E Olofsen

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint The influence of remifentanil on the dynamic relationship between sevoflurane and surrogate anesthetic effect measures derived from the EEG
    Erik Olofsen
    Department of Anesthesiology, Leiden University Medical Center, Leiden, The Netherlands
    Anesthesiology 96:555-64. 2002
  2. ncbi request reprint Nonlinear mixed-effects modeling: individualization and prediction
    Erik Olofsen
    Department of Anesthesiology, Leiden University Medical Center, Leiden, The Netherlands
    Aviat Space Environ Med 75:A134-40. 2004
  3. pmc Population pharmacokinetics/pharmacodynamics of anesthetics
    Erik Olofsen
    Department of Anesthesiology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    AAPS J 7:E383-9. 2005
  4. ncbi request reprint Response surface modeling of alfentanil-sevoflurane interaction on cardiorespiratory control and bispectral index
    A Dahan
    Department of Anesthesiology, Leiden University Medical Center, The Netherlands
    Anesthesiology 94:982-91. 2001
  5. ncbi request reprint Recirculatory and compartmental pharmacokinetic modeling of alfentanil in pigs: the influence of cardiac output
    J A Kuipers
    Department of Anesthesiology, Leiden University Medical Center, The Netherlands
    Anesthesiology 90:1146-57. 1999
  6. ncbi request reprint Propofol alters the pharmacokinetics of alfentanil in healthy male volunteers
    M J Mertens
    Department of Anesthesiology, Leiden University Medical Center, The Netherlands
    Anesthesiology 94:949-57. 2001
  7. doi request reprint Permutation entropy of the electroencephalogram: a measure of anaesthetic drug effect
    E Olofsen
    Department of Anesthesiology, Leiden University Medical Center, Leiden University, Leiden, The Netherlands
    Br J Anaesth 101:810-21. 2008
  8. ncbi request reprint Speed of onset and offset and mechanisms of ventilatory depression from sevoflurane: an experimental study in the cat
    A Dahan
    Department of Anesthesiology, Leiden University Medical Center, The Netherlands
    Anesthesiology 90:1119-28. 1999
  9. ncbi request reprint The dynamic relationship between end-tidal sevoflurane and isoflurane concentrations and bispectral index and spectral edge frequency of the electroencephalogram
    E Olofsen
    Department of Anesthesiology, Leiden University Medical Center, The Netherlands
    Anesthesiology 90:1345-53. 1999
  10. ncbi request reprint Mechanism-based PK/PD modeling of the respiratory depressant effect of buprenorphine and fentanyl in healthy volunteers
    A Yassen
    Department of Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden, The Netherlands
    Clin Pharmacol Ther 81:50-8. 2007

Collaborators

Detail Information

Publications34

  1. ncbi request reprint The influence of remifentanil on the dynamic relationship between sevoflurane and surrogate anesthetic effect measures derived from the EEG
    Erik Olofsen
    Department of Anesthesiology, Leiden University Medical Center, Leiden, The Netherlands
    Anesthesiology 96:555-64. 2002
    ....
  2. ncbi request reprint Nonlinear mixed-effects modeling: individualization and prediction
    Erik Olofsen
    Department of Anesthesiology, Leiden University Medical Center, Leiden, The Netherlands
    Aviat Space Environ Med 75:A134-40. 2004
    ..The results serve to demonstrate the usefulness of mixed-effects modeling for data-driven development of individualized predictive models of fatigue and performance...
  3. pmc Population pharmacokinetics/pharmacodynamics of anesthetics
    Erik Olofsen
    Department of Anesthesiology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    AAPS J 7:E383-9. 2005
    ....
  4. ncbi request reprint Response surface modeling of alfentanil-sevoflurane interaction on cardiorespiratory control and bispectral index
    A Dahan
    Department of Anesthesiology, Leiden University Medical Center, The Netherlands
    Anesthesiology 94:982-91. 2001
    ..The authors examined the influence of the combined administration of sevoflurane and alfentanil on ventilatory control, heart rate (HR), and Bispectral Index (BIS) in healthy volunteers...
  5. ncbi request reprint Recirculatory and compartmental pharmacokinetic modeling of alfentanil in pigs: the influence of cardiac output
    J A Kuipers
    Department of Anesthesiology, Leiden University Medical Center, The Netherlands
    Anesthesiology 90:1146-57. 1999
    ..The influence of CO on the pharmacokinetic parameters of alfentanil in pigs was evaluated using compartmental and recirculatory models...
  6. ncbi request reprint Propofol alters the pharmacokinetics of alfentanil in healthy male volunteers
    M J Mertens
    Department of Anesthesiology, Leiden University Medical Center, The Netherlands
    Anesthesiology 94:949-57. 2001
    ..The influence of propofol on the pharmacokinetics of alfentanil is poorly understood. The authors therefore studied the effect of a pseudo-steady state concentration of propofol on the pharmacokinetics of alfentanil...
  7. doi request reprint Permutation entropy of the electroencephalogram: a measure of anaesthetic drug effect
    E Olofsen
    Department of Anesthesiology, Leiden University Medical Center, Leiden University, Leiden, The Netherlands
    Br J Anaesth 101:810-21. 2008
    ....
  8. ncbi request reprint Speed of onset and offset and mechanisms of ventilatory depression from sevoflurane: an experimental study in the cat
    A Dahan
    Department of Anesthesiology, Leiden University Medical Center, The Netherlands
    Anesthesiology 90:1119-28. 1999
    ..To learn more about the mechanisms of sevoflurane-induced respiratory depression, the authors also studied its influence on the dynamic ventilatory response to carbon dioxide...
  9. ncbi request reprint The dynamic relationship between end-tidal sevoflurane and isoflurane concentrations and bispectral index and spectral edge frequency of the electroencephalogram
    E Olofsen
    Department of Anesthesiology, Leiden University Medical Center, The Netherlands
    Anesthesiology 90:1345-53. 1999
    ..The authors analyzed the relationship between end-tidal sevoflurane and isoflurane concentrations (FET) and BIS and SEF and determined the speed of onset and offset of effect (t1/2k(e0))...
  10. ncbi request reprint Mechanism-based PK/PD modeling of the respiratory depressant effect of buprenorphine and fentanyl in healthy volunteers
    A Yassen
    Department of Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden, The Netherlands
    Clin Pharmacol Ther 81:50-8. 2007
    ..56, 95% confidence interval (CI): 0.50-0.62), whereas fentanyl displayed full respiratory depressant effect (alpha=0.91, 95% CI: 0.19-1.62)...
  11. ncbi request reprint Buprenorphine induces ceiling in respiratory depression but not in analgesia
    A Dahan
    Department of Anesthesiology, Leiden University Medical Center PO Box 9600, 2300 RC Leiden, The Netherlands
    Br J Anaesth 96:627-32. 2006
    ..The aim of the study was to compare buprenorphine's behaviour with respect to the occurrence of ceiling (or apparent maximum) in these typical micro-opioid protein-(MOP) receptor effects...
  12. ncbi request reprint Comparison of the respiratory effects of intravenous buprenorphine and fentanyl in humans and rats
    A Dahan
    Department of Anesthesiology, Leiden University Medical Center, Leiden, The Netherlands
    Br J Anaesth 94:825-34. 2005
    ..To study whether an apparent ceiling effect exists for respiratory depression induced by buprenorphine, we compared the respiratory effects of buprenorphine and fentanyl in humans and rats...
  13. ncbi request reprint A novel approach to identify responder subgroups and predictors of response to low- and high-dose capsaicin patches in postherpetic neuralgia
    C H Martini
    Department of Anesthesiology, Leiden University Medical Center, The Netherlands
    Eur J Pain 17:1491-501. 2013
    ..An alternative approach is the identification of specific patient subgroups characterized by differential response patterns in their analgesic response and to determine the presence of significant predictors of effect...
  14. doi request reprint Validation of a novel respiratory rate monitor based on exhaled humidity
    M Niesters
    Department of Anesthesiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Br J Anaesth 109:981-9. 2012
    ..measurement is inadequate when used with supplemental oxygen and ECG-derived RR is subject to artifacts. A new monitor measures RR by quantifying the humidity of exhaled air (respiR8(®))...
  15. ncbi request reprint Recirculatory pharmacokinetics and pharmacodynamics of rocuronium in patients: the influence of cardiac output
    J A Kuipers
    Department of Anesthesiology, Leiden University Medical Center, Leiden, The Netherlands
    Anesthesiology 94:47-55. 2001
    ..For drugs with a fast onset of effect, a recirculatory model, which includes CO, can give a good description of the relation between concentration and effect, in contrast to a conventional compartmental pharmacokinetic model...
  16. ncbi request reprint Modeling population pharmacokinetics of lidocaine: should cardiac output be included as a patient factor?
    J A Kuipers
    Department of Anesthesiology, Leiden University Medical Center, The Netherlands
    Anesthesiology 94:566-73. 2001
    ..Inclusion of cardiac output and other physiologic parameters, in addition to or instead of, demographic variables might improve the population pharmacokinetic modeling of lidocaine...
  17. ncbi request reprint Pharmacokinetic-pharmacodynamic modeling of morphine-6-glucuronide-induced analgesia in healthy volunteers: absence of sex differences
    Raymonda Romberg
    Department of Anesthesiology, Leiden University Medical Center, The Netherlands
    Anesthesiology 100:120-33. 2004
    ....
  18. ncbi request reprint Mechanism-based pharmacokinetic-pharmacodynamic modelling of the reversal of buprenorphine-induced respiratory depression by naloxone : a study in healthy volunteers
    Ashraf Yassen
    Division of Pharmacology, Leiden Amsterdam Centre for Drug Research, Leiden, The Netherlands
    Clin Pharmacokinet 46:965-80. 2007
    ..The aim of this study was to characterise the pharmacodynamic interaction between buprenorphine and naloxone in healthy volunteers...
  19. pmc Pharmacokinetic-pharmacodynamic modeling of the effectiveness and safety of buprenorphine and fentanyl in rats
    Ashraf Yassen
    Division of Pharmacology, Gorlaeus Laboratories, Leiden Amsterdam Center for Drug Research, Leiden, The Netherlands
    Pharm Res 25:183-93. 2008
    ..The objective of this investigation was to characterize the relationship between buprenorphine or fentanyl exposure and the effectiveness and safety outcome in rats...
  20. ncbi request reprint The interaction between propofol and clonidine for loss of consciousness
    Hideyuki Higuchi
    Department of Anesthesia, Self Defense Force Central Hospital, Tokyo, Japan
    Anesth Analg 94:886-91, table of contents. 2002
    ..These results indicate that propofol and clonidine act additively for loss of consciousness...
  21. ncbi request reprint Response surface modeling of remifentanil-propofol interaction on cardiorespiratory control and bispectral index
    Diederik J F Nieuwenhuijs
    Department of Anesthesiology, Leiden University Medical Center, The Netherlands
    Anesthesiology 98:312-22. 2003
    ..Since propofol and remifentanil are frequently combined for monitored anesthesia care, we examined the influence of the separate and combined administration of these agents on cardiorespiratory control and bispectral index in humans...
  22. ncbi request reprint Propofol reduces perioperative remifentanil requirements in a synergistic manner: response surface modeling of perioperative remifentanil-propofol interactions
    Martijn J Mertens
    Department of Anesthesiology, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands
    Anesthesiology 99:347-59. 2003
    ..The authors studied the effect of propofol on remifentanil requirements for suppression of responses to clinically relevant stimuli and evaluated this in relation to previously published data on propofol and alfentanil...
  23. ncbi request reprint Mixed-model regression analysis and dealing with interindividual differences
    Hans P A Van Dongen
    Unit for Experimental Psychiatry, University of Pennsylvania School of Medicine, Pennsylvania, Philadelphia 19104 6021, USA
    Methods Enzymol 384:139-71. 2004
  24. ncbi request reprint Mixed-effects modeling of the influence of alfentanil on propofol pharmacokinetics
    Martijn J Mertens
    Department of Anesthesiology, Leiden University Medical Center, The Netherlands
    Anesthesiology 100:795-805. 2004
    ..The influence of alfentanil on the pharmacokinetics of propofol is poorly understood. Therefore, the authors studied the effect of a pseudo-steady state concentration of alfentanil on the pharmacokinetics of propofol...
  25. ncbi request reprint Influence of propofol on the control of breathing
    Albert Dahan
    Department of Anaesthesiology, Leiden University Medical Center, Leiden, The Netherlands
    Adv Exp Med Biol 523:81-92. 2003
  26. ncbi request reprint Pharmacodynamic effect of morphine-6-glucuronide versus morphine on hypoxic and hypercapnic breathing in healthy volunteers
    Raymonda Romberg
    Department of Anesthesiology, Leiden University Medical Center, The Netherlands
    Anesthesiology 99:788-98. 2003
    ..Because M6G will be on the market in the near future, the authors assessed the time profile and relative potency of M6G's effect versus morphine's effect on carbon dioxide-driven and hypoxic breathing...
  27. ncbi request reprint Simultaneous measurement and integrated analysis of analgesia and respiration after an intravenous morphine infusion
    Albert Dahan
    Department of Anesthesiology, Leiden University Medical Center, The Netherlands
    Anesthesiology 101:1201-9. 2004
    ..Both respiratory and pain measurements were performed over single 24-h time spans...
  28. ncbi request reprint Alfentanil and placebo analgesia: no sex differences detected in models of experimental pain
    Erik Olofsen
    Department of Anesthesiology, Leiden University Medical Center, Leiden, The Netherlands
    Anesthesiology 103:130-9. 2005
    ....
  29. ncbi request reprint Animal-to-human extrapolation of the pharmacokinetic and pharmacodynamic properties of buprenorphine
    Ashraf Yassen
    Leiden Amsterdam Center for Drug Research, Division of Pharmacology, Gorleaus Laboratories, Leiden, The Netherlands
    Clin Pharmacokinet 46:433-47. 2007
    ..This investigation describes the interspecies scaling of the pharmacokinetics and pharmacodynamics of buprenorphine...
  30. ncbi request reprint Naloxone reversal of buprenorphine-induced respiratory depression
    Eveline van Dorp
    Department of Anesthesiology, Leiden University Medical Center, The Netherlands
    Anesthesiology 105:51-7. 2006
    ..The studies were designed in light of the claims that buprenorphine is relatively resistant to the effects of naloxone...
  31. ncbi request reprint Mechanism-based pharmacokinetic-pharmacodynamic modeling of the antinociceptive effect of buprenorphine in healthy volunteers
    Ashraf Yassen
    Leiden Amsterdam Center for Drug Research, Division of Pharmacology, Gorlaeus Laboratories, The Netherlands
    Anesthesiology 104:1232-42. 2006
    ..The objective of this investigation was to characterize the pharmacokinetic-pharmacodynamic relation of buprenorphine's antinociceptive effect in healthy volunteers...
  32. ncbi request reprint Pharmacokinetic-pharmacodynamic modeling of the antinociceptive effect of buprenorphine and fentanyl in rats: role of receptor equilibration kinetics
    Ashraf Yassen
    Leiden Amsterdam Center for Drug Research, Division of Pharmacology, Gorlaeus Laboratories, The Netherlands
    J Pharmacol Exp Ther 313:1136-49. 2005
    ..In contrast to earlier reports in the literature, the findings of this study show that the rate-limiting step in the onset and offset of buprenorphine's antinociceptive effect is distribution to the brain...
  33. ncbi request reprint Polymorphism of mu-opioid receptor gene (OPRM1:c.118A>G) does not protect against opioid-induced respiratory depression despite reduced analgesic response
    Raymonda R Romberg
    Department of Anesthesiology, Leiden University Medical Center, The Netherlands
    Anesthesiology 102:522-30. 2005
    ..118A>G) was investigated on morphine-6-glucuronide (M6G)-induced analgesia and respiratory depression in a group of healthy volunteers...
  34. ncbi request reprint Increased margin of safety of morphine-6-glucuronide relative to morphine
    Raymonda Romberg
    Anesthesiology 100:1622; author reply 1622-3. 2004