers...
  18. ncbi Pharmacokinetic-pharmacodynamic modeling of the effectiveness and safety of buprenorphine and fentanyl in rats
    Ashraf Yassen
    Division of Pharmacology, Gorlaeus Laboratories, Leiden Amsterdam Center for Drug Research, Leiden, The Netherlands
    Pharm Res 25:183-93. 2008
    ..The objective of this investigation was to characterize the relationship between buprenorphine or fentanyl exposure and the effectiveness and safety outcome in rats...
  19. ncbi The interaction between propofol and clonidine for loss of consciousness
    Hideyuki Higuchi
    Department of Anesthesia, Self Defense Force Central Hospital, Tokyo, Japan
    Anesth Analg 94:886-91, table of contents. 2002
    ..These results indicate that propofol and clonidine act additively for loss of consciousness. IMPLICATIONS: Oral clonidine 2.5 and 5.0 microg/kg premedication decreases the propofol concentration required for loss of consciousness...
  20. ncbi Response surface modeling of remifentanil-propofol interaction on cardiorespiratory control and bispectral index
    Diederik J F Nieuwenhuijs
    Department of Anesthesiology, Leiden University Medical Center, The Netherlands
    Anesthesiology 98:312-22. 2003
    ..When combined, their effect on respiration is strikingly synergistic, resulting in severe respiratory depression...
  21. ncbi Propofol reduces perioperative remifentanil requirements in a synergistic manner: response surface modeling of perioperative remifentanil-propofol interactions
    Martijn J Mertens
    Department of Anesthesiology, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands
    Anesthesiology 99:347-59. 2003
    ..The authors studied the effect of propofol on remifentanil requirements for suppression of responses to clinically relevant stimuli and evaluated this in relation to previously published data on propofol and alfentanil...
  22. ncbi Influence of propofol on the control of breathing
    Albert Dahan
    Department of Anaesthesiology, Leiden University Medical Center, Leiden, The Netherlands
    Adv Exp Med Biol 523:81-92. 2003
  23. ncbi Mixed-model regression analysis and dealing with interindividual differences
    Hans P A Van Dongen
    Unit for Experimental Psychiatry, University of Pennsylvania School of Medicine, Pennsylvania, Philadelphia 19104-6021, USA
    Methods Enzymol 384:139-71. 2004
  24. ncbi Mixed-effects modeling of the influence of alfentanil on propofol pharmacokinetics
    Martijn J Mertens
    Department of Anesthesiology, Leiden University Medical Center, The Netherlands
    Anesthesiology 100:795-805. 2004
    ..CONCLUSIONS: Alfentanil alters the pharmacokinetics of propofol. Cardiac output and heart rate have an important influence on the pharmacokinetics of propofol...
  25. ncbi Simultaneous measurement and integrated analysis of analgesia and respiration after an intravenous morphine infusion
    Albert Dahan
    Department of Anesthesiology, Leiden University Medical Center, The Netherlands
    Anesthesiology 101:1201-9. 2004
    ..Both respiratory and pain measurements were performed over single 24-h time spans...
  26. ncbi Pharmacodynamic effect of morphine-6-glucuronide versus morphine on hypoxic and hypercapnic breathing in healthy volunteers
    Raymonda Romberg
    Department of Anesthesiology, Leiden University Medical Center, The Netherlands
    Anesthesiology 99:788-98. 2003
    ..Furthermore, the speed of onset/offset of M6G is faster than morphine by a factor of approximately 2. The authors discuss some of the possible mechanisms for the observed differences in opioid behavior...
  27. ncbi Animal-to-human extrapolation of the pharmacokinetic and pharmacodynamic properties of buprenorphine
    Ashraf Yassen
    Leiden Amsterdam Center for Drug Research, Division of Pharmacology, Gorleaus Laboratories, Leiden, The Netherlands
    Clin Pharmacokinet 46:433-47. 2007
    ..This investigation describes the interspecies scaling of the pharmacokinetics and pharmacodynamics of buprenorphine...
  28. ncbi Increased margin of safety of morphine-6-glucuronide relative to morphine
    Raymonda Romberg
    Anesthesiology 100:1622; author reply 1622-3. 2004
  29. ncbi Naloxone reversal of buprenorphine-induced respiratory depression
    Eveline van Dorp
    Department of Anesthesiology, Leiden University Medical Center, The Netherlands
    Anesthesiology 105:51-7. 2006
    ..Because respiratory depression from buprenorphine may outlast the effects of naloxone boluses or short infusions, a continuous infusion of naloxone may be required to maintain reversal of respiratory depression...
  30. ncbi Mechanism-based pharmacokinetic-pharmacodynamic modeling of the antinociceptive effect of buprenorphine in healthy volunteers
    Ashraf Yassen
    Leiden/Amsterdam Center for Drug Research, Division of Pharmacology, Gorlaeus Laboratories, The Netherlands
    Anesthesiology 104:1232-42. 2006
    ..In the dose range studied, no saturation of receptor occupancy occurred explaining the lack of a ceiling effect for antinociception...
  31. ncbi Pharmacokinetic-pharmacodynamic modeling of the antinociceptive effect of buprenorphine and fentanyl in rats: role of receptor equilibration kinetics
    Ashraf Yassen
    Leiden/Amsterdam Center for Drug Research, Division of Pharmacology, Gorlaeus Laboratories, The Netherlands
    J Pharmacol Exp Ther 313:1136-49. 2005
    ..In contrast to earlier reports in the literature, the findings of this study show that the rate-limiting step in the onset and offset of buprenorphine's antinociceptive effect is distribution to the brain...
  32. ncbi Alfentanil and placebo analgesia: no sex differences detected in models of experimental pain
    Erik Olofsen
    Department of Anesthesiology, Leiden University Medical Center, Leiden, The Netherlands
    Anesthesiology 103:130-9. 2005
    ..e., placebo) contributes to the large between-subject response variability with alfentanil analgesia. The difference in alfentanil analgesia onset and offset between pain tests is discussed...
  33. ncbi Polymorphism of mu-opioid receptor gene (OPRM1:c.118A>G) does not protect against opioid-induced respiratory depression despite reduced analgesic response
    Raymonda R Romberg
    Department of Anesthesiology, Leiden University Medical Center, The Netherlands
    Anesthesiology 102:522-30. 2005
    ..118A>G) was investigated on morphine-6-glucuronide (M6G)-induced analgesia and respiratory depression in a group of healthy volunteers...