T Mutis

Summary

Affiliation: Leiden University
Country: The Netherlands

Publications

  1. ncbi request reprint Feasibility of immunotherapy of relapsed leukemia with ex vivo-generated cytotoxic T lymphocytes specific for hematopoietic system-restricted minor histocompatibility antigens
    T Mutis
    Department of Immunohematology and Blood Bank, Leiden University Medical Center, Leiden, The Netherlands
    Blood 93:2336-41. 1999
  2. ncbi request reprint Tetrameric HLA class I-minor histocompatibility antigen peptide complexes demonstrate minor histocompatibility antigen-specific cytotoxic T lymphocytes in patients with graft-versus-host disease
    T Mutis
    The Department of Immunohematology and Blood Bank, Leiden University Medical Center, The Netherlands
    Nat Med 5:839-42. 1999
  3. ncbi request reprint Polyriboinosinic polyribocytidylic acid (poly(I:C)) induces stable maturation of functionally active human dendritic cells
    R M Verdijk
    Department of Immunohematology and Blood Bank, Leiden University Medical Center, Leiden, The Netherlands
    J Immunol 163:57-61. 1999
  4. ncbi request reprint Escherichia coli-nitroreductase suicide gene control of human telomerase reverse transcriptase-transduced minor histocompatibility antigen-specific cytotoxic T cells
    R M Verdijk
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Bone Marrow Transplant 33:963-7. 2004
  5. ncbi request reprint Targeting alloreactive T cells to hematopoietic system specific minor histocompatibility antigens for cellular immunotherapy of hematological malignancies after stem cell transplantation
    T Mutis
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Ann Hematol 81:S38-9. 2002
  6. pmc Small intestinal T cells of celiac disease patients recognize a natural pepsin fragment of gliadin
    Y van de Wal
    Department of Immunohaematology and Bloodbank, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Proc Natl Acad Sci U S A 95:10050-4. 1998

Collaborators

  • E Goulmy
  • O Molberg
  • L M Sollid
  • R M Verdijk
  • A Brand
  • Y van de Wal
  • A Kloosterman
  • M Wilke
  • V Beslier
  • C J Melief
  • J Kamp
  • B Esendam
  • F Koning
  • K E Lundin
  • P A van Veelen
  • Y M Kooy
  • L M Mearin
  • S A Peña
  • J W Drijfhout
  • W E Benckhuijsen

Detail Information

Publications6

  1. ncbi request reprint Feasibility of immunotherapy of relapsed leukemia with ex vivo-generated cytotoxic T lymphocytes specific for hematopoietic system-restricted minor histocompatibility antigens
    T Mutis
    Department of Immunohematology and Blood Bank, Leiden University Medical Center, Leiden, The Netherlands
    Blood 93:2336-41. 1999
    ..Sufficient numbers of the CTLs can be obtained for the adoptive immunotherapy purposes. In conclusion, we present a feasible, novel therapy for the treatment for relapsed leukemia after BMT with a low risk of GVHD...
  2. ncbi request reprint Tetrameric HLA class I-minor histocompatibility antigen peptide complexes demonstrate minor histocompatibility antigen-specific cytotoxic T lymphocytes in patients with graft-versus-host disease
    T Mutis
    The Department of Immunohematology and Blood Bank, Leiden University Medical Center, The Netherlands
    Nat Med 5:839-42. 1999
    ..HLA class I-mHag peptide tetramers may serve as clinical tools for the diagnosis and monitoring of GvHD patients...
  3. ncbi request reprint Polyriboinosinic polyribocytidylic acid (poly(I:C)) induces stable maturation of functionally active human dendritic cells
    R M Verdijk
    Department of Immunohematology and Blood Bank, Leiden University Medical Center, Leiden, The Netherlands
    J Immunol 163:57-61. 1999
    ..In conclusion, we present a simple methodology for the preparation of clinically applicable mature DC...
  4. ncbi request reprint Escherichia coli-nitroreductase suicide gene control of human telomerase reverse transcriptase-transduced minor histocompatibility antigen-specific cytotoxic T cells
    R M Verdijk
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Bone Marrow Transplant 33:963-7. 2004
    ..This is the first application of the E. coli-nitroreductase gene for the elimination of human T cells with metronidazole...
  5. ncbi request reprint Targeting alloreactive T cells to hematopoietic system specific minor histocompatibility antigens for cellular immunotherapy of hematological malignancies after stem cell transplantation
    T Mutis
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Ann Hematol 81:S38-9. 2002
  6. pmc Small intestinal T cells of celiac disease patients recognize a natural pepsin fragment of gliadin
    Y van de Wal
    Department of Immunohaematology and Bloodbank, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Proc Natl Acad Sci U S A 95:10050-4. 1998
    ..The characterization of such epitopes is a key step toward the development of strategies to interfere in mechanisms involved in the pathogenesis of celiac disease...